DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Trpm and TRPM4

DIOPT Version :9

Sequence 1:NP_001097320.1 Gene:Trpm / 36694 FlyBaseID:FBgn0265194 Length:2023 Species:Drosophila melanogaster
Sequence 2:NP_060106.2 Gene:TRPM4 / 54795 HGNCID:17993 Length:1214 Species:Homo sapiens


Alignment Length:1328 Identity:368/1328 - (27%)
Similarity:614/1328 - (46%) Gaps:228/1328 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 PLKEHQPRSWIETNFQKRECIKFIPCPKD--DTKCCCGQAQITHQTIPGIES--GSPGDLWLPTK 168
            |.||   :|||...|:|:.|..||....|  .|.|.||:.:..|..:...::  .:...:|....
Human     4 PEKE---QSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDA 65

  Fly   169 HTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFD 233
            ||..:||||||.::|. ||....:.::|||..|.|..:..|.|:.|....|.|:::|.||.....
Human    66 HTTEKPTDAYGELDFT-GAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPV 129

  Fly   234 LQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIV 296
            ||..|:..:|:||::||::|||||.|||.:||:.:.||.|:.......||  :||::|:||||:|
Human   130 LQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVV 194

  Fly   297 ERNHELLGHNREVPCH---------SISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKL 352
            .....|:......|..         .:..|      |:..::.|.|||:||....|.|...|.:|
Human   195 RNRDTLINPKGSFPARYRWRGDPEDGVQFP------LDYNYSAFFLVDDGTHGCLGGENRFRLRL 253

  Fly   353 EKFISNLKLH-PFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHK 416
            |.:||..|.. ..|....||:.|:|:|....:..: |..|.: .:|.::..|||.|||.||    
Human   254 ESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRI-ENATQA-QLPCLLVAGSGGAADCLA---- 312

  Fly   417 YASDGEEQPVLESMRDYLI------------GTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVF 469
                       |::.|.|.            ..|::.|..|  ..|.|..::.:....|.|:||:
Human   313 -----------ETLEDTLAPGSGGARQGEARDRIRRFFPKG--DLEVLQAQVERIMTRKELLTVY 364

  Fly   470 RIQEKPEGEAQELDQTILTALFK----SQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGAL 530
                ..|..::|.:..:|.||.|    |:..:..::|.||:.|||||||:||:|....:|.:..|
Human   365 ----SSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHL 425

  Fly   531 DEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIP---- 591
            :.::|.||.:||.:||:||:.:|:|:..|||..||.:||:.  .|:|:|...|.|...|..    
Human   426 EASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHSAGTKA 488

  Fly   592 ---KGYIYTLH--DIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAG- 650
               ||....|.  |:|.|:..|:|                 |:.     |.|..|...:..:.| 
Human   489 PALKGGAAELRPPDVGHVLRMLLG-----------------KMC-----APRYPSGGAWDPHPGQ 531

  Fly   651 --ANSLSLVT--GLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLY 711
              ..|:.|::  ...|.:.:..|.:.|:::||:||:|..|.|||:..|..|..|::.:|.:|.|.
Human   532 GFGESMYLLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLL 596

  Fly   712 KAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSL 776
            :.||..    :.|.|.....:..|.:||..|..|....||....:|.|||......|.:.:||.|
Human   597 RVMARL----EPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQL 657

  Fly   777 AVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMP--FYIRQLDFKSKEELQQMPQ 839
            |:.|:.||..|....|.:|...|.|.:.: ....:.::|....|  .|.|.:.|:..||      
Human   658 AMQADARAFFAQDGVQSLLTQKWWGDMAS-TTPIWALVLAFFCPPLIYTRLITFRKSEE------ 715

  Fly   840 TEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNE 904
                               :|..|.|..|    .|:.::..|.|...|.                
Human   716 -------------------EPTREELEFD----MDSVINGEGPVGTADP---------------- 741

  Fly   905 VKQHQPL-------------------RLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKM 950
             .:..||                   |..::::.|:.||:|.|..:.::|:.||::||..:||..
Human   742 -AEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDF 805

  Fly   951 EQMPRWQ-EWYSIAYITTLGFEKVRE--------IISSEP----VAITHKFSVWAWNMWNPCDGA 1002
            :..|... |.....:..||..|::|:        :.|..|    .:::.:..::..:.||.||..
Human   806 QPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLV 870

  Fly  1003 AIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVV 1067
            |:..|::|:..|.......:||.:.|:|.:.:.:|:|:|..|||.|||.:.::.||:|::.:|:.
Human   871 ALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLF 935

  Fly  1068 LLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID------PPCGEDPS-- 1124
            .|.|.|:::||:.:.:|.|......|:::.|.::||..::|::...|:|      ..|..:|.  
Human   936 FLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFW 1000

  Fly  1125 --QPG-----CVT--GHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTV 1180
              .||     ||:  .:|:..:.:.::||:|||||:|||||:|:..|.:|...|...|..||:.:
Human  1001 AHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL 1065

  Fly  1181 VMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRD--NGLKLFLEKDDLERLYDFEEECVE 1243
            :.|:..:|.|.||||.:.|...||:...|:.:..:....  ...:::|.|:...:|..:|.    
Human  1066 IREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWES---- 1126

  Fly  1244 GFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILS 1308
              .|::..:|.::.|:| ::.:||::..|||: |:..|   |...::..|.||:.:|...:|...
Human  1127 --VHKENFLLARARDKR-ESDSERLKRTSQKV-DLALK---QLGHIREYEQRLKVLEREVQQCSR 1184

  Fly  1309 HLAVIHRFMSTHTAGADDLRGSTINIPG 1336
            .|..:          |:.|..|.:..||
Human  1185 VLGWV----------AEALSRSALLPPG 1202

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpmNP_001097320.1 Ion_trans 951..1167 CDD:278921 69/245 (28%)
TRPM_tetra 1262..1313 CDD:293127 14/50 (28%)
TRPM4NP_060106.2 LSDAT_euk 90..357 CDD:423023 87/291 (30%)
trp <851..1083 CDD:273311 72/231 (31%)
Selectivity filter. /evidence=ECO:0000305|PubMed:29211723 975..977 0/1 (0%)
Calmodulin-binding 1076..1176 27/110 (25%)
Mediates modulation by decavanadate and PIP2-binding. /evidence=ECO:0000269|PubMed:16424899 1136..1141 1/4 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146030
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323456at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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