Protein Alignment Trpm and Trpm2

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_038954482.1
• Gene: Trpm2 / 294329
• RGDID: 1311889
• Length: 1545
• Species: Rattus norvegicus
• Alignment Length: 1741
• Identity: 491/1741 - (28%)
• Similarity: 764/1741 - (43%)
• Gaps: 376/1741 - (21%)

  Fly    80 KRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPK--DDTK--C 140
            :||:.|...|:.|:.:.        .||  |:....|||..|.:|:||:.|:...|  |..|  |
  Rat    34 RRSNSSLCKSRRLLCSF--------SSE--KQENLSSWIPENIKKKECVYFVESSKLSDAGKVVC 88

  Fly   141 CCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPEL 205
            .||.....|..:........|..|.|.||....||||:|.|.|.|.:... .:|||||.||...:
  Rat    89 ECGYTHEQHIEVAIKPHTFQGKEWDPKKHVHEMPTDAFGDIVFTGLSQKV-GKYVRLSQDTSSIV 152

  Fly   206 LVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQV 270
            :.||.|:.|.|::|.|||:|.||..||:::.:||...|:||:|.|:||||||.|||::|||.|||
  Rat   153 IYQLMTQHWGLDVPSLLISVTGGAKNFNMKLRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQV 217

  Fly   271 GDAL---LLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSI----------SSPRSKLA 322
            |:|:   .|....:.|.|::||||.||.:        ||||...|.:          ...:..|.
  Rat   218 GEAVRDFSLSSSCKEGDVITIGIATWGTI--------HNREALIHPMGGFPAEYMLDEEGQGNLT 274

  Fly   323 VLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISN---------LKLHPFTHSSTPVVCLVIEG 378
            .|::.|::|:|||:||..:||.|:.||.|||||||.         :|:        |:||:|:||
  Rat   275 CLDSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKI--------PIVCVVLEG 331

  Fly   379 GTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFE 443
            |..|:..:...:|:.  .|.|:.:||||.||::|.|       ...||.|    ..|..||:...
  Rat   332 GPGTLHTIYNAITNG--TPCVIVEGSGRVADVIAQV-------AALPVSE----ITISLIQQKLS 383

  Fly   444 VGLDQSEKLYQE---------LLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQ----- 494
            |...:..:.:.|         :....|.:.|:||||  |..:|: |::|..||.||.|:.
  Rat   384 VFFQEMFETFTENQIVEWTKKIQDIVRRRQLLTVFR--EGKDGQ-QDVDVAILQALLKASRSQDH 445

  Fly   495 --HLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMK 557
              |.:...||.||:.||||||||||||....:|....|...|..||..::.:||:|.|||||.:|
  Rat   446 FGHENWDHQLKLAVAWNRVDIARSEIFTDEWQWKPSDLHPMMTAALISNKPEFVRLFLENGVRLK 510

  Fly   558 KFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYT-------LHDIGLVINKLMGGAYRS 615
            :|:|...|..||.... |:......|:.|.....:...|.       :|.:..|:.:|:|.:.:.
  Rat   511 EFVTWDTLLCLYENLE-PSCLFHSKLQKVLAEEHERLAYASETPRLQMHHVAQVLRELLGDSTQL 574

  Fly   616 YYTRRKF--RPIYAKVM-NSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNEL 677
            .|.|.::  ||..:..| :...|....|....|:|         .||.:.||.:      |..:|
  Rat   575 LYPRPRYTDRPRLSLPMPHIKLNVQGVSLRSLYKR---------STGHVTFTID------PVRDL 624

  Fly   678 LIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKG 742
            ||||::...:::|.::|...::..|.:|...|:.|    |.::::.||:..||:.:.|.|||.:.
  Rat   625 LIWAIIQNHRELAGIIWAQSQDCTAAALACSKILK----ELSKEEEDTDSSEEMLALADEFEHRA 685

  Fly   743 NKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRK 807
            ..:....||:|.|:||:||.....:|...:||.||:.|.....::|...|..|..:|.|.|.. .
  Rat   686 IGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLCV-D 749

  Fly   808 NTNFKVIL-GLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYS 871
            |..:::|| .||.|...
  Rat   750 NGLWRIILCMLAFPLLF------------------------------------------------ 766

  Fly   872 VRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYM 936
                    .|.:|        |||          |:.|.|....:...|:.||:..|:.:.::|.
  Rat   767 --------TGFIS--------FRE----------KRLQALCRLARVRAFFNAPVVIFYLNILSYF 805

  Fly   937 FFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREII-SSEPVAITHKFSVWAWNMWNPCD 1000
            .||.:|::.::|..:..|.|.|:....::.:|..|:.|::. ..:...:....|::..:.||..|
  Rat   806 AFLCLFAYVLMVDFQPSPSWCEYLIYLWLFSLVCEETRQLFYDPDGCGLMKMASLYFSDFWNKLD 870

  Fly  1001 GAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYF 1065
            ..||:||:.||..|....|:..||:|..:|.|.:.||:::|..::|.|||.:.::.:|:|::.:|
  Rat   871 VGAILLFIAGLTCRLIPATLYPGRIILSLDFIMFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFF 935

  Fly  1066 VVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEV--------FAGDIDPPCGED 1122
            :.||||.::||||::||||..|:.....:.:.|.:..|..::|::        |:.|...|.|.|
  Rat   936 LFLLAVWVVSFGVAKQAILIHNESRVDWIFRGVIYHSYLTIFGQIPTYIDGVNFSMDQCSPNGTD 1000

  Fly  1123 PSQPGCV----TG------HWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQR 1177
            |.:|.|.    ||      .|:|...:.:|||.|||||:|||||:||..|.||...:.|:|.|||
  Rat  1001 PYKPKCPESDWTGQAPAFPEWLTVTLLCLYLLFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQR 1065

  Fly  1178 FTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECV 1242
            ..::.||..:|..|||.|.|.|...|:|..|.|   :..:|...||..|||::...|..:|....
  Rat  1066 HDLIEEYHGRPPAPPPLILLSHLQLLIKRIVLK---IPAKRHKQLKNKLEKNEEAALLSWELYLK 1127

  Fly  1243 EGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQIL 1307
            |.:...|:....|..::::::.:|:|:||...::....|.:..|      |.||..:||...|:.
  Rat  1128 ENYLQNQQYQHKQRPEQKIQDISEKVDTMVDLLDMDRVKRSGST------EQRLASLEEQVTQMG 1186

  Fly  1308 SHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGG----------NGGGG 1362
            ..|   |..::|                          :.|:..|||.|.          ||...
  Rat  1187 RSL---HWIVTT--------------------------LKDSGFGSGAGALTLARKEMDVNGHSL 1222

  Fly  1363 GGGGAIVPLGLGAGLNLNSLQV---TTRRRFNRSLTEVRPDAYIF--------DEGTHFEVVPLP 1416
            ...|.::..|..|..::...|.   ..:|.|:      .|||.:.        .:|.|.....|
  Rat  1223 PQVGPLIWTGPVAAGDVTPAQCGFSAAQRAFD------EPDAELSIRKKGEEGGDGYHVSARHL- 1280

  Fly  1417 EEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKD 1481
            ..||..:......||:|      ..||:..||.|              |:.|        .|.||
  Rat  1281 LYPDARIMRFPVPNEKV------PWEAEFLIYDP--------------PFYT--------AEKKD 1317

  Fly  1482 -TLT-PMGNNDDDQTLVGGDNSDDATPDINFEAA------------RHRALR------------- 1519
             ||| |:|:..:..:.:..:..|......:|...            ....||
  Rat  1318 ATLTDPVGDTAEPLSKINYNVVDGLMDRCSFHGTYVVQYGFPLNPMGRTGLRGRGSLSWFGPNHT 1382

  Fly  1520 -QRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMS-LTQSEPDSDKDAPIAQGSAHPGK 1582
             |..|:..:||.      |..|.|..:         |:.:. |....|.|:..| :..||..|||
  Rat  1383 LQPVVTRWKRNQ------GGGICRKSV---------RKMLEVLVVKLPQSEHWA-LPGGSREPGK 1431

  Fly  1583 SVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRPK-TEMSRAEAAALLE 1646
            .:     .|.:...|..||. :|.|.     ::...|   ...|..:|.|: |:.:..|..|:
  Rat  1432 ML-----PRKLKQVLQQEYW-VTFET-----LLRQGT---EVYKGYVDDPRNTDNAWIETVAV-- 1480

  Fly  1647 KKHLKECEENDYMILEGLIESRGSID--ASAQGFEIGVS---IDYSHRYPL 1692
            ..|.:  ::|| :.|:.|.|:..:.|  .||:|.|:...   :|  .|.||
  Rat  1481 SIHFQ--DQND-VELKRLEENLQTHDPKESARGLEMSTEWQVVD--RRIPL 1526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	79/234 (34%)
		TRPM_tetra	1262..1313	CDD:293127	13/50 (26%)
Trpm2	XP_038954482.1	LSDAT_euk	140..363	CDD:423023	98/240 (41%)
		trp	<717..1072	CDD:273311	117/429 (27%)
		Ion_trans	801..>977	CDD:395416	53/175 (30%)
		Nudix_Hydrolase	1361..1541	CDD:412381	47/203 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11407
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920