DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and Trpm6

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_700466.1	Gene:	Trpm6 / 225997	MGIID:	2675603	Length:	2028	Species:	Mus musculus

Alignment Length:	2048	Identity:	661/2048 - (32%)
Similarity:	994/2048 - (48%)	Gaps:	400/2048 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIP-------------------GIESGSP 160
            :||||..|.||||.||||..||..:|..| .||.|..:.                   .:..|..
Mouse     5 KSWIEGVFYKRECNKFIPSSKDPHRCTPG-CQICHNLVRCYCGRLIEEHHGLDRAWNLSVTEGHG 68

  Fly   161 GDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITV 225
            .:.|...|||...|||.:|||.||.|.|...::|:|.|:||:.:.|:.|..||||:|||||:|:|
Mouse    69 DEQWSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVISV 133

  Fly   226 QGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGI 290
            .||..||.:.:|||:...:||:|||:||||||.|.|.|:||:|.|||||.....:...::.::||
Mouse   134 HGGLQNFKISSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDALKAHSSKSLRKIWTVGI 198

  Fly   291 APWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLE 353
            .|||::|...||:|  ::|.|  .::.:|.|||..||..|::|:|.|:||...||.|..|||.||
Mouse   199 PPWGVIENQRELVG--KDVVCMYQTLGNPLSKLTTLNCMHSHFILCDDGTVGMYGNEEKLRRNLE 261

  Fly   354 KFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYA 418
            |.:|..|:|..:....|||.||:|||.|.|..|.|.|.:..  |||||:|:|||||||||.:|:.
Mouse   262 KHLSMQKIHTCSRQGVPVVGLVMEGGPNVILWVWETVKNKE--PVVVCEGTGRAADLLAFTYKHL 324

  Fly   419 SDGEEQPVLE-SMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQEL 482
            .||   .:|. .:::.|...||..|...|.||:.|:|.|::|..:|:.||:|   :....|.|:|
Mouse   325 EDG---GILRPQVKEELFCLIQNMFNFSLRQSKHLFQILMECMVHKDSITIF---DADSEEHQDL 383

  Fly   483 DQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVK 547
            |..|||||.|...||..|||:||:.|:|:|||:..|..|||.|..|||::||:.||..||:||||
Mouse   384 DLAILTALLKGTSLSISEQLNLAMAWDRMDIAKKHILTYGQHWKPGALEQAMLDALVMDRVDFVK 448

  Fly   548 LLLENGVSMKKFLTIPRLEELYNTKHGPANT-LGYILRDVRPH-IPKGYIYTLHDIGLVINKLMG 610
            ||:||||::.:||||||||||||||.||.|. |.::::||:.| :...|..||.||||||..|:|
Mouse   449 LLIENGVNLHRFLTIPRLEELYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDIGLVIEYLIG 513

  Fly   611 GAYRSYYTRRKFRPIY------AKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLL-------- 661
            |||||.|||:.||.:|      .|.::|:|....:.|.  :||::..|........|
Mouse   514 GAYRSSYTRKSFRILYNNLYRKHKSVSSFAQGLSQHSL--HQRHSLRNRKESSESTLHSQFFRTA 576

  Fly   662 -PFTS------------------------EMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEAL 701
             |:.|                        |.|.|.:|:|:||:||||.|||.||:..|.|||||.
Mouse   577 QPYKSKEKPEDSQKSKKKSKERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEAT 641

  Fly   702 AKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELH 766
            .|::::..||:|||.||.|.::..:..|||::|:::|......:|:.:::|:...|.:|||.||.
Mouse   642 VKAVIASILYRAMAREAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLLTYELK 706

  Fly   767 SWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSK 831
            :|||.:||.|||:...|..::|.|:|::|.|:|||.|:.|||:..|:|:.:.:|..|..|:||||
Mouse   707 NWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPPMILTLEFKSK 771

  Fly   832 EELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFREF 896
            .|:..:||:::...                       |::..|..: .|.|.|....|
Mouse   772 AEMSHVPQSQDFQF-----------------------TWNYSDQGL-SNTKESACVKD------- 805

  Fly   897 FNLSEYNEVKQHQPLRL-----------KKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKM 950
            ::|....:.|..:||.|           .::.||||:||..|||..::||:.||::|::||||:|
Mouse   806 YDLERGPDEKPDEPLHLDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEM 870

  Fly   951 EQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRF 1015
            :..|...||..|.||.|...||||||..|||.....|..:|....||..:..||.||.:|...|:
Mouse   871 QPQPSVHEWLVIIYIFTNAIEKVREICISEPSKFKQKVKMWLSEYWNLMETVAIGLFAVGFGLRW 935

  Fly  1016 RENTMD-IGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVS 1079
            ....:. .||:|||:|.|:|:.|:::...||::.||.|||:.||..||.|.|:::|:||:||||:
Mouse   936 GHPPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPYVTMIAKMAANMFYIVIIMAIVLLSFGVA 1000

  Fly  1080 RQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLL 1144
            |:|||.|.:.|:|.|.:::.|:||:|:||||:|.||| .|..:.|   |..|.::||...::||.
Mouse  1001 RKAILSPKEPPSWRLARDIVFEPYWMMYGEVYASDID-VCSNETS---CPPGSFLTPFLQAVYLF 1061

  Fly  1145 IANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLK-YCV 1208
            :..|:::|||||.||||:.::.|:|:::|.:.|:..:|.|.|||.||||||.|.|...||: .|.
Mouse  1062 VQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWLPPPFILLNHLCLLLRGLCC 1126

  Fly  1209 RKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQ 1273
            |.|...:.:.|.||||:|.||||::|:||||:|||.:|||:...||.|.:|:::.|:|||..|..
Mouse  1127 RPAPQDQEEGDGGLKLYLTKDDLKKLHDFEEQCVEKYFHEKTEGLNCSFEEQIRMTSERVSEMFF 1191

  Fly  1274 KIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEM 1338
            :::::|:|       |..|:..|..::..    :.||              .||...|::
Mouse  1192 QLKEMNEK-------VSFIKDSLLSLDSQ----VGHL--------------QDLSAITVD----- 1226

  Fly  1339 QRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYI 1403
             .::.:|..||                           |..:.:.:..|:   .|....||.::.
Mouse  1227 -TLKVLSAVDT---------------------------LQEDEILLANRK---HSTCRKRPHSWT 1260

  Fly  1404 FDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRT---P 1465
                   .|:..     :|:...|:..::.::..||.              ||...::.|:   |
Mouse  1261 -------NVICA-----KVLSDMESCGKKKLQYYSMP--------------PSLLRSLARSQLPP 1299

  Fly  1466 YVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNS 1530
            .|    ..||..|...:.....:..::|                    ..|.:.|||.:
Mouse  1300 SV----QRGALVEVTHSKREASHVREEQ--------------------EEREMEQRTTA------ 1334

  Fly  1531 ETYSLTG-ADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIA-QGSAHPGKSVLHAKPSRNI 1593
                 :| :.:.::|....|...:           |.|.|..|:: :...|..:|...|.....:
Mouse  1335 -----SGISHVRQAHSKYGQFLLV-----------PSSGKQVPLSLETPPHLFRSSEEAGIDGLV 1383

  Fly  1594 LLKLHSE--YTSITDELESVCHMIASPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEEN 1656
            |..:|..  .|.:..:..:..|.      :|.:.........|:||...|.|           |.
Mouse  1384 LEHIHQSDLTTHLPQQTPAASHQ------ALVAEHKDQHEAVTQMSDKPAKA-----------EQ 1431

  Fly  1657 DYMILEGL--------IESR--------GSID-ASAQGFEIGVSIDYSHRYPLRRETAVEL---- 1700
            |.:...|.        :.||        |.:: |.::..|.||       :..:::....|
Mouse  1432 DLLAFSGTPAPMTVTSLPSRAISMQDEGGYVNWAFSENDETGV-------FSFKKKWKTCLASTC 1489

  Fly  1701 -SPSKPSVDGDLMGGGEGGGAGGGDSSDTSG--AGSCGAMVGISSGFQLKNERPWQRNSSMEQQT 1762
             |.|.|..|..|..||..|       .|.|.  |.||....|           ||   :...:..
Mouse  1490 NSDSNPGGDYFLHTGGRSG-------LDNSRRLAQSCECPAG-----------PW---TQARRSF 1533

  Fly  1763 YPSPLVPTRATSDFLNPPYEGRLFKKS-----------SESLQKNSS-------TETDYSAHPYR 1809
            :.:||...:|    |...:..|..|:.           |:||:..|:       |:|       |
Mouse  1534 WINPLCRDKA----LIKSHSFRFHKEEKLRKTWKNNSHSKSLETRSTWLKAKLLTKT-------R 1587

  Fly  1810 FIKQSSNETN------TSLTGSYNVDTPSLTAEP-SLDAGDSHSATGISISVGAVGGTATARYQ- 1866
            .:.:...:|.      .::...|..|  .|.||| ..:..:..|...:|:|..:..|.....||
Mouse  1588 SLSKKKRKTQGLQVPVITVNACYQSD--QLNAEPGETNTTEEFSKKWLSVSNFSQIGLEPYIYQK 1650

  Fly  1867 ----PIRTASVGAADGRRLREESSSSLDLSSSGPVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTA 1927
                .|:..:..|:|..|..:|:.......:||..::.       |..|.:....|.:...|..:
Mouse  1651 MKMKEIKRHTTQASDHLRQPQENRDKTPTWNSGSTSLS-------RSFLTRSPNEVHKISTSLKS 1708

  Fly  1928 AEAVPQTPE-----AAQAGQAKLISTLKPQPFASKLGMNV----LKESSSST-DESVGSSAKSSN 1982
                ||.|.     ..:....:|..|:...|.....|..|    |:|||..| |:|:.|.::...
Mouse  1709 ----PQEPHHHYSAIERNNLMRLSQTIPFTPIQLFTGEEVTIYKLEESSPLTLDKSMSSWSQHGR 1769

  Fly  1983 PALSIPQISTHLVQDEIAKLSSNIKSSTESEKD 2015
            .|: |..:|...:...:.|....|  ||.||.|
Mouse  1770 AAM-IQVLSQEEMDGGLRKAMRVI--STWSEDD 1799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	93/216 (43%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	12/50 (24%)
Trpm6	NP_700466.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..601		2/23 (9%)
		TRP_2	<661..1111	CDD:331598	181/484 (37%)
		TRPM_tetra	1180..1231	CDD:318673	15/81 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1313..1339		6/56 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1658..1694		8/42 (19%)
		Alpha_kinase	1760..1978	CDD:214828	12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2009..2028
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836106
Domainoid	1	1.000	403	1.000	Domainoid score	I724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1152	1.000	Inparanoid score	I207
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	1	1.000	-	-		FOG0002675
OrthoInspector	1	1.000	-	-		otm43010
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900