DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and Trpm4

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001129701.1	Gene:	Trpm4 / 171143	RGDID:	620244	Length:	1208	Species:	Rattus norvegicus

Alignment Length:	1321	Identity:	366/1321 - (27%)
Similarity:	609/1321 - (46%)	Gaps:	249/1321 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 EHQPRSWIETNFQKRECIKFIPCPKDD---TKCCCGQAQITHQTIPGIESGSPGDL---WLPTKH 169
            :.:.:|||...|:|:.|..||....||   |.|.|||.:..|.:: .:|......:   |...:|
  Rat     4 QEKEQSWIPKIFRKKVCTTFIVDLHDDAGGTLCQCGQPRDAHPSV-AVEDAFGAAVVTEWNSDEH 67

  Fly   170 TRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDL 234
            |..:||||||.::|......: :.::|||..|.|..:..|.|:.|....|.|:::|.||.....|
  Rat    68 TTEKPTDAYGDLDFTYSGRKS-SNFLRLSDRTDPATVYSLVTRSWGFRAPNLVVSVLGGSEGPVL 131

  Fly   235 QAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIVE 297
            |..|:..:|:||::||::|||||.|||.:||:.:.||.|:.......||  :||::|:||||:|
  Rat   132 QTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQTASTGGSKVVAMGVAPWGVV- 195

  Fly   298 RNHELLGHN----------REVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKL 352
            ||.::|.:.          |..|...:..|      |:..::.|.|||:||..:.|.|...|.:.
  Rat   196 RNRDMLINPKGSFPARYRWRGDPEDGVEFP------LDYNYSAFFLVDDGTYGRMGGENRFRLRF 254

  Fly   353 EKFISNLKLH-PFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHK 416
            |.:::..|.. ..|....||:.|:|||....::.: |..|.: .:|.::..|||.|||.|
  Rat   255 ESYVAQQKTGVGGTGIDIPVLLLLIEGDEKMLKRI-EDATQA-QLPCLLVAGSGGAADCL----- 312

  Fly   417 YASDGEEQPVLESMRDYLI------------GTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVF 469
                      :|::.|.|.            ..|::.|..|  ..|.|..::.:....|.|:||:
  Rat   313 ----------VETLEDTLAPGSGGLRRGEARDRIRRYFPKG--DPEVLQAQVERIMTRKELLTVY 365

  Fly   470 RIQEKPEGEAQELDQTILTALFK----SQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGAL 530
                ..|..::|.:..:|.||.|    |:..:..::|.||:.|||||||:||:|....:|.:..|
  Rat   366 ----SSEDGSEEFETIVLRALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHL 426

  Fly   531 DEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELY--------------------NTKHGP 575
            :.::|.||.:||.:||:||:.:|:|:..|||..||.:||                    ::|..|
  Rat   427 EASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYSAVSPNSLIRNLLDQASHASSSKSPP 491

  Fly   576 ANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKS 640
            ||...    ::||          .::|.|:..|:|......|..|.               .|.|
  Rat   492 ANGAA----ELRP----------PNVGQVLRTLLGETCAPRYPARN---------------TRHS 527

  Fly   641 STYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSL 705
            ...|..|    .:.||:........:.:..:.|:::|||||:|..|.|||:..|..|..::|.:|
  Rat   528 LLGQDHR----ENDSLLMDWANMQQDASFEQAPWSDLLIWALLLNRAQMAIYFWEKGSNSVASAL 588

  Fly   706 VSCKLYKAMAHEAAEDDLDTEIYEELR--SYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSW 768
            .:|.|.:.||.      |:.|..|..|  ..|.:|||....|....|.....:|.|||......|
  Rat   589 GACLLLRVMAR------LEWEAEEAARRKDLAAKFESMSVDLFGECYHNSEYRAARLLLRRCPLW 647

  Fly   769 SNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDF----- 828
            ...:||.||:.|:.||..|....|.:|...|.|.:   .:||  .|..|.:.|:...|.:
  Rat   648 GEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEM---DSTN--PIWALLLTFFCPPLIYTNLIL 707

  Fly   829 --KSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTA 891
              ||:||..|           ::|| .|.|.|...|..|         .....:.||:|
  Rat   708 FRKSEEEPTQ-----------KDLD-FDMDSSMNGAGPL---------GPAEPSAKVAL------ 745

  Fly   892 QFREFFNLSEYNEVKQHQPLR------LKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKM 950
                       ...::.:|..      ..|::..|:.||:|.|..:.::|:.||::|:..:||..
  Rat   746 -----------ERRRRRRPGHTLCCGGCSKRWSYFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDF 799

  Fly   951 E-QMPRWQEWYSIAYITTLGFEKVRE--------IISSEP----VAITHKFSVWAWNMWNPCDGA 1002
            : ..|...|.....:..||..|::|:        :.:..|    ..:.|:..::..:.||.||..
  Rat   800 QPTKPGVFELLLYFWAFTLLCEELRQGLGGGWGTLANGGPGPGKAPLRHRLHLYLLDTWNQCDLL 864

  Fly  1003 AIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVV 1067
            |:..|::|:..|......|:||.:.|:|.:.:.||:|:|..|||.|||.:.::.||:|::.:|:.
  Rat   865 ALTCFLLGVGCRLTPGLFDLGRTVLCLDFMIFTLRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLF 929

  Fly  1068 LLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID------PPCG------ 1120
            .|.|.|:::||:.:.||.|..:...|:::.|.::||..::|::...::|      ..|.
  Rat   930 FLCVWLVAYGVATEGILRPQDRSLPSILRRVFYRPYLQIFGQIPQEEMDVALMNPSNCSAERGSW 994

  Fly  1121 ---EDPSQPGCVT--GHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTV 1180
               |.|....||:  .:|:..:.:.::||:|||||:|||||:|:..||:|:..|...|..||:::
  Rat   995 AHPEGPVAGSCVSQYANWLVVLLLIVFLLVANILLLNLLIAMFSYTFNKVHGNSDLYWKAQRYSL 1059

  Fly  1181 VMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDN--------GLKLFLEKDDLERLYDF 1237
            :.|:..:|.|.||.|.:.|...|.|:..|      ..|.|        ..::.|.|:....|..:
  Rat  1060 IREFHSRPALAPPLIIISHLRLLFKWLRR------CHRTNLPASPVFEHFRVCLSKEAERTLLTW 1118

  Fly  1238 EEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEES 1302
            |.      .|::..:|.|:.|:| .:.:||::..|||::...:    |...::..:.|||.:|..
  Rat  1119 ES------VHKENFLLAQARDKR-DSDSERLKRTSQKVDTALK----QLGQIREYDRRLRGLERE 1172

  Fly  1303 SE----------QILSHLAVI 1313
            .:          :.|||.|::
  Rat  1173 VQHCSRVLTWMAEALSHSALL 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	71/245 (29%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	14/60 (23%)
Trpm4	NP_001129701.1	Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q7TN37	969..971		0/1 (0%)
		Calmodulin-binding. /evidence=ECO:0000250	1070..1170		27/116 (23%)
		Mediates modulation by decavanadate and PIP2-binding. /evidence=ECO:0000250\|UniProtKB:Q8TD43	1130..1135		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1189..1208		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850