Protein Alignment Trpm and trpm2

DIOPT Version :9

• Sequence 1: NP_001097320.1
• Gene: Trpm / 36694
• FlyBaseID: FBgn0265194
• Length: 2023
• Species: Drosophila melanogaster
• Sequence 2: XP_031749423.1
• Gene: trpm2 / 100124999
• XenbaseID: XB-GENE-996775
• Length: 1491
• Species: Xenopus tropicalis
• Alignment Length: 1696
• Identity: 464/1696 - (27%)
• Similarity: 754/1696 - (44%)
• Gaps: 302/1696 - (17%)

  Fly    77 RMRKRSSVSSTLSKVLILNVRDLLKAHAGSEPLKEHQPR---SWIETNFQKRECIKFI--PCPKD 136
            |.::.:.|.|.|.     :...:.:..|...||.|.:..   |||..|.:|:||:.|:  ||..|
 Frog    15 RFKRIADVVSNLK-----HTNKIRRKAARFSPLAEQKQENLSSWISENIKKKECVYFVKNPCISD 74

  Fly   137 DTK--CCCGQAQITHQTI---PGIESGSPGDLWLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVR 196
            ..|  |.||..:..|..:   |  :|.....||...:|.:..||||:|.|.|.|.......||||
 Frog    75 LRKNVCMCGYTKDQHMDMAIRP--QSFESKVLWDFKEHIKEVPTDAFGDISFIGLGPRVGKQYVR 137

  Fly   197 LSFDTRPELLVQLFTKEWNLELPKLLITVQGGKANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGG 261
            :|.||..::|.||.|:.|.||:|.|||:|.||..||.:|.:||...|:||:|||:||||||.|||
 Frog   138 VSSDTPSDVLYQLMTEHWGLEVPSLLISVTGGAKNFRMQMRLKNIFRRGLVKAAQTTGAWIITGG 202

  Fly   262 TNTGVTKQVGDAL--LLEGQQRTGRVVSIGIAPWGIVERNHELLGHNREVPCHSI--SSPRSKLA 322
            ::.||.||||:|:  ...|..:...:|:||||.||||.....|:......|...:  ...:..|:
 Frog   203 SHAGVMKQVGEAVRDYSFGSIKDSEIVTIGIATWGIVHNRRSLISATGAFPADYLLEEENQGNLS 267

  Fly   323 VLNNRHAYFLLVDNGTQAKYGAELILRRKLEKFISN---------LKLHPFTHSSTPVVCLVIEG 378
            .|:|.|::|:|||:||..|||.|::||.|||||||.         :|:        |:||:|:||
 Frog   268 CLDNNHSHFILVDDGTNGKYGVEILLRAKLEKFISEQTTEKGGVAIKI--------PIVCVVLEG 324

  Fly   379 GTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAFV-HKYASDGEEQPVLESMRDYLIGTIQKTF 442
            |..|:..:...:.::  .|.|:.:||||.||::|.| |...|......:.|.:|.....|.....
 Frog   325 GPGTLDTIYNAIRNN--TPCVIVEGSGRVADVIAQVAHLPISKITISLIQEKIRTLFPDTFDTFT 387

  Fly   443 EVGLDQSEKLYQELLQCTRNKNLITVFRIQEKPEGEAQELDQTILTALFKSQ-------HLSPPE 500
            |..:....|..|:::   ||..|:|:|::.   :.:..::|..||.||.|:.       |.:...
 Frog   388 EYKIADWTKKIQDIM---RNNQLLTIFQVD---KDDQHDIDFAILQALLKASLSHDQQGHENWDH 446

  Fly   501 QLSLALTWNRVDIARSEIFVYGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRL 565
            ||.||:.||||||||||||....:|....|...|..||..::.|||||.||.||.::::.|...:
 Frog   447 QLKLAVAWNRVDIARSEIFTDELQWKPSDLHPLMTAALIGNKPDFVKLFLEQGVRLEEYATQETI 511

  Fly   566 EELYNTKHGPA----NTLGYILRD--VRPHIPKGYIYTLHDIGLVINKLMGGAYRSYYTRRKFRP 624
            ..|||.. .|:    :.|..:..|  :|....|.:...||.:..|:.:|.|.     :|:.
 Frog   512 INLYNNT-DPSCLFHSKLAKVFEDERLRLETSKSFKLQLHHVSQVLRELFGD-----FTKH---- 566

  Fly   625 IYAKVMNSYANACRKSSTYQYQRYAGANSLSL---VTGLLPFTSEMALFEFPFNELLIWAVLTKR 686
            :|.|..||...:...:..:......|....|.   ..|..|.|.:      |..:||||.|:..|
 Frog   567 LYPKPKNSEKPSVSIAVPHMKINVQGVTLRSFHKRSQGRAPCTMD------PIRDLLIWCVVQNR 625

  Fly   687 QQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFESKGNKLLDFSYR 751
            :::|.::|:...:.:|.:|...||.|.::.|  |:|.||.  ||:.:.|:|||.:...:....||
 Frog   626 KEVAEIIWSQCHDCIAAALACSKLLKELSKE--EEDTDTS--EEMLALAEEFEQRAIGIFTECYR 686

  Fly   752 QDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRTRKNTNFKVILG 816
            :|.|:|.:||.....:|...:.|.||:.|.....::|...|..|..:|.|.|.........:|..
 Frog   687 KDEERALKLLIRVSEAWGKTTSLKLALEAKDMKFVSHGGVQAFLTRVWWGELCVDNGIWRVIICM 751

  Fly   817 LAMP-FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLADTYSVRDTKVHEN 880
            |..| .|.|.:.|                            |:.|.|
 Frog   752 LFFPLIYTRFITF----------------------------RTTPCA------------------ 770

  Fly   881 GKVSLTDSDTAQFREFFNLSEYNEVKQHQPLRLKKKFYEFYTAPITKFWADSIAYMFFLIMFSFT 945
                                    .|:.|.....::...|:.|||..|..:.::|..||::|::.
 Frog   771 ------------------------AKKMQATTFSERLQAFFMAPIVIFHLNILSYFGFLLLFAYV 811

  Fly   946 VLVKMEQMPRWQEWYSIAYITTLGFEKVREII-SSEPVAITHKFSVWAWNMWNPCDGAAIILFVI 1009
            :::..:..|.|:|.....::.:...|:||::: ..:......:.|::..:.||..|..|||:|::
 Frog   812 LMINFQPFPSWRELVIYVWLFSFVCEEVRQVVYDPDGFGFLRQASIYINDFWNKLDLCAIIIFIV 876

  Fly  1010 GLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLGPLVTMMGKMVKNMIYFVVLLAVVLM 1074
            ||..|.:..|:..||:|..:|.:.:.||:::|..::|.|||.:.::.:|:|::.:|:.||||.::
 Frog   877 GLICRSQPATLYSGRIILSLDFVIFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVV 941

  Fly  1075 SFGVSRQAILYPNKQPTWSLIKEVTFQPYFMLYGEV--------FAGDIDPPCGEDPSQPGC--- 1128
            ||||::||||..|:.....:.:.|.:..|..|:|::        ::.|.....|.||::..|
 Frog   942 SFGVAKQAILIHNEVRVDWIFRGVVYHSYMTLFGQIPSYIDGVNYSPDQCTLNGTDPNKQKCPET 1006

  Fly  1129 ------VTGHWVTPITMSMYLLIANILLINLLIAVFNNIFNEVNSVSHQVWMFQRFTVVMEYQQK 1187
                  |...|:|.|.:..|||..||||:|||||:||..|.:|...:.|:|.|||..::.||..:
 Frog  1007 NETNQPVFPQWLTVILLCFYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGR 1071

  Fly  1188 PVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLKLFLEKDDLERLYDFEEECVEGFFHEQEII 1252
            |..|||||...|.|..:|..:.......:::   ||..|||::...|..:|....|.:....:..
 Frog  1072 PPAPPPFILCSHMYLFIKQVILHEPAGRLKQ---LKEKLEKNEEAALLSWETYLKENYLQNYQHF 1133

  Fly  1253 LNQSTDERVKNTTERVETMSQKIEDINQKENIQTATVQNIEFRLRKMEESSEQILSHLAVIHRFM 1317
            ..||||:|:|:|:|:|.::.:.:| :.|.:  :|..::|   ||..:||.:.:....|..|...:
 Frog  1134 QKQSTDQRIKDTSEKVASVLEMLE-LEQAK--RTGLMEN---RLLFLEEQALRSAKALNWIVNTL 1192

  Fly  1318 STHTAGADDLRGSTINIPGEMQRMRTISISDTEGGSGPGGNGGGGGGGGAIVPLGLGAGLNLNSL 1382
            ..:..|:.|.....::     .:.....:.|||.                 |.:         ..
 Frog  1193 LENGFGSKDSAPVIVS-----SKFNVTDLGDTED-----------------VKI---------QT 1226

  Fly  1383 QVTTRRRFNRSLTEVR---PDAYIFDEGTHFEVVPLPEEPDEVVKSREALNEQVVRKASMQSEAD 1444
            .|..|..:......:|   ||..:..| .||::...|             ....|||       |
 Frog  1227 HVIARNIWYPDSNIIRFPVPDEKVSWE-VHFKIYNPP-------------FYTAVRK-------D 1270

  Fly  1445 SDIYIPVSQRPSTCETVKRTPYVTV-----RQDTGASTESKDTL--TPMGNNDDDQTLVGGDNSD 1502
            ...|.|.:   .:.:.:.:..|.|:     ||...|:.|.||.|  .|:|...    |.|..:..
 Frog  1271 KKYYDPFN---DSMQALSKISYNTMDGNINRQSFCATYEVKDGLPMNPVGRTG----LKGRGSLC 1328

  Fly  1503 DATPDINFEAARHRALRQRTVSLCRRNSETYSLTGADINRSHISLNQLASLSRRQMSLTQSEPDS 1567
            ...|:....:...:..|.:..|:||:             ||...|..|...|:
 Frog  1329 WFGPNHALHSIITKLRRNKDGSICRK-------------RSKKMLETLVIKSK------------ 1368

  Fly  1568 DKDAPIAQGSAHPGKSVLHAKPSRNILLKLHSEYTSITDELESVCHMIASPTVSLPSNKASLDRP 1632
                 :::..|.||.|:   :|...:..||.....|  |.|.:...|:..   .:...|..:|.|
 Frog  1369 -----LSENWALPGGSM---EPGEALPYKLRKILKS--DFLSTFQSMLKK---GIEVYKGYVDDP 1420

  Fly  1633 K-TEMSRAEAAAL------LEKKHLKECEEN------DYMILEGLIESRGSIDASAQGFEIGVSI 1684
            : |:.:..|..|:      |:...|...|:|      |..:...:::.:..:.|:.:.. :..::
 Frog  1421 RNTDNAWIETTAVSLHFDNLDDLQLYALEQNLQIHHQDIFVRWQVVDQKIPLYANHKDI-LQKAV 1484

  Fly  1685 DYSHRY 1690
            ||.|.|
 Frog  1485 DYHHAY 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	74/233 (32%)
		TRPM_tetra	1262..1313	CDD:293127	13/50 (26%)
trpm2	XP_031749423.1	LSDAT_euk	134..356	CDD:423023	100/231 (43%)
		trp	<709..1086	CDD:273311	118/446 (26%)
		Ion_trans	798..>974	CDD:395416	51/175 (29%)
		Nudix_Hydrolase	1314..1487	CDD:412381	38/215 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010