Protein Alignment Trpm and trpm8

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: NP_001155105.1
• Gene: trpm8 / 100302008
• XenbaseID: XB-GENE-998832
• Length: 1141
• Species: Xenopus tropicalis
• Alignment Length: 1267
• Identity: 356/1267 - (28%)
• Similarity: 600/1267 - (47%)
• Gaps: 211/1267 - (16%)

  Fly    75 RQRMRKR-SSVSSTLSKV------LILNVRDLLKAHAGSEPLK--EHQPRSWIETNFQKRECIKF 130
            |:|.|:| ..|||.|.|:      |:.:.|.|..:.:.|..|.  |.....:|:.||:||||:.:
 Frog    33 RERPRQRLVDVSSDLIKMRSRRSGLMESSRTLYSSFSRSIELSLDEIDAAKFIQENFKKRECVTY 97

  Fly   131 IPCPKD-DTKCCCGQAQITHQTIPGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQY 194
            ...|:. :..|.||.::..|  ..||:| :..:.|...|:|:..||||||.|:|:  |...:.:|
 Frog    98 TKDPRSPEGVCKCGYSRSQH--TEGIQS-NQNEKWNYKKNTKEVPTDAYGDIQFE--AFGRRGKY 157

  Fly   195 VRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFT 259
            :|||.||.||:|.:|.||.|.|:.|.|:|:|.||..||.|:.:::| |...|:..|:|.||||||
 Frog   158 IRLSRDTTPEILYELMTKYWQLKTPNLIISVTGGAKNFSLKPRMRK-IFSRLIYIAQTKGAWIFT 221

  Fly   260 GGTNTGVTKQVGDALLLEGQQRTG--RVVSIGIAPWGIVERNHELL-GHNRE--VPCHSI--SSP 317
            |||:.|:.|.:|:.:......|:.  :|::||||.||:|.....|: ..|.|  ...|.:  ...
 Frog   222 GGTHYGLMKYIGEVVRDNTISRSSEEKVIAIGIAAWGMVSNRESLIRSPNNEGNYVAHYVMDEQK 286

  Fly   318 RSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTH-SSTPVVCLVIEGGTN 381
            |..|..|:|.|.:.:||||||..:...|..||..|||:||.|.:....: ...|:||....||..
 Frog   287 RDPLYCLDNNHTHLILVDNGTHGQPTTEAELRASLEKYISELNVPDSNYGGKVPIVCFAQGGGKE 351

  Fly   382 TIRAVLEYVTDSPPVPVVVCDGSGRAADLLA-FVHKYASDGEEQPVLESMRDYLIGTIQKTFEVG 445
            |::|:...:...  :|.||.:|||:.||::| .|....:......:.|.:..:|..|:.:..|
 Frog   352 TLKAINTAIKSK--IPCVVVEGSGQTADVIASLVEAEGTTLASSAIKEKLLRFLPRTVSRLTE-- 412

  Fly   446 LDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPE------QLSL 504
             |:.|...:.:.:...|.:|:||.:|::..:   :.:...|..||:|:...:..:      ||.|
 Frog   413 -DEMESWIRWIKEIMENLHLLTVIKIEQAGD---EIVSNAISFALYKAYSTNEQDKDNWNAQLKL 473

  Fly   505 ALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELY 569
            .|.||::|:|..|||...:.|.:..|::||..||..||..||:||||||::::||||...|.||:
 Frog   474 LLEWNQLDLASEEIFTNDRRWESADLEDAMFAALVKDRPKFVRLLLENGLNLRKFLTSEILSELF 538

  Fly   570 NTKHGPANTLGYILRDVRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYA 634
            :...   :||.|  |:::                        ..::.|.......::..|:|
 Frog   539 SENF---STLVY--RNLQ------------------------IAKNSYNDTLLTFVWKMVLN--- 571

  Fly   635 NACRKSSTYQ--YQRYAGANSLSLVTGLLPFTSEMALFEFPFNELLIWAVLTKRQQMALLMWTHG 697
                    ||  |:....:...|.:..|.|      :.:.|...|.|||:|..::|::.::|...
 Frog   572 --------YQRTYKEERNSRDFSDIQDLSP------IIKHPIQVLFIWAILQNKRQLSKVIWEQT 622

  Fly   698 EEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLT 762
            ......:|.:.||.|::|  ..::|::..  .|....|.|:|::..:|....|..|.:.|:.||.
 Frog   623 RGCTLAALGASKLLKSLA--KVKNDINAA--GESEEIANEYETRAVELFTECYSNDEDLAEMLLV 683

  Fly   763 CELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLD 827
            ....:|...:||.:||.|..:..:|.|..|..|:..|.|.: :|...|:|::|.|.. |.:....
 Frog   684 YSCEAWGMSNCLEMAVEAKDQQFIAQPGVQNFLSKQWYGEI-SRDTKNWKILLCLFF-FPLISCG 746

  Fly   828 FKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQ 892
            |                         .|.|.:|                           ||
 Frog   747 F-------------------------ISFRKKP---------------------------SD--- 756

  Fly   893 FREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQ 957
                         |:...||   |:::|:|:|...|....|.|:.||::|::.:|:..:.:|...
 Frog   757 -------------KKRSHLR---KYFDFFTSPFVVFSWTVIFYIGFLLVFAYVLLMDFQPVPTGL 805

  Fly   958 EWYSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRF-RENTMD 1021
            |......:..|..:::|::..|.....|        ::||..|..||:.|:.|:.||. |.|:..
 Frog   806 EIAVYVLVFILLCDEIRQMYMSGIKYFT--------DLWNVMDILAILYFIAGIVFRLHRSNSSA 862

  Fly  1022 I--GRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAIL 1084
            :  ||||:|:|.|.:.:|:::|..|::.|||.:.|:.:|:.::.:|:.|.||.:::|||:||.||
 Frog   863 LYTGRVIFCLDYIIFTVRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWVIAFGVARQGIL 927

  Fly  1085 YPNKQPTWSLIKEVTFQPYFMLYGEVFAGDIDPPCGE--------DPSQPGCV---TGH------ 1132
            ..|:.....:.:.|.::||..::|:..| |:|....:        :.|:|.||   ..|
 Frog   928 RLNEHRWEWIFRSVIYEPYLAVFGQYIA-DVDGTTYDFDHCTITGNESKPLCVEMDNDHNPRFPE 991

  Fly  1133 WVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIAL 1197
            |:|...:.:|:|..||||:|||||:|......|...:.|||.|||:.:|.||..:..:|.||:.|
 Frog   992 WITIPLVCIYMLSTNILLVNLLIAMFGYTVGSVQENNDQVWKFQRYFLVQEYCSRLTIPFPFVIL 1056

  Fly  1198 CHFYSLLK----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTD 1258
            .:||.:|:    .|.::      |.........:|:|.|.|      ..|....|..::...|.:
 Frog  1057 AYFYMILRKMFSCCCKQ------QEPEPTHCCSKKEDTETL------AWEAVMKENYLVKLSSQN 1109

  Fly  1259 ERVKNTTERVETMSQKIEDINQKENIQTATVQ 1290
            .:.....::.:.:..|:.|:  |..::..|::
 Frog  1110 NKCTEMEQKFKQLEGKLHDL--KRMMKDITIK 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	71/235 (30%)
		TRPM_tetra	1262..1313	CDD:293127	4/29 (14%)
trpm8	NP_001155105.1	LSDAT_euk	156..427	CDD:393402	96/276 (35%)
		trp	<695..1094	CDD:273311	129/492 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920