DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm4

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	XP_002934673.1	Gene:	trpm4 / 100491327	XenbaseID:	XB-GENE-960842	Length:	1218	Species:	Xenopus tropicalis

Alignment Length:	1292	Identity:	371/1292 - (28%)
Similarity:	631/1292 - (48%)	Gaps:	197/1292 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RSWIETNFQKRECIKFIPCPKDD---TKCC-CGQAQITHQTIPGIESGSPGDL---WLPTKHTRP 172
            :|||...|:|:.|..||...||.   ||.| ||...|.|.:: .:|......:   |...:||..
Frog     9 QSWIPKLFKKKTCTTFIEDTKDSSSPTKLCQCGALMINHVSV-AMEDNFGAAMVSTWNSAEHTTE 72

  Fly   173 QPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAK 237
            :||||||.:||. ||....::::|||.||.|..:..|.|..|.:..|.|:::|.||..:|.::..
Frog    73 EPTDAYGDVEFV-GAGRKHSKFIRLSNDTDPASVYSLITYNWKIPPPNLVVSVVGGDGDFKMKTW 136

  Fly   238 LKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL----LLEGQQRTGRVVSIGIAPWGIVER 298
            ||..:||||:|||::|||||.|||...|:.|.||:|:    ......|| :||::||||||||
Frog   137 LKDILRKGLVKAAQSTGAWIMTGGMQVGIGKYVGEAVRDHATANSNSRT-KVVAMGIAPWGIV-- 198

  Fly   299 NHELLGHNREVPCHSISSPRSKLAV-------------LNNRHAYFLLVDNGTQAKYGAELILRR 350
                  |||:    |:.:|:.....             |:|.::.|||.|:||..:.|.|...|.
Frog   199 ------HNRQ----SLVNPKGSFPATYYMDNVDGPTYSLDNNYSVFLLADDGTHGQMGGETSFRF 253

  Fly   351 KLEKFISNLKLHPFTHSS--TPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAF 413
            :||:.||..|.......|  .||:|::|.|.:..:..|  |.....|:|.::..|||..||.||.
Frog   254 RLEEHISRQKTGAGGKGSIEIPVLCMLIAGESKMLGRV--YNATKSPIPCLLVAGSGGVADCLAE 316

  Fly   414 VHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGE 478
            :.      ||...|||:|..:...::..|.  .:...|:.:::.:...|::|:||:   ...:|
Frog   317 IL------EESIALESIRGLIEEKLKHYFP--NENLTKMVEKVERIVENRDLVTVY---SDADG- 369

  Fly   479 AQELDQTILTALFKS--QHLSPP----EQLSLALTWNRVDIARSEIFVYGQ-EWPNGALDEAMMQ 536
            .::.:..||.||.|:  :|.|..    ::|.||:.|||.|||::|:| :|: .|....||:.|..
Frog   370 IEDFETVILKALVKACKKHSSDAVEYLDELKLAVAWNREDIAKTELF-HGEILWKATDLDDTMTD 433

  Fly   537 ALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYIL----------RDVRPHIP 591
            ||.:::..||||.::||:::..:||..||||||::...  |||.|.|          ...:.|..
Frog   434 ALINNKPKFVKLFVDNGLNIVDYLTYGRLEELYSSVLD--NTLLYQLLKSKHDEHRNSKTKDHHE 496

  Fly   592 --------KGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRY 648
                    ||..:.|:::..::..|:|....::||.         |:.:...:..|       |.
Frog   497 LLFMESNGKGREFKLYEVSKILRDLLGDVCTTFYTH---------VLGNMKGSVNK-------RN 545

  Fly   649 AGANSLSLVTGLLPFTSEMALFEF-------PFNELLIWAVLTKRQQMALLMWTHGEEALAKSLV 706
            :|..|:          .::|:.::       |:.:|.|||:|..|.:||...|..|.||:..:|.
Frog   546 SGKKSM----------EQIAVEKYQPRKSTSPWIDLFIWAILQNRDEMATYFWEMGSEAVTSALA 600

  Fly   707 SCKLYKAMAHEAAEDDLDTEIYEEL--RSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWS 769
            :.|:.|.::.      :::|..|.|  |..|.:||.....:.:..||....:|.:||......|.
Frog   601 AMKILKELSR------MESEAEESLAMRDLAAKFEQLAIGVFNECYRNSENRAFKLLVRRSVIWG 659

  Fly   770 NQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTN-FKVILGLAMP--FYIRQLDFKSK 831
            ..:||.||..|:.|...|....|.:|.:.|.|  :..:||. :.::|....|  .|...:.|||.
Frog   660 GATCLQLAYEADARNFFAQDGVQSMLTENWWG--QMAQNTPVWAMVLTFFCPPLIYTDLITFKSI 722

  Fly   832 EELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHE--NGKVSLTDSDTAQFR 894
            :.     :...|..:...:|:.|:|.....||.:..:.   :|....|  ..|:|:..|.|.:
Frog   723 DH-----ENGIESAQRMEMDSLDTDIKTTVAEIMEGEE---KDDNAEEVPLKKMSVKKSKTKK-- 777

  Fly   895 EFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQM----PR 955
                ..|...:|:.|..|..:::.:|::||:|.|:.:.:.|..||.:||:.:|::.:..    |.
Frog   778 ----APEAEIIKEKQRPRWMQRWKQFWSAPVTAFFGNVVMYFAFLFLFSYVLLLEFKMPPPDGPA 838

  Fly   956 WQEWYSIAYITTLGFEKVRE--IISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFREN 1018
            ..|:....:|.|:..|::|:  .:.:.|||  .|...:..:.||..|..|:.||:|||..|....
Frog   839 NSEFILYFWIFTMVCEEIRQSFFVGTMPVA--QKVKQYLQDSWNHVDIIALCLFIIGLICRMFNE 901

  Fly  1019 TMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAI 1083
            :.:.||.|.|.|.:.:.||:::|..|||.|||.:.::.||:|::.:|:..|.|.|:::||:.:.:
Frog   902 SFEAGRTILCFDFMVFTLRLIHIFAVNKQLGPKIIIVRKMMKDVFFFLFFLGVWLIAYGVTTEGL 966

  Fly  1084 LYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPP------CGEDP-------SQPGCVT--GHW 1133
            |:|.......:.:.|.::||..::|::...:.|..      |..||       ::| |..  .:|
Frog   967 LHPTDMRLSWIFRRVFYRPYLQIFGQIPQEEFDASKIASSNCTNDPIAIMLEEAEP-CTNTYANW 1030

  Fly  1134 VTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALC 1198
            :..:.:.::||:|||||:|||||:|:..|::|...|...|.|||:.:::||..:|.|.||||.:.
Frog  1031 LVILLLVVFLLVANILLLNLLIAMFSYTFSKVQGNSDIYWKFQRYNLIVEYHNRPALAPPFIIIS 1095

  Fly  1199 HFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDL--ERLYDFEEECVEGFF-----HEQEIILNQS 1256
            |..:.:|..:||....:::.     ..||..:.  .|:..:|....|.:.     |:::     |
Frog  1096 HINTFIKRKIRKVASQKIRH-----FMLELTETLDNRMLIWEAVQKENYMVSVAKHKRD-----S 1150

  Fly  1257 TDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVI 1313
            ..||::.|:::|:...:.:.:|.:.:.           ||:.||...|...:.|:.|
Frog  1151 DTERLRRTSQKVDNALKLLNEIKEHDR-----------RLKAMENEMEYCRNALSWI 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	71/236 (30%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	9/50 (18%)
trpm4	XP_002934673.1	LSDAT_euk	91..340	CDD:393402	93/269 (35%)
		recJ	324..>379	CDD:273193	12/60 (20%)
		RILP-like	<1153..1215	CDD:390044	12/55 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010