DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and Trpm2

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_612174.2	Gene:	Trpm2 / 28240	MGIID:	1351901	Length:	1506	Species:	Mus musculus

Alignment Length:	1699	Identity:	464/1699 - (27%)
Similarity:	739/1699 - (43%)	Gaps:	381/1699 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KEHQPRSWIETNFQKRECIKFIPCPK--DDTK--CCCGQAQITHQTIPGIESGSPGDLWLPTKHT 170
            |:....|||..|.:|:||:.|:...|  |..|  |.||.....|..:........|..|.|.||.
Mouse    54 KQENLSSWIPENIKKKECVYFVESSKLSDAGKVVCACGYTHEQHLEVAIKPHTFQGKEWDPKKHV 118

  Fly   171 RPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQ 235
            :..||||:|.|.|...:... .:|||:|.||...::.||.|:.|.|::|.|||:|.||..||:::
Mouse   119 QEMPTDAFGDIVFTDLSQKV-GKYVRVSQDTPSSVIYQLMTQHWGLDVPNLLISVTGGAKNFNMK 182

  Fly   236 AKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL---LLEGQQRTGRVVSIGIAPWGIVE 297
            .:||...|:||:|.|:||||||.|||::|||.||||:|:   .|....:.|.|::||:|.||.:
Mouse   183 LRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSCKEGEVITIGVATWGTI- 246

  Fly   298 RNHELLGHNREVPCHSI----------SSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKL 352
                   ||||...|.:          ...:..|..|::.|::|:|||:||..:||.|:.||.||
Mouse   247 -------HNREGLIHPMGGFPAEYMLDEEGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTKL 304

  Fly   353 EKFISN---------LKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAA 408
            |||||.         :|:        |:||:|:|||..|:..:...:.:.  .|.|:.:||||.|
Mouse   305 EKFISEQTKERGGVAIKI--------PIVCVVLEGGPGTLHTIYNAINNG--TPCVIVEGSGRVA 359

  Fly   409 DLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQE---------LLQCTRNKN 464
            |::|.|       ...||.|    ..|..||:...:...:..:.:.|         :....|.:.
Mouse   360 DVIAQV-------ATLPVSE----ITISLIQQKLSIFFQEMFETFTENQIVEWTKKIQDIVRRRQ 413

  Fly   465 LITVFRIQEKPEGEAQELDQTILTALFKSQ-------HLSPPEQLSLALTWNRVDIARSEIFVYG 522
            |:|:||  |..:|: |::|..||.||.|:.       |.:...||.||:.||||||||||||...
Mouse   414 LLTIFR--EGKDGQ-QDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSEIFTDE 475

  Fly   523 QEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKH-------------G 574
            .:|....|...|..||..::.:||:|.|||||.:|:|:|...|..||....             .
Mouse   476 WQWKPADLHPMMTAALISNKPEFVRLFLENGVRLKEFVTWDTLLCLYENLEPSCLFHSKLQKVLA 540

  Fly   575 PANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRK 639
            ....|.|.....|.|        :|.:..|:.:|:|.:.:..|.|.:           |.:..|.
Mouse   541 EEQRLAYASATPRLH--------MHHVAQVLRELLGDSTQLLYPRPR-----------YTDRPRL 586

  Fly   640 SSTYQYQR--YAGANSLSLV---TGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEE 699
            |.|..:.:  ..|.:..||.   ||.:.||.:      |..:||||||:...:::|.::|...::
Mouse   587 SMTVPHIKLNVQGVSLRSLYKRSTGHVTFTID------PVRDLLIWAVIQNHRELAGIIWAQSQD 645

  Fly   700 ALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCE 764
            ..|.:|...|:.|    |.::::.||:..||:.:.|.|||.:...:....||:|.|:||:||...
Mouse   646 CTAAALACSKILK----ELSKEEEDTDSSEEMLALADEFEHRAIGVFTECYRKDEERAQKLLVRV 706

  Fly   765 LHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVIL-GLAMPFYIRQLDF 828
            ..:|...:||.||:.|.....::|...|..|..:|.|.|.. .|..:::|| .||.|...
Mouse   707 SEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLCV-DNGLWRIILCMLAFPLLF----- 765

  Fly   829 KSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQF 893
                                                               .|.:|        |
Mouse   766 ---------------------------------------------------TGFIS--------F 771

  Fly   894 REFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQE 958
            ||          |:.|.|....:...|:.||:..|..:.::|..||.:|::.::|..:..|.|.|
Mouse   772 RE----------KRLQALCRPARVRAFFNAPVVIFHMNILSYFAFLCLFAYVLMVDFQPSPSWCE 826

  Fly   959 WYSIAYITTLGFEKVREII-SSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDI 1022
            :....::.:|..|:.|::. ..:...:....|::..:.||..|..||:||::||..|....|:..
Mouse   827 YLIYLWLFSLVCEETRQLFYDPDGCGLMKMASLYFSDFWNKLDVGAILLFIVGLTCRLIPATLYP 891

  Fly  1023 GRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPN 1087
            ||:|..:|.|.:.||:::|..::|.|||.:.::.:|:|::.:|:.||||.::||||::||||..|
Mouse   892 GRIILSLDFIMFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHN 956

  Fly  1088 KQPTWSLIKEVTFQPYFMLYGEV--------FAGDIDPPCGEDPSQPGCV----TG------HWV 1134
            :.....:.:.|.:..|..::|::        |:.|...|.|.||.:|.|.    ||      .|:
Mouse   957 ESRVDWIFRGVVYHSYLTIFGQIPTYIDGVNFSMDQCSPNGTDPYKPKCPESDWTGQAPAFPEWL 1021

  Fly  1135 TPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCH 1199
            |...:.:|||.|||||:|||||:||..|.||...:.|:|.|||..::.||..:|..|||.|.|.|
Mouse  1022 TVTLLCLYLLFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQRHDLIEEYHGRPPAPPPLILLSH 1086

  Fly  1200 FYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNT 1264
            ...|:|..|.|   :..:|...||..|||::...|..:|....|.:...|:....|..::::::.
Mouse  1087 LQLLIKRIVLK---IPAKRHKQLKNKLEKNEETALLSWELYLKENYLQNQQYQQKQRPEQKIQDI 1148

  Fly  1265 TERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRG 1329
            :|:|:||...::....|.:..|      |.||..:||...|:   ...:|..::|
Mouse  1149 SEKVDTMVDLLDMDQVKRSGST------EQRLASLEEQVTQV---TRALHWIVTT---------- 1194

  Fly  1330 STINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSL 1394
                            :.|:..|||.|                        :|.:..:|.|:
Mouse  1195 ----------------LKDSGFGSGAG------------------------ALTLAPQRAFD--- 1216

  Fly  1395 TEVRPDAYIFDEGTHFEVVPLPEEPDE--VVKSREAL--NEQVVR------KASMQSE------- 1442
               .|||       ...:....|||.:  .|.:|..|  |.:::|      |....:|
Mouse  1217 ---EPDA-------ELSIRRKVEEPGDGYHVSARHLLYPNARIMRFPVPNEKVPWAAEFLIYDPP 1271

  Fly  1443 ---ADSDIYI--PVSQRPSTCETVKRTPYVTVRQDTGAST-------ESKDTLTPMGNNDDDQTL 1495
               |:.|:.:  ||.   .|.|.:.:..|..|...|...:       |....|.|||...    |
Mouse  1272 FYTAEKDVALTDPVG---DTAEPLSKISYNVVDGPTDRRSFHGVYVVEYGFPLNPMGRTG----L 1329

  Fly  1496 VGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSL 1560
            .|..:.....|:...:....|..|.:..::||:                       |:.:....|
Mouse  1330 RGRGSLSWFGPNHTLQPVVTRWKRNQGGAICRK-----------------------SVRKMLEVL 1371

  Fly  1561 TQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSN 1625
            ....|.|:..| :..||..||:.:     .|.:...|..|:            .:|..|:.:...
Mouse  1372 VMKLPRSEHWA-LPGGSREPGEML-----PRKLKRVLRQEF------------WVAFETLLMQGT 1418

  Fly  1626 ---KASLDRPK-TEMSRAEAAALLEKKHLKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDY 1686
               |..:|.|: |:.:..|..|:  ..|.:  ::|| |.|:.|.|:..:.|......::.:|.::
Mouse  1419 EVYKGYVDDPRNTDNAWIETVAV--SIHFQ--DQND-MELKRLEENLHTHDPKELTRDLKLSTEW 1478

  Fly  1687 ---SHRYPL 1692
               ..|.||
Mouse  1479 QVVDRRIPL 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	79/234 (34%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	12/50 (24%)
Trpm2	NP_612174.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		LSDAT_euk	140..363	CDD:423023	95/240 (40%)
		trp	<716..1071	CDD:273311	117/429 (27%)
		Ion_trans	800..>976	CDD:395416	53/175 (30%)
		Nudix_Hydrolase	1322..1502	CDD:412381	42/216 (19%)
		Nudix box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00794	1386..1407		7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920