Protein Alignment Trpm and trpm1

DIOPT Version :10

• Sequence 1: NP_001401007.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_031755011.1
• Gene: trpm1 / 100216447
• XenbaseID: XB-GENE-492528
• Length: 1679
• Species: Xenopus tropicalis
• Alignment Length: 1820
• Identity: 671/1820 - (36%)
• Similarity: 959/1820 - (52%)
• Gaps: 414/1820 - (22%)

  Fly    39 RSWIETNFQKRECIKFIPCPKDDTKCCCGQAQITHQTIPGIESGSPG-----------DLWLPTK 92
            ::|||..|.|||||..:...||..:|||||....|..:|...:|:..           :.|..:|
 Frog    47 KAWIEKTFSKRECIYVLANSKDSNRCCCGQLLTQHIPVPQNATGNKNGEECKQLEAVPEKWSISK 111

  Fly    93 HTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFD 157
            ||:..||||:|.:|||||.|..||.|:|:|:|::|:.|:.|..|||.||||||||:|.||..||:
 Frog   112 HTQLSPTDAFGILEFQGGGHSNKAMYIRVSYDSKPDSLLHLMVKEWQLELPKLLISVHGGLQNFE 176

  Fly   158 LQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVER 222
            :|.|||:...|||:|||.||||||||||.:|||.:.|||||.....:..||:.:||||||||||.
 Frog   177 MQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVIRHVGDALKDHSSKSRGRICAIGIAPWGIVEN 241

  Fly   223 NHELLGHNREVPCHSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHP 287
            ..:|:|.:...|..::|:|.|||:|||:.|.:|:|.||||..|||||:.|||:|||.||..|::.
 Frog   242 KEDLIGKDVTKPYQTMSNPLSKLSVLNSSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINT 306

  Fly   288 SKNHWLKTNVTHSSTPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYAS 352
            ...         ...|||.|::|||.|.|..|||.:.:.||||||||||||||:|:::|.|||:.
 Frog   307 RLG---------QGVPVVALIVEGGPNVITIVLECLREEPPVPVVVCDGSGRASDIMSFAHKYSE 362

  Fly   353 DGEEQPVLESMRDYLIGTIQKTFEVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQ 417
            :|  ..:.||:||.|:.||||||....:|:.:|...|::|.:.|.||||||:..  ||: |:::.
 Frog   363 EG--GIISESLRDQLLVTIQKTFNYSRNQAHQLLVVLMECMKKKELITVFRMGS--EGQ-QDIEM 422

  Fly   418 TILTALFKSQHLSPPEQLSLALTWNRVDIARSEIFVYGQEWPN---------------------- 460
            .|||||.|..:.|.|:||||||.|||||||||:|||:|..||.
 Frog   423 AILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGHHWPPLGSLTAADGTTQDKDKKSPAAQ 487

  Fly   461 -----------------------------------GALDEAMMQALEHDRIDFVKLLLENGVSMK 490
                                               .:|::|||.||..||:||||||:||||||:
 Frog   488 PKATRGKGKGKKKGKGKEEPAEETDPRKIELLNWVSSLEQAMMDALVLDRVDFVKLLIENGVSMQ 552

  Fly   491 KFLTIPRLEELYNTKHGPANTLGYILRDVRP-HIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRK 554
            :|||||||||||||:.||.|||.||:|||:. ::|..|..:|.|||||:..|||||||.:|||:.
 Frog   553 RFLTIPRLEELYNTRLGPPNTLHYIVRDVKKGNLPPDYHVSLIDIGLVLEYLMGGAYRCHYTRKT 617

  Fly   555 FRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTS------------------EMA 601
            ||.:|             ::.:..:|......|.:.....|...                  |::
 Frog   618 FRTLY-------------NNLFGPKRPKALKLLGMEDDEPPTKGKKKKKKKEEEIDMDVDDPEVS 669

  Fly   602 LFEFPFNELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRS 666
            .|::||:||::||||.|||:|||.:|..|||.:||:||:|||||:||||::|.:|..:|.::|.:
 Frog   670 RFKYPFHELMVWAVLLKRQKMALFLWQRGEETMAKALVACKLYKSMAHESSESELVDDISQDLDN 734

  Fly   667 YAKEFESKGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADL 731
            .:|:|.....:|||.||:.|.:.|.:|||.||.:|||.:||.|||||.||..:||.|||::|.|:
 Frog   735 NSKDFGQLALELLDQSYKHDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDM 799

  Fly   732 WMGGLRTRKNTNFKVILGLAMPFYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAE 796
            |||.||.|||...|||:|:..|..|..|:|:|:::|..  .|.:|:.|.:..::::.|.:
 Frog   800 WMGRLRMRKNPGLKVIMGILFPPTILFLEFRSQDDLSF--HTSKEYEEGKEKEDENMDGN----- 857

  Fly   797 SALLKAKRSISLRYRMGAGANNRDKALLADTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYN 861
                                        |||.|.:..:  |||.
 Frog   858 ----------------------------ADTTSRKGDE--ENGN--------------------- 871

  Fly   862 EVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEWYSIAYITTL 926
              ::.:.:.:..|.||||.|||.|||..:|:|:.:|::|::.:|||||:.|..|||..|:||.||
 Frog   872 --RKQKSIPIGTKIYEFYNAPIVKFWFYTISYLAYLMLFNYVILVKMERWPSVQEWVVISYIVTL 934

  Fly   927 GFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENT-MDIGRVIYCVDSI 990
            ..||||||:.|||..::.|..||....||..|..||.:|:||...|.:... |..||||||||.|
 Frog   935 ALEKVREILMSEPGKLSQKVKVWLQEYWNITDLVAISVFLIGAILRLQNQPYMGYGRVIYCVDII 999

  Fly   991 YWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNKQPTWSLIKE 1055
            :||:|:|:|.||||||||.|.|:|||:.:|:|||:::.||||||||:|||||:|:::|:|.|.:
 Frog  1000 FWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVIIMLVVLMSFGVARQAILHPDEEPSWRLAR- 1063

  Fly  1056 VIAGSITAPGFLGALGHNTRSSYHRGYHTMGAPPVTTTAASTTTGSSSTVPAATTSTTAPIHNEH 1120
                                                                             
 Frog  1064 ----------------------------------------------------------------- 1063

  Fly  1121 SNLTSGNLTNVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHWVTPITM 1172
                     |:.:.||:|:||||||..||       |||||:      ...|.|:.|.|:||..|
 Frog  1064 ---------NIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEDGKRLPPCIPGAWLTPALM 1119

  Fly  1173 SMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLL 1237
            :.|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|...|.|.:|
 Frog  1120 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIIFSHLYIIL 1184

  Fly  1238 K----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTT 1298
            |    .|.:..:|.:.:||.||||||..::|::||:|||:|||.:|.|:|.....|.|||::.|:
 Frog  1185 KRICCRCKKIQEGDQDERDRGLKLFLNDEELKKLYEFEEQCVEEYFQEKEDEQQSSNDERIRVTS 1249

  Fly  1299 ERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGS 1363
            ||||.||.::|::|::|:...|::|.::.||.::||.|.::::.|        ...||.|  :..
 Frog  1250 ERVENMSMRLEEVNEREHFMKASLQTVDLRLSQLEELSGRMVNAL--------ERLAGID--KSE 1304

  Fly  1364 TINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLT 1428
            .||     :|.|..|:.|                  |...|..|   ::||...|:..:::....
 Frog  1305 LIN-----ERSRASSVCD------------------AAFLLRQG---SVNSSDGTSVYKYHVETD 1343

  Fly  1429 EV---------------RPDAYIF-------DEGTHFEVVPLP-----EEPDEVVKSREALNEQV 1466
            ||               |..||.|       ::....::||..     ......|.:::| |:..
 Frog  1344 EVTCDESTGSISPALGLRRKAYSFGMRTEKGEQDNKAQLVPRQASLRYASSANAVATKDA-NKVT 1407

  Fly  1467 VRKASMQSEADS--DIYIP-------VSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNN 1522
            :...|..|...|  ||:||       :::.||| :.:.:|..||..|..|..||...:.....:.
 Frog  1408 LGIVSKSSRPISCVDIWIPECDKKETINESPST-QHLSQTDIVTNCQSEGEVTEVSKSEFANSHL 1471

  Fly  1523 DDDQTLVGGDNSDDATPDINFEAARHRALR----------QRTVSLCRR--NSETYSLTGADINR 1575
            ..::|.:      :||  |:|...|.:|::          |.|::..|.  .:|...|.|...|.
 Frog  1472 TVERTKL------EAT--ISFPLERSKAMKYYSGQSFNTCQTTMTKSRSFVFTEGGKLVGGVNNW 1528

  Fly  1576 SHIS--LNQLASLS---------------RRQMS------------------LTQSEPDSDKDAP 1605
            :..|  ::|::..|               |:|..                  ||.:|.||| ...
 Frog  1529 TEYSTIIDQVSPTSLEEWTDQWNNQGDSPRKQSPELATIISEAEIQAELKPLLTDTEDDSD-IGE 1592

  Fly  1606 IAQGSAHPGKSVLHAKPSRNILL------------KLHS---EYTSITDELESVCHMIASPTVSL 1655
            ....:::|.......|...::.|            .|||   :..|:.|:||...|  ||..:::
 Frog  1593 TGNSASYPCTERTETKNLLSVQLDRTCGFSSPRSKSLHSHTGKSRSLIDKLERPGH--ASSVMNI 1655

  Fly  1656  1655
             Frog  1656  1655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001401007.1	LSDAT_euk	116..392	CDD:465665	142/275 (52%)
		TRPV	<872..1227	CDD:454755	157/368 (43%)
		TRPM_tetra	1291..1346	CDD:465156	21/54 (39%)
trpm1	XP_031755011.1	LSDAT_euk	135..400	CDD:465665	142/275 (52%)
		TRPV	<890..1196	CDD:454755	158/380 (42%)
		PRK12704	1211..>1324	CDD:237177	45/145 (31%)
		TRPM_tetra	1242..1297	CDD:465156	21/62 (34%)