DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itgad

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_113879.2	Gene:	Itgad / 64350	RGDID:	71075	Length:	1161	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	214/915 - (23%)
Similarity:	343/915 - (37%)	Gaps:	212/915 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 YSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPE 257
            :.|.:.|.|:.::.|..  ::||.|...|.|...|...               ||       .|.
  Rat   350 HEMSQEGFSSALTSDGP--VLGAVGSFSWSGGAFLYPP---------------NT-------RPT 390

  Fly   258 PKNFGQEEF----SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHEF 318
            ..|..||..    ||.||:.:..::...: |.:|   .||| :...|:..||...........|.
  Rat   391 FINMSQENVDMRDSYLGYSTAVAFWKGVH-SLIL---GAPR-HQHTGKVVIFTQEARHWRPKSEV 450

  Fly   319 RGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDD---GAIYVFI---NKGSFTFEER 376
            ||...|.|||.|:.:.|::.||.|| |:|.||.|     |:.   |.:.|..   .:|.:..|..
  Rat   451 RGTQIGSYFGASLCSVDVDRDGSTDLVLIGAPHY-----YEQTRGGQVSVCPVPGVRGRWQCEAT 510

  Fly   377 IIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAP--FAGNGSVFIYLGSENGLRDPPSQCLDAP 439
            :........||||..|:.:||:|.|...|||:|||  ....|:|:|:.|:..      .:.:.:|
  Rat   511 LHGEQGHPWGRFGVALTVLGDVNGDNLADVAIGAPGEEESRGAVYIFHGASR------LEIMPSP 569

  Fly   440 SQQPSKYGSYM------FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKL 498
            ||:.:  ||.:      ||..||.|.|:..:|..|.|:||..  .|.|.|:.|::|:...|:
  Rat   570 SQRVT--GSQLSLRLQYFGQSLSGGQDLTQDGLVDLAVGAQG--HVLLLRSLPLLKVELSIR--- 627

  Fly   499 QNVNPEE----------------ERVNITVCYRLSSKSDSKAKALMEQELVIRID--IDTKSKIK 545
              ..|.|                |....|||..:...|..   .|...:..:|.|  :|....|.
  Rat   628 --FAPMEVAKAVYQCWERTPTVLEAGEATVCLTVHKGSPD---LLGNVQGSVRYDLALDPGRLIS 687

  Fly   546 LAVFDEEHGSQMSFKAKAFHEEICSEFQIEMDKRAK--FTPIALEMQYELSKKIPNSGDFCEDCA 608
            .|:|||.....::.:......:.|...::.:....:  .:||.|.:.:.|
  Rat   688 RAIFDETKNCTLTGRKTLGLGDHCETVKLLLPDCVEDAVSPIILRLNFSL--------------- 737

  Fly   609 VVDPAEPK------------FVTEYITFNTGCATD-VCVADLKISCINAS--STLVLGTTAVLRL 658
            |.|.|.|:            .:|..:.|...|..: :|..||.|| .|.|  ..||:|.:..|.:
  Rat   738 VRDSASPRNLHPVLAVGSQDHITASLPFEKNCKQELLCEGDLGIS-FNFSGLQVLVVGGSPELTV 801

  Fly   659 TYNITNNGEFAYHPKFSVTNSAGLSLAQVPGN-----------CKVNEAVM------VCDLNHGQ 706
            |..:.|.||.:|.........||||..:|.|.           |:...|..      .|.:|| .
  Rat   802 TVTVWNEGEDSYGTLVKFYYPAGLSYRRVTGTQQPHQYPLRLACEAEPAAQEDLRSSSCSINH-P 865

  Fly   707 RMAKGDTDSLTISFDV--RQLRGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQT 769
            ...:|...:..|:|||  :...|..|.::|:..|  :.:.|:.||....|.|..|..:|....:.
  Rat   866 IFREGAKTTFMITFDVSYKAFLGDRLLLRAKASS--ENNKPDTNKTAFQLELPVKYTVYTLISRQ 928

  Fly   770 ND---HVVLKES--PYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKI 829
            .|   ||....|  ....|..:.|.:.:..|..|. :.|:.::||..   :...|..:..|||..
  Rat   929 EDSTNHVNFSSSHGGRRQEAAHRYRVNNLSPLKLA-VRVNFWVPVLL---NGVAVWDVTLSSPAQ 989

  Fly   830 QSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLP 894
            ......::.|                                         .|||  ..|.:
  Rat   990 GVSCVSQMKP-----------------------------------------PQNP--DFLTQ--- 1008

  Fly   895 VNNTLVLNCQDTNVTLCVPVEIRLEN-GLQLKPEELMNMTVSF---TVNLKDADDIWEYFVIQTD 955
            :....||:|   ::..|:.....:.: |:|.:.:.::...:||   :..|::...:.....|..|
  Rat  1009 IQRRSVLDC---SIADCLHFRCDIPSLGIQDELDFILRGNLSFGWVSQTLQEKVLLVSEAEITFD 1070

  Fly   956 LKVHK--IGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRA 1018
            ..|:.  .|........:|..:|..|:.:    .|:.:..|.:.|:|:.:..|..|||.|||||.
  Rat  1071 TSVYSQLPGQEAFLRAQVETTLEEYVVYE----PIFLVAGSSVGGLLLLALITVVLYKLGFFKRQ 1131

  Fly  1019 IKDDL 1023
            .|:.|
  Rat  1132 YKEML 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	26/79 (33%)
		Int_alpha	384..434	CDD:214549	19/51 (37%)
		Int_alpha	447..>492	CDD:214549	18/50 (36%)
		Integrin_alpha2	484..808	CDD:285619	83/382 (22%)
Itgad	NP_113879.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	21..78
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	79..138
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	341..392		13/65 (20%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	393..444		15/55 (27%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	445..505		22/64 (34%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	508..566		20/63 (32%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	571..631		20/68 (29%)
		GFFKR motif	1126..1130		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940