DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Trpm and Trpm3

DIOPT Version :9

Sequence 1:NP_001097320.1 Gene:Trpm / 36694 FlyBaseID:FBgn0265194 Length:2023 Species:Drosophila melanogaster
Sequence 2:XP_006527017.1 Gene:Trpm3 / 226025 MGIID:2443101 Length:1758 Species:Mus musculus


Alignment Length:1850 Identity:716/1850 - (38%)
Similarity:1000/1850 - (54%) Gaps:349/1850 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 RRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDD 137
            |||.|...|...:.:..:   |:.:......:|....:....:||||..|.||||:..||..||.
Mouse    25 RRRSRSASRGRFAESWKR---LSSKQGSTKRSGLPAQQTPAQKSWIERAFYKRECVHIIPSTKDP 86

  Fly   138 TKCCCGQAQITHQTI-PGI--------ESG-SPGDL----WLPTKHTRPQPTDAYGTIEFQGGAH 188
            .:||||:....|..: |.|        ||. |..|:    |..:|||:..||||:||||||||.|
Mouse    87 HRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGH 151

  Fly   189 PTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTT 253
            ..||.|||:||||:|:||:.|.||||.||||||||:|.||..||:||.|||:...|||:|||.||
Mouse   152 SNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 216

  Fly   254 GAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPR 318
            ||||||||.||||.:.|||||.....:..|::.:||||||||||...:|:|.:...|..::|:|.
Mouse   217 GAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPM 281

  Fly   319 SKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFIS----NLKLHPF--------------- 364
            |||.|||:.|::|:|.||||..|||||:.|||:|||.||    |.:..||               
Mouse   282 SKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSC 346

  Fly   365 ------THSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEE 423
                  .....|||.|::|||.|.|..||||:.|:||||||||||||||:|:|||.|||:.:|  
Mouse   347 QLDPIGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEG-- 409

  Fly   424 QPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILT 488
            ..:.||:||.|:.||||||.....|::.|:..|::|.:.|.||||||:..  ||. |::|..|||
Mouse   410 GLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGS--EGH-QDIDLAILT 471

  Fly   489 ALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENG 553
            ||.|..:.|.|:||||||.|||||||||:||:|||:||.|:|::||:.||..||:||||||:|||
Mouse   472 ALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENG 536

  Fly   554 VSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRP-------------HIPKGYIYTLHDIGLVI 605
            |||.:||||.||||||||:|||:|||.:::|||:.             ::|..|..:|.||||||
Mouse   537 VSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNLPPDYRISLIDIGLVI 601

  Fly   606 NKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMAL- 669
            ..|||||||..|||::||.:|..:.........|                    ||....::.| 
Mouse   602 EYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK--------------------LLGMEDDIPLR 646

  Fly   670 ------------------------FEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKL 710
                                    |.|||:||::||||.|||:|||..|.|||||:||:||:|||
Mouse   647 RGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKL 711

  Fly   711 YKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLS 775
            .|||||||:|:|:..:|.:||...:::|.....:|||.||:||.:.|.:|||.||.:|||.:||.
Mouse   712 CKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQ 776

  Fly   776 LAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQT 840
            |||||.||..:||.|||::|.|:|||.||.|||:..|||||:.:|..|..|:||:|:::..|.|.
Mouse   777 LAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMTQA 841

  Fly   841 EEEHLENQNLDNDDSDRSQPDAE-----ALLADTYSVRDTKVHENGKVS-LTDSDTAQFREFFNL 899
            :|.||:.:..:..:....:.|.|     |:|.          ..||:.| ..|.:..|.|     
Mouse   842 QEIHLQEKEPEEPEKPTKEKDEEDMELTAMLG----------RSNGESSRKKDEEEVQSR----- 891

  Fly   900 SEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAY 964
                    |:.:.:.:|.||||.|||.|||..::||:.:|::|::.||||||:.|..|||..|:|
Mouse   892 --------HRLIPVGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISY 948

  Fly   965 ITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTM-DIGRVIYC 1028
            |.|||.||:|||:.|||..:..|..||....||..|..||:||.:|:..|.::... ..||||||
Mouse   949 IFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYC 1013

  Fly  1029 VDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWS 1093
            |:.||||:|:|:|.||||||||.|.|:|||:.:|:|||:::.||||||||:|||||:||::|:|.
Mouse  1014 VNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWK 1078

  Fly  1094 LIKEVTFQPYFMLYGEVFAGDID------------PPCGEDPSQ--------PGCVTGHWVTPIT 1138
            |.|.:.:.||:|:||||||..||            .|||::.::        |.|.||.|:.|..
Mouse  1079 LAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKTIQLPPCKTGAWIVPAI 1143

  Fly  1139 MSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSL 1203
            |:.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:.::||||||.|...|...:
Mouse  1144 MACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMI 1208

  Fly  1204 LKY-CV--RKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTT 1265
            .:: |.  ||.:..:.:||.|||||:..|:|::::||||:|:|.:|.|::...|.|.|||::.|:
Mouse  1209 FQHVCCRWRKHESDQDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTS 1273

  Fly  1266 ERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLA-VIHRFMSTHTAGADDLRG 1329
            ||||.||.::|::|::|:...|::|.::.||.::|:    ::..:| .:.|......|.::.:|.
Mouse  1274 ERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLED----LIGRMATALERLTGLERAESNKIRS 1334

  Fly  1330 ST-INIPGEMQRMRTISISDTEGGS-------GPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTT 1386
            .| .:.......:|..|.:..||.:       .|.|..........::|                
Mouse  1335 RTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETISPTSPTLMP---------------- 1383

  Fly  1387 RRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSE-------AD 1444
             |..:.|...|.    :.|:|.       .|:.:.:.|.|.....:.....|:..|       |:
Mouse  1384 -RMRSHSFYSVN----VKDKGG-------IEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPAN 1436

  Fly  1445 SDIYIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVG-GDNSDDA---- 1504
            :...:|.|:|||:|..:    ||:...:.....|      |:   |:...::| |:.|..|    
Mouse  1437 TLAIVPDSRRPSSCIDI----YVSAMDELHCDIE------PL---DNSMNILGLGEPSFSALAPS 1488

  Fly  1505 -TPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMS-----LTQS 1563
             ||..:..|                   |.:.|....:|| |....|.|:..|..|     |.:.
Mouse  1489 TTPSSSAYA-------------------TLAPTDRPPSRS-IDFEDLTSMDTRSFSSDYTHLPEC 1533

  Fly  1564 EPDSDKDAPIAQGSAHPGKSVLHAKPSRNI-----------LLKLHS------------------ 1599
            :...|.|.|    :.|   ::..:|.||.:           ::|.||                  
Mouse  1534 QNPWDTDPP----TYH---TIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVK 1591

  Fly  1600 --EYTSITDELE---------------------------SVCHMIASPTVSLPSNKASLDRPKTE 1635
              |||||||.::                           |.||         |..:|.|..|.::
Mouse  1592 TAEYTSITDCIDTRCVNAPQAIADRATFPGGLGDKVEDLSCCH---------PEREAELSHPSSD 1647

  Fly  1636 MSRAEAAALLEKKHL--KECEENDYMILEGL----IESRGSIDA---------SAQGFEIGVSID 1685
            ....||........:  :|.|..|..:...:    ||...|..|         :.:.|.|...:|
Mouse  1648 SEENEARGQRAANPISSQEAENADRTLSNNITVPKIERANSYSAEEPNVPYAHTRKSFSISDKLD 1712

  Fly  1686 -----YSHRYPLRRETAVELSPSKPSVDGD 1710
                 .|.|.|.:|..:     |||...||
Mouse  1713 RQRNTASLRNPFQRSKS-----SKPEGRGD 1737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpmNP_001097320.1 Ion_trans 951..1167 CDD:278921 122/236 (52%)
TRPM_tetra 1262..1313 CDD:293127 16/51 (31%)
Trpm3XP_006527017.1 LSDAT_euk 155..445 CDD:375584 154/291 (53%)
trp <908..1238 CDD:273311 163/329 (50%)
TRPM_tetra 1266..1321 CDD:374598 19/58 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836103
Domainoid 1 1.000 403 1.000 Domainoid score I724
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H62287
Inparanoid 1 1.050 1152 1.000 Inparanoid score I207
Isobase 1 0.950 - 0 Normalized mean entropy S4414
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323456at33208
OrthoFinder 1 1.000 - - FOG0002675
OrthoInspector 1 1.000 - - otm43010
orthoMCL 1 0.900 - - OOG6_101222
Panther 1 1.100 - - LDO PTHR13800
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2859
SonicParanoid 1 1.000 - - X538
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.880

Return to query results.
Submit another query.