Protein Alignment Trpm and Trpm3

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: NP_001178491.1
• Gene: Trpm3 / 309407
• RGDID: 1304888
• Length: 1721
• Species: Rattus norvegicus
• Alignment Length: 1806
• Identity: 715/1806 - (39%)
• Similarity: 997/1806 - (55%)
• Gaps: 298/1806 - (16%)

  Fly    73 RRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDD 137
            |||.|...|...:.:..:   |:.:......:|....:....:||||..|.||||:..||..||.
  Rat    25 RRRSRSASRGRFAESWKR---LSSKQGSTKRSGLPAQQTPAQKSWIERAFYKRECVHIIPSTKDP 86

  Fly   138 TKCCCGQAQITHQTI-PGI--------ESG-SPGDL----WLPTKHTRPQPTDAYGTIEFQGGAH 188
            .:||||:....|..: |.|        ||. |..|:    |..:|||:..||||:||||||||.|
  Rat    87 HRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGH 151

  Fly   189 PTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTT 253
            ..||.|||:||||:|:||:.|.||||.||||||||:|.||..||:||.|||:...|||:|||.||
  Rat   152 SNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 216

  Fly   254 GAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPR 318
            ||||||||.||||.:.|||||.....:..|::.:||||||||||...:|:|.:...|..::|:|.
  Rat   217 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPM 281

  Fly   319 SKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTI 383
            |||.|||:.|::|:|.||||..|||||:.|||:|||.||..|::.......|||.|::|||.|.|
  Rat   282 SKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVALIVEGGPNVI 346

  Fly   384 RAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQ 448
            ..||||:.|:||||||||||||||:|:|||.|||:.:|  ..:.||:||.|:.||||||.....|
  Rat   347 SIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEG--GLINESLRDQLLVTIQKTFTYTRTQ 409

  Fly   449 SEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDI 513
            ::.|:..|::|.:.|.||||||:..  ||. |::|..|||||.|..:.|.|:||||||.||||||
  Rat   410 AQHLFIILMECMKKKELITVFRMGS--EGH-QDIDLAILTALLKGANASAPDQLSLALAWNRVDI 471

  Fly   514 ARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANT 578
            |||:||:|||:||.|:|::||:.||..||:||||||:||||||.:||||.||||||||:|||:||
  Rat   472 ARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNT 536

  Fly   579 LGYILRDVRP-HIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSST 642
            |.:::|||:. ::|..|..:|.||||||..|||||||..|||::||.:|..:.........|
  Rat   537 LYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK--- 598

  Fly   643 YQYQRYAGANSLSLVTGLLPFTSEMAL-------------------------FEFPFNELLIWAV 682
                             ||....::.|                         |.|||:||::|||
  Rat   599 -----------------LLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAV 646

  Fly   683 LTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLD 747
            |.|||:|||..|.|||||:||:||:|||.|||||||:|:|:..:|.:||...:::|.....:|||
  Rat   647 LMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLD 711

  Fly   748 FSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFK 812
            .||:||.:.|.:|||.||.:|||.:||.|||||.||..:||.|||::|.|:|||.||.|||:..|
  Rat   712 QSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLK 776

  Fly   813 VILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAE-----ALLADTYSV 872
            ||||:.:|..|..|:||:|:::..|.|.:|.||:.:..:..:....:.|.|     |:|.
  Rat   777 VILGILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLG----- 836

  Fly   873 RDTKVHENGKVS-LTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYM 936
                 ..||:.| ..|.:..|.|             |:.:.:.:|.||||.|||.|||..::||:
  Rat   837 -----RNNGESSRKKDEEEVQSR-------------HRLIPVGRKIYEFYNAPIVKFWFYTLAYI 883

  Fly   937 FFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDG 1001
            .:|::|::.||||||:.|..|||..|:||.|||.||:|||:.|||..:..|..||....||..|.
  Rat   884 GYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDL 948

  Fly  1002 AAIILFVIGLAFRFRENTM-DIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYF 1065
            .||:||.:|:..|.::... ..|||||||:.||||:|:|:|.||||||||.|.|:|||:.:|:||
  Rat   949 IAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYF 1013

  Fly  1066 VVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID------------PP 1118
            |:::.||||||||:|||||:||::|:|.|.|.:.:.||:|:||||||..||            .|
  Rat  1014 VIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAP 1078

  Fly  1119 CGEDPSQ--------PGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMF 1175
            ||::.::        |.|.||.|:.|..|:.|||:|||||:|||||||||.|.||.|:|:|||.|
  Rat  1079 CGQNETREDGKTIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKF 1143

  Fly  1176 QRFTVVMEYQQKPVLPPPFIALCHFYSLLKY-CV--RKAKGLEVQRDNGLKLFLEKDDLERLYDF 1237
            ||:.::|.:.::||||||.|...|...:.:: |.  ||.:....:||.|||||:..|:|::::||
  Rat  1144 QRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDPDERDYGLKLFITDDELKKVHDF 1208

  Fly  1238 EEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEES 1302
            ||:|:|.:|.|::...|.|.|||::.|:||||.||.::|::|::|:...|::|.::.||.::|:
  Rat  1209 EEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED- 1272

  Fly  1303 SEQILSHLA-VIHRFMSTHTAGADDLRGST-INIPGEMQRMRTISISDTEGGS-------GPGGN 1358
               ::..:| .:.|......|.::.:|..| .:.......:|..|.:..||.:       .|.|.
  Rat  1273 ---LIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGE 1334

  Fly  1359 GGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVV 1423
            .........::|                 |..:.|...|.    :.|:|.       .|:.:.:.
  Rat  1335 ETMSPTSPTLMP-----------------RMRSHSFYSVN----VKDKGG-------IEKLESIF 1371

  Fly  1424 KSREALNEQVVRKASMQSE-------ADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKD 1481
            |.|.....:.....|:..|       |::...:|.|:|||:|..:    ||:      |..|...
  Rat  1372 KERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDI----YVS------AMDELHC 1426

  Fly  1482 TLTPMGNNDDDQTLVG-GDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSL---TGADINR 1542
            .:.|:   |:...::| |:.|             ..||...|..    :|..|:.   |....:|
  Rat  1427 DIDPL---DNSMNILGLGEPS-------------FSALAPSTAP----SSSAYATLAPTDRPPSR 1471

  Fly  1543 SHISLNQLASLSRRQMS-----LTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNI--------- 1593
            | |....|.|:..|..|     |.:.:...|.|.|:..       ::..:|.||.:
  Rat  1472 S-IDFEDLTSMDTRSFSSDYTHLPECQNPWDTDPPMYH-------TIERSKSSRYLATTPFLLEE 1528

  Fly  1594 --LLKLHS--------------------EYTSITDELE--------------------------- 1609
              ::|.||                    |||||||.::
  Rat  1529 APIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRATFPGGLGDKVEDL 1593

  Fly  1610 SVCHMIASPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHL--KECEENDYMILEGL----IESR 1668
            |.||         |..:|.|..|.::....||........:  :|.|..|..:...:    ||..
  Rat  1594 SCCH---------PEREAELSHPSSDSEENEARGRRAANPISSQETENADRTLSNNITVPKIERA 1649

  Fly  1669 GSIDA---SAQGFEIGVSIDYSHRYPLRRETAVELSP------SKPSVDGD 1710
            .|..|   ||.......|...|.:...:|.||...:|      |||...||
  Rat  1650 NSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGD 1700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	122/236 (52%)
		TRPM_tetra	1262..1313	CDD:293127	16/51 (31%)
Trpm3	NP_001178491.1	TRPM_tetra	1233..1284	CDD:293127	16/54 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339768
Domainoid	1	1.000	408	1.000	Domainoid score	I675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62287
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I195
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	1	1.000	-	-		FOG0002675
OrthoInspector	1	1.000	-	-		otm45074
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	LDO	PTHR13800
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900