Protein Alignment Trpm and ced-11

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: NP_499021.1
• Gene: ced-11 / 176288
• WormBaseID: WBGene00000425
• Length: 1418
• Species: Caenorhabditis elegans
• Alignment Length: 1334
• Identity: 243/1334 - (18%)
• Similarity: 444/1334 - (33%)
• Gaps: 395/1334 - (29%)

  Fly   150 QTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEW 214
            |..|.:..|||..|....||...:...|...:: ||                .|:|::.|
 Worm    31 QLCPALILGSPQALPGAIKHIYSRLAAAASEVD-QG----------------VPDLIISL----- 73

  Fly   215 NLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQ 279
                      :..|.:   |..|....:..||.......|.|:.:.|       :|.|.:
 Worm    74 ----------ISHGNS---LSTKYMSSVENGLKSFLIGCGTWLISSG-------EVNDPM----- 113

  Fly   280 QRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGA 344
               .||.|      |.::.....|.|..||           |.:|.|...  ::..:.|.:|...
 Worm   114 ---SRVAS------GALKNVLPQLEHQAEV-----------LHILVNSDD--MIASDTTNSKSVV 156

  Fly   345 E-------LILRRK-------LEKFISNLKLHPFTHSSTPVVCLVIEGGT-----------NTIR 384
            :       ||.|::       :...|:.|:.......:.|...|:|  |.           |:..
 Worm   157 DTSLNTLLLICRKEPNDSYETVASSIAKLRAATAVKLAHPPPALLI--GVPSEPMSPSTYGNSAA 219

  Fly   385 AVLEYVTDSPPVPVVVCDGSGR---------------------AADLLAFVHK-----YASDGEE 423
            .:|....|..|.||.:..|:.:                     :.:|.|.:|.     ..|:.:.
 Worm   220 ILLSPSNDKRPFPVAIFAGASKESLIELLFFVEHGIPVIILQDSCELCAILHSSHLLLETSNFDN 284

  Fly   424 QPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTIL- 487
            ...:..:|..|       :.:||.....|..:||.   :.|...|..|:.....:..||...::
 Worm   285 DKFISWLRSQL-------YPLGLADCYTLITKLLV---SSNSGDVQLIEFIDSSQLSELSSVVVD 339

  Fly   488 -------------TALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQAL- 538
                         ..|..:..|:.|..||      .:|:|             ..|||.::..:
 Worm   340 RCLECYATTGEERQVLLLAAKLNSPSVLS------SMDVA-------------AQLDEELLTMIL 385

  Fly   539 -----EHDRIDFVKLLLE-----NGVSMKKFLTIPRLEELYNTKHGPANTLG--YILRDVRPHIP 591
                 :.|::.|:..:|:     ...|......:...:|.:.|.......:|  ||..::.|..
 Worm   386 CECITKDDQLHFLSSVLQLSPPIRVTSNMLIRMMHHADEHFFTTIVLCQCMGYSYIPSEIDPRF- 449

  Fly   592 KGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSL 656
                  .:||..::.||      |:.....|.|      |.:.|.......::..|.
 Worm   450 ------ANDIQKLVKKL------SFGVDNLFDP------NVFCNDSSHRDKHESIRI-------- 488

  Fly   657 VTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAED 721
                                |.||::|..|..:...:....:|.:|.|:|..::.:::.||:.
 Worm   489 --------------------LAIWSLLLHRPGIVKCLAAFADEPVAFSMVLSRIARSLGHESH-- 531

  Fly   722 DLDTEIYEE-LRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRAL 785
              |...||: |.:.:.........|.|..:.....||.:||...:..:...:...||...|.|.:
 Worm   532 --DWHFYEKSLNTLSDSLSGSATTLFDTVFSTSPAKAYQLLCQPMEYFYGFNMTQLAFHCNAREI 594

  Fly   786 LAHPCSQVILADLWMGGLRTRKNTNFKVILG----------LAMPFYIRQLDFKSKEELQQ---- 836
            :||.|.|..:.....|.|:.:   ||.:.|.          |.:|.....| .:.:|..:|
 Worm   595 IAHECCQRWVHRKLYGNLQAK---NFPIFLPKWAKICISAVLIIPVKFWML-VRPRERTKQDTVS 655

  Fly   837 ----------MPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTA 891
                      .|| ::..:...::   .|.||    |||.|.|..: .|....|..::..:|.|.
 Worm   656 PTVALLDVGKFPQ-KQRAISTYSV---ISSRS----EALTALTAPL-STAFGFNSALNGAESATP 711

  Fly   892 QFREF-FNLSEYNEVKQHQPLRLKKKFYE--------FYTAPITKFWADSIAYMFFLIMFSFTVL 947
            |...| .|:.|.:  |..:|...|.:...        ||:.||.|:|...:..:.|:...:::|:
 Worm   712 QSMVFPLNIEEID--KDPRPFGKKNRIRRAHAPTLSTFYSTPIVKYWLSLLFRIVFICCLAYSVV 774

  Fly   948 VKMEQMPRWQE---------WYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAA 1003
            :.......|..         |....::.|....|:       |:::.         .|...|..|
 Worm   775 LPGCGSNLWDTGMWVWSFFWWIENCFVLTARARKI-------PLSLM---------PWRVFDVFA 823

  Fly  1004 IILFVIGLAFRFRENTMDIGRV-----IYCVDSIY-------------WYLRILNILGVNKYLGP 1050
            ..:|:|.|.      .|.:..|     :..:||||             .|..:...:.::...||
 Worm   824 FFVFLILLL------VMKVFPVTPVLEVLGIDSIYSAKVVSAFFVLYVSYSTLFTYIPLSDIFGP 882

  Fly  1051 LVTMMGKM-VKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLY------- 1107
            ::..:..| :::...|:.::|:|::|..|:.||:::|::..|..:.::.....:..|:
 Worm   883 MIVRVKLMLLRDFTNFLFMIALVMLSSAVAIQAVVFPDRPVTMEVFRKTLSWIWLSLFTTDLSNL 947

  Fly  1108 ------GEVFAGDIDPPCGE--DPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNE 1164
                  .:.|.|.....|..  ..:.|.|.:......:.:..|.:|..:||..:|.|.|:.....
 Worm   948 SESETCRKSFLGAPKRYCSSVGQYANPSCPSQSLPAYLIVIEYFVILKLLLWPILFAFFSKTAKN 1012

  Fly  1165 VNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKD 1229
            |:..:.::|.||.:::..:::.:|.||||....|...|.   |.|.:        |....|....
 Worm  1013 VDDEADKIWRFQLYSLAEDFRLRPPLPPPLTIFCLICSA---CCRFS--------NSFSGFFSDF 1066

  Fly  1230 DLERLYDFE------------------------EECVEGFFHEQEIILNQSTDERVKNTTERVET 1270
            |..   |||                        .|.|..|:.:..:       |:.|||.::.:.
 Worm  1067 DHP---DFEARDKCRTTWKFGSIYRNPSVPFKRNEFVNSFWRKLSM-------EQWKNTQQKAKI 1121

  Fly  1271 MSQKIEDINQKENIQTATVQNIEFRLRKMEESSE 1304
            .:.|.| :.:..||..      ..|:..:.:|.|
 Worm  1122 SANKSE-LQELHNIHN------HIRMMTLRDSYE 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	44/258 (17%)
		TRPM_tetra	1262..1313	CDD:293127	10/43 (23%)
ced-11	NP_499021.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010