DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and Trpm1

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001034193.2	Gene:	Trpm1 / 17364	MGIID:	1330305	Length:	1622	Species:	Mus musculus

Alignment Length:	1724	Identity:	662/1724 - (38%)
Similarity:	935/1724 - (54%)	Gaps:	330/1724 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 IRRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKD 136
            :|:.....||.|:.|:.|               ||    :...::|||..|.|||||..||..||
Mouse     4 MRKMSSSFKRGSIKSSTS---------------GS----QKGQKAWIEKTFCKRECIFVIPSTKD 49

  Fly   137 DTKCCCGQAQITHQTIPGIESGSPGDL-------------WLPTKHTRPQPTDAYGTIEFQGGAH 188
            ..:||||  |:|:|.||.:.||:|...             |..:|||:..|||:||.:|||||.:
Mouse    50 PNRCCCG--QLTNQHIPPLPSGAPSTTGEDTKQADTQSGKWSVSKHTQSYPTDSYGILEFQGGGY 112

  Fly   189 PTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTT 253
            ..||.|:|:|:||:|:.|:.|..|:|.||||||||:|.||..:|::|.|||:...|||:|||.||
Mouse   113 SNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQPKLKQVFGKGLIKAAMTT 177

  Fly   254 GAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPR 318
            ||||||||.:|||...|||||.....:..||:.:|||||||:||...:|:|.:......::|:|.
Mouse   178 GAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWGMVENKEDLIGKDVTRVYQTMSNPL 242

  Fly   319 SKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTI 383
            |||:||||.|.:|:|.||||..|||||:.|||:|||.||..|::.......|||.||:|||.|.:
Mouse   243 SKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVGLVVEGGPNVV 307

  Fly   384 RAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQ 448
            ..||||:.:.||||||||||||||:|:|:|.|||..:|  ..:.||:||.|:.||||||.....|
Mouse   308 SIVLEYLKEDPPVPVVVCDGSGRASDILSFAHKYCDEG--GVINESLRDQLLVTIQKTFNYSKSQ 370

  Fly   449 SEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDI 513
            |.:|:..:::|.:.|.|:||||:..  ||: |:::..|||||.|..:.|.|:||||||.||||||
Mouse   371 SYQLFAIIMECMKKKELVTVFRMGS--EGQ-QDVEMAILTALLKGTNASAPDQLSLALAWNRVDI 432

  Fly   514 ARSEIFVYGQEWPN--------------------------------------------------- 527
            |||:|||:|..||.
Mouse   433 ARSQIFVFGPHWPPLGSLAPPVDTKATEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKL 497

  Fly   528 ------GALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDV 586
                  .||::||:.||..||:||||||:||||:|:.|||||||||||||:.||.|||..::|||
Mouse   498 ELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDV 562

  Fly   587 -RPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAG 650
             :.::|..|..:|.|||||:..|||||||..|||:.||.:|             ::.:..:|...
Mouse   563 KKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLY-------------NNLFGPKRPKA 614

  Fly   651 ANSLSLVTGLLPFTSE-------------------MALFEFPFNELLIWAVLTKRQQMALLMWTH 696
            ...|.:.....|...:                   ::.|::||:||::||||.|||:||:.:|..
Mouse   615 LKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQR 679

  Fly   697 GEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLL 761
            |||.:||:||:||||||||||::|.:|..:|.::|.:.:|:|.....:|||.||:.|.:.|.:||
Mouse   680 GEECMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVAMKLL 744

  Fly   762 TCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQL 826
            |.||.:|||.:||.|||||.||..:||.|||::|.|:|||.||.|||...|||:|:.:|..|..|
Mouse   745 TYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILIPPTILFL 809

  Fly   827 DFKSKEELQQMPQTEEE---HLENQNLD-NDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTD 887
            :|::.::.......|.|   ..|.:|:| |.|:...:.|.|
Mouse   810 EFRTYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEE------------------------ 850

  Fly   888 SDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQ 952
                           ||.|:.:.:.:..|..|||.|||.|||..:|:|:.:|::|::.:||:|:.
Mouse   851 ---------------NEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDG 900

  Fly   953 MPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRE 1017
            .|..|||..|:||.:|..||:|||:.|||..::.|..||....||..|..||.:|::|...|.:.
Mouse   901 WPSPQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQS 965

  Fly  1018 NT-MDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQ 1081
            .. |..||||||||.|.||:|:|:|.||||||||.|.|:|||:.:|:||||::.||||||||:||
Mouse   966 QPYMGYGRVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQ 1030

  Fly  1082 AILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHW 1133
            |||:|.::|:|.|.:.:.:.||:|:||||||..||       |||||:      ...|.|:.|.|
Mouse  1031 AILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAW 1095

  Fly  1134 VTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALC 1198
            :||..|:.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|.|.
Mouse  1096 LTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILS 1160

  Fly  1199 HFYSLLK----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDE 1259
            |.|.::.    .|.:|.:|.:.:||.||||||..::|::|::|||:||:..|.|:|.....|:||
Mouse  1161 HIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFEEQCVQEHFREKEDEQQSSSDE 1225

  Fly  1260 RVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILS---HLAVIHR--FMST 1319
            |::.|:||||.||.::|:||::||....::|.::.||.::||.|.:::|   :||.|.|  .:..
Mouse  1226 RIRVTSERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSGRMVSALENLAGIDRSDLIQA 1290

  Fly  1320 HTAGADD------LRGSTIN--------------------------IPGEMQRMRTIS------- 1345
            .:..:.:      ||.|:||                          .||...|.:|.|
Mouse  1291 RSRASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEEPALSTSPGTAFRKKTYSFRVKDED 1355

  Fly  1346 ----------ISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPD 1400
                      :..|.|.|.|...|..        .|.|...|:                ||:||.
Mouse  1356 AKSHLDQPSNLHHTPGPSPPATPGRS--------RLALEGPLS----------------TELRPG 1396

  Fly  1401 AYIFDEGTHFEVVPLPE-EPDEVVKSREA---LNEQVVRKASMQSEA-------DSDI--YIPVS 1452
            :   |.|     :...| :|....||.||   ||...|....:..|:       :|.:  |.|..
Mouse  1397 S---DPG-----ISAGEFDPRADFKSTEAAPSLNAAGVTGTQLTVESTDSHPLRESKLVRYYPGD 1453

  Fly  1453 QRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRA 1517
              |:|.:|:|...:|        .||.:..:..:.|...:.:.:    .|.|.....:.....|.
Mouse  1454 --PNTYKTMKSRSFV--------YTEGRKLVRGLSNWSAEYSSI----MDQAWNATEWRCQVQRI 1504

  Fly  1518 LRQRTVSLCRRNSETY-----------SLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDA 1571
            .|.|:..:....||..           ||....|:||.::::.    ...:.:|...:|......
Mouse  1505 TRSRSTDIPYIVSEAASQDELEDEHRGSLLDPQISRSALTVSD----RPEKENLLSVKPHQTLGF 1565

  Fly  1572 PIAQG--------SAHPGKSVL----HAKPSRNI 1593
            |..:.        ||.|..|.|    ||..:.|:
Mouse  1566 PCLRSRSLHGRPRSAEPAPSKLDRAGHASSTSNL 1599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	120/229 (52%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	21/53 (40%)
Trpm1	NP_001034193.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..95		7/30 (23%)
		Bac_export_2	<273..342	CDD:302774	40/68 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	450..490		0/39 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..641		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..856		12/72 (17%)
		Ion_trans	899..1129	CDD:278921	120/229 (52%)
		TRPM_tetra	1228..1279	CDD:293127	19/50 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1354..1383		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1389..1408		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1567..1622		8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836107
Domainoid	1	1.000	403	1.000	Domainoid score	I724
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1152	1.000	Inparanoid score	I207
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	1	1.000	-	-		FOG0002675
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	O	PTHR13800
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900