Protein Alignment Trpm and trim26

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_031753324.1
• Gene: trim26 / 100491139
• XenbaseID: XB-GENE-6257461
• Length: 1497
• Species: Xenopus tropicalis
• Alignment Length: 1654
• Identity: 467/1654 - (28%)
• Similarity: 731/1654 - (44%)
• Gaps: 290/1654 - (17%)

  Fly   116 SWIETNFQKRECIKFIP----CPKDDTKCCCGQAQITH---QTIPGIESGSPGDLWLPTKHTRPQ 173
            ||:..|.:|:||:.|||    .|.|...|.||..:.||   |....:|   ||.:|.|.||.|..
 Frog    55 SWVTRNIRKKECVAFIPPAPEAPGDRDTCGCGHTRRTHFAAQVSAPLE---PGTVWDPHKHVREF 116

  Fly   174 PTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKL 238
            |:||:|.:.|.|... |.|:|||.|.||.|..|..|.|::|:|.:|.|||:|.||..||::..:|
 Frog   117 PSDAHGDLTFTGTTR-TWAKYVRASNDTPPRSLFDLMTQQWDLRVPNLLISVTGGAKNFNISPRL 180

  Fly   239 KKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALL-LEGQQRTGRVVSIGIAPWGIVERNHEL 302
            |.|..:||:.||::|||||.|||::.||.|.||:|:. ..|.|....:|.||||.||||.....|
 Frog   181 KTEFSRGLVTAAQSTGAWIITGGSHAGVMKHVGEAVRDFSGGQHETEIVLIGIATWGIVHNRESL 245

  Fly   303 LGHNREVPC--HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKL-HPF 364
            :......|.  ......:..|..|:|.|.:|:||||||..|||.|:.||.|||||||...: :..
 Frog   246 ISEAGGAPAVYPMDEGSQGALCCLDNNHTHFILVDNGTYGKYGVEIPLRTKLEKFISEQTMENAG 310

  Fly   365 THSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLES 429
            |....|:||:|:|||..|:..:...:.::  .|.|:.:||||.||::|.|   |:....|..:..
 Frog   311 TAIKIPIVCVVLEGGPGTLDTIYNSMCNN--TPCVIVEGSGRVADIIAQV---ANLSISQITISV 370

  Fly   430 MRDYLIGTIQKTFEVGLDQSEKLYQELLQ-CTRNKNLITVFRIQEKPEGEAQELDQTILTALFKS 493
            :::.|....|.|||...:....::.:.:| ..|..:|:|:.|   :.:.|.|.:|..||.||.|:
 Frog   371 VKEKLQNLFQDTFESFTEAQIIMWTKKIQDIVRMGSLLTILR---EDKTEEQGMDVAILQALLKA 432

  Fly   494 QHLSP-------PEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLE 551
            ...:.       ..||.||:.|||.|||.|:||.....|....|..::|.:|..|:..|::|.||
 Frog   433 SRSTDYSGQENWDHQLKLAVAWNRADIAESQIFTEDWMWKPSDLYPSLMVSLIDDKPSFLRLFLE 497

  Fly   552 NGVSMKKFLTIPRLEELYNTKHGPANTLGYILR-----DVRPHIPKGYIYTLHDIGLVINKLMGG 611
            .|||:.:|:|...|.||||... |::.:...|.     |....:..|....||.:..|:.:|:||
 Frog   498 RGVSLSEFITWDMLTELYNNTE-PSSLIHSKLERQAMLDESTEMNGGLKIQLHHVSHVLQELLGG 561

  Fly   612 AYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNE 676
            ...|.|..|:               ..::.|..|.....:..:|.:......|.::   |.|..:
 Frog   562 LTESLYLDRR---------------SHRTRTLPYINIKISGKVSSMRSECDSTVKL---EHPVRD 608

  Fly   677 LLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESK 741
            ||||.::..|.::|.::|...::.:..:|...|:.||::.|  ||  |||..|.::..|..:|.:
 Frog   609 LLIWCIVQNRAELAEIIWCQSQDCMVSALACSKMLKALSKE--ED--DTESMESMKVLANVYEER 669

  Fly   742 GNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTR 806
            ...:....|..|..:|::||......|...:.|.||..:..:..::....|:.|...|.|.|...
 Frog   670 AAGVFSECYASDESRAEQLLIRVSSKWGKTTSLDLAQESQGQLFMSQSGVQMFLTKTWFGRLSVD 734

  Fly   807 KNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYS 871
            ......::..|..|.....|....||.:  .|::      ::..|...:.||......|.
 Frog   735 NGLLAILLCMLLFPLIYTDLIMYRKESV--APRS------SRGQDKRSAARSSRARNCLW----- 786

  Fly   872 VRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYM 936
                                                        ||::|::|||.||:.:.::|:
 Frog   787 --------------------------------------------KFFDFFSAPIVKFYYNVVSYI 807

  Fly   937 FFLIMFSFTVLVKMEQMPRWQEWYSIAYITTLGFEKVREII-SSEPVAITHKFSVWAWNMWNPCD 1000
            .||.:|::.:::..:..|.|.|:....::.::..|::|::: ..:.:....|...:....||..|
 Frog   808 GFLWLFAYVLMMDFQTYPSWTEYLLYVWVFSILCEELRQLLYDPDRLGFVVKSMQYISEFWNQVD 872

  Fly  1001 GAAIILFVIGLAFRFRE-NTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIY 1064
            ..|:.||.:||..|... ||:.:|||...||.:.:.:|::||..|:|.|||.:.|:.:|:.::.:
 Frog   873 TLALSLFAVGLICRLASLNTVYLGRVFLSVDYMIFCIRLMNIFTVSKVLGPKIIMLRRMIMDLFF 937

  Fly  1065 FVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYG----EVFAGDIDP-PC---GE 1121
            |:.|||:.::||||::||||..|:.....:.:.|.:.||.:|:|    ||...:.|| .|   |.
 Frog   938 FLFLLAIWIVSFGVAKQAILTSNETRLDWIFRNVIYGPYLILFGQIPSEVDGLNFDPTKCSQSGT 1002

  Fly  1122 DPSQPGCVTG---------HWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQR 1177
            ||:.|.||..         .|:|.:.:.:|||:|||||:|||||:|:|.|.:|.|.:.|:|.|.|
 Frog  1003 DPTLPKCVYNDGSGKTLFPEWLTILLLCIYLLMANILLLNLLIAMFSNTFGDVESHTDQIWKFYR 1067

  Fly  1178 FTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECV 1242
            |.::.||.::||.|||||.|.|.|.||||.:.|...|..|   .::..:::.....|..:|....
 Frog  1068 FGLIKEYNERPVAPPPFILLSHLYFLLKYGLSKRSTLSHQ---AMRSVMDEAGESSLLSWELYMR 1129

  Fly  1243 EGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEE----SS 1303
            :.:.|.|:::.:||.:..||||.:.|   |..:..:|.:::   ...|.:|.||..:||    ||
 Frog  1130 DNYLHNQQLVDSQSQENVVKNTAQSV---SAVLNLLNMRKD---GEGQQLETRLILLEEEVLKSS 1188

  Fly  1304 EQ---ILSHLAVIHRFMSTHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGG 1365
            ||   |:|.|..               :|.|    |..||:...|..|    ||.....|
 Frog  1189 EQLQWIISALGE---------------KGFT----GRAQRLVHSSSQD----SGDSATHG----- 1225

  Fly  1366 GAIVPLGLGAGLNLNSLQVTTRRR---FNRSLTEVRPDAYIF-----DEGTHFEVVPLP-EEPDE 1421
                            |..:|.|:   ...|.|...||:.:.     ||...:| ||.| .||..
 Frog  1226 ----------------LDPSTERKSIYHVNSRTLQYPDSPVSRYPVPDEMVPWE-VPFPGYEPPF 1273

  Fly  1422 VVKSREALNEQVVRKASMQSEADSDIYIPVSQRPSTCETVKRTP-YVTVRQDTGA-STESKDTLT 1484
            ....|                .|...|.|.|:...|........ .:.:|...|. :.:....|.
 Frog  1274 YTAER----------------GDRGAYDPHSEMSQTNRKYNAVDGALDLRSSCGTYAVQDGFPLN 1322

  Fly  1485 PMGNNDDDQTLVGGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQ 1549
            |||...                             .|.|...|.....:||        |:.:.:
 Frog  1323 PMGRTG-----------------------------LRGVGSLRWFGPNHSL--------HLVITR 1350

  Fly  1550 LASLSRRQMSLTQSEPDSDKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHM 1614
            ..         |::...:||..|      .....||..|..:|.|..|.....|..:|:.|....
 Frog  1351 WN---------TRANGSADKKLP------RKMLEVLVVKEKKNELWALPGGTLSPGEEIPSKLQS 1400

  Fly  1615 IASPTVSLPSN----------KASLDRPK-TEMSRAEAAALLEKKHLKECEENDYMILEGLIESR 1668
            |.|.|.....:          :..||.|: |:.|..|..|:  ..|| :.||.....|:.|.:|.
 Frog  1401 ILSQTYGERFSELLRGGREVFRGYLDDPRNTDNSWIETLAV--NIHL-DTEETLSQFLQNLNQSS 1462

  Fly  1669 GSIDASAQGFEIGVSIDYSHRYPLRRETA 1697
            ..:....|..:..:.| |::...:.:.||
 Frog  1463 PEVSLRWQILDHKIPI-YANEKEILQRTA 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	80/234 (34%)
		TRPM_tetra	1262..1313	CDD:293127	19/57 (33%)
trim26	XP_031753324.1	LSDAT_euk	134..384	CDD:423023	104/254 (41%)
		trp	<762..1093	CDD:273311	115/387 (30%)
		Nudix_Hydrolase	1322..1493	CDD:412381	44/225 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D738147at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010