Protein Alignment Trpm and trpm8b

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_012825655.2
• Gene: trpm8b / 100302009
• XenbaseID: XB-GENE-12442826
• Length: 1090
• Species: Xenopus tropicalis
• Alignment Length: 1219
• Identity: 330/1219 - (27%)
• Similarity: 555/1219 - (45%)
• Gaps: 209/1219 - (17%)

  Fly   121 NFQKRECIKFIPCP-KDDTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQ 184
            :.:|||||.|...| ..::.|.||  .:..|...|::: :..|.|..|:||:...|||||.|:|:
 Frog    39 DIKKRECIVFTQDPSSQESLCKCG--YLKRQHTEGVQT-NQNDRWNYTRHTKELSTDAYGEIQFE 100

  Fly   185 GGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKA 249
              ....:|:|:|||.||.|.:|.:|.|..|.|:.|.|:|:|.||..||.|:.:::|.||: |:..
 Frog   101 --TFGRRAKYIRLSRDTAPAILYKLMTSYWQLKTPNLIISVTGGARNFSLKPRIRKIIRR-LIYI 162

  Fly   250 AKTTGAWIFTGGTNTGVTKQVGDALL--LEGQQRTGRVVSIGIAPWGIVERNHELL---GHNREV 309
            |::.|||||||||:.|:||.:|:.:.  ...|...|:|.:||||.||::.....|:   ....:.
 Frog   163 AQSKGAWIFTGGTHNGLTKYIGEVVRDNTISQSSEGKVAAIGIAAWGMISNRDSLIRSPDDEGKY 227

  Fly   310 PCHSISSPRSK--LAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHS-STPV 371
            ..|.:...:.:  |..|:|.|.:|:|||||:......|..||..||..||.|......:| ..|:
 Frog   228 IAHYVMDEKKEDGLYCLDNNHTHFILVDNGSHKHPTIEAELRASLEGCISELTAPDSDYSGKIPI 292

  Fly   372 VCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQP---VLESMRDY 433
            ||.|..||..|::|:...:...  :|.||.:|||:.||::|.:  ..::|...|   :.|.|..:
 Frog   293 VCFVHSGGKETLKAINRAIKSK--IPCVVVEGSGQIADVIASL--VETEGTSVPSTIIKEKMLHF 353

  Fly   434 LIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSP 498
            |..|:.:..|   |:.|...|.:.:...:.||:||.:|.|..:   :.:...|..||:|:.....
 Frog   354 LKYTVSRLTE---DELEAWIQWIKEIMESPNLLTVIKIDEAGD---ETVSDAISAALYKAYSTRE 412

  Fly   499 PE------QLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMK 557
            .:      ||.|.|.||::::|.:|:|..||.|....|::||..||..||.:||:||||||:.:.
 Frog   413 LDKGNWNAQLKLLLEWNQLELANNELFANGQHWKTADLEDAMFTALVKDRPEFVRLLLENGLDLD 477

  Fly   558 KFLTIPRLEELYNTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKF 622
            |||:...|.:|::                 .|.......:|.......|.|:...:|....   :
 Frog   478 KFLSSEVLRQLFS-----------------EHFSTHAFKSLEMADKSYNPLLTFVWRMVLV---Y 522

  Fly   623 RPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQ 687
            :|...:..|        ||.|:.|     |..||:.            ..|...|.|||:|..::
 Frog   523 QPSNKEKWN--------SSDYKIQ-----NISSLIK------------RHPTQVLFIWAILQNKR 562

  Fly   688 QMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQ 752
            :::.::|...:.....:|.:.||.|.:    |:.:.|.:..:|....|.|:|::...|....|..
 Frog   563 ELSTVIWEQTKACTLAALGASKLLKHL----AKVNKDIKTAQESEEMAHEYETRAVDLFTECYSN 623

  Fly   753 DAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGL 817
            |.:.|..||.....:|...:||.:|||||.:..:|.|..|..|:..|.|.: :|....:|::|.|
 Frog   624 DKKLAGMLLVHSCEAWGKSNCLDMAVAANDQQFIAQPGVQNFLSKQWYGAI-SRDTKTWKILLSL 687

  Fly   818 AMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGK 882
            .:                 .|......:..:|:.|....|..
 Frog   688 FI-----------------FPLISCGFITFRNISNRKRSRLW----------------------- 712

  Fly   883 VSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVL 947
                                             |:.:|:|:|...|....|.|:.||.:|::.:|
 Frog   713 ---------------------------------KYCDFFTSPFVVFSWTVIFYIGFLFLFAYVLL 744

  Fly   948 VKMEQMPRWQEWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLA 1012
            :..:.:|...|......:..|...::|::|.|.        :.::.:.||..|..||:.|::|:.
 Frog   745 MDFQPIPTGLEIVVYLLVFILLCIEIRQMIISR--------AEYSRDCWNIMDCMAILYFIVGVL 801

  Fly  1013 FRFRE---NTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLM 1074
            ||.:.   :.:.:||||.|:|.|.:.||::.|..:::.|||.:.|:.:|..::.:|:.|.||.::
 Frog   802 FRLQNSNPSALYVGRVILCLDYIIFTLRLIQIFTISQNLGPKIIMLQRMFVDVFFFLFLFAVWIV 866

  Fly  1075 SFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEVFAGDID-----------------PPCGED 1122
            :|||:.|.||..|:.....:.:.|.:|||..::|..|: |:|                 |.|.|.
 Frog   867 AFGVANQGILRLNEHRWEWIFRSVIYQPYLAMFGGPFS-DVDEATYDFDKCTITGNESKPLCVEV 930

  Fly  1123 PSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQK 1187
            .|:.......|:|...:|:|:|..||||:|||||:|......|...:.|||.|||:.:|.||..:
 Frog   931 DSENNPRFPEWITIPLVSVYMLSTNILLVNLLIAMFGYTVGSVQDNNEQVWKFQRYFLVQEYCSR 995

  Fly  1188 PVLPPPFIALCHFY----SLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHE 1248
            ..:|.||:...:.|    :|..:|.:|      |....|.....|:|.:.|      ..|....|
 Frog   996 ITIPFPFVIFGYIYLIMRNLFSWCYKK------QEPPPLPCCFNKEDNKTL------AWEAVMKE 1048

  Fly  1249 QEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLR 1297
            ..::...|..:..:....|.:.:..|:.:::       :.|.::..|::
 Frog  1049 NYLVKKISETQNNREMEHRFKQLEGKLNELH-------SLVMDLTVRIK 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	69/235 (29%)
		TRPM_tetra	1262..1313	CDD:293127	4/36 (11%)
trpm8b	XP_012825655.2	LSDAT_euk	106..378	CDD:423023	97/279 (35%)
		trp	<577..1043	CDD:273311	139/564 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920