DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itgae

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_113956.2	Gene:	Itgae / 83577	RGDID:	621644	Length:	1169	Species:	Rattus norvegicus

Alignment Length:	935	Identity:	205/935 - (21%)
Similarity:	372/935 - (39%)	Gaps:	232/935 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 YSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPE 257
            |.:.:.|.||.:. |..::|:|..|...|.|...|      ..|.:|| .|.:|...|
  Rat   394 YQLAQTGFSAQIL-DKGQVLLGTVGAFNWSGGALL------YNTQNGR-GRFLNQTAK------- 443

  Fly   258 PKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIY-EDSIYKY-HEFRG 320
             ::|...::||.||:|::.:    ....|.|||.|||...:   ..:|::. ||....: ....|
  Rat   444 -EDFRAAQYSYLGYSVAALH----KAHGVSYVAGAPRHKLR---GAVFELQKEDGEETFMRRIEG 500

  Fly   321 NHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDDGAIYVF---INKGSFTFEERIIRSP 381
            ...|.|||..:...|:|.||.|| ::::||.|.:|.  ::|.:||:   .....|:....:...|
  Rat   501 EQMGSYFGSVLCPVDINMDGITDFLLVAAPFYHIRG--EEGRVYVYRVHEQDAPFSLVYTLSGYP 563

  Fly   382 AGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAG--------NGSVFIYLGSENGLRDPPSQCLDA 438
            ..:..|||..::.:||||:|.:.|||:|||..|        .|||:||.|...||...|||.:.|
  Rat   564 GLTSSRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLHASPSQQIRA 628

  Fly   439 PSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNP 503
            .|   ...|.|.||..:|.|.|..|:...|..:|:.:...|  .|:.|||.:...:     ...|
  Rat   629 SS---VALGLYYFGMSVSGGLDFSGDDLADITVGSQDVAVV--LRSRPVVDLTVSM-----TFTP 683

  Fly   504 E------EERVNITVCYRLSSKSDSKAKALMEQELVIRIDID-TKSKIKLAVFDE---------- 551
            :      ::::::.:|:::.|.:......|....|...:|:| ||.|.:|...|.
  Rat   684 DALPMAFKDKMDVELCFKVDSSAVPSEPGLRGMSLNFTVDVDVTKQKQRLQCADRSCCQSCLMKW 748

  Fly   552 EHGSQM--SFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYELS-----KKIPNSGDFCEDCAV 609
            ..||.:  .|...:..||:|.:        ..|:.|.:::.||..     :..||        .:
  Rat   749 SGGSSLCEHFGLISTEEELCED--------DCFSNITIKVSYEFQTSEERRNHPN--------PI 797

  Fly   610 VDP-AEPKFVTEYITFNTGCATDV-CVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYHP 672
            :|. .||..:.: :.:...|...| |:|:::::...:...||:|.|..:.:..::||:||.:|..
  Rat   798 LDHYKEPSAIFQ-LPYEKDCKNKVFCIAEIQLTTAISQQDLVVGITKEVTMNISLTNSGEDSYMT 861

  Fly   673 KFSVTNSAGLSLAQVPG------NC---KVNEAVMVCDLNHGQRMAKGDTDSLTISFDVRQ--LR 726
            ..::.....|...::..      .|   |...:|:|.:...|..:.|..:.::::::.:.:  ..
  Rat   862 NMALNYPRNLQFKKIQKPLSPDIQCDDPKPVASVLVMNCKIGHPILKRSSVNVSVTWQLEESIFP 926

  Fly   727 GRSLEIQAEVLSARDES-NPENNKL----TNVLSLREKADIYVSGVQ-TNDHVVLKESPYTAEVV 785
            .|:.:|...:.::.::| ..|.:.|    ..:..|...:.:|::..| ::||   ||..:.....
  Rat   927 NRTADITVTISNSNEKSLARETHSLQFRHAFIAVLSRPSVMYMNTSQSSSDH---KEFFFNVHGE 988

  Fly   786 NY----YEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQN 846
            |:    ::::...|.||.:|.:   |.|.:.|....:.:...:..|...|.      |:..::
  Rat   989 NHFGAVFQLQICVPITLRDLQI---IRVKHLTKTQAHTECTQSQEPTCGSD------PVQNVE-- 1042

  Fly   847 NALANNFAIDHDQSTLLFSATPQHENV--------GNLSGIVEQNPSISLLNEDLPVNNTLV--L 901
                       :..:::.:.|...|||        |:...::.....:.:|.| :..|.:|.  |
  Rat  1043 -----------EWHSVICAITSNKENVTVAAEISMGHTKQLLRDISELQILGE-ISFNKSLYEGL 1095

  Fly   902 NCQD--TNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDP 964
            |.::  |.:|:           :.||.|                             |.|.:  |
  Rat  1096 NAENHRTKITV-----------IFLKEE-----------------------------KPHSL--P 1118

  Fly   965 TLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRD 1029
            .                         ||.|.|.|:||.......|:|.|||||..|.
  Rat  1119 L-------------------------IIGSSIGGLLVLVVIIAILFKCGFFKRKYKQ-------- 1150

  Fly  1030 SFEDGIIRTEMEENAQSQGDADLDE 1054
                  :..|....||.:.|:.|::
  Rat  1151 ------LNLESVRKAQLKSDSLLED 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/76 (33%)
		Int_alpha	384..434	CDD:214549	24/57 (42%)
		Int_alpha	447..>492	CDD:214549	15/44 (34%)
		Integrin_alpha2	484..808	CDD:285619	67/370 (18%)
Itgae	NP_113956.2	vWA_integrins_alpha_subunit	196..373	CDD:238746
		Int_alpha	503..559	CDD:214549	18/57 (32%)
		Int_alpha	568..626	CDD:214549	26/57 (46%)
		Integrin_alpha2	669..>952	CDD:285619	54/304 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840