DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpm and trpm4a

DIOPT Version :9

Sequence 1:	NP_001097320.1	Gene:	Trpm / 36694	FlyBaseID:	FBgn0265194	Length:	2023	Species:	Drosophila melanogaster
Sequence 2:	NP_001275744.2	Gene:	trpm4a / 100004946	ZFINID:	ZDB-GENE-090302-3	Length:	1260	Species:	Danio rerio

Alignment Length:	1330	Identity:	367/1330 - (27%)
Similarity:	633/1330 - (47%)	Gaps:	227/1330 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GSEPLKEHQPRSWIETNFQKRECIKFI--PCPKDDTKCCCGQAQITHQTIPGIESGSPGD----L 163
            |....|..:.:|||....:||.|..|:  .| .:...|.||.|:..|      .|.:..|    .
Zfish    15 GGGERKAQKDQSWIPKMIKKRVCTTFVEDSC-SNGALCQCGGARDLH------VSTTADDHVVGQ 72

  Fly   164 WLPTKHTRPQPTDAYGTIEFQGGAHPTKAQYVRLSFDTRPELLVQLFTKEWNLELPKLLITVQGG 228
            |...:.|...||||:|.:||. ||......::||||||.|:.:..|.|.:|.|.:|.|::::.||
Zfish    73 WDRARDTSDYPTDAFGQLEFV-GAGRRHCPFLRLSFDTPPDNVYSLMTSQWGLPVPNLVVSMVGG 136

  Fly   229 KANFDLQAKLKKEIRKGLLKAAKTTGAWIFTGGTNTGVTKQVGDAL----LLEGQQRTGRVVSIG 289
            ......:..:::.||:||:.||::|||||.|.|...||::.||:|:    .:.......:|:::|
Zfish   137 DEKEMAKPWVREVIRQGLVHAAQSTGAWIMTSGLKEGVSRCVGEAVRHHCAMASSLSQAKVIAVG 201

  Fly   290 IAPWGIVERNHELLGHNREVPC----HSISSPRSKLAVLNNRHAYFLLVDNGTQAKYGAELILRR 350
            :||||::.:.|:|:......|.    |.:.|..|   .|:|.|..|||||:|:....|:|...|.
Zfish   202 VAPWGLIYQRHQLVNPQGSFPARYYVHDMPSASS---CLDNNHQAFLLVDDGSVGHRGSETSFRA 263

  Fly   351 KLEKFISNLKLHPFTHSS--TPVVCLVIEGGTNTIRAVLEYVTDSPPVPVVVCDGSGRAADLLAF 413
            .||.|||:.:...:...|  .||:|::|.|....:..|...:.:|  .|.:|..|||.|:||:|.
Zfish   264 NLEDFISHQRTGIWGSGSIEIPVLCVLIAGDATMLERVDLSLKNS--TPWLVLAGSGSASDLIAG 326

  Fly   414 VHK-------------YASDGEEQPVLES--MRDYLIGTIQKTF--EVGLDQSEKLYQELLQCTR 461
            :.|             ..||.||.....|  :||.:...|:|.|  |..||   ||..:.|....
Zfish   327 ILKDLSAPLSPPVSPTLQSDSEESSKSSSIELRDRVKERIRKHFPSETELD---KLVDQALSIYH 388

  Fly   462 NKNLITVFRIQEKPEGEAQELDQTILTALFKSQHLSP------PEQLSLALTWNRVDIARSEIFV 520
            |::|||:|...|  :| :.:.|..||.||.::.....      .|:|.||:.|||||||::|:|.
Zfish   389 NRDLITIFHGDE--DG-SDDFDTIILKALVRAAKRDSNDASEYTEELKLAVAWNRVDIAKTELFN 450

  Fly   521 YGQEWPNGALDEAMMQALEHDRIDFVKLLLENGVSMKKFLTIPRLEELYNTKHGPANTLGYILRD 585
            ....|....|:|:|..||.:|:.|||:|.:|:|:::..:||..|||.||::.........::.|.
Zfish   451 GDVHWRYEDLEESMTDALVNDKPDFVRLFVESGLNILAYLTYHRLESLYSSLSDCDLVSSFLQRR 515

  Fly   586 VRPHI----------PK-------------------GYIYTLHDIGLVINKLMGGAYRSYY---- 617
            ::..:          |:                   ....||:::..|::::|....:.:|
Zfish   516 LQERVGLAASQTRLTPQPDDNSSFKSQATNLTTPSAARDLTLYEVSRVLSEIMEDVCQPFYYTTL 580

  Fly   618 -------TRRKFRPIYAKVMNSYANACRKSSTYQYQRYAGANSLSLVTGLLPFTSEMALFEFPFN 675
                   :|:..:.:...::|        .|||:.||...                      |:.
Zfish   581 GLDHRVNSRKAMKHVNKLLLN--------ESTYRRQRCTS----------------------PWI 615

  Fly   676 ELLIWAVLTKRQQMALLMWTHGEEALAKSLVSCKLYKAMAHEAAEDDLDTEIYEELRSYAKEFES 740
            .|.|||||..|::|:|..|....|::..:|..||:.:    |.::.:.:||....::..|:.||:
Zfish   616 SLFIWAVLQNRREMSLYFWKMTGESVLSALAGCKILR----ELSKLETETETKLSMKELAQTFEN 676

  Fly   741 KGNKLLDFSYRQDAEKAQRLLTCELHSWSNQSCLSLAVAANHRALLAHPCSQVILADLWMGGLRT 805
            ..:.:....|:.:.:::.:||..:...|...:||.:|.:|:.|...:|...|.:|:::|.|.:.:
Zfish   677 LAHDVFSECYQSNEKRSFKLLIRQSPIWGGATCLQMATSADARLFFSHDGVQTLLSEIWWGDMDS 741

  Fly   806 RKNTN-FKVILGLAMP--FYIRQLDFKSKEELQQMPQTEEEHLENQNLDNDDSDRSQPDAEALLA 867
              ||. :|::....:|  .|.:.::||    :::..:..|:..:.:..|:.|.      ||. ||
Zfish   742 --NTEVWKLVFSFFLPPFIYTKLINFK----VEEADEKAEDFGQGKEFDSTDG------AET-LA 793

  Fly   868 DTYSVRDTKVHENGKVSLTDSDTAQFREFFNLSEYNEV----KQHQPLRLKKKFY-----EFYTA 923
            |                :|:.|.       ::.|.|.:    |..:.:..|:.|.     :|:.|
Zfish   794 D----------------MTNMDE-------DVEECNALRGKPKASKVIAKKRPFIFHRWRQFWFA 835

  Fly   924 PITKFWADSIAYMFFLIMFSFTVLVKME----QMPRWQEWYSIAYITTLGFEKVREIISSEPVAI 984
            |:|.|..:.:.|..||.:|::.:|:..:    ..|...|.....::.||..|::|:........:
Zfish   836 PVTSFLGNVLMYFLFLFLFAYVLLIDFKPPPPDGPAPLELVLYFWVFTLACEEIRQSFFVGSTTL 900

  Fly   985 THKFSVWAWNMWNPCDGAAIILFVIGLAFRFRENTMDIGRVIYCVDSIYWYLRILNILGVNKYLG 1049
            |.:..|:..::||.||..|:.|||:||..|....|.:.||.:.|||...:.||:::|..|:|.||
Zfish   901 TQRMKVYIQDIWNKCDITALGLFVLGLLCRMFPWTYNFGRAVMCVDYTVFTLRLIHIFAVHKQLG 965

  Fly  1050 PLVTMMGKMVKNMIYFVVLLAVVLMSFGVSRQAILYP-NKQPTWSLIKEVTFQPYFMLYGEVFAG 1113
            |.:.::|||||::.:|:..|.|.||::||:.||:||. :.:|.| :.:.|.::||..:||::...
Zfish   966 PKIIIVGKMVKDVFFFLFFLGVWLMAYGVANQALLYSYDSRPGW-VARRVFYRPYMHIYGQIPLD 1029

  Fly  1114 DID--------------------PPCGEDPSQPGCVTGHWVTPITMSMYLLIANILLINLLIAVF 1158
            :||                    .||.:..:       :|:..|.:|:|||:.||||:|||||:|
Zfish  1030 EIDADKRHDKRCTDNVTLIHEGAEPCPDSDA-------NWLVLILLSVYLLVTNILLVNLLIAMF 1087

  Fly  1159 NNIFNEVNSVSHQVWMFQRFTVVMEYQQKPVLPPPFIALCHFYSLLKYCVRKAKGLEVQRDNGLK 1223
            :..||:|...|...|.|||:.:::||..:|.|.||||.:.|.:..:|..:::...|:.|.   ..
Zfish  1088 SYTFNKVQERSDVYWKFQRYNLIVEYHSRPCLAPPFIIISHLHIFIKRVIQRLPSLKSQH---FM 1149

  Fly  1224 LFLEKDDLERLYDFEEECVEGFFHEQEIILNQSTDERVKNTTERVETMSQKIEDINQKENIQTAT 1288
            |.|...:...|..:|....|.....:.....:|..||:|.|:.:|:::.:::.:|...:.
Zfish  1150 LDLTSKETSLLNTWELSLKENLLSTESKKKRESDTERLKRTSTKVDSVLKQMVEIRDHDR----- 1209

  Fly  1289 VQNIEFRLRKMEESSEQILSHLAVIHRFMS 1318
                  ||||:|...|...:.|:.|...:|
Zfish  1210 ------RLRKLESEVEYCSTALSWIVEALS 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpm	NP_001097320.1	Ion_trans	951..1167	CDD:278921	79/240 (33%)
Trpm	NP_001097320.1	TRPM_tetra	1262..1313	CDD:293127	11/50 (22%)
trpm4a	NP_001275744.2	TRP_2	<907..1127	CDD:331598	84/227 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323456at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850