DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm4b3

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001314961.1	Gene:	trpm4b3 / 102659286	-ID:	-	Length:	1225	Species:	Danio rerio

Alignment Length:	1319	Identity:	374/1319 - (28%)
Similarity:	639/1319 - (48%)	Gaps:	207/1319 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 ILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKDDT-----KCCCGQAQITHQTI 152
            ::|.:|:   ..|...:.:....|||...|:||.|..|:    :|:     :|.||..:..|:::
Zfish     1 MMNEKDI---EGGRVSVIKKTDLSWIPKFFKKRLCTTFV----EDSFSYGGRCQCGAMRDDHRSM 58

  Fly   153 PGIESGSPGD--------LWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQL 209
                  :.||        .||.::||..|||||||.:||.|... ..:.::|||..|.|..:..|
Zfish    59 ------ALGDNFSTAVVSQWLSSQHTSEQPTDAYGDLEFDGIGR-RHSYFLRLSSTTDPARVFDL 116

  Fly   210 FTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL 274
            ..:.|.|:.|.|:::|.||:....:::.::..:|:||:|||::|||||.|||...|:::.||:|:
Zfish   117 MKEHWKLQQPNLVVSVVGGEGRSVVKSWVRDVLRQGLVKAAQSTGAWIITGGLRQGISRCVGEAV 181

  Fly   275 ----LLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSI---SSPRSKLAVLNNRHAYFL 332
                .........:|:.|||||||:||...:|:......|...:   .||.|  ..|:|.|..||
Zfish   182 KDNAAAVSSITLNKVLPIGIAPWGLVENRQQLVNLEGSFPARYMVRNISPDS--CSLDNNHKAFL 244

  Fly   333 LVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHS-STPVVCLVIEGGTNTIRAVLEYVTDS--P 394
            |||:||..:.|.||..|..||.:||  :..|...| ..||:.::|.|.|    ::||::..|  .
Zfish   245 LVDDGTSGRKGGELAFRACLEDYIS--RQRPGNASIDIPVLNMLIAGDT----SMLEFLEMSLKN 303

  Fly   395 PVPVVVCDGSGRAADLLAFVHKY--------ASDGEE-QPVLESMRDYLIGTIQKTFEVGLDQSE 450
            ..|.:|..|||..|:|::.:.:.        ||:.|: .|::| :|:.|...::|.|....| ::
Zfish   304 STPCLVLAGSGGLANLVSDIVENVQSAAMPGASEEEDASPIME-LREQLAAKVKKYFPAEND-TD 366

  Fly   451 KLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPE-------QLSLALTW 508
            ||..::|...:||::|:::  ..|.|| |::.:..:|..|.::...:..|       :|.||:||
Zfish   367 KLVDKVLSIYQNKDIISIY--NAKQEG-AEDFEIVMLKVLVQASKRNVSENTNSYADELRLAVTW 428

  Fly   509 NRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKH 573
            ||||||:||:|....:|....|.::|..|||:::..||:||:::|:::..:||..|||:|||:..
Zfish   429 NRVDIAKSELFNGNIDWKYEELVDSMTDALENNKPQFVRLLIDSGLNILSYLTYGRLEKLYNSIS 493

  Fly   574 GP--ANTLGYILRDVRPHIPKGYIY--TLHDIGLVINKLMGGAYRSYY----------TRRKFRP 624
            ..  |.||.....|.|.|.....||  :|:::..::..|:|.....:|          ||||
Zfish   494 DTCLAKTLLLHHLDERMHESNVQIYSISLYEVSQLLTDLLGEVCHPFYWTELKLEASSTRRK--- 555

  Fly   625 IYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQM 689
                   |...|||                 ::.|...:..||.  :.|:..|.|||||..|.:|
Zfish   556 -------SMKKACR-----------------ILMGSCKYRDEMC--KHPWFCLFIWAVLQNRSEM 594

  Fly   690 ALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDA 754
            |:..|...:|::..:|..|||..    |.::.:::||....::..|.:||...:.:....|...|
Zfish   595 AIFCWEMCDESVLTALAGCKLLL----ELSKQEIETEAKLSMKELALKFERMAHDVFGTCYLSKA 655

  Fly   755 EKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAM 819
            ..:.:||..:...|.:.:||.:|:||:.:...:|...|.:|:.:|.|.:. |....::::|.:..
Zfish   656 SHSYKLLIRKSKLWGDATCLEMAIAADAQIFFSHDGVQSLLSQIWWGDIE-RGTPLWRILLVIIC 719

  Fly   820 P-------FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKV 877
            |       ...|:.|...||:....|...|            .||...:.      .:|..|.|
Zfish   720 PPVCYSNFIEYRKTDQAEKEKSVMAPPCSE------------IDRQYEET------VFSFNDNK- 765

  Fly   878 HENGKVSLTDSD----TAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFF 938
            |:| :....||:    ||:....|       :|..:...:..::.:|:.||:|.|..:.:.|..|
Zfish   766 HQN-EAEHKDSENIRRTAKGAPAF-------IKPKKSSFVVSRWKQFWYAPVTSFIGNLLMYFLF 822

  Fly   939 LIMFSFTVLVKME----QMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFS----VWAWNM 995
            |.::::.:||..:    ..|...|:....::.||..::::|..    :|...||.    ::|.::
Zfish   823 LFLYAYVLLVDFKPPPPDGPAVSEYVLYFWVFTLVCQEIQEAF----IAGNKKFPQTLFLYAQDV 883

  Fly   996 WNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVK 1060
            ||..|..||.||:.||..|....:.::||.|.|||.:.:.||::.|..::|.|||.:.::|||:|
Zfish   884 WNKFDVLAISLFITGLCCRMFSWSFNMGRGILCVDYMVFTLRLIYIFAIHKELGPKIIILGKMIK 948

  Fly  1061 NMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID--------- 1116
            :..:|:..|.|.|:::||:.||:||........:.:.|.::||..::|::...:||
Zfish   949 HAFFFLFFLLVWLIAYGVANQALLYQYDPSPARVFRRVLYRPYLHIFGDIPVEEIDTGKHWERDC 1013

  Fly  1117 -----------PPCGEDPSQPGCVTGH-WVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVS 1169
                       .||.:        |.| |:..|.:.::||:.||||||||||.|:..|.:|...|
Zfish  1014 TDNLTLINEGIEPCRD--------TSHNWLVVILLVIFLLVTNILLINLLIATFSYTFTKVQEHS 1070

  Fly  1170 HQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERL 1234
            .:.|.|||:.:::||..:|.|.||||...|...|:|..:||....:.||   ..|.::..:..:|
Zfish  1071 DKYWKFQRYNLIVEYHSRPTLAPPFIIFSHINILIKRYLRKVPSAKTQR---FALRVKGPEANKL 1132

  Fly  1235 YDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKM 1299
            ..:|.:..|.:...:......|..:|:|....:|:.|.:           |.|.:::::.|||.:
Zfish  1133 VKWENQQKENYLALENKKHRDSDSQRLKRMAAKVDCMVR-----------QVAEMRDVDRRLRAV 1186

  Fly  1300 EESSEQILSHLAVIHRFMS 1318
            |...|...|.|..|...:|
Zfish  1187 ESEIEFCTSSLQWIMETLS 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	73/244 (30%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	12/50 (24%)
trpm4b3	NP_001314961.1	Ion_trans	830..1071	CDD:278921	75/252 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850