DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Trpm and TRPM6

DIOPT Version :9

Sequence 1:NP_001097320.1 Gene:Trpm / 36694 FlyBaseID:FBgn0265194 Length:2023 Species:Drosophila melanogaster
Sequence 2:NP_060132.3 Gene:TRPM6 / 140803 HGNCID:17995 Length:2022 Species:Homo sapiens


Alignment Length:2059 Identity:673/2059 - (32%)
Similarity:1001/2059 - (48%) Gaps:419/2059 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 EPLKE--HQPRSWIETNFQKRECIKFIPCPKDDTKC------------C-CGQ-----AQITHQT 151
            :|:.|  ...:|||:..|.||||...||..|:..:|            | ||:     |.|.:..
Human     4 QPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSW 68

  Fly   152 IPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNL 216
            ......|...:.|...|||...|||.:|||.||.|.|...|:|:|.|:||:.:.|:.|..|||.:
Human    69 TISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEWKM 133

  Fly   217 ELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQR 281
            |||||:|:|.||..||.:.:|.|:...:||:|||:||||||.|.|.||||:|.|||||.......
Human   134 ELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSSHS 198

  Fly   282 TGRVVSIGIAPWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGA 344
            ..::.::||.|||::|...:|:|  ::|.|  .::.:|.|||..||:.|::|:|.|:||..|||.
Human   199 LRKIWTVGIPPWGVIENQRDLIG--KDVVCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKYGN 261

  Fly   345 ELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAAD 409
            |:.|||.|||::|..|:|..:....|||.||:|||.|.|.:|.|.|.|..  |||||:|:|||||
Human   262 EMKLRRNLEKYLSLQKIHCRSRQGVPVVGLVVEGGPNVILSVWETVKDKD--PVVVCEGTGRAAD 324

  Fly   410 LLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEK 474
            ||||.||:.:|  |..:...:::.:|..||.||...|.||:.|:|.|::|..:::.||:|   :.
Human   325 LLAFTHKHLAD--EGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHRDCITIF---DA 384

  Fly   475 PEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALE 539
            ...|.|:||..|||||.|..:||..|||:||:.|:|||||:..|.:|.|.|...||::||..||.
Human   385 DSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALV 449

  Fly   540 HDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANT-LGYILRDVRPH-IPKGYIYTLHDIG 602
            .||:||||||:|.||::.:||||||||||||||.||.|| |.::::||:.| :..||..||.|||
Human   450 MDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLLSGYRITLIDIG 514

  Fly   603 LVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLL------ 661
            ||:..|:|.||||.|||:.||.:       |.|..||   |::||::..|........|      
Human   515 LVVEYLIGRAYRSNYTRKHFRAL-------YNNLYRK---YKHQRHSSGNRNESAESTLHSQFIR 569

  Fly   662 ---PF-----------------------TSEMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 700
               |:                       ..|...|.:|:|:||:||||.|||:||:..|.|||||
Human   570 TAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEA 634

  Fly   701 LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCEL 765
            ..|::::|.||:||||||.|..:..:..|||::|:|:|......||:.:::|:...|..|||.||
Human   635 TVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYEL 699

  Fly   766 HSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKS 830
            .:|||.:||.|||:...|..::|.|:|::|.|:|||.|:.|||:..|:|:.:.:|..|..|:|||
Human   700 RNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILTLEFKS 764

  Fly   831 KEELQQMPQTEE----EHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTA 891
            |.|:..:||:::    .:..:||     :..|:..|.....|.....|.|:.||           
Human   765 KAEMSHVPQSQDFQFMWYYSDQN-----ASSSKESASVKEYDLERGHDEKLDEN----------- 813

  Fly   892 QFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRW 956
               :.|.|.     ..||.|...:|.||||:|||.|||..::||:.||::|::||||:|:..|..
Human   814 ---QHFGLE-----SGHQHLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSV 870

  Fly   957 QEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTM- 1020
            |||....||.|...|.||||..|||...|.|..||....||..:..||.||..|...|:.:... 
Human   871 QEWLVSIYIFTNAIEVVREICISEPGKFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFH 935

  Fly  1021 DIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILY 1085
            ..||:|||:|.|:|:.|:|:...||::.||.|||:.||..||.|.|:::|:||:||||:|:|||.
Human   936 TAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILS 1000

  Fly  1086 PNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILL 1150
            |.:.|:|||.:::.|:||:|:||||:||:|| .|.   |||.|..|.::||...::||.:..|::
Human  1001 PKEPPSWSLARDIVFEPYWMIYGEVYAGEID-VCS---SQPSCPPGSFLTPFLQAVYLFVQYIIM 1061

  Fly  1151 INLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLL-KYCVRKAKGL 1214
            :|||||.|||::.::.|:|:.:|.:.|:..:|.|.:||.||||.|.|.|...|| :.|..:|...
Human  1062 VNLLIAFFNNVYLDMESISNNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHD 1126

  Fly  1215 EVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDIN 1279
            :.:.|.||||:|.|:||::|:||||:|||.:|||:...:|.|.:||::.|:|||..|..:::::|
Human  1127 QEEGDVGLKLYLSKEDLKKLHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMN 1191

  Fly  1280 QKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTI 1344
            :|       |..|:..|..::..    :.||              .||...|::      .::.:
Human  1192 EK-------VSFIKDSLLSLDSQ----VGHL--------------QDLSALTVD------TLKVL 1225

  Fly  1345 SISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTH 1409
            |..||                                               ::.|..:..:..|
Human  1226 SAVDT-----------------------------------------------LQEDEALLAKRKH 1243

  Fly  1410 FEVVPLPEEPD-----EVVKSREALNEQVVRKASMQSEADSDI----YIPVSQRPSTCETVKRTP 1465
            .....||....     ||:.|.|...|:..:..||.|.....:    :.|..||.:..|.     
Human  1244 STCKKLPHSWSNVICAEVLGSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEI----- 1303

  Fly  1466 YVTVRQDTGASTESKDTLTPMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNS 1530
                       |.||...|.:.|:.:                           ||.|.|      
Human  1304 -----------TNSKREATNVRNDQE---------------------------RQETQS------ 1324

  Fly  1531 ETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILL 1595
                    .|..|.:|.|:.|.....|..|.   |.:.|..|.:..:..|     .::||...:|
Human  1325 --------SIVVSGVSPNRQAHSKYGQFLLV---PSNLKRVPFSAETVLP-----LSRPSVPDVL 1373

  Fly  1596 KLHSEYTSITDELESVCHMIA-SPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYM 1659
            ....:.     :.|.:.|:.. :|.|   |:.||:|.||   .:.|..|     ||.:.::....
Human  1374 ATEQDI-----QTEVLVHLTGQTPVV---SDWASVDEPK---EKHEPIA-----HLLDGQDKAEQ 1422

  Fly  1660 ILEGLIESRGSIDASAQGFEIGVSIDYSHRYPLRRETAVELSPSKPSVDGDLM--GGGEGGGAGG 1722
            :|                             |....|...::.|.|.....:|  |||.      
Human  1423 VL-----------------------------PTLSCTPEPMTMSSPLSQAKIMQTGGGY------ 1452

  Fly  1723 GDSSDTSGAGSCGAMVGISSGFQLKNERPWQ------------RNSSMEQQTYPSPLV--PTRA- 1772
                 .:.|.|.|...|:   |.:|  :.||            |:...::|...|.|.  .||: 
Human  1453 -----VNWAFSEGDETGV---FSIK--KKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSA 1507

  Fly  1773 ---------------TSDFLNPPYEGRLFKKS-------SESLQK-------NSSTETDYSAHPY 1808
                           ||.::||....|.|.:|       .|.|.|       :.|:|....|   
Human  1508 QSSECSEVGPWLQPNTSFWINPLRRYRPFARSHSFRFHKEEKLMKICKIKNLSGSSEIGQGA--- 1569

  Fly  1809 RFIKQ---------SSNETNTS------LTGSYNVDTPSLTAEPSLD--AGDSHSATGISISVGA 1856
             ::|.         |..:.||.      :|.:....:..|..||..:  :.:.:|....::|..:
Human  1570 -WVKAKMLTKDRRLSKKKKNTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYSKNWFTVSKFS 1633

  Fly  1857 VGGTATARYQPIRTASVG-----AADGRRLREESSSSLDLSSSGPVTMQAAPAPPVRPMLLKKQF 1916
            ..|.....:|.::|..:|     .:|..:..:|..|...|.:|....:.       |..|||...
Human  1634 HTGVEPYIHQKMKTKEIGQCAIQISDYLKQSQEDLSKNSLWNSRSTNLN-------RNSLLKSSI 1691

  Fly  1917 SVDQGKPSQTAAEAVPQTP----EAAQAGQAKLISTLKP----QPFA-SKLGMNVLKESSS-STD 1971
            .||:    .:|:...||.|    .|.:......:|...|    |.|| .::.:..|:|||. :.|
Human  1692 GVDK----ISASLKSPQEPHHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLD 1752

  Fly  1972 ESVGSSAKSSNPALSIPQISTHLVQDEIAKLSSNIKSSTESEKD 2015
            :|:.|.::....|: |..:|...:...:.|....:  ||.||.|
Human  1753 KSMSSWSQRGRAAM-IQVLSREEMDGGLRKAMRVV--STWSEDD 1793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpmNP_001097320.1 Ion_trans 951..1167 CDD:278921 97/216 (45%)
TRPM_tetra 1262..1313 CDD:293127 12/50 (24%)
TRPM6NP_060132.3 Ion_trans 853..1073 CDD:278921 104/223 (47%)
TRPM_tetra 1174..1225 CDD:293127 15/81 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1479..1516 6/36 (17%)
Alpha_kinase 1754..1972 CDD:214828 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1997..2022
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146032
Domainoid 1 1.000 408 1.000 Domainoid score I698
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1161 1.000 Inparanoid score I207
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D323456at33208
OrthoFinder 1 1.000 - - FOG0002675
OrthoInspector 1 1.000 - - otm40938
orthoMCL 1 0.900 - - OOG6_101222
Panther 1 1.100 - - O PTHR13800
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X538
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.900

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