Protein Alignment Trpm and trpm7

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_002939674.2
• Gene: trpm7 / 100329113
• XenbaseID: XB-GENE-486884
• Length: 1875
• Species: Xenopus tropicalis
• Alignment Length: 1695
• Identity: 629/1695 - (37%)
• Similarity: 927/1695 - (54%)
• Gaps: 198/1695 - (11%)

  Fly   115 RSWIETNFQKRECIKFIPCPKDD-------------TKCCCGQAQITHQTIPGIESGSPGDL--- 163
            :||||.:|.||||...||..||.             .:||||:....|.......:....|:
 Frog     5 KSWIENSFTKRECTYIIPSSKDPHRCLPGCQICQQLVRCCCGRLVRQHACFTASVATKYSDVKLG 69

  Fly   164 ---------WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELP 219
                     |...|||...||||||.|.||||:|..:|:|||||:|::||.::||..|||.:|||
 Frog    70 EQFNEELEEWSVEKHTEESPTDAYGVINFQGGSHSYRAKYVRLSYDSKPEAILQLMLKEWQMELP 134

  Fly   220 KLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGR 284
            ||:|:|.||...|:|..::|:.|.|||:|||.||||||.|||.|.||.|.|||||.....:.:.:
 Frog   135 KLVISVHGGMQKFELHPRIKQLIGKGLIKAAVTTGAWILTGGVNAGVAKHVGDALKEHASRSSRK 199

  Fly   285 VVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILR 349
            :.:|||||||::|..::|:|.:...|..::.:|.|||.||||.|::|:|||:||..|||||:.||
 Frog   200 ICTIGIAPWGVIENRNDLIGRDVIAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVNLR 264

  Fly   350 RKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFV 414
            |:|||.|:..::|.......|||.|:.|||.|.|..||||:.:|||||||||:|:|||||:||:|
 Frog   265 RELEKTINLQRIHARIGQGVPVVALIFEGGPNVILTVLEYLQESPPVPVVVCEGTGRAADILAYV 329

  Fly   415 HKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEA 479
            ||...:|...|  |.....:|.||:|||.....::..|:|..::|.::|.|||||.|   ...|.
 Frog   330 HKQTEEGGTLP--EGADLEIISTIKKTFNFSQSEAIHLFQTTMECMKSKELITVFHI---GSDEH 389

  Fly   480 QELDQTILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRID 544
            |::|..|||||.|..:.|..:||.|.|.|:|||||::.:|||||:|..|:|::||:.||..||:.
 Frog   390 QDIDVAILTALLKGTNASALDQLVLTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVA 454

  Fly   545 FVKLLLENGVSMKKFLTIPRLEELYNTKHGPAN-TLGYILRDVRP-HIPKGYIYTLHDIGLVINK 607
            |||||:||||||.|||||||||||||||.||.| ||.:::|||:. ::|.||..||.|:||||..
 Frog   455 FVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPTLFHLVRDVKQGNLPPGYKITLIDVGLVIEF 519

  Fly   608 LMGGAYRSYYTRRKFRPIYAKVM---------------------NSYANACRKSSTYQY------ 645
            ||||.||..|||::||.||..:.                     .|:.|...|....::
 Frog   520 LMGGTYRCTYTRKRFRIIYNNIQGGNRRSGRNTSSNTPQMRKSHESFGNRADKKEKMRHNHFIKT 584

  Fly   646 -QRYAGANSLSLVTGLLPFTS---------EMALFEFPFNELLIWAVLTKRQQMALLMWTHGEEA 700
             |.|.....:|...|....|.         ||..|::||||||:|:||.|||:|||..|.||||:
 Frog   585 AQPYKPKQDVSADDGKKKKTKEEIVDIDDPEMKRFQYPFNELLVWSVLMKRQKMALFFWQHGEES 649

  Fly   701 LAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCEL 765
            :||:||:|||.:.||:||.:.|:..||.||.:.::.||......|||.::|||...|.:|||.||
 Frog   650 MAKALVACKLCRTMAYEAKQSDVVDEIAEEFKEHSSEFGQLAVDLLDQAFRQDETMAMKLLTYEL 714

  Fly   766 HSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFKS 830
            .:|||.:||.|||::..|..:||.|:|::|:|:|||.|..|||:.:||||.:.:|..|..|::|:
 Frog   715 KNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILVPPTILMLEYKT 779

  Fly   831 KEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFRE 895
            |.|:..:||:::.    ..:..|||:.:                   .:|...::..:...:.|.
 Frog   780 KAEMSHIPQSQDA----LQMTMDDSENN-------------------FQNLPENIAMNVFREVRP 821

  Fly   896 FFNLSEYNEVK-QHQP--LRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ 957
            |..:...:|:: |.:|  |.:.:|||.||.|||.|||.:::.|:.||::|::.||||||.:|..|
 Frog   822 FDTMEVKHEIETQAKPRKLPITQKFYAFYHAPIVKFWFNTLFYLGFLMLFTYVVLVKMESLPSVQ 886

  Fly   958 EWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFR-------- 1014
            ||..|:||.|...||:|||..||...|..|..||..:.:|..|..|||.|.||...|
 Frog   887 EWIVISYIFTSAVEKIREIFMSEAGKINQKVKVWFGDYFNITDTIAIITFFIGCGLRLGAYRDVP 951

  Fly  1015 --------FRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAV 1071
                    :.|.....||:.||::.|:||:|:|:.|.||:..||.|.|:||||.||.|.||::||
 Frog   952 EDQLKDDEYNETISLAGRLTYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMAV 1016

  Fly  1072 VLMSFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGEDPSQPG-CVTGHWVT 1135
            ||:||||.|||||||:::|:|.|.:::.||||:|::|||:|.:|| .|..:...|. |..|.|:|
 Frog  1017 VLLSFGVPRQAILYPHQEPSWRLARDIVFQPYWMIFGEVYAYEID-VCANNSEVPDLCDVGTWLT 1080

  Fly  1136 PITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHF 1200
            |...::||.:..|:::|||||.|||::.||.::||.||.:||:..:|.|.:|||||||.|.|.|.
 Frog  1081 PFLQAVYLFVQYIIMVNLLIAFFNNVYFEVKAISHIVWKYQRYHFIMAYHEKPVLPPPLIILSHL 1145

  Fly  1201 YSLLKY-CVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNT 1264
            .||..: |.|:.|.   :..:|.||||.::|.::|:||||:|||.:|:|::...:..::||::.|
 Frog  1146 ASLFGFVCKRRKKD---KTSHGPKLFLTEEDQKKLHDFEEQCVETYFNEKDDKFHLGSEERIRVT 1207

  Fly  1265 TERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESS-----------EQILSHLAVIHRFMS 1318
            :||||.|..:|:::..:.|....::.:::.::..:::.|           .|..|..:.:|..::
 Frog  1208 SERVEQMCIQIKEVGDRVNYIKRSLHSLDTQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEIT 1272

  Fly  1319 THTAGADDLRGSTINIPGEMQRMR-TISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSL 1382
            ...:.:..| |.|:...|.::.:| ..|:.:..|.|.|.||  .......|..:.|....|..|.
 Frog  1273 RELSISKHL-GQTVVDDGPLRSLRKKHSVGNFFGSSFPQGN--QESNSNLIFNISLRNERNSQSR 1334

  Fly  1383 QVTTR-----RRFNRSLTEVRPDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSE 1442
            :....     ||.|.::.|..|.....   .|.:  ..|.:..|..:..|:|.:..:......||
 Frog  1335 KTGDEFCFPYRRENLNIPEAGPSGSAL---LHSK--DCPTDAMENTEGTESLTDNQIVDNVASSE 1394

  Fly  1443 ADS-----DIYIPVSQRPSTCETVKRTPYVT--VRQDTGASTESKDTLTPMGNNDD----DQTLV 1496
            .:|     ..::....:|::...::..|.:.  :.|......||.:....:|:.|:    .....
 Frog  1395 PNSVSGMATFFVSTPTQPNSASQLELEPKMEKYINQRAAREAESIEFGAFVGHRDNVILHKYKEP 1459

  Fly  1497 GGDNSDDATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLT 1561
            .|.:.::|.......|....:|:|  |..|....:.     :.|:||. .||:|.|.|||.....
 Frog  1460 EGKSKEEAKATDVVVAPALPSLKQ--VRSCAGFMDL-----STISRSS-QLNKLHSSSRRASLTE 1516

  Fly  1562 QSEPDSDKDAPIAQGSAHPGKSVLHAKP--------------------------SRNILLKLHSE 1600
            .|..:..|:|.:.........|...|||                          .||.|::|...
 Frog  1517 DSNLEETKEAFLTNWLQAHSSSTSKAKPPEDDAFNAIGSPFKPIVDINYCYSAVERNNLMRLAQS 1581

  Fly  1601 --YTSI--TDELESVCHMIASPTVSLPSNKASLDR----PKTE-MSRAEAAALLEKKHLKEC--E 1654
              :|.:  ..||.:|..:..|....|.::.:|..:    .|.| :|:.|....|.:.....|  .
 Frog  1582 IPFTPVPPKGELVTVYRLEESSPNMLNNSMSSWSQRGLCAKIEFLSKEEMGGGLRRAVKVVCTWS 1646

  Fly  1655 ENDYM 1659
            |||.:
 Frog  1647 ENDIL 1651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	104/232 (45%)
		TRPM_tetra	1262..1313	CDD:293127	11/61 (18%)
trpm7	XP_002939674.2	Ion_trans	868..1112	CDD:278921	111/244 (45%)
		TRPM_tetra	1205..1256	CDD:293127	9/50 (18%)
		Alpha_kinase	1610..1828	CDD:214828	10/42 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I685
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1172	1.000	Inparanoid score	I201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48134
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060