Protein Alignment Trpm and gtl-1

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: NP_502111.3
• Gene: gtl-1 / 178031
• WormBaseID: WBGene00001795
• Length: 1694
• Species: Caenorhabditis elegans
• Alignment Length: 1771
• Identity: 557/1771 - (31%)
• Similarity: 859/1771 - (48%)
• Gaps: 364/1771 - (20%)

  Fly    25 RRYSNTPAV---VVGSFRASTSAFIAAESAAHLPTCSSPTTRTPVSTPRGIRRRQRMRKRSSVSS 86
            :|.|..||:   |..|.||::......||.....|.:.             |||::.|..||..:
 Worm     4 KRGSIVPAIHKAVAESLRANSVTVEENESERETETQTK-------------RRRKKQRSTSSDKA 55

  Fly    87 TLSK----VLILNVRDLL--------------KAHAGSEPLKEHQPR-------SWIETNFQKRE 126
            .|:.    |...:.:|:|              .:|:|      |..|       :|||...:.|:
 Worm    56 PLNSAPRHVQKFDWKDMLHLADISGRKRGNSTTSHSG------HATRAGSLKGKNWIECRLKMRQ 114

  Fly   127 CIKFIPCPKDDTKCCCGQAQ-----------------ITHQTIPGIESGSPGDL----------- 163
            |..|:|..:...:|.||:.:                 :.|.|:|||......|.
 Worm   115 CSYFVPSQRFSERCGCGKERSKHTEEVLERSQNKNHPLNHLTLPGIHEVDTTDADADDNEVNLTP 179

  Fly   164 --WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQ 226
              |....||...||||||.|.|:|.||  .|||.|:|||:.|..:|.|..|.|.|:.|||:||:.
 Worm   180 GRWSIQSHTEIVPTDAYGNIVFEGTAH--HAQYARISFDSDPRDIVHLMMKVWKLKPPKLIITIN 242

  Fly   227 GGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRT-GRVVSIGI 290
            ||...||||.||.:..|||::|.||:|.|||.|.|.:.||.|.:..||...|...: ..||:|||
 Worm   243 GGLTKFDLQPKLARTFRKGIMKIAKSTDAWIITSGLDEGVVKHLDSALHDHGNHTSKNHVVAIGI 307

  Fly   291 APWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKF 355
            |.||::::....:|.:..|...:.....::|..||:.|:|||..||||..:||||:|:|::||.:
 Worm   308 ASWGMLKQRSRFVGKDSTVTYATNVFNNTRLKELNDNHSYFLFSDNGTVNRYGAEIIMRKRLEAY 372

  Fly   356 ISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASD 420
            ::.   .....|:.|:||:|:|||..||:.|.:|||..|.:||:||||||||||:|||.|:..|
 Worm   373 LAQ---GDKKRSAIPLVCVVLEGGAFTIKMVHDYVTTIPRIPVIVCDGSGRAADILAFAHQAVS- 433

  Fly   421 GEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQT 485
             :...:.:::|:.|:..:::.|......::||.:::::|:.||:|:|:||:   .|...::||..
 Worm   434 -QNGFLSDNIRNQLVNIVRRIFGYDPKTAQKLIKQIVECSTNKSLMTIFRL---GESSREDLDHV 494

  Fly   486 ILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLL 550
            |::.|.|.|:|||||||.|||.|||.||||:|||..|.||....|..||::||.:||||||.|||
 Worm   495 IMSCLLKGQNLSPPEQLQLALAWNRADIARTEIFANGTEWTTQDLHNAMIEALSNDRIDFVHLLL 559

  Fly   551 ENGVSMKKFLTIPRLEELYNTKHGPANTL-GYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYR 614
            ||||||:||||..|||.||||..||.||| ..:|.|.:.||      .|.::|.::..|||..|:
 Worm   560 ENGVSMQKFLTYGRLEHLYNTDKGPQNTLRTNLLVDSKHHI------KLVEVGRLVENLMGNLYK 618

  Fly   615 SYYTRRKF---------RPIYAKVMNSYANACR-------------KSSTYQYQRYAGANS--LS 655
            |.||:.:|         |..:.|.::|.:|..|             :.|:.|......|.:  :|
 Worm   619 SNYTKEEFKNQYFLFNNRKQFGKRVHSNSNGGRNDVIGPSGDAGRERMSSMQISLINNARNSIIS 683

  Fly   656 LVTG--------------------LLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 700
            |..|                    .:.||     |.:|:::|:|||||||||:||.||||||||.
 Worm   684 LFNGGGRKRESDDEDDFSNLEEEANMDFT-----FRYPYSDLMIWAVLTKRQKMAKLMWTHGEEG 743

  Fly   701 LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCEL 765
            :||:||:.:||.::|..|:....:..:.::...::.||.....::|::..:...::..|||||||
 Worm   744 MAKALVASRLYVSLAKTASLATGEIGMSQDFTEFSDEFSELAVEVLEYCTKHGRDQTLRLLTCEL 808

  Fly   766 HSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKS 830
            .:|.:::|||||....||..|||||.|::|:|||.|||..:.|.|.||:..||.|..|..|.||:
 Worm   809 ANWGDETCLSLAANNGHRKFLAHPCCQMLLSDLWQGGLLMKNNQNSKVLTCLAAPPLIFLLGFKT 873

  Fly   831 KEELQQMPQTEEEHLE-----------------NQNLDNDDSDRSQPD--AEALLAD-------- 868
            ||:|...|:|..||.|                 :.:.|:||||.....  |::|.||
 Worm   874 KEQLMLQPKTAAEHDEEMSDSEMNSAEDTDTSSDSSSDSDDSDEEDAKLRAQSLSADQPLSIHRL 938

  Fly   869 ----------------------------------TYSVRDTK----------------------- 876
                                              |.|::.:|
 Worm   939 VRDKLNFSEKKKPDMGISRIVVAPPIVTGRNRARTMSIKKSKKNVIKPPACLKIETSDDDEQEQK 1003

  Fly   877 ------VHENGK-----VSLT------------DSDTAQ--FREFFNLSEYN-EVKQHQPLRLKK 915
                  ::..||     |::.            |:.|.|  .|||.:..... :|...:||..||
 Worm  1004 KATEMYINRTGKRGSVAVAMNHDDMYIDPSEELDTQTRQKSSREFSSSRNVTVQVYTQRPLSWKK 1068

  Fly   916 KFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIIS-- 978
            |..|||.||||.:|....|:::|||:.::.:|||.:::..|.|||..|||.....|..|:::|
 Worm  1069 KIMEFYKAPITTYWLWFFAFIWFLILLTYNLLVKTQRIASWSEWYVFAYIFVWTLEIGRKVVSTI 1133

  Fly   979 ----SEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRIL 1039
                |:||  ..:..|:.:...|......::.::|....|....|..:||::...:|:.|.|:::
 Worm  1134 MMDTSKPV--LKQLRVFFFQYRNGLLAFGLLTYLIAYFIRLSPTTKTLGRILIICNSVIWSLKLV 1196

  Fly  1040 NILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYF 1104
            :.|.|.:.|||.:.::.:|:..||...||:.:.|.:||:.||:|.||.:...|.|::.:..||||
 Worm  1197 DYLSVQQGLGPYINIVAEMIPTMIPLCVLVFITLYAFGLLRQSITYPYEDWHWILVRNIFLQPYF 1261

  Fly  1105 MLYGEVFAGDIDPPCG-------EDPSQP---------GCVTGHWVTPITMSMYLLIANILLINL 1153
            ||||||:|.:|| .||       ||.:.|         .||.|:|:.|:.:::::|..|:||:|:
 Worm  1262 MLYGEVYAAEID-TCGDEIWQTHEDENIPISMLNVTHETCVPGYWIAPVGLTVFMLATNVLLMNV 1325

  Fly  1154 LIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQR 1218
            ::|....||.:....:.::::|:|:..||||:..|.|||||..:.|...|.|.....::..|.:.
 Worm  1326 MVAGCTYIFEKHIQSTREIFLFERYGQVMEYESTPWLPPPFTIIYHVIWLFKLIKSSSRMFERKN 1390

  Fly  1219 --DNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQK 1281
              |..|||||..|::|:::.||||.||....|.|.....|.|||:..|.||.:.:..::..:.|.
 Worm  1391 LFDQSLKLFLSPDEMEKVHTFEEESVEDMKRETEKKNLSSNDERIHRTAERTDAILNRVSHLTQL 1455

  Fly  1282 ENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISI 1346
            |......::.:|.:::.|:...::.::.:..:::.:....:|... |||.
 Worm  1456 EFTLKEEIRELEHKMKNMDSRHKEQMNLMLDMNKKLGKFISGKYK-RGSF--------------- 1504

  Fly  1347 SDTEGGSGPGGNGGGGGGGGAIV---------------PLG----LGAGLNLNSLQ----VTTRR 1388
                |||  |.:||||....:.:               |:|    .|..|..:|||    :|..|
 Worm  1505 ----GGS--GSDGGGGSSDNSKLEPNNSVPMITVDGPSPIGSRRTSGQYLKRDSLQAKKKITENR 1563

  Fly  1389 RFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQV----------VRKA--SMQS 1441
            |  .||.:.:..:..|:         |.|:.||  .:.|:..|:|          ||:.  |.:|
 Worm  1564 R--SSLEQPKIPSIQFN---------LMEDQDE--SAAESATEEVSISIPVPQMRVRQVTESDKS 1615

  Fly  1442 EADSDIYIPVSQRPSTCETVKRTP-----YVTV------RQDTGASTESKDTLTPMGNNDDDQTL 1495
            :...|..|.....|.|...:.|.|     |.|:      ..|..|.:.....:||:  ...|.:.
 Worm  1616 DLSEDDLITREDAPPTSINLPRGPRRHALYSTIADAIETEDDFYADSPVPMPMTPV--QPADGSF 1678

  Fly  1496 VGGDNSDDATPDINFE 1511
            .|.::|.....|.::|
 Worm  1679 FGENDSRYQRDDSDYE 1694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	74/237 (31%)
		TRPM_tetra	1262..1313	CDD:293127	7/50 (14%)
gtl-1	NP_502111.3	LSDAT_euk	208..471	CDD:375584	110/267 (41%)
		Ion_trans	1081..1328	CDD:366146	79/249 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	255	1.000	Domainoid score	I1102
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4414
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870