DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga7

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_110469.1	Gene:	Itga7 / 81008	RGDID:	71022	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1233	Identity:	294/1233 - (23%)
Similarity:	476/1233 - (38%)	Gaps:	326/1233 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CLLVIVLLA--LQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVI------REKS-IMVAA 58
            |.|:..|||  |....:|:|:     .|:.....|| ...|.||||:.:      |.:| ::|.|
  Rat    16 CYLLSFLLAGLLLPRASAFNL-----DVMGAIRKEG-EPGSLFGFSVALHRQLQPRPQSWLLVGA 74

  Fly    59 PRANSSLEAQRNISEPGVIFRCYFE-SGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLG--- 119
            |:|.:....|.|  ..|.:|.|... ...:|...:||...|         :..::|:.:|||
  Rat    75 PQALALPGQQAN--RTGGLFACPLSLEETDCYRVDIDRGAN---------VQKESKENQWLGVSV 128

  Fly   120 ---GAMDGGTRDSDKFLVCAPRFYSINNENDYNN-----GMCYWLSDTPKNIDSTEVMEKWPLRI 176
               ||  ||     |.:.||.|:.|....:....     |.|:.||......|..:..| |
  Rat   129 RSQGA--GG-----KVVTCAHRYESRQRVDQVLETRDVIGRCFVLSQDLAIRDELDGGE-W---- 181

  Fly   177 EKKQVLKLADTNLIPYYSMG--ELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSG 239
                  |..:.....:...|  :.|.:|..|.|:..|:.||||...|||.:.    |.:|.:|..
  Rat   182 ------KFCEGRPQGHEQFGFCQQGTAATFSPDSHYLIFGAPGTYNWKGLLF----VTNIDSSDP 236

  Fly   240 RQRRGMNTNRKCNECNPEPKNFGQEE----FSYFGYAVSS--GYFDSSNLSTVLYVATAPRGNNQ 298
            .|       ......:|..:..|...    .||.|:::.|  |...|..||   :||.|||.|::
  Rat   237 DQ-------LVYKTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRSEELS---FVAGAPRANHK 291

  Fly   299 FGEAYIFDIYEDSIYKYHE---FRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDG 360
             |...|  :.:||..:...   ..|......||||:...|||.||..|:|:.||.:..|.....|
  Rat   292 -GAVVI--LRKDSASRLIPEVVLSGERLTSGFGYSLAVTDLNSDGWADLIVGAPYFFERQEELGG 353

  Fly   361 AIYVFINKGSFTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIYLGSE 425
            |:||::|:|....:...:|........||.:|:.:||:|:||:.|:||||||.|:|.||||.||.
  Rat   354 AVYVYMNQGGHWADISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSS 418

  Fly   426 NGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKI 490
            .|:...|||.|:..:     .|...||:.||.|.|:|||.:.|..:|: .|:...|:||.||:.:
  Rat   419 LGVVTKPSQVLEGEA-----VGIKSFGYSLSGGLDVDGNHYPDLLVGS-LADTAALFRARPVLHV 477

  Fly   491 --HAIIKPK---LQNVNPEEER---VNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKIK-- 545
              ...|.|:   |:..|..:.|   |::.||:...:...|.:..::   |...:|.||..:::
  Rat   478 SQEIFIDPRAIDLEQPNCADGRLVCVHVKVCFSYVAVPSSYSPIVV---LDYVLDGDTDRRLRGQ 539

  Fly   546 --LAVF------DEEHGSQMSFKAKAFHEEICSE--FQIEMDKRAKFTPIALEMQY-----ELSK 595
              ...|      |.:|.|..:...|..|:.:|.:  ||::.:.:.|...|.:.:.|     .|.:
  Rat   540 APRVTFPGRGPDDLKHQSSGTVSLKHQHDRVCGDTVFQLQENVKDKLRAIVVTLSYGLQTPRLRR 604

  Fly   596 KIPNSGDFCEDCAVVDPA----EPKFV-TEYITFNTGCATD-VCVADLKIS----CINASST--- 647
            :.|:.|     ..:|.|.    :|... ||......||..| :|.::|:::    |...|.|
  Rat   605 QAPDQG-----LPLVAPILNAHQPSTQRTEIHFLKQGCGDDKICQSNLQLAQAQFCSRISDTEFQ 664

  Fly   648 ---LVLGTTAVLRLT--------YNITN----------NGEFAYHPKFSVTNSAGLSLAQV---- 687
               :.|..||:..|:        ..:||          :|:.|:..:...|..|.|..:.|
  Rat   665 ALPMDLDGTALFALSGQPFIGLELTVTNLPSDPARPQADGDDAHEAQLLATLPASLRYSGVRTLD 729

  Fly   688 ---PGNCKVNEAVMVCDLNHGQRMAKGDTDSLTISFDVRQLRGRSLEIQAEVLSA---RDESNPE 746
               ...|..||.....:...|..|.:|...:..:......:...:.|::.|:|.|   ..:.:|.
  Rat   730 SVEKPLCLSNENASHVECELGNPMKRGTQVTFYLILSTSGITIETTELKVELLLATISEQDLHPV 794

  Fly   747 NNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAY 811
            :.:....:.|    .:.:|||.|...:             ::..|..|.|.:.:
  Rat   795 SVRAHVFIEL----PLSISGVATPQQL-------------FFSGKVKGESAMRS----------- 831

  Fly   812 KTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALAN---NFAIDHDQST---LLFSATPQH 870
            :....:.||:.||.|.:.||.              |.|.:   |....|:.:.   ||:....:.
  Rat   832 ERDVGSKVKYEVTVSNQGQSL--------------NTLGSAFLNIMWPHEIANGKWLLYPMRVEL 882

  Fly   871 ENVG---NLSGIVEQNPSISLLNED---------------------------LPVNNTLVLNCQD 905
            |. |   ...||....|:|..|:.|                           .||:     :.:.
  Rat   883 EG-GQGPEKKGICSPRPNILHLDVDSRDRRRRELGQPEPQEPPEKVEPSTSWWPVS-----SAEK 941

  Fly   906 TNVTL--------CV----PV-----------------EIRLENGLQLKPEELM---NMTVSFTV 938
            .||||        ||    |:                 ...||..:.:|..|::   |:||..::
  Rat   942 RNVTLDCAQGTAKCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYMSVKSLEVIVRANITVKSSI 1006

  Fly   939 N---LKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGIL 1000
            .   |:||..:....|....:.|...|.|.                       |.|:::|:.|:|
  Rat  1007 KNLLLRDASTVIPVMVYLDPVAVVAEGVPW-----------------------WVILLAVLAGLL 1048

  Fly  1001 VFSAATYALYKRGFFKRA---------------IKDDLKQLIRDSFEDGIIRTEMEENAQSQG 1048
            |.:.....|:|.||||||               :::|.:|...:  :.|.|:.....|:|.:|
  Rat  1049 VLALLVLLLWKLGFFKRAKHPEATVPQYHAVKILREDRQQFKEE--KTGTIQRSNWGNSQWEG 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	26/72 (36%)
		Int_alpha	384..434	CDD:214549	25/49 (51%)
		Int_alpha	447..>492	CDD:214549	18/46 (39%)
		Integrin_alpha2	484..808	CDD:285619	75/392 (19%)
Itga7	NP_110469.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	38..103		19/67 (28%)
		Int_alpha	48..109	CDD:214549	17/62 (27%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..165		16/70 (23%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..238		16/56 (29%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	248..305		19/62 (31%)
		Int_alpha	260..311	CDD:214549	18/56 (32%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..367		21/60 (35%)
		Int_alpha	318..371	CDD:214549	20/52 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	368..423		25/54 (46%)
		Int_alpha	377..429	CDD:214549	27/51 (53%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	427..486		21/64 (33%)
		Int_alpha	439..>479	CDD:214549	17/40 (43%)
		Integrin_alpha2	471..960	CDD:285619	104/544 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..933		1/27 (4%)
		GFFKR motif	1061..1065		3/3 (100%)
		3 X 4 AA repeats of D-X-H-P	1111..1130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335714
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740