Protein Alignment Trpm and Trpm8

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_599198.2
• Gene: Trpm8 / 171384
• RGDID: 620762
• Length: 1104
• Species: Rattus norvegicus
• Alignment Length: 1323
• Identity: 339/1323 - (25%)
• Similarity: 568/1323 - (42%)
• Gaps: 324/1323 - (24%)

  Fly    40 SWIETNFQKRECIKFIPCPKD-DTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYG 103
            ::|:.||:||||:.|....|. ::.|.||.||..|  |.|.:. :..:.|...|||:..||||:|
  Rat    43 NFIQANFKKRECVFFTRDSKAMESICKCGYAQSQH--IEGTQI-NQNEKWNYKKHTKEFPTDAFG 104

  Fly   104 TIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRK 168
            .|:|:  ....|.:|:|||.||..|.|.:|.|:.|:|:.|.|:|:|.||..||.|:.:::| |..
  Rat   105 DIQFE--TLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRK-IFS 166

  Fly   169 GLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIVERNHELLGHNR 231
            .|:..|::.||||.||||:.|:.|.:|:.:......|..  .:|:||||.||:|. |.:.|..|.
  Rat   167 RLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVS-NRDTLIRNC 230

  Fly   232 EVPCHSISS------PRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPSKN 290
            :...|..:.      .|..|.:|:|.|.:.||||||.......|..||.:|||:||. :.....|
  Rat   231 DDEGHFSAQYIMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISE-RTSQDSN 294

  Fly   291 HWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGE 355
            :..|       .|:||....||..|::|:...|...  :|.||.:|||:.||::|.:.:......
  Rat   295 YGGK-------IPIVCFAQGGGRETLKAINTSVKSK--IPCVVVEGSGQIADVIASLVEVEDVLT 350

  Fly   356 EQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTIL 420
            ...|.|.:..:|..|:.:..|..::...|..:|:|:   :.:|:||.:::|..:   :.:...|.
  Rat   351 SSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILE---SPHLLTVIKMEEAGD---EVVSSAIS 409

  Fly   421 TALFKSQHLSPPE------QLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFV 479
            .||:|:...:..:      ||.|.|.||::|:|..|||...:.|.:..|.|.|..||..||..||
  Rat   410 YALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFV 474

  Fly   480 KLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLV-INKLMG 543
            :|.||||::::||||...|.||::|..   :||.|  |:::  |.|.   :.:|..|. :.||:.
  Rat   475 RLFLENGLNLQKFLTNEVLTELFSTHF---STLVY--RNLQ--IAKN---SYNDALLTFVWKLVA 529

  Fly   544 GAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFN 608
            ...||::...:              :.|:....:      .:..||.|            ..|..
  Rat   530 NFRRSFWKEDR--------------SSREDLDVE------LHDASLTT------------RHPLQ 562

  Fly   609 ELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFES 673
            .|.|||:|..:::::.::|...:.....:|.:.||.|.:|  ..::|::..  .|....|.|:|:
  Rat   563 ALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLA--KVKNDINAA--GESEELANEYET 623

  Fly   674 KGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRT 738
            :..:|....|..|.:.|::||.....:|...:||.|||.|..:..:|.|..|..|:..|.|.: :
  Rat   624 RAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEI-S 687

  Fly   739 RKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAESALLKAK 803
            |...|:|:||.|.:
  Rat   688 RDTKNWKIILCLFI--------------------------------------------------- 701

  Fly   804 RSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQP 868
                                                 :.|.......||:             :|
  Rat   702 -------------------------------------IPLVGCGLVSFRK-------------KP 716

  Fly   869 LRLKKK----FYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFE 929
            :...||    :..|:|:|...|..:.:.|:.||::|::.:|:....:|...|....|.:..|..:
  Rat   717 IDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCD 781

  Fly   930 KVREIISSEPVAITHKFSVWAWN-------MWNPCDGAAIILFVIGLAFRF---RENTMDIGRVI 984
            :||:               |..|       :||..|...:..|:.|:.||.   .::::..||||
  Rat   782 EVRQ---------------WYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVI 831

  Fly   985 YCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPT 1049
            :|:|.|.:.||:::|..|::.|||.:.|:.:|:.::.:|:.|.||.:::|||:||.||..|:| .
  Rat   832 FCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQ-R 895

  Fly  1050 WSLIKEVIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTA 1114
            |..|
  Rat   896 WRWI------------------------------------------------------------- 899

  Fly  1115 PIHNEHSNLTSGNLTNVTFQPYFMLYGEVFAGDIDPPCGE--------DPSQPGCVT-------- 1163
                         ..:|.::||..::|:| ..|:|....:        :.|:|.||.
  Rat   900 -------------FRSVIYEPYLAMFGQV-PSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPR 950

  Fly  1164 -GHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPF 1227
             ..|:|...:.:|:|..||||:|||:|:|......|...:.|||.|||:.:|.||..:..:|.||
  Rat   951 FPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPF 1015

  Fly  1228 IALCHFYSLLKYCVR---KAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEII-LNQ 1288
            :...:||.::|.|.:   |.|..|    :....|..:|:       |....||...|..:: :|.
  Rat  1016 VVFAYFYMVVKKCFKCCCKEKNTE----SSACCFRNEDN-------ETLAWEGVMKENYLVKINT 1069

  Fly  1289 STDERVKNTTERVETMSQKIEDI 1311
            ..::..:....|...:..|:.|:
  Rat  1070 KANDNAEEMRHRFRQLDTKLNDL 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	95/283 (34%)
		TRPV	<872..1227	CDD:454755	92/385 (24%)
		TRPM_tetra	1291..1346	CDD:465156	3/21 (14%)
Trpm8	NP_599198.2	LSDAT_euk	116..359	CDD:476852	89/254 (35%)
		TRPV	<657..1005	CDD:454755	110/540 (20%)