DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and TRPM1

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001238949.1	Gene:	TRPM1 / 4308	HGNCID:	7146	Length:	1642	Species:	Homo sapiens

Alignment Length:	1826	Identity:	680/1826 - (37%)
Similarity:	978/1826 - (53%)	Gaps:	333/1826 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDDTKCCCGQ 144
            ||.|:.|:.|               ||    :...:||||..|.|||||..||..||..:||||
Human     5 KRGSLKSSTS---------------GS----QKGQKSWIEKTFCKRECIFVIPSMKDSNRCCCG- 49

  Fly   145 AQITHQTIPGIESGSPG-------------DLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVR 196
             |.|:|.||.:.|.:|.             :.|...|||:..|||:||.:|||||.:..||.|:|
Human    50 -QFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGGYSNKAMYIR 113

  Fly   197 LSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGG 261
            :|:||:|:.|:.|..|:|.||||||||:|.||..||::|.|||:...|||:|||.||||||||||
Human   114 VSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGG 178

  Fly   262 TNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNN 326
            .:|||...|||||.....:..|||.:||||||||||...:|:|.:......::|:|.|||:||||
Human   179 VSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNN 243

  Fly   327 RHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVT 391
            .|.:|:|.||||..|||||:.|||.|||.||..|::.......|:|.||:|||.|.:..||||:.
Human   244 SHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQ 308

  Fly   392 DSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQEL 456
            :.||:|||:|||||||:|:|:|.|||..:|  ..:.||:|:.|:.||||||.....||.:|:..:
Human   309 EEPPIPVVICDGSGRASDILSFAHKYCEEG--GIINESLREQLLVTIQKTFNYNKAQSHQLFAII 371

  Fly   457 LQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVY 521
            ::|.:.|.|:||||:..  ||: |:::..|||||.|..::|.|:||||||.|||||||||:|||:
Human   372 MECMKKKELVTVFRMGS--EGQ-QDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVF 433

  Fly   522 GQEWPN----------------------------------------------------------G 528
            |..||.                                                          .
Human   434 GPHWPPLGSLAPPTDSKATEKEKKPPMATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVN 498

  Fly   529 ALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDV-RPHIPK 592
            ||::||:.||..||:||||||:||||:|:.|||||||||||||:.||.|||..::||| :.::|.
Human   499 ALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPP 563

  Fly   593 GYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLV 657
            .|..:|.|||||:..|||||||..|||:.||.:|             ::.:..:|......|.:.
Human   564 DYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLY-------------NNLFGPKRPKALKLLGME 615

  Fly   658 TGLLPFTSE-------------------MALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAK 703
            ....|...:                   ::.|::||:||::||||.|||:||:.:|..|||::||
Human   616 DDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAK 680

  Fly   704 SLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSW 768
            :||:||||||||||::|.||..:|.::|.:.:|:|.....:|||.||:.|.:.|.:|||.||.:|
Human   681 ALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNW 745

  Fly   769 SNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEE 833
            ||.:||.|||||.||..:||.|||::|.|:|||.||.|||...|||:|:.:|..|..|:|::.::
Human   746 SNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDD 810

  Fly   834 LQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFN 898
            ...  ||.:|:.:.:..:.:::| :..||.:...|
Human   811 FSY--QTSKENEDGKEKEEENTD-ANADAGSRKGD------------------------------ 842

  Fly   899 LSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIA 963
              |.||.|:.:.:.:..|..|||.|||.|||..:|:|:.:|::|::.:||:|:..|..|||..|:
Human   843 --EENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVIS 905

  Fly   964 YITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENT-MDIGRVIY 1027
            ||.:|..||:|||:.|||..::.|..||....||..|..||..|:||...|.:... |..|||||
Human   906 YIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIY 970

  Fly  1028 CVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTW 1092
            |||.|:||:|:|:|.||||||||.|.|:|||:.:|:||||::.||||||||:|||||:|.::|:|
Human   971 CVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSW 1035

  Fly  1093 SLIKEVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHWVTPITMSMYLL 1144
            .|.:.:.:.||:|:||||||..||       |||||:      ...|.|:.|.|:||..|:.|||
Human  1036 KLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLL 1100

  Fly  1145 IANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLK---- 1205
            :|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|.|.|.|.::.
Human  1101 VANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSG 1165

  Fly  1206 YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVET 1270
            .|.:|.:|.:.:||.||||||..::|:||::|||:||:..|.|:|.....|:|||::.|:||||.
Human  1166 RCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVEN 1230

  Fly  1271 MSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGAD--DLRGSTIN 1333
            ||.::|:||::|.....::|.::.||.::||.|.::::.|        .:.||.|  ||..:...
Human  1231 MSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNAL--------ENLAGIDRSDLIQARSR 1287

  Fly  1334 IPGEMQR---MRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLT 1395
            ...|.:.   :|..||:..:|.|                               ..|..||
Human  1288 ASSECEATYLLRQSSINSADGYS-------------------------------LYRYHFN---- 1317

  Fly  1396 EVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREA---LNEQVVRKASMQSEADSDIYIPVSQRPS- 1456
                     .|...||...|...|...|:.:..   :.|:...|..:..|..:.:::.:....|
Human  1318 ---------GEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPECQNSLHLSLGTSTSA 1373

  Fly  1457 -------------TCETVKRTPYVTV-RQDTGASTESK--DTLTPMGNNDDDQTLVGGDNSDDAT 1505
                         ..|..|..|.:.: ::|....|:||  :|::|..|..|  .:.|.|.||...
Human  1374 TPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPSLNKTD--VIHGQDKSDVQN 1436

  Fly  1506 PDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKD 1570
                         .|.||       ||.::.|.            .|....:..:|:..||...:
Human  1437 -------------TQLTV-------ETTNIEGT------------ISYPLEETKITRYFPDETIN 1469

  Fly  1571 APIAQGSAHPGKSVLHAKPSRNIL--LKLHSEYTSITDE---LESVCHMIASPTVSLPSNKASLD 1630
            |.....|    :|.:::: .|.::  :....||:||||:   .|..|.      |...:...|.|
Human  1470 ACKTMKS----RSFVYSR-GRKLVGGVNQDVEYSSITDQQLTTEWQCQ------VQKITRSHSTD 1523

  Fly  1631 RPKTEMSRAEAAALLEKKHLKECEENDYMILEGL--IESRGSIDASAQGFE--IGVSIDYSHRYP 1691
            .|...   :|||...|.|......::::.:.|.:  |...........|.|  :.|..|.:..:|
Human  1524 IPYIV---SEAAVQAEHKEQFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPDQTLGFP 1585

  Fly  1692 LRRETAVELSP-SKPSVDGDLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQLKNERPWQRN 1755
            ..|..::...| :..|:.|.|               |.||..|..:.:.|.||...:.::..:..
Human  1586 SLRSKSLHGHPRNVKSIQGKL---------------DRSGHASSVSSLVIVSGMTAEEKKVKKEK 1635

  Fly  1756 SSMEQQ 1761
            :|.|.:
Human  1636 ASTETE 1641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	121/229 (53%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	18/50 (36%)
TRPM1	NP_001238949.1	Ion_trans	893..1123	CDD:278921	121/229 (53%)
TRPM1	NP_001238949.1	TRPM_tetra	1222..1273	CDD:293127	18/58 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146033
Domainoid	1	1.000	408	1.000	Domainoid score	I698
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I207
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	1	1.000	-	-		FOG0002675
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2859
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930