Protein Alignment Trpm and TRPM5

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_016873117.1
• Gene: TRPM5 / 29850
• HGNCID: 14323
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 1387
• Identity: 351/1387 - (25%)
• Similarity: 599/1387 - (43%)
• Gaps: 286/1387 - (20%)

  Fly    70 QITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLF 134
            :.|.|.:.|...|||||     ...|.:.....|.:.| ||:...:.::||:.....|.:|..|.
Human    16 EATMQDVQGPRPGSPGD-----AEDRRELGLHRGEVNF-GGSGKKRGKFVRVPSGVAPSVLFDLL 74

  Fly   135 TKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL- 198
            ..||:|..|.|::::.|.:..|.:::.|:..:||||:|||::|||||.|.....|:.:.||.|:
Human    75 LAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVR 139

  Fly   199 --LLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCH---SISSPRSKLAVLNNRHAYFLLV 258
              .|.......|||::|:|..|.|.....|.....:.|.|   .....:..|..|::..::|:||
Human   140 DHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILV 204

  Fly   259 DNGTQAKYGAELILRRKLEKFISNLKLHPSKNHWLKTNVTHSST-----PVVCLVIEGGTNTIRA 318
            :.|...|......||.:|||.||            :....:..|     ||:||::.|..||:..
Human   205 EPGPPGKGDGLTELRLRLEKHIS------------EQRAGYGGTGSIEIPVLCLLVNGDPNTLER 257

  Fly   319 VLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTI-QKTFEVGLDQS 382
            :...|..:.|..::|  |||..||:||.:       ..||.|      |:..: :|.|:......
Human   258 ISRAVEQAAPWLILV--GSGGIADVLAAL-------VNQPHL------LVPKVAEKQFKEKFPSK 307

  Fly   383 EKLYQELLQCTR-------NKNLITVFRIQEKPEGEAQELDQTILTALFKS--QHLSPP----EQ 434
            ...::::::.|:       :::|:||:..::  || ::|||..||.||.|:  .|...|    ::
Human   308 HFSWEDIVRWTKLLQNITSHQHLLTVYDFEQ--EG-SEELDTVILKALVKACKSHSQEPQDYLDE 369

  Fly   435 LSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLE 499
            |.||:.|:|||||:||||....||.:..|:|.|:.||..::.:||:|.::||..:..|||..||:
Human   370 LKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQ 434

  Fly   500 ELYNT-------------KHGPAN-TLGYILRDVRPHIPKG-YIYTLHDIGLVINKLMGGAYRSY 549
            |||.:             |...|. ||..:........|.| ..::||::..|:...:..|.|.:
Human   435 ELYRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGF 499

  Fly   550 YTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWA 614
            |  :..||          ...|::.....:|..|..      .||....:.   |.|:.:|.:||
Human   500 Y--QDGRP----------GDRRRAEKGPAKRPTGQK------WLLDLNQKS---ENPWRDLFLWA 543

  Fly   615 VLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLL 679
            ||..|.:||...|..|:|.:|.:|.:||:.|.|:|      |:||......:...::|.....|.
Human   544 VLQNRHEMATYFWAMGQEGVAAALAACKILKEMSH------LETEAEAARATREAKYERLALDLF 602

  Fly   680 DFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNF 744
            ...|.....:|..||......||..:||.||..|:.:|..||...|..|..:|.|.:..  .|..
Human   603 SECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAA--GTPI 665

  Fly   745 KVILGLAM-P--FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSI 806
            ..:||..: |  .|...:.|..:..|    :|..|.|  |:||:.|:::|
Human   666 LRLLGAFLCPALVYTNLITFSEEAPL----RTGLEDL--QDLDSLDTEKS--------------- 709

  Fly   807 SLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQF----REFFNLSEYNEVKQHQ 867
                               ..|.:: ::|.|     |.::..||.    |..|.|:.:.
Human   710 -------------------PLYGLQ-SRVEE-----LVEAPRAQGDRGPRAVFLLTRWR------ 743

  Fly   868 PLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKME---QMPRWQEWYSIAYITTLGFE 929
                     :|:.||:|.|..:.:.|..||.:|::.:||...   |.|...|.....::.||..|
Human   744 ---------KFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLE 799

  Fly   930 KVRE-IISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWY 993
            ::|: ..:.|...:..||:::..:.||.||..||.||::|:..|...:..:.||.:..:|.:.:.
Human   800 EIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFT 864

  Fly   994 LRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIA 1058
            ||:::|..::|.|||.:.::.:|:|::.:|:..|:|.|:::||:.||:|:|
Human   865 LRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHP-------------- 915

  Fly  1059 GSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNL 1123
                                                                         |...
Human   916 -------------------------------------------------------------HDGR 919

  Fly  1124 TSGNLTNVTFQPYFMLYGEVFAGDIDPP---CGEDP----SQPGC--VTGHWVTPITMSMYLLIA 1179
            .......|.::||..::|::...:||..   |...|    ..|.|  :..:|:..:.:..:||:.
Human   920 LEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVT 984

  Fly  1180 NILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKA 1244
            |:||:|||||:|:..|..|...:...|.|||:.:::||.::|.|.||||.|.|....|:...:|.
Human   985 NVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKE 1049

  Fly  1245 KGLEVQRDNGLKLFLEKD-----DLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETM 1304
              .|.:|::     ||:|     | :::..:|....|.|..:.|.....|..|.::.|...:.|.
Human  1050 --AEHKREH-----LERDLPDPLD-QKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHSLTTC 1106

  Fly  1305 SQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGST---IN 1366
            |.:..|...|   ....::..|.|::.:|..    :::.:|:...::...|.....|.:|   .|
Human  1107 SCRRVDFIAK---YLGGLREQEKRIKCLESQ----INYCSVLVSSVADVLAQGGGPRSTTPRAEN 1164

  Fly  1367 IPGEMQRMRTISISDTEGGSGP 1388
            :|..:...:..|:..  |.:||
Human  1165 VPHRIPTWKLTSLHC--GKAGP 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	79/287 (28%)
		TRPV	<872..1227	CDD:454755	87/367 (24%)
		TRPM_tetra	1291..1346	CDD:465156	9/54 (17%)
TRPM5	XP_016873117.1	LSDAT_euk	57..282	CDD:476852	71/238 (30%)
		TRPV	<733..1059	CDD:454755	100/422 (24%)