Protein Alignment ItgaPS4 and ITGA10

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: XP_016858111.1
• Gene: ITGA10 / 8515
• HGNCID: 6135
• Length: 1181
• Species: Homo sapiens
• Alignment Length: 926
• Identity: 208/926 - (22%)
• Similarity: 357/926 - (38%)
• Gaps: 252/926 - (27%)

  Fly   195 MGELGLSAHVSDDNSKLLMGAPGIDQWKGSV------H--------LKQEVPSIKTSSGRQRRGM 245
            |.::|.|.|...|.  :|.|..|...|.|||      |        |:.|.|
Human   386 MSQIGFSTHRLKDG--ILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDEFP------------- 435

  Fly   246 NTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYED 310
                      |..:|..    :|.||:|||........   |:::.|||..:: |:...|.:.:|
Human   436 ----------PALQNHA----AYLGYSVSSMLLRGGRR---LFLSGAPRFRHR-GKVIAFQLKKD 482

  Fly   311 SIYKY-HEFRGNHFGEYFGYSVLAEDLNGDGKTDV-IISAPLYALRNSYDDGAIYVFI--NKGSF 371
            ...:. ...:|...|.|||..:...|.:.||.||| :::||::....:.:.|.:||::  .:...
Human   483 GAVRVAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQQSLL 547

  Fly   372 TFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPF--AGNGSVFIYLGSENGLRDPPSQ 434
            |.:..:...|. ...|||..:..:.|:|:||:.|||||||.  ...|::::|.|:::|:|..|:|
Human   548 TLQGTLQPEPP-QDARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQSGVRPHPAQ 611

  Fly   435 CLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQ 499
            .:.|.|...:.  || ||..:....|:||:...|.|:||..  |..|..:.|:|.    :.|.|:
Human   612 RIAAASMPHAL--SY-FGRSVDGRLDLDGDDLVDVAVGAQG--AAILLSSRPIVH----LTPSLE 667

  Fly   500 NVNPE-------------EERVNIT--VCYRLSSKSDSKAKALMEQELVIRI--DIDTKSKIKLA 547
             |.|:             :|.|.:|  :|::::|::..:    .:.:..:|.  .:|..:....|
Human   668 -VTPQAISVVQRDCRRRGQEAVCLTAALCFQVTSRTPGR----WDHQFYMRFTASLDEWTAGARA 727

  Fly   548 VFDEEHGSQMSFKAKAFHEEI----CSEFQIE-MDKRAKFTPIALEMQYEL---SKKIPNSGDFC 604
            .||   ||......:.....:    |.:.... :|......|:||.:.:.|   :|..|
Human   728 AFD---GSGQRLSPRRLRLSVGNVTCEQLHFHVLDTSDYLRPVALTVTFALDNTTKPGP------ 783

  Fly   605 EDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCIN-------ASSTLVLGTTAVLRLTYN 661
                |::...|..:.:.:.|:..|..| .||.||.:. :|       .:..:|.|....:.::..
Human   784 ----VLNEGSPTSIQKLVPFSKDCGPDNECVTDLVLQ-VNMDIRGSRKAPFVVRGGRRKVLVSTT 843

  Fly   662 ITNNGEFAYHPKFSVTNSAGLSLAQ--------VPGNCKVNEA-VMVCDLNHG--QRMAKGDTDS 715
            :.|..|.||:...|:..|..|.||.        :...|....| ..:|.:.|.  |..|| .|..
Human   844 LENRKENAYNTSLSLIFSRNLHLASLTPQRESPIKVECAAPSAHARLCSVGHPVFQTGAK-VTFL 907

  Fly   716 LTISFDVRQLRGRSLEIQAEV-LSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKESP 779
            |...|..     .||..|..| |:|..:|...|..|                 |.|
Human   908 LEFEFSC-----SSLLSQVFVKLTASSDSLERNGTL-----------------QDN--------- 941

  Fly   780 YTAEVVNYYEIKSH----GPSTLENLTVSLY--IPVA----YKTPDSTNVKHIVTSSPKIQSKYA 834
             ||:...|.:.:.|    ..|||....|..|  :||.    :||            :.::|:...
Human   942 -TAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKT------------TLRVQNLGC 993

  Fly   835 HKIMPINFIDQNNALANNFAIDHDQSTLLFSA-TPQHENVGN----LSGIVEQNPSISLLN---- 890
            :.:                      |.|:.|| .|...:.||    ||.::..|.|..:.|
Human   994 YVV----------------------SGLIISALLPAVAHGGNYFLSLSQVITNNASCIVQNLTEP 1036

  Fly   891 -------EDLPVNNTL--------VLNC------QDTNVTLCVPVEIRLENGLQLKPEELMNMTV 934
                   |:|...|.|        |:.|      :.|.|::.:   :||.:....:..:..::||
Human  1037 PGPPVHPEELQHTNRLNGSNTQCQVVRCHLGQLAKGTEVSVGL---LRLVHNEFFRRAKFKSLTV 1098

  Fly   935 SFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGI 999
            ..|..|...:.           .|.::.:.:..|.::.:.:::..|.    |::|.:|.||:.|:
Human  1099 VSTFELGTEEG-----------SVLQLTEASRWSESLLEVVQTRPIL----ISLWILIGSVLGGL 1148

  Fly  1000 LVFSAATYALYKRGFF 1015
            |:.:...:.|:|.|||
Human  1149 LLLALLVFCLWKLGFF 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	22/75 (29%)
		Int_alpha	384..434	CDD:214549	20/51 (39%)
		Int_alpha	447..>492	CDD:214549	15/44 (34%)
		Integrin_alpha2	486..808	CDD:462478	77/372 (21%)
ITGA10	XP_016858111.1	vWA_integrins_alpha_subunit	180..360	CDD:238746
		Int_alpha	496..546	CDD:214549	15/49 (31%)
		Int_alpha	559..613	CDD:214549	21/53 (40%)
		Integrin_alpha2	657..1064	CDD:462478	99/496 (20%)