DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and Trpm6

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	XP_038957309.1	Gene:	Trpm6 / 293874	RGDID:	1309942	Length:	2024	Species:	Rattus norvegicus

Alignment Length:	2004	Identity:	652/2004 - (32%)
Similarity:	984/2004 - (49%)	Gaps:	402/2004 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIE--------SG 158
            :||||..|.||||.||||..||.             .:|.||:....||   |::        .|
  Rat     5 KSWIERVFYKRECNKFIPSSKDPHRCTPGCQICQNLVRCYCGRLIQEHQ---GLDRAWSLSATEG 66

  Fly   159 SPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLI 223
            :..:.|...|||...|||.:|||.||.|.|...::|:|.|:||:.:.|:.|..||||:|||||:|
  Rat    67 NGNEQWSVEKHTVKSPTDTFGTINFQDGEHIYHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVI 131

  Fly   224 TVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSI 288
            :|.||..||.:.:|||:...:||:|||:||||||.|.|.|:||:|.|||||.........::.::
  Rat   132 SVHGGLQNFKMPSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDALKAHSSMSLRKIWTV 196

  Fly   289 GIAPWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRK 351
            ||.|||::|...||:|  ::|.|  .::|:|.|||..||..|::|:|.|:||..|||.|..|||.
  Rat   197 GIPPWGVIENQRELVG--KDVVCMYQTLSNPLSKLTTLNCMHSHFILCDDGTVGKYGNEEKLRRN 259

  Fly   352 LEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHK 416
            |||.:|..|:|..:....|||.||:|||.|.|..|.|.|.:..  |||||:|:|||||||||.:|
  Rat   260 LEKHLSMQKIHTCSRQGVPVVGLVVEGGPNVILWVWETVRNKE--PVVVCEGTGRAADLLAFTYK 322

  Fly   417 YASDGEEQPVLE-SMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQ 480
            ::.||   .:|. .:::.::..||..|...|.||:.|:|.|::|..:|:.||:|   :....|.|
  Rat   323 HSEDG---GILRPQVKEEILCLIQNMFNFSLRQSKHLFQILMECMVHKDSITIF---DADSEEHQ 381

  Fly   481 ELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDF 545
            :||..||.||.|...||..|||:||:.|:|:|||:..|.:|||.|..|||::||..||..||:||
  Rat   382 DLDLAILKALLKGTSLSISEQLNLAMAWDRMDIAKKHILIYGQHWKPGALEQAMRDALVMDRVDF 446

  Fly   546 VKLLLENGVSMKKFLTIPRLEELYNTKHGPANT-LGYILRDVRPH-IPKGYIYTLHDIGLVINKL 608
            ||||:||||::.:||||.|||:|||||.||.|. |.::::||:.| :...|..||.||||||..|
  Rat   447 VKLLIENGVNLHRFLTISRLEDLYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDIGLVIEYL 511

  Fly   609 MGGAYRSYYTRRKFRPIY------AKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLL------ 661
            :||||||.|||:.||.:|      .|.|.|:|...  |....:||::..|........|
  Rat   512 IGGAYRSSYTRKSFRVLYNDLYRKHKGMTSFAQGL--SQHPLHQRHSLGNRKESSESTLHSQFFR 574

  Fly   662 ---PFTSE------------------------MALFEFPFNELLIWAVLTKRQQMALLMWTHGEE 699
               |:.|:                        .|.|.:|:|:||:||||.|||:||:..|.||||
  Rat   575 TAQPYKSKDKPEDSHKPKKKSKERHSLSEDPGSAGFIYPYNDLLVWAVLMKRQKMAMFFWQHGEE 639

  Fly   700 ALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCE 764
            |..|::::..||:|||.||.|.::..:..|||:.|:::|......:|:.:::|:...|.:|||.|
  Rat   640 ATVKAVIASILYRAMAREAKESNMVDDTSEELKKYSEQFGQLALDVLEKAFKQNEPMAMKLLTYE 704

  Fly   765 LHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFK 829
            |.:|||.:||.|||:...|..::|.|:|::|.|:|||.|:.|||:..|:|:.:.:|..|..|:||
  Rat   705 LKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPPMILTLEFK 769

  Fly   830 SKEELQQMPQTEE----EHLENQNLDND------DSDRSQPDA---EALLADTYSVRDTKVHENG 881
            ||.|:..:||:::    .:..:|.|.|.      |.:|. ||.   |||..|..:|
  Rat   770 SKAEMSHVPQSQDFQFTWNYSDQGLSNTKEAKDYDLERG-PDEKLDEALHLDLRNV--------- 824

  Fly   882 KVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTV 946
                                      .|.|...::.||||:||..|||..::||:.||::|::||
  Rat   825 --------------------------PQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTV 863

  Fly   947 LVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGL 1011
            ||:|:..|..|||..|.||.|...||||||..|||...|.|..:|....||..:..||.||.:|.
  Rat   864 LVEMQPQPSVQEWLVIIYIFTNAIEKVREICISEPSKFTQKVKMWLSEYWNLMETVAIGLFAVGF 928

  Fly  1012 AFRFRENTM-DIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMS 1075
            ..|:....: ..||:|||:|.|:|:.|:|:...||::.||.|||:.||..||.|.|:::|:||:|
  Rat   929 GLRWGHPPLHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMAANMFYIVIIMAIVLLS 993

  Fly  1076 FGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMS 1140
            |||:|:|||.|.:.|:|.|.:::.|:||:|:||||:|.:|| .|..:.|   |..|.::||...:
  Rat   994 FGVARKAILSPKEPPSWRLARDIVFEPYWMMYGEVYASEID-VCSNETS---CPPGSFLTPFLQA 1054

  Fly  1141 MYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLK 1205
            :||.:..|:::|||||.||||:.::.|:|:::|.:.|:..:|.|.|||.||||||.:.|...||:
  Rat  1055 VYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWLPPPFILISHLCLLLR 1119

  Fly  1206 -YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVE 1269
             .|.|.|...:.:.|.||||:|.||||::|:||||:|||.:|||:...||.|.:|:::.|:|||.
  Rat  1120 GLCCRPAPQDQEEGDMGLKLYLTKDDLKKLHDFEEQCVEKYFHEKTEGLNCSCEEQIRATSERVS 1184

  Fly  1270 TMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINI 1334
            .|..:::::|:|       |..|:..|..::..    :.||              .||...|::
  Rat  1185 EMFFQLKEMNEK-------VSFIKDSLLSLDSQ----VGHL--------------QDLSALTVD- 1223

  Fly  1335 PGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRP 1399
                 .::.:|..||                           |..:.:.:..|:   .|....||
  Rat  1224 -----TLKVLSAVDT---------------------------LQEDEILLANRK---HSTCRKRP 1253

  Fly  1400 DAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRT 1464
            .::.       .|:..     :|:...|:..:|..:..||.              ||...::.|:
  Rat  1254 HSWT-------NVICA-----KVLTDMESCGKQKFQYYSMP--------------PSLLRSLARS 1292

  Fly  1465 ---PYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLC 1526
               |.|    ..||..|.........:..:||                    :.|.:.|||::
  Rat  1293 QLPPGV----QRGALVEVTHNTREASHVREDQ--------------------KEREVEQRTIA-- 1331

  Fly  1527 RRNSETYSLTG-ADINRSHISLNQ--LASLSRRQMSLTQSEP--------DSDKDAPIAQGSAHP 1580
                     :| :.:.::|....|  |...|.:|:||:...|        ::..| .:|....||
  Rat  1332 ---------SGVSHVRQAHSKYGQFLLVPPSEKQVSLSLENPPHLFRASGETGTD-DVALQHRHP 1386

  Fly  1581 GKSVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRPKTEMSRAE-AAAL 1644
            ....:|. |.:...:...:......|:.|:|..|...|      :||..|..|...:.|. |...
  Rat  1387 SDVTIHL-PGQTPAVSHQALGAEHKDQHEAVIQMSGKP------DKAEQDSLKFSGTPAPMAVTS 1444

  Fly  1645 LEKKHLKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVDG 1709
            |..:.:...:|..|:..           |.::..|.|| ..:..::.....:..: |.|||..|.
  Rat  1445 LPSRAISMQDEGGYVNW-----------AFSESDEAGV-FSFKKKWKTCLASTCD-SGSKPGGDC 1496

  Fly  1710 DLMGGGEGGGAGGGDSSDTSGAGSCGAMVGISSGFQLKNERPWQRNSSMEQQTYPSPLVPTRATS 1774
            .|    :..|..|.|:|..  |.||....|           ||                 |:|..
  Rat  1497 SL----QAAGRSGLDNSRL--AQSCEWPAG-----------PW-----------------TQARR 1527

  Fly  1775 DF-LNPPYEGRLFKKSSESLQKNSSTETDYSAHPYRFIKQ--------SSNETNTSLTGSYNVDT 1830
            .| :||....:...||                |.:||.|:        :::.:..|.|||..:..
  Rat  1528 SFWINPLCRDKPLLKS----------------HSFRFHKEEKLRKTWKNNSHSKASETGSTWLKA 1576

  Fly  1831 PSLTAEPSLDAGDSHSATGISISVGAVGGTATARYQPIRTASVGAADGRRLREESSSSLDLSSSG 1895
            ..||...|| :.....|.|:.:.|    .|..|.||..:..| .:.:.....:.|.:.|.:|:..
  Rat  1577 KLLTKNRSL-SKKRRKAQGLQVPV----ITVNACYQSDQLTS-ESGETNTTEDYSKNWLSVSNFS 1635

  Fly  1896 PVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTAAEAVPQTPEAAQAGQAKLISTLKPQPFASKLGM 1960
            .:.::        |.:.:|....:..:.:..|:..:.|..|....
  Rat  1636 QIGLE--------PYIYQKMKMKEIERHTTQASYHLRQMQEDPDK-------------------- 1672

  Fly  1961 NVLKESSSSTDESVGSSAKSSNPALSIPQISTHLVQDEIAKLSSNIKSSTESEK 2014
               ..|.:|...||..|..:.:|             :|:.|:|:::||..|..:
  Rat  1673 ---NPSWNSRSASVSRSFLTRSP-------------NEVDKISASLKSPPEPHR 1710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	95/216 (44%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	12/50 (24%)
Trpm6	XP_038957309.1	LSDAT_euk	101..363	CDD:407971	125/268 (47%)
		trp	<661..1221	CDD:273311	234/624 (38%)
		Alpha_kinase	1738..1976	CDD:355793
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339771
Domainoid	1	1.000	408	1.000	Domainoid score	I675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45074
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850