Protein Alignment Trpm and TRPM6

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_060132.3
• Gene: TRPM6 / 140803
• HGNCID: 17995
• Length: 2022
• Species: Homo sapiens
• Alignment Length: 2170
• Identity: 676/2170 - (31%)
• Similarity: 1005/2170 - (46%)
• Gaps: 534/2170 - (24%)

  Fly    35 RHQP--------RSWIETNFQKRECIKFIPCPKDDTKC------------C-CGQ-----AQITH 73
            :.||        :|||:..|.||||...||..|:..:|            | ||:     |.|.:
Human     2 KEQPVLERLQSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDY 66

  Fly    74 QTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEW 138
            ........|...:.|...|||...|||.:|||.||.|.|...|:|:|.|:||:.:.|:.|..|||
Human    67 SWTISAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKEW 131

  Fly   139 NLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQ 203
            .:|||||:|:|.||..||.:.:|.|:...:||:|||:||||||.|.|.||||:|.|||||.....
Human   132 KMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDALKSHSS 196

  Fly   204 QRTGRVVSIGIAPWGIVERNHELLGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKY 266
            ....::.::||.|||::|...:|:|  ::|.|  .::.:|.|||..||:.|::|:|.|:||..||
Human   197 HSLRKIWTVGIPPWGVIENQRDLIG--KDVVCLYQTLDNPLSKLTTLNSMHSHFILSDDGTVGKY 259

  Fly   267 GAELILRRKLEKFISNLKLHPSKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPV 331
            |.|:.|||.|||::|..|:|..         :....|||.||:|||.|.|.:|.|.|.|..  ||
Human   260 GNEMKLRRNLEKYLSLQKIHCR---------SRQGVPVVGLVVEGGPNVILSVWETVKDKD--PV 313

  Fly   332 VVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNK 396
            |||:|:|||||||||.||:.:|  |..:...:::.:|..||.||...|.||:.|:|.|::|..::
Human   314 VVCEGTGRAADLLAFTHKHLAD--EGMLRPQVKEEIICMIQNTFNFSLKQSKHLFQILMECMVHR 376

  Fly   397 NLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNG 461
            :.||:|   :....|.|:||..|||||.|..:||..|||:||:.|:|||||:..|.:|.|.|...
Human   377 DCITIF---DADSEEQQDLDLAILTALLKGTNLSASEQLNLAMAWDRVDIAKKHILIYEQHWKPD 438

  Fly   462 ALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANT-LGYILRDVRPH-IP 524
            ||::||..||..||:||||||:|.||::.:||||||||||||||.||.|| |.::::||:.| :.
Human   439 ALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTIPRLEELYNTKQGPTNTLLHHLVQDVKQHTLL 503

  Fly   525 KGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSL 589
            .||..||.|||||:..|:|.||||.|||:.||.:       |.|..||   |::||::..|....
Human   504 SGYRITLIDIGLVVEYLIGRAYRSNYTRKHFRAL-------YNNLYRK---YKHQRHSSGNRNES 558

  Fly   590 VTGLL---------PF-----------------------TSEMALFEFPFNELLIWAVLTKRQQM 622
            ....|         |:                       ..|...|.:|:|:||:||||.|||:|
Human   559 AESTLHSQFIRTAQPYKFKEKSIVLHKSRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKM 623

  Fly   623 ALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDA 687
            |:..|.|||||..|::::|.||:||||||.|..:..:..|||::|:|:|......||:.:::|:.
Human   624 AMFFWQHGEEATVKAVIACILYRAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNE 688

  Fly   688 EKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAM 752
            ..|..|||.||.:|||.:||.|||:...|..::|.|:|::|.|:|||.|:.|||:..|:|:.:.:
Human   689 RMAMTLLTYELRNWSNSTCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIIL 753

  Fly   753 PFYIRQLDFKSKEELQQMPQTEE----EHLENQNLDNDDSDRSQPDAESALLKAKRSISLRYRMG 813
            |..|..|:||||.|:..:||:::    .:..:||        :....|||.:|       .|.:.
Human   754 PPTILTLEFKSKAEMSHVPQSQDFQFMWYYSDQN--------ASSSKESASVK-------EYDLE 803

  Fly   814 AGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEF 878
            .|               .|.|:.||              :.|.|.     ..||.|...:|.|||
Human   804 RG---------------HDEKLDEN--------------QHFGLE-----SGHQHLPWTRKVYEF 834

  Fly   879 YTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAIT 943
            |:|||.|||..::||:.||::|::||||:|:..|..|||....||.|...|.||||..|||...|
Human   835 YSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVQEWLVSIYIFTNAIEVVREICISEPGKFT 899

  Fly   944 HKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTM-DIGRVIYCVDSIYWYLRILNILGVNKYLG 1007
            .|..||....||..:..||.||..|...|:.:... ..||:|||:|.|:|:.|:|:...||::.|
Human   900 QKVKVWISEYWNLTETVAIGLFSAGFVLRWGDPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAG 964

  Fly  1008 PLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVIAGSITAPGFLGALGH 1072
            |.|||:.||..||.|.|:::|:||:||||:|:|||.|.:.|:|||.::::
Human   965 PYVTMIAKMTANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWSLARDIV--------------- 1014

  Fly  1073 NTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEHSNLTSGNLTNVTFQPYF 1137
                                                                        |:||:
Human  1015 ------------------------------------------------------------FEPYW 1019

  Fly  1138 MLYGEVFAGDIDPPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVS 1202
            |:||||:||:|| .|.   |||.|..|.::||...::||.:..|:::|||||.|||::.::.|:|
Human  1020 MIYGEVYAGEID-VCS---SQPSCPPGSFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESIS 1080

  Fly  1203 HQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLL-KYCVRKAKGLEVQRDNGLKLFLEKDDLER 1266
            :.:|.:.|:..:|.|.:||.||||.|.|.|...|| :.|..:|...:.:.|.||||:|.|:||::
Human  1081 NNLWKYNRYRYIMTYHEKPWLPPPLILLSHVGLLLRRLCCHRAPHDQEEGDVGLKLYLSKEDLKK 1145

  Fly  1267 LYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRK 1331
            |:||||:|||.:|||:...:|.|.:||::.|:|||..|..:::::|:|       |..|:..|..
Human  1146 LHDFEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNEK-------VSFIKDSLLS 1203

  Fly  1332 MEESSEQILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGG 1396
            ::..    :.||              .||...|::      .::.:|..||
Human  1204 LDSQ----VGHL--------------QDLSALTVD------TLKVLSAVDT-------------- 1230

  Fly  1397 GGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPD-----EVV 1456
                                             ::.|..:..:..|.....||....     ||:
Human  1231 ---------------------------------LQEDEALLAKRKHSTCKKLPHSWSNVICAEVL 1262

  Fly  1457 KSREALNEQVVRKASMQSEADSDI----YIPVSQRPSTCETVKRTPYVTVRQDTGASTESKDTLT 1517
            .|.|...|:..:..||.|.....:    :.|..||.:..|.                |.||...|
Human  1263 GSMEIAGEKKYQYYSMPSSLLRSLAGGRHPPRVQRGALLEI----------------TNSKREAT 1311

  Fly  1518 PMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQ 1582
            .:.|:.:                           ||.|.|              .|..|.:|.|:
Human  1312 NVRNDQE---------------------------RQETQS--------------SIVVSGVSPNR 1335

  Fly  1583 LASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHM 1647
            .|.....|..|.   |.:.|..|.:..:..|     .::||...:|....:.     :.|.:.|:
Human  1336 QAHSKYGQFLLV---PSNLKRVPFSAETVLP-----LSRPSVPDVLATEQDI-----QTEVLVHL 1387

  Fly  1648 IA-SPTVSLPSNKASLDRPKTEMSRAEAAALLEKKHLKECEENDYMILEGLIESRGSIDASAQGF 1711
            .. :|.|   |:.||:|.||   .:.|..|     ||.:.::....:|
Human  1388 TGQTPVV---SDWASVDEPK---EKHEPIA-----HLLDGQDKAEQVL----------------- 1424

  Fly  1712 EIGVSIDYSHRYPLRRETAVELSPSKPSVDGDLM--GGGEGGGAGGGDSSDTSGAGSCGAMVGIS 1774
                        |....|...::.|.|.....:|  |||.           .:.|.|.|...|:
Human  1425 ------------PTLSCTPEPMTMSSPLSQAKIMQTGGGY-----------VNWAFSEGDETGV- 1465

  Fly  1775 SGFQLKNERPWQ------------RNSSMEQQTYPSPLV--PTRA----------------TSDF 1809
              |.:|  :.||            |:...::|...|.|.  .||:                ||.:
Human  1466 --FSIK--KKWQTCLPSTCDSDSSRSEQHQKQAQDSSLSDNSTRSAQSSECSEVGPWLQPNTSFW 1526

  Fly  1810 LNPPYEGRLFKKS-------SESLQK-------NSSTETDYSAHPYRFIKQ---------SSNET 1851
            :||....|.|.:|       .|.|.|       :.|:|....|    ::|.         |..:.
Human  1527 INPLRRYRPFARSHSFRFHKEEKLMKICKIKNLSGSSEIGQGA----WVKAKMLTKDRRLSKKKK 1587

  Fly  1852 NTS------LTGSYNVDTPSLTAEPSLD--AGDSHSATGISISVGAVGGTATARYQPIRTASVG- 1907
            ||.      :|.:....:..|..||..:  :.:.:|....::|..:..|.....:|.::|..:|
Human  1588 NTQGLQVPIITVNACSQSDQLNPEPGENSISEEEYSKNWFTVSKFSHTGVEPYIHQKMKTKEIGQ 1652

  Fly  1908 ----AADGRRLREESSSSLDLSSSGPVTMQAAPAPPVRPMLLKKQFSVDQGKPSQTAAEAVPQTP 1968
                .:|..:..:|..|...|.:|....:.       |..|||....||:    .:|:...||.|
Human  1653 CAIQISDYLKQSQEDLSKNSLWNSRSTNLN-------RNSLLKSSIGVDK----ISASLKSPQEP 1706

  Fly  1969 ----EAAQAGQAKLISTLKP----QPFA-SKLGMNVLKESSS-STDESVGSSAKSSNPALSIPQI 2023
                .|.:......:|...|    |.|| .::.:..|:|||. :.|:|:.|.::....|: |..:
Human  1707 HHHYSAIERNNLMRLSQTIPFTPVQLFAGEEITVYRLEESSPLNLDKSMSSWSQRGRAAM-IQVL 1770

  Fly  2024 STHLVQDEIAKLSSNIKSSTESEKD 2048
            |...:...:.|....:  ||.||.|
Human  1771 SREEMDGGLRKAMRVV--STWSEDD 1793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	126/277 (45%)
		TRPV	<872..1227	CDD:454755	129/355 (36%)
		TRPM_tetra	1291..1346	CDD:465156	14/54 (26%)
TRPM6	NP_060132.3	LSDAT_euk	109..372	CDD:465665	126/277 (45%)
		TRPV	<657..1098	CDD:454755	189/568 (33%)
		TRPM_tetra	1170..1225	CDD:465156	17/85 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1479..1516		6/36 (17%)
		Alpha_kinase_ChaK2_TRPM6	1736..1974	CDD:341222	16/61 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1997..2022