DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm7

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001025232.1	Gene:	trpm7 / 280653	ZFINID:	ZDB-GENE-021115-2	Length:	1774	Species:	Danio rerio

Alignment Length:	1655	Identity:	623/1655 - (37%)
Similarity:	926/1655 - (55%)	Gaps:	216/1655 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGI---------ES 157
            :||||..|.:|||:..:|..||.             .:||||:....|......         |.
Zfish     4 KSWIEHTFTRRECVYILPVSKDPHRCLPGCQICQQLVRCCCGRLVRQHVGFTATLAVKYSEVSEE 68

  Fly   158 GSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLL 222
            .|..:.|...|||...||||||.|.||||:|..:|:|||||.|:|||.:::|..|||.:||||::
Zfish    69 LSELEQWSVEKHTEESPTDAYGVINFQGGSHSYRAKYVRLSHDSRPEAVLRLMLKEWLMELPKIV 133

  Fly   223 ITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVS 287
            |:|.||..||:|..::|:.:.|||:|||.||||||.|||.||||.|.|||||.....:...::.:
Zfish   134 ISVHGGIQNFELHPRIKQVVGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHLSRSARKICT 198

  Fly   288 IGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKL 352
            :||||||::|..::|:|.:...|..::.:|.|||.||||.|::|||||:||..|||||:.|||:|
Zfish   199 VGIAPWGVIENRNDLIGRDVVAPYQTLLNPLSKLNVLNNFHSHFLLVDDGTVGKYGAEVRLRREL 263

  Fly   353 EKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKY 417
            ||.|...::|.......|||.|:.|||.|.|..||||:.:|||||||||:|:|||||:||:|||.
Zfish   264 EKHIQLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILAYVHKQ 328

  Fly   418 ASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQEL 482
            .......|  :.:...:|.||:|||......:..|:|.|::|.:||.|||||.:..:   :.|::
Zfish   329 TEQDGALP--DGVESDIIATIKKTFNFSHGDALHLFQTLMECMKNKELITVFPVGSE---DHQDI 388

  Fly   483 DQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVK 547
            |..||.||.|..:.:..:||.|.|.|:|||||:..:|||||:...|:|::||:.||..||::|||
Zfish   389 DVAILKALLKGTNATAFDQLVLTLAWDRVDIAKDHVFVYGQQLLVGSLEQAMLDALVMDRVEFVK 453

  Fly   548 LLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRP-HIPKGYIYTLHDIGLVINKLMG 610
            ||:||||||.:||||.|||||||||..|.| ||.:::|||:. ::|..|..||.|:||||..|||
Zfish   454 LLIENGVSMHRFLTITRLEELYNTKQTPTNPTLYHLVRDVKQGNLPPNYKITLIDVGLVIEYLMG 518

  Fly   611 GAYRSYYTRRKFRPIYAKVM-NSYANACRKSSTYQYQRYA-GANS-------------------L 654
            |.||..|||::||.||..:. ||..:....||::.::.:: .|:.                   |
Zfish   519 GTYRCNYTRKRFRIIYNNLHGNSRRSGRHTSSSHSHESFSIQADKKEKTRHNHFIKTAQPYKPRL 583

  Fly   655 SLVTGLLPFTS----------EMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCK 709
            ..|:.|....|          |...|.:||||||:||||.|||:|:|..|.||||::||:||:|:
Zfish   584 DSVSELQKKKSKEEVVDVDDPETRRFPYPFNELLVWAVLMKRQKMSLFFWQHGEESMAKALVACR 648

  Fly   710 LYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCL 774
            |.:::..||.:.|:..:..|||:.|:.||.:....||:.|:|||...|.:|||.||.:|||.:||
Zfish   649 LLRSLGDEAKKSDVVDDTSEELKEYSSEFGTLAVDLLEQSFRQDETMAMKLLTYELKNWSNSTCL 713

  Fly   775 SLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQ 839
            .|||::..|..:||.|:|::|:|:|||.|..|||:.:||||.:.:|..|..|::|:|.|:..:||
Zfish   714 KLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPAILLLEYKTKAEMSHIPQ 778

  Fly   840 TEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNE 904
            :::.|   |::::.:.:...||            |.::....:|.:  ||.|:.:        :|
Zfish   779 SQDAH---QSMEDSEHNLQHPD------------DIQMDVFKEVRM--SDNAEMK--------SE 818

  Fly   905 VKQH---QPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYIT 966
            ::.|   :.|.:.:|||.||.|||.|||.:::.|:.||:::||.|||||:.:|..|||..|.||.
Zfish   819 LEVHVRSRRLPITRKFYAFYHAPIVKFWFNTLFYIGFLMLYSFVVLVKMQDLPSPQEWVVILYIF 883

  Fly   967 TLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDS 1031
            ||..||:||:..||...|:.|..||..:.:|..|..||::|.:|...|........||::||::.
Zfish   884 TLAVEKIREMFMSEGGKISQKIKVWFSDYFNISDFLAILMFFVGFGLRLVSEVFIAGRIVYCLNI 948

  Fly  1032 IYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIK 1096
            |:||:|:|:||.||:..||.|.|:||||.||.|.||::||||:||||.|:|||||.::|:|:|.|
Zfish   949 IFWYVRLLDILAVNQQAGPYVMMIGKMVANMFYIVVIMAVVLLSFGVPRKAILYPEEEPSWTLAK 1013

  Fly  1097 EVTFQPYFMLYGEVFAGDIDPPC---GEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVF 1158
            :|.||||:|:||||:|.:|| .|   .|:..:..|.||.|:||:..::||.:..||::|||||.|
Zfish  1014 DVVFQPYWMMYGEVYAYEID-VCANSSEEHVRDLCTTGVWLTPLLQAVYLFVQYILMVNLLIAFF 1077

  Fly  1159 NNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDN--- 1220
            ||::.:|.|:|:.||.:||:..::.|..||:||||.|.|.|..|||....||.|     :|:
Zfish  1078 NNVYLQVKSISNLVWKYQRYHFILAYHDKPILPPPLILLSHAASLLSSICRKRK-----KDSSTY 1137

  Fly  1221 GLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQ 1285
            |.||||.::|.::|:||||:|||.:|||::...:..:|||::.|::|||||..:::::..|.|..
Zfish  1138 GPKLFLTEEDQKKLHDFEEQCVETYFHEKDDQFHSGSDERIRLTSDRVETMCVQLKEVGNKVNFI 1202

  Fly  1286 TATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRM-----RTIS 1345
            ..::..::.::..:::     ||.|.|            |.|:..|.....|..::     |.:|
Zfish  1203 KRSLHTLDSQIGHLQD-----LSALTV------------DTLKALTAQRASEASKVHNQITRELS 1250

  Fly  1346 IS-----DTEGGSGPG---------------GNGGGGGGGGAIVPLGL-GAGLNLNSLQV-TTRR 1388
            :|     :....|.||               .:...|||..|:...|| .|.|..:.:|. ..||
Zfish  1251 VSRNLAPEAVPPSKPGALVRCSVAFMPPNSMADSLFGGGVEAVQGAGLPHASLTADGVQTPQMRR 1315

  Fly  1389 RFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQ 1453
            |.::......|.|    ..:.|...|||::.|     .:|..|:.......:.|       |..|
Zfish  1316 RGHQEHLSSAPAA----AASFFLSTPLPQQQD-----LQAPPEEFGAFVGHKDE-------PEGQ 1364

  Fly  1454 RPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRAL 1518
            |             ::.:::..|:.|:.| ..:||.....:..|....|
Zfish  1365 R-------------SIPKESAVSSPSRKT-RDVGNMRTVNSYAGFTELD---------------- 1399

  Fly  1519 RQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAP------IAQGS 1577
              |..||....|     |.:...|:.:||.   .:||.:..|......|.|.:|      .|.||
Zfish  1400 --RNPSLLHPES-----TLSKQERTRVSLE---DVSRYEDLLLGKSAQSSKLSPGDDASNTAIGS 1454

  Fly  1578 A-HPGKSVLHAKPSRNILLKLHSE--YTSITDELE--SVCHMIASPTVSLPSNKASLDR----PK 1633
            . .|.:|..::...||.|::|...  :|.:....|  ||..:..|...|:.::.:|..:    .|
Zfish  1455 PFKPMESYQYSAVERNNLMRLSQSIPFTPVPPRGEPVSVYRLEESSPGSINNSMSSWAQRGLCAK 1519

  Fly  1634 TE-MSRAEAAALLEKKHLKECEENDYMILE 1662
            .| :|:.|....|.:.....|..::|.||:
Zfish  1520 IEFLSKEEMGGGLRRALKVLCTWSEYDILK 1549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	104/218 (48%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	11/50 (22%)
trpm7	NP_001025232.1	Ion_trans	868..1086	CDD:278921	104/218 (48%)
		TRPM_tetra	1179..1230	CDD:293127	14/67 (21%)
		Alpha_kinase	1507..1725	CDD:214828	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579565
Domainoid	1	1.000	422	1.000	Domainoid score	I609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850