Protein Alignment Trpm and Trpm3

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_006527017.1
• Gene: Trpm3 / 226025
• MGIID: 2443101
• Length: 1758
• Species: Mus musculus
• Alignment Length: 1904
• Identity: 712/1904 - (37%)
• Similarity: 993/1904 - (52%)
• Gaps: 429/1904 - (22%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTI-PGI--------ESG-SPGDL----WL 89
            :||||..|.||||:..||..||..:||||:....|..: |.|        ||. |..|:    |.
Mouse    64 KSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWS 128

  Fly    90 PTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKA 154
            .:|||:..||||:||||||||.|..||.|||:||||:|:||:.|.||||.||||||||:|.||..
Mouse   129 ISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQ 193

  Fly   155 NFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGI 219
            ||:||.|||:...|||:|||.||||||||||.||||.:.|||||.....:..|::.:||||||||
Mouse   194 NFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGI 258

  Fly   220 VERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFIS--- 281
            ||...:|:|.:...|..::|:|.|||.|||:.|::|:|.||||..|||||:.|||:|||.||
Mouse   259 VENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQK 323

  Fly   282 -NLKLHPSKNHWLKTNVTHS--------------STPVVCLVIEGGTNTIRAVLEYVTDSPPVPV 331
             |.:..|..:  |.:.:.:|              ..|||.|::|||.|.|..||||:.|:|||||
Mouse   324 INTRCLPFFS--LDSRLFYSFWGSCQLDPIGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPV 386

  Fly   332 VVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 396
            |||||||||:|:|||.|||:.:|  ..:.||:||.|:.||||||.....|::.|:..|::|.:.|
Mouse   387 VVCDGSGRASDILAFGHKYSEEG--GLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKK 449

  Fly   397 NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNG 461
            .||||||:..  ||. |::|..|||||.|..:.|.|:||||||.|||||||||:||:|||:||.|
Mouse   450 ELITVFRMGS--EGH-QDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVG 511

  Fly   462 ALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRP----- 521
            :|::||:.||..||:||||||:||||||.:||||.||||||||:|||:|||.:::|||:.
Mouse   512 SLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPG 576

  Fly   522 --------HIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQY 578
                    ::|..|..:|.||||||..|||||||..|||::||.:|..:.........|
Mouse   577 FGWIYFKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALK------ 635

  Fly   579 QRYAGANSLSLVTGLLPFTSEMAL-------------------------FEFPFNELLIWAVLTK 618
                          ||....::.|                         |.|||:||::||||.|
Mouse   636 --------------LLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMK 686

  Fly   619 RQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSY 683
            ||:|||..|.|||||:||:||:|||.|||||||:|:|:..:|.:||...:::|.....:|||.||
Mouse   687 RQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSY 751

  Fly   684 RQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVIL 748
            :||.:.|.:|||.||.:|||.:||.|||||.||..:||.|||::|.|:|||.||.|||:..||||
Mouse   752 KQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVIL 816

  Fly   749 GLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMG 813
            |:.:|..|..|:||:|:::..|.|.:|.||:.:..:..:....:.|.|...|.|....|
Mouse   817 GILLPPSILSLEFKNKDDMPYMTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLGRS------ 875

  Fly   814 AGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEF 878
            .|.::|.|                       |.:..|.|             |:.:.:.:|.|||
Mouse   876 NGESSRKK-----------------------DEEEVQSR-------------HRLIPVGRKIYEF 904

  Fly   879 YTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAIT 943
            |.|||.|||..::||:.:|::|::.||||||:.|..|||..|:||.|||.||:|||:.|||..:.
Mouse   905 YNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLL 969

  Fly   944 HKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTM-DIGRVIYCVDSIYWYLRILNILGVNKYLG 1007
            .|..||....||..|..||:||.:|:..|.::... ..|||||||:.||||:|:|:|.|||||||
Mouse   970 QKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLG 1034

  Fly  1008 PLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALGH 1072
            |.|.|:|||:.:|:|||:::.||||||||:|||||:||::|:|.|.|
Mouse  1035 PYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK------------------ 1081

  Fly  1073 NTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYF 1137
                                                                     |:.:.||:
Mouse  1082 ---------------------------------------------------------NIFYMPYW 1089

  Fly  1138 MLYGEVFAGDID------------PPCGEDPSQ--------PGCVTGHWVTPITMSMYLLIANIL 1182
            |:||||||..||            .|||::.::        |.|.||.|:.|..|:.|||:||||
Mouse  1090 MIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKTIQLPPCKTGAWIVPAIMACYLLVANIL 1154

  Fly  1183 LINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKY-CV--RKA 1244
            |:|||||||||.|.||.|:|:|||.|||:.::|.:.::||||||.|...|...:.:: |.  ||.
Mouse  1155 LVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKH 1219

  Fly  1245 KGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIE 1309
            :..:.:||.|||||:..|:|::::||||:|:|.:|.|::...|.|.|||::.|:||||.||.::|
Mouse  1220 ESDQDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLE 1284

  Fly  1310 DINQKENIQTATVQNIEFRLRKMEESSEQILSHLA-VIHRFMSTHTAGADDLRGST-INIPGEMQ 1372
            ::|::|:...|::|.::.||.::|:    ::..:| .:.|......|.::.:|..| .:......
Mouse  1285 EVNEREHSMKASLQTVDIRLAQLED----LIGRMATALERLTGLERAESNKIRSRTSSDCTDAAY 1345

  Fly  1373 RMRTISISDTEGGS-------GPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEV 1430
            .:|..|.:..||.:       .|.|..........::|                 |..:.|...|
Mouse  1346 IVRQSSFNSQEGNTFKLQESIDPAGEETISPTSPTLMP-----------------RMRSHSFYSV 1393

  Fly  1431 RPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSE-------ADSDIYIPVSQRP 1488
            .    :.|:|.       .|:.:.:.|.|.....:.....|:..|       |::...:|.|:||
Mouse  1394 N----VKDKGG-------IEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRP 1447

  Fly  1489 STCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVG-GDNSDDA-----TPDINFEAAR 1547
            |:|..:    ||:...:.....|      |:   |:...::| |:.|..|     ||..:..|
Mouse  1448 SSCIDI----YVSAMDELHCDIE------PL---DNSMNILGLGEPSFSALAPSTTPSSSAYA-- 1497

  Fly  1548 HRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMS-----LTQSEPDSDKDAPIA 1607
                             |.:.|....:|| |....|.|:..|..|     |.:.:...|.|.|
Mouse  1498 -----------------TLAPTDRPPSRS-IDFEDLTSMDTRSFSSDYTHLPECQNPWDTDPP-- 1542

  Fly  1608 QGSAHPGKSVLHAKPSRNI-----------LLKLHS--------------------EYTSITDEL 1641
              :.|   ::..:|.||.:           ::|.||                    |||||||.:
Mouse  1543 --TYH---TIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCI 1602

  Fly  1642 E---------------------------SVCHMIASPTVSLPSNKASLDRPKTEMSRAEAAALLE 1679
            :                           |.||         |..:|.|..|.::....||.....
Mouse  1603 DTRCVNAPQAIADRATFPGGLGDKVEDLSCCH---------PEREAELSHPSSDSEENEARGQRA 1658

  Fly  1680 KKHL--KECEENDYMILEGL----IESRGSIDA---------SAQGFEIGVSID-----YSHRYP 1724
            ...:  :|.|..|..:...:    ||...|..|         :.:.|.|...:|     .|.|.|
Mouse  1659 ANPISSQEAENADRTLSNNITVPKIERANSYSAEEPNVPYAHTRKSFSISDKLDRQRNTASLRNP 1723

  Fly  1725 LRRETAVELSPSKPSVDGD 1743
            .:|..:     |||...||
Mouse  1724 FQRSKS-----SKPEGRGD 1737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	155/293 (53%)
		TRPV	<872..1227	CDD:454755	157/375 (42%)
		TRPM_tetra	1291..1346	CDD:465156	19/55 (35%)
Trpm3	XP_006527017.1	LSDAT_euk	155..445	CDD:465665	155/293 (53%)
		TRPV	<908..1238	CDD:454755	164/404 (41%)
		TRPM_tetra	1266..1321	CDD:465156	19/58 (33%)