DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and Trpm7

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	XP_038961765.1	Gene:	Trpm7 / 679906	RGDID:	620053	Length:	1878	Species:	Rattus norvegicus

Alignment Length:	1638	Identity:	611/1638 - (37%)
Similarity:	902/1638 - (55%)	Gaps:	233/1638 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSPGDL--- 163
            :||||:...||||:..||..||.             .:|.||:....|.......:....|:
  Rat    20 KSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLATKYSDVKLG 84

  Fly   164 ---------WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELP 219
                     |...|||...||||||.|.||||:|..:|:|||||:||:||:::||..|||.:|||
  Rat    85 EHFNQAIEEWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEIILQLLLKEWQMELP 149

  Fly   220 KLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGR 284
            ||:|:|.||...|:|..::|:.:.|||:|||.||||||.|||.||||.|.|||||.....:.:.:
  Rat   150 KLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHASRSSRK 214

  Fly   285 VVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILR 349
            :.:|||||||::|..::|:|.:...|..::.:|.|||.||||.|::|:|||:||..|||||:.||
  Rat   215 ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVRLR 279

  Fly   350 RKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFV 414
            |:|||.|:..::|.......|||.|:.|||.|.|..||||:.:|||||||||:|:||||||||::
  Rat   280 RELEKTINQQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADLLAYI 344

  Fly   415 HKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEA 479
            ||...:|...|  ::....:|.||:|||..|..::..|:|.:::|.:.|.|||||.|..:   :.
  Rat   345 HKQTEEGGNLP--DAAEPDIISTIKKTFNFGQSEAVHLFQTMMECMKKKELITVFHIGSE---DH 404

  Fly   480 QELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRID 544
            |::|..|||||.|..:.|..:||.|.|.|:|||||::.:|||||:|..|:|::||:.||..||:.
  Rat   405 QDIDVAILTALLKGTNASAFDQLILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVS 469

  Fly   545 FVKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRP-HIPKGYIYTLHDIGLVINK 607
            |||||:||||||.|||||||||||||||.||.| .|.:::|||:. ::|.||..||.||||||..
  Rat   470 FVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPMLFHLIRDVKQGNLPPGYKITLIDIGLVIEY 534

  Fly   608 LMGGAYRSYYTRRKFRPIY---------------------AKVMNSYANACRKSSTYQY------ 645
            ||||.||..|||::||.||                     .|...::.|...|....::
  Rat   535 LMGGTYRCTYTRKRFRLIYNSLGGNNRRSGRNASSSTPQLRKSHETFGNRADKKEKMRHNHFIKT 599

  Fly   646 -QRYAGANSLSLVTGLLPFTS---------EMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 700
             |.|......|:..|....|.         |...|.:|.|||||||.|.|||.||..:|.||||:
  Rat   600 AQPYRPKMDASMEEGKKKRTKDEIVDIDDPETKRFPYPLNELLIWACLMKRQVMARFLWQHGEES 664

  Fly   701 LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCEL 765
            :||:||:||:|::||:||.:.||..:..|||:.|:.:|.....:||:.|:|||...|.:|||.||
  Rat   665 MAKALVACKIYRSMAYEAKQSDLVDDTSEELKQYSNDFGQLAVELLEQSFRQDETMAMKLLTYEL 729

  Fly   766 HSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKS 830
            .:|||.:||.|||::..|..:||.|:|::|:|:|||.|..|||:.:||||.:.:|..|..|::|:
  Rat   730 KNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILMLEYKT 794

  Fly   831 KEELQQMPQTEEEHLENQNLDNDDSDRSQPD-AEALLADTYSVRDTKVHENGKVSLTDSDTAQFR 894
            |.|:..:||:::.|    .:..:||:.:..: .|.:..:.:.          :|.:.||...:
  Rat   795 KAEMSHIPQSQDAH----QMTMEDSENNFHNITEEIPMEVFK----------EVKILDSSEGK-- 843

  Fly   895 EFFNLSEYNEVKQH---QPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRW 956
                    ||::.|   :.|.:.:|||.||.|||.|||.:::||:.||::::|.|||:|||:|..
  Rat   844 --------NEMEIHIKSKKLPITRKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVQMEQLPSV 900

  Fly   957 QEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRE---- 1017
            |||..||||.|...||:||:..||...|:.|..||..:.:|..|..|||.|.:|...||..
  Rat   901 QEWIVIAYIFTYAIEKIREVFMSEAGKISQKIKVWFSDYFNVSDTIAIISFFVGFGLRFGAKWNY 965

  Fly  1018 -NTMD-----IGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSF 1076
             |..|     .||:|||::.|:||:|:|:.|.||:..||.|.|:||||.||.|.||::|:||:||
  Rat   966 INAYDNHVFVAGRLIYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSF 1030

  Fly  1077 GVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPG-CVTGHWVTPITMS 1140
            ||.|:|||||:::|:|||.|::.|.||:|::|||:|.:|| .|..|.:.|. |..|.|:||...:
  Rat  1031 GVPRKAILYPHEEPSWSLAKDIVFHPYWMIFGEVYAYEID-VCANDSALPTICGPGTWLTPFLQA 1094

  Fly  1141 MYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLL- 1204
            :||.:..|:::|||||.|||::.:|.::|:.||.:||:..:|.|.:|||||||.|.|.|..||.
  Rat  1095 VYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHIVSLFC 1159

  Fly  1205 KYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVE 1269
            ..|.|:.|.   :..:|.||||.::|.::|:||||:|||.:|.|::...|..::||::.|.||||
  Rat  1160 CICKRRKKD---KTSDGPKLFLTEEDQKKLHDFEEQCVEMYFDEKDDKFNSGSEERIRVTFERVE 1221

  Fly  1270 TMSQKIEDINQKENIQTATVQNIEFRLRKMEESS-----------EQILSHLAVIHRFMSTHTAG 1323
            .||.:|:::..:.|....::|:::.::..:::.|           .|..|..:.:|..::...:.
  Rat  1222 QMSIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSI 1286

  Fly  1324 ADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRR 1388
            :..|..:.|:........:..|:.:|...|.|.|:                            |.
  Rat  1287 SKHLAQNLIDDVPVRPMWKKPSVVNTLSSSLPQGD----------------------------RE 1323

  Fly  1389 RFNRSLTEVRPDAYIFDE--------GTHFEVVP------LPE-------------EPDEVVKSR 1426
            ..|..|..:    ::.||        |....|:|      :||             .|.|:.:.|
  Rat  1324 SNNPFLCNI----FMKDEKDPQYNLFGQDLPVIPQRKEFNIPEAGSSCGALFPSAVSPPELRQRR 1384

  Fly  1427 EALNEQVV--RKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTL---TPM 1486
            ..:....:  :...:.|..:|.   |....|.|..:|......:.:....::|:..:.:   ...
  Rat  1385 HGVEMLKIFNKNQKLGSSPNSS---PHMSSPPTKFSVSTPSQPSCKSHLESTTKDPEPIFYKAAE 1446

  Fly  1487 GNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLT---GADINRSHISLN 1548
            |:|.:....||..:|.|        ..|.:....:...|...::...:|.   .|..|..|.:..
  Rat  1447 GDNIEFGAFVGHRDSMD--------LQRFKETSNKIRELLSNDTPENTLKHVGAAGYNECHKTPT 1503

  Fly  1549 QL----ASLSRRQMSLTQSEPDSD----------KDAP----------IAQGSAHPGKSVL---- 1585
            .|    .|.|||  :.|:..||.|          :|.|          ...|.|.|.|.||
  Rat  1504 SLHSEQESCSRR--ASTEDSPDVDSRAALLPDWLRDRPTNREMPSEGGTLNGLASPFKPVLDTNY 1566

  Fly  1586 -HAKPSRNILLKL 1597
             ::...||.|::|
  Rat  1567 YYSAVERNNLMRL 1579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	106/226 (47%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	13/61 (21%)
Trpm7	XP_038961765.1	LSDAT_euk	122..387	CDD:407971	135/266 (51%)
		trp	<738..1188	CDD:273311	196/477 (41%)
		TRPM_tetra	1210..1263	CDD:406826	13/52 (25%)
		Alpha_kinase_ChaK1_TRMP7	1593..1831	CDD:341221
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339770
Domainoid	1	1.000	408	1.000	Domainoid score	I675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I195
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45074
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900