Protein Alignment Trpm and trpm1

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_031755011.1
• Gene: trpm1 / 100216447
• XenbaseID: XB-GENE-492528
• Length: 1679
• Species: Xenopus tropicalis
• Alignment Length: 1754
• Identity: 677/1754 - (38%)
• Similarity: 969/1754 - (55%)
• Gaps: 324/1754 - (18%)

  Fly    72 IRRRQRMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPRSWIETNFQKRECIKFIPCPKD 136
            :||.....||:|:.                   ||....:...::|||..|.|||||..:...||
 Frog    23 LRRMSGSFKRTSLK-------------------GSSSGSQKGQKAWIEKTFSKRECIYVLANSKD 68

  Fly   137 DTKCCCGQAQITHQTIPGIESGSPG-----------DLWLPTKHTRPQPTDAYGTIEFQGGAHPT 190
            ..:|||||....|..:|...:|:..           :.|..:|||:..||||:|.:|||||.|..
 Frog    69 SNRCCCGQLLTQHIPVPQNATGNKNGEECKQLEAVPEKWSISKHTQLSPTDAFGILEFQGGGHSN 133

  Fly   191 KAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGA 255
            ||.|:|:|:|::|:.|:.|..|||.||||||||:|.||..||::|.|||:...|||:|||.||||
 Frog   134 KAMYIRVSYDSKPDSLLHLMVKEWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGA 198

  Fly   256 WIFTGGTNTGVTKQVGDALLLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSISSPRSK 320
            ||||||.:|||.:.|||||.....:..||:.:||||||||||...:|:|.:...|..::|:|.||
 Frog   199 WIFTGGVSTGVIRHVGDALKDHSSKSRGRICAIGIAPWGIVENKEDLIGKDVTKPYQTMSNPLSK 263

  Fly   321 LAVLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISNLKLHPFTHSSTPVVCLVIEGGTNTIRA 385
            |:|||:.|.:|:|.||||..|||||:.|||:|||.||..|::.......|||.|::|||.|.|..
 Frog   264 LSVLNSSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVALIVEGGPNVITI 328

  Fly   386 VLEYVTDSPPVPVVVCDGSGRAADLLAFVHKYASDGEEQPVLESMRDYLIGTIQKTFEVGLDQSE 450
            |||.:.:.||||||||||||||:|:::|.|||:.:|  ..:.||:||.|:.||||||....:|:.
 Frog   329 VLECLREEPPVPVVVCDGSGRASDIMSFAHKYSEEG--GIISESLRDQLLVTIQKTFNYSRNQAH 391

  Fly   451 KLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSPPEQLSLALTWNRVDIAR 515
            :|...|::|.:.|.||||||:..  ||: |:::..|||||.|..:.|.|:||||||.||||||||
 Frog   392 QLLVVLMECMKKKELITVFRMGS--EGQ-QDIEMAILTALLKGTNASAPDQLSLALAWNRVDIAR 453

  Fly   516 SEIFVYGQEWPN----------------------------------------------------- 527
            |:|||:|..||.
 Frog   454 SQIFVFGHHWPPLGSLTAADGTTQDKDKKSPAAQPKATRGKGKGKKKGKGKEEPAEETDPRKIEL 518

  Fly   528 ----GALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRDVRP 588
                .:|::|||.||..||:||||||:||||||::|||||||||||||:.||.|||.||:|||:.
 Frog   519 LNWVSSLEQAMMDALVLDRVDFVKLLIENGVSMQRFLTIPRLEELYNTRLGPPNTLHYIVRDVKK 583

  Fly   589 -HIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGAN 652
             ::|..|..:|.|||||:..|||||||.:|||:.||.:|             ::.:..:|.....
 Frog   584 GNLPPDYHVSLIDIGLVLEYLMGGAYRCHYTRKTFRTLY-------------NNLFGPKRPKALK 635

  Fly   653 SLSLVTGLLPFTS------------------EMALFEFPFNELLIWAVLTKRQQMALLMWTHGEE 699
            .|.:.....|...                  |::.|::||:||::||||.|||:|||.:|..|||
 Frog   636 LLGMEDDEPPTKGKKKKKKKEEEIDMDVDDPEVSRFKYPFHELMVWAVLLKRQKMALFLWQRGEE 700

  Fly   700 ALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYRQDAEKAQRLLTCE 764
            .:||:||:|||||:||||::|.:|..:|.::|.:.:|:|.....:|||.||:.|.:.|.:|||.|
 Frog   701 TMAKALVACKLYKSMAHESSESELVDDISQDLDNNSKDFGQLALELLDQSYKHDEQVAMKLLTYE 765

  Fly   765 LHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILGLAMPFYIRQLDFK 829
            |.:|||.:||.|||||.||..:||.|||::|.|:|||.||.|||...|||:|:..|..|..|:|:
 Frog   766 LKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILFPPTILFLEFR 830

  Fly   830 SKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHENGKVSLTDSDTAQFR 894
            |:::|..  .|.:|:.|.:..::::.|.:        |||.|.:..:  |||.
 Frog   831 SQDDLSF--HTSKEYEEGKEKEDENMDGN--------ADTTSRKGDE--ENGN------------ 871

  Fly   895 EFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFTVLVKMEQMPRWQEW 959
                       ::.:.:.:..|.||||.|||.|||..:|:|:.:|::|::.:|||||:.|..|||
 Frog   872 -----------RKQKSIPIGTKIYEFYNAPIVKFWFYTISYLAYLMLFNYVILVKMERWPSVQEW 925

  Fly   960 YSIAYITTLGFEKVREIISSEPVAITHKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENT-MDIG 1023
            ..|:||.||..||||||:.|||..::.|..||....||..|..||.:|:||...|.:... |..|
 Frog   926 VVISYIVTLALEKVREILMSEPGKLSQKVKVWLQEYWNITDLVAISVFLIGAILRLQNQPYMGYG 990

  Fly  1024 RVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYPNK 1088
            |||||||.|:||:|:|:|.||||||||.|.|:|||:.:|:|||:::.||||||||:|||||:|::
 Frog   991 RVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVIIMLVVLMSFGVARQAILHPDE 1055

  Fly  1089 QPTWSLIKEVTFQPYFMLYGEVFAGDID-------PPCGED------PSQPGCVTGHWVTPITMS 1140
            :|:|.|.:.:.:.||:|:||||||..||       |||||:      ...|.|:.|.|:||..|:
 Frog  1056 EPSWRLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEDGKRLPPCIPGAWLTPALMA 1120

  Fly  1141 MYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLK 1205
            .|||:|||||:|||||||||.|.||.|:|:|||.|||:.::|.:..:||||||.|...|.|.:||
 Frog  1121 CYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIIFSHLYIILK 1185

  Fly  1206 ----YCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTE 1266
                .|.:..:|.:.:||.||||||..::|::||:|||:|||.:|.|:|.....|.|||::.|:|
 Frog  1186 RICCRCKKIQEGDQDERDRGLKLFLNDEELKKLYEFEEQCVEEYFQEKEDEQQSSNDERIRVTSE 1250

  Fly  1267 RVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFMSTHTAGADDLRGST 1331
            |||.||.::|::|::|:...|::|.::.||.::||.|.::::.|        ...||.|  :...
 Frog  1251 RVENMSMRLEEVNEREHFMKASLQTVDLRLSQLEELSGRMVNAL--------ERLAGID--KSEL 1305

  Fly  1332 INIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSLQVTTRRRFNRSLTE 1396
            ||     :|.|..|:.|                  |...|..|   ::||...|:..:::....|
 Frog  1306 IN-----ERSRASSVCD------------------AAFLLRQG---SVNSSDGTSVYKYHVETDE 1344

  Fly  1397 V---------------RPDAYIF-------DEGTHFEVVPLP-----EEPDEVVKSREALNEQVV 1434
            |               |..||.|       ::....::||..     ......|.:::| |:..:
 Frog  1345 VTCDESTGSISPALGLRRKAYSFGMRTEKGEQDNKAQLVPRQASLRYASSANAVATKDA-NKVTL 1408

  Fly  1435 RKASMQSEADS--DIYIP-------VSQRPSTCETVKRTPYVTVRQDTGASTESKDTLTPMGNND 1490
            ...|..|...|  ||:||       :::.||| :.:.:|..||..|..|..||...:.....:..
 Frog  1409 GIVSKSSRPISCVDIWIPECDKKETINESPST-QHLSQTDIVTNCQSEGEVTEVSKSEFANSHLT 1472

  Fly  1491 DDQTLVGGDNSDDATPDINFEAARHRALR----------QRTVSLCRR--NSETYSLTGADINRS 1543
            .::|.:      :||  |:|...|.:|::          |.|::..|.  .:|...|.|...|.:
 Frog  1473 VERTKL------EAT--ISFPLERSKAMKYYSGQSFNTCQTTMTKSRSFVFTEGGKLVGGVNNWT 1529

  Fly  1544 HIS--LNQLASLS---------------RRQMS------------------LTQSEPDSDKDAPI 1573
            ..|  ::|::..|               |:|..                  ||.:|.||| ....
 Frog  1530 EYSTIIDQVSPTSLEEWTDQWNNQGDSPRKQSPELATIISEAEIQAELKPLLTDTEDDSD-IGET 1593

  Fly  1574 AQGSAHPGKSVLHAKPSRNILL------------KLHS---EYTSITDELESVCHMIASPTVSL 1622
            ...:::|.......|...::.|            .|||   :..|:.|:||...|  ||..:::
 Frog  1594 GNSASYPCTERTETKNLLSVQLDRTCGFSSPRSKSLHSHTGKSRSLIDKLERPGH--ASSVMNI 1655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	123/229 (54%)
		TRPM_tetra	1262..1313	CDD:293127	18/50 (36%)
trpm1	XP_031755011.1	LSDAT_euk	135..400	CDD:407971	142/266 (53%)
		trp	<890..1196	CDD:273311	157/305 (51%)
		PRK12704	1211..>1324	CDD:237177	45/145 (31%)
		TRPM_tetra	1242..1296	CDD:406826	21/61 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	408	1.000	Domainoid score	I685
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1172	1.000	Inparanoid score	I201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	1	1.000	-	-		FOG0002675
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13800
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X538
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160