DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga2b

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_001063315.1	Gene:	Itga2b / 685269	RGDID:	1596428	Length:	1037	Species:	Rattus norvegicus

Alignment Length:	1096	Identity:	279/1096 - (25%)
Similarity:	472/1096 - (43%)	Gaps:	197/1096 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREK-----SIMVAAPRANSSLEAQRNISEPGVI 77
            |.|:.....||...|      ..|:||||:...:.     ||:|.||||.::     |..|.|.:
  Rat    31 ALNLDSVKFSVYTGP------NGSHFGFSVDFHKDSHGSVSIVVGAPRALNA-----NQEETGGV 84

  Fly    78 FRCYFESGN-NCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAP-RFY 140
            |.|.:::.| .|:....|.:...:.:......|.|..  :.||.::   ...:|..:.||| :.:
  Rat    85 FLCPWKANNGTCTSLLFDLRDETRKLSLQTFQTFKTG--QGLGASV---LSWNDVIVACAPWQHW 144

  Fly   141 SINNENDYNN----GMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLIPYYSMG----- 196
            ::..:.|...    |.|:     ...:.|....|..|.|          ...:...||.|
  Rat   145 NVLEKYDEAEKTPVGGCF-----VAELQSGGRAEYSPCR----------SNTMSSVYSQGFSGDK 194

  Fly   197 ---ELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGM----NTNRKCNEC 254
               |.|.|..|: ...:|::||||...:.|   |...|| |:......|.|.    .:|::.:..
  Rat   195 RYCEAGFSLAVT-QAGELVLGAPGGYFFLG---LLVRVP-IENIISSYRPGTLLWHVSNQRFSYD 254

  Fly   255 NPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHEFR 319
            :..|..|    ..|.||:|:.|.|| .:|||..|:..||..:...|...|.|.|..::::.|
  Rat   255 SSNPVYF----HGYRGYSVAVGEFD-GDLSTTEYIFGAPTWSWTLGAVEILDSYYQTLHRLH--- 311

  Fly   320 GNHFGEYFGYSVLAEDLNGDGKTDVIISAPLY----ALRNSYDDGAIYVFIN-KGSFTFEERIIR 379
            |.....|||:||...|:||||:.|:::.||||    ..|...:.|.:|:|:. ||.     :.:.
  Rat   312 GEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRVDRKLAEVGRVYLFLQPKGL-----QALS 371

  Fly   380 SP----AGSG--GRFGTTLSRIGDINKDGYNDVAVGAPF---AGNGSVFIYLGSENGLRDPPSQC 435
            ||    .|:.  ||||:.::.:||:|:||||||||.||:   :|.|.|.|:||...||...|||.
  Rat   372 SPTLVLTGTQVYGRFGSAIAPLGDLNRDGYNDVAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQV 436

  Fly   436 LDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVV------KIHAII 494
            ||:|.  |:..|   ||..|....|||.||:.|..:||..|..|.:|||.|||      .:...:
  Rat   437 LDSPF--PTGSG---FGFSLRGSVDIDDNGYPDLIVGAYGASKVAVYRAQPVVMATVQLMVQDSL 496

  Fly   495 KPKLQNVNPEEERV-----NITVC-----YRLSSKSDSKAKALMEQELVIRIDIDTKSKIKLAVF 549
            .|.|:|...|:.:.     |:.:|     :.:..|...||      ||.:.:....:::..|.:.
  Rat   497 NPTLKNCVLEQTKTPVSCFNVQMCVGATGHNIPQKLHLKA------ELQLDLQKPRQARRVLLLA 555

  Fly   550 DEEHGSQMSFKAKAFHEEICSEFQI----EMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVV 610
            ..:....:|......::.||...:.    |.|.|.|.:||.|.:...|..         |:..|.
  Rat   556 SRQASLTLSLDLGGRNKPICHTIKAFLRDEADFRDKLSPIVLSLNVSLPP---------EETGVA 611

  Fly   611 DPAEPKFVT---EYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYH 671
            .......||   |.......|..| :||..|:::.....|.|::|...||.|..|.:|:||.||.
  Rat   612 PAVVLHGVTHVQEQTRIILDCGEDNLCVPQLQLTATAGDSPLLIGADNVLELKVNASNDGEGAYE 676

  Fly   672 PKFSVTNSAGLSLAQVPGN--------C---KVNEA-VMVCDLNHGQRMAKGDTDSLT--ISFDV 722
            .:.:|....|....:...|        |   |.||: :.:|:|  |..|.|.....:|  :|.::
  Rat   677 AELAVHLPPGAHYIRAFSNVKGFERLVCTQKKENESRLALCEL--GNPMKKDTRIGITMLVSVEI 739

  Fly   723 RQLRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVL------KE---- 777
            .:..|.|:..|.::.| ::..||.:..:...:::|.:|.:.:.|......:|:      ||
  Rat   740 LEEAGDSVSFQLQIRS-KNSQNPNSEAVLLPVAVRAEAAVELRGNSFPASLVVAAEEVDKEQDGL 803

  Fly   778 SPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPK----IQSKYAHKIM 838
            ..:.:.|.:.||:.::||.|:..|::.:::|...:..|   :.:|:...||    ..::...|::
  Rat   804 DSWVSRVEHTYELHNNGPGTVNGLSLIIHLPGQSQPSD---LLYILDVQPKGGLLCSTQPPPKLL 865

  Fly   839 PINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVNNTLVLNC 903
            .::......:.::...|.||:...  .|:||......     :|:|.:...|...|
  Rat   866 KVDRRLTTPSPSSIRRIHHDRDRR--EASPQGSKQTE-----QQDPVLVSCNGSAP--------- 914

  Fly   904 QDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKD-ADDIWEYFVIQT----DLKVHKIGD 963
                   |..||..|:.  .::.:..| :||..|:.|.. .....|.||:|:    ::.......
  Rat   915 -------CTVVECELQE--MVRGQRAM-VTVQATLGLSILRQRPQEQFVLQSHAWFNVSSLPYSV 969

  Fly   964 PTLSSFTIEKKIESNVI--CKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKR 1017
            |.:|..:.:..::::::  .:..:|.:|.::|.|:.|:|:.:....|::|.|||||
  Rat   970 PVVSLPSGQGLVQTHLLRALEERDIPVWWVLVGVLGGLLLLTLLVLAMWKAGFFKR 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	32/83 (39%)
		Int_alpha	384..434	CDD:214549	26/54 (48%)
		Int_alpha	447..>492	CDD:214549	20/50 (40%)
		Integrin_alpha2	484..808	CDD:285619	82/371 (22%)
Itga2b	XP_001063315.1	Int_alpha	46..102	CDD:214549	19/60 (32%)
		Int_alpha	315..375	CDD:214549	23/64 (36%)
		Int_alpha	383..437	CDD:214549	28/53 (53%)
		Int_alpha	444..>484	CDD:214549	18/42 (43%)
		Integrin_alpha2	480..920	CDD:285619	100/483 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740