Protein Alignment Trpm and gon-2

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: NP_492315.4
• Gene: gon-2 / 172646
• WormBaseID: WBGene00001651
• Length: 2032
• Species: Caenorhabditis elegans
• Alignment Length: 2023
• Identity: 660/2023 - (32%)
• Similarity: 969/2023 - (47%)
• Gaps: 525/2023 - (25%)

  Fly     1 MVVTDS-------PLAPHKYVRRISKDFSTVRRYSNTPAVVVGSFRASTSAFIAAESAAHLPTCS 58
            :.:||:       .|...:|::  ||....|...|.|.....|...|     :...|.|...|.:
 Worm   176 LAITDNKDDKLMKTLGVTRYLQ--SKGGDQVPPTSTTTGGAGGDGNA-----VPTTSQAQAQTFN 233

  Fly    59 SPTTRTPVSTPRGIRRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQ 123
            |....|.:|:  |.|..:.:   |:.:::...||...:.:.::....:..|..|   :|:...|.
 Worm   234 SGRQTTGMSS--GDRLNEDV---SATANSAQLVLPTPLFNQMRFTESNMSLNRH---NWVRETFT 290

  Fly   124 KRECIKFIPCPKDDTKCCCGQAQITHQTIPGIES------------------------------- 157
            :|||.:||...:|..||.||:.:..|:.||.:.|
 Worm   291 RRECSRFIASSRDLHKCGCGRTRDAHRNIPELTSEFLRQKRSVAALEQQRSISNVNDDINTQNMY 355

  Fly   158 --GSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPK 220
              ....:.|...|||....|:|:|.:|||||.||.||||||::|||.|..::.||...|.:..|:
 Worm   356 TKRGANEKWSLRKHTVSLATNAFGQVEFQGGPHPYKAQYVRVNFDTEPAYIMSLFEHVWQISPPR 420

  Fly   221 LLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQ--RTG 283
            |:|||.||.:|||||.||.:..||||||||.||||||.|.|.:|||.|.|  |..|||.|  :..
 Worm   421 LIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHV--AAALEGAQSAQRN 483

  Fly   284 RVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELIL 348
            ::|.|||||||::::..:.:|.::.||.:. ||.:.:...|||||:|||||||||..:||||:||
 Worm   484 KIVCIGIAPWGLLKKREDFIGQDKTVPYYP-SSSKGRFTGLNNRHSYFLLVDNGTVGRYGAEVIL 547

  Fly   349 RRKLEKFIS-NLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLA 412
            |::||.:|| ..|:...|. |.||||:|:|||:.|||:||:|||:.|.|||||||||||||||||
 Worm   548 RKRLEMYISQKQKIFGGTR-SVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLA 611

  Fly   413 FVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEG 477
            |.|:..::....|  :.:|..::..::.||......:.:|..||..|.::|||:|:||:.|:.|
 Worm   612 FAHQNVTEDGLLP--DDIRRQVLLLVETTFGCSEAAAHRLLHELTVCAQHKNLLTIFRLGEQGE- 673

  Fly   478 EAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDR 542
              .::|..|||||.|.|:||..:||:|||.|||||||||::|..|.|||..||..|||:||.|||
 Worm   674 --HDVDHAILTALLKGQNLSAADQLALALAWNRVDIARSDVFAMGHEWPQAALHNAMMEALIHDR 736

  Fly   543 IDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINK 607
            :|||:||||.|::|:|||||.||:|||||..||.|||.||:||| ..:.:||.:.|.||||||.|
 Worm   737 VDFVRLLLEQGINMQKFLTISRLDELYNTDKGPPNTLFYIVRDV-VRVRQGYRFKLPDIGLVIEK 800

  Fly   608 LMGGAYRSYYTRRKFRPIYAKVMNSYANACRKS-------------------STYQYQRYAGANS 653
            |||.:|:..||..:||..|.:.|....:|.:|:                   ||.......|.:|
 Worm   801 LMGNSYQCSYTTSEFRDKYKQRMKRVKHAQKKAMGVFSSRPSRTGSGIASRQSTEGMGGVGGGSS 865

  Fly   654 LSLVTG-------------------------------------------LLP------------F 663
            ::.|.|                                           :.|            |
 Worm   866 VAGVFGNSFGNQDPPLDPHVNRSALSGSRALSNHILWRSAFRGNFPANPMRPPNLGDSRDCGSEF 930

  Fly   664 TSEMAL------------FEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAH 716
            ..|::|            |.:|::||:|||||||||.||:.||.|||||:||:||:|:|||::|.
 Worm   931 DEELSLTSASDGSQTEPDFRYPYSELMIWAVLTKRQDMAMCMWQHGEEAMAKALVACRLYKSLAT 995

  Fly   717 EAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAAN 781
            |||||.|:.||.|||:.||:||.....:|||..|..|..:..:|||.||.:|||::||:|||..|
 Worm   996 EAAEDYLEVEICEELKKYAEEFRILSLELLDHCYHVDDAQTLQLLTYELSNWSNETCLALAVIVN 1060

  Fly   782 HRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLE 846
            ::..|||||.|::|||||.||||.|.::|.||:|||..|.:|:.|:||::|||...|||..||..
 Worm  1061 NKHFLAHPCCQILLADLWHGGLRMRTHSNIKVVLGLICPPFIQMLEFKTREELLNQPQTAAEHQN 1125

  Fly   847 NQNL-----------------------DNDDSDR------------SQPDAEAL-LADTYSVRDT 875
            :.|.                       |:||.:.            ||..|::| :...:..|..
 Worm  1126 DMNYSSSSSSSSSSSSSSSSSDSSSFEDDDDENNAHNHDQKRTRKTSQGSAQSLNITSLFHSRRR 1190

  Fly   876 KVHENGKVSL-TDSD--------------TAQFREFF---------------------------- 897
            |..:|.|... ||:.              ||::..|.
 Worm  1191 KAKKNEKCDRETDASACEAGNRQIQNGGLTAEYGTFGESNGVSPPPPYMRANSRSRYNNRSDMSK 1255

  Fly   898 ----------NLSEY-----------NEVKQHQ---PLRLKKKFYEFYTAPITKFWADSIAYMFF 938
                      |||:.           |.::|.|   .::::::|||||:|||:.||:.:|:::.|
 Worm  1256 TSSVIFGSDPNLSKLQKSNITSTDRPNPMEQFQGTRKIKMRRRFYEFYSAPISTFWSWTISFILF 1320

  Fly   939 LIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAA 1003
            :..|::|:|||....|...|:..|||:...|.|:||:||.|:......|...:..:.||.....|
 Worm  1321 ITFFTYTLLVKTPPRPTVIEYILIAYVAAFGLEQVRKIIMSDAKPFYEKIRTYVCSFWNCVTILA 1385

  Fly  1004 IILFVIGLAFR-FRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVV 1067
            ||.:::|...| |  .::..||||...||:.|.:::|:.:.|:..|||.|||.|||::||.|.:|
 Worm  1386 IIFYIVGFFMRCF--GSVAYGRVILACDSVLWTMKLLDYMSVHPKLGPYVTMAGKMIQNMSYIIV 1448

  Fly  1068 LLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGED---------- 1122
            :|.|.|:|||::||:|.||::...|.|::.:..:|||||||||:|.:|| .||::
 Worm  1449 MLVVTLLSFGLARQSITYPDETWHWILVRNIFLKPYFMLYGEVYADEID-TCGDEAWDQHLENGG 1512

  Fly  1123 PSQPG-------CVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTV 1180
            |...|       ||.|:|:.|:.|:.:||||||||:::|||:||:||:..:.:|.|:|:|||:..
 Worm  1513 PVILGNGTTGLSCVPGYWIPPLLMTFFLLIANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQ 1577

  Fly  1181 VMEYQQKPVLPPPFIALCHFYSLLKYCVR------KAKGLEVQRDNGLKLFLEKDDLERLYDFEE 1239
            ||||:..|.||||...|.|...:|:: ||      |::......|..|||||:.|.:|:|:||||
 Worm  1578 VMEYESTPFLPPPLTPLYHGVLILQF-VRTRLSCSKSQERNPMFDFSLKLFLDNDQIEKLHDFEE 1641

  Fly  1240 ECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSE 1304
            :|:|....::....|.|.::|:.....|.:.:..::.|:..||::....:.::|.||..:|::..
 Worm  1642 DCMEDLARQKLNEKNTSNEQRILRADIRTDQILNRLIDLQAKESMGRDVINDVESRLASVEKAQN 1706

  Fly  1305 QILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIV 1369
            :||..:..:
 Worm  1707 EILECVRAL-------------------------------------------------------- 1715

  Fly  1370 PLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVV 1434
                   ||.|:......|.|:.|                         ||.:|
 Worm  1716 -------LNQNNAPTAIGRCFSPS-------------------------PDPLV----------- 1737

  Fly  1435 RKASMQSEADSDIYIPVSQRPSTCETVKRTPYVTVRQDTGAS--TESKDTLTPMGNNDDDQTLVG 1497
                                    ||...||...:.:..|..  .|.||       :|      .
 Worm  1738 ------------------------ETANGTPGPLLLKLPGTDPILEEKD-------HD------S 1765

  Fly  1498 GDNSDDATPDINFEAARHRALRQRTVSLC------RRNSETYSLTGADINRSHISLNQLASLSRR 1556
            |:||:...|.        |..|.||.::|      .||....|...:|::    .:.|     :|
 Worm  1766 GENSNSLPPG--------RIRRNRTATICGGYVSEERNMMLLSPKPSDVS----GIPQ-----QR 1813

  Fly  1557 QMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDEL------------- 1608
            .||:|..:|     .|:..           ||.|...:.:.|.|||||||.:
 Worm  1814 LMSVTSMDP-----LPLPL-----------AKLSTMSIRRRHEEYTSITDSIAIRHPERRIRNNR 1862

  Fly  1609 -------------ESVCHMIASP----TVSL---PSNKA----------SLDRPKTEMSRAEAAA 1643
                         |...::.:||    |..|   ||::.          .:|.|:.|...|:|
 Worm  1863 SNSSEHDESAVDSEGGGNVTSSPRKRSTRDLRMTPSSQVEESTSRDQIFEIDHPEHEEDEAQA-- 1925

  Fly  1644 LLEKKHLKECEENDYMILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVD 1708
                    :||..|.:..|         :...:..|...|.:..|.:|.|:.:.....||. :::
 Worm  1926 --------DCELTDVITEE---------EDEEEDDEEDDSHERHHIHPRRKSSRQNRQPSH-TLE 1972

  Fly  1709 GDLMGGGE 1716
            .||..|.|
 Worm  1973 TDLSEGEE 1980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	93/233 (40%)
		TRPM_tetra	1262..1313	CDD:293127	10/50 (20%)
gon-2	NP_492315.4	7TMR-DISM_7TM	<1299..1462	CDD:284997	66/164 (40%)
		Ion_trans	1328..1567	CDD:278921	96/241 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166604
Domainoid	1	1.000	452	1.000	Domainoid score	I257
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1031	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	1	1.000	-	-		FOG0002675
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101222
Panther	1	1.100	-	-	LDO	PTHR13800
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2859
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.020