DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ItgaPS4 and itga1

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_021334930.1	Gene:	itga1 / 570868	ZFINID:	ZDB-GENE-091118-115	Length:	1183	Species:	Danio rerio

Alignment Length:	907	Identity:	199/907 - (21%)
Similarity:	371/907 - (40%)	Gaps:	169/907 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 MGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQ----EVPSIKTSSGRQRRGMNTNRKCNECN 255
            |.:.|.|||.|  .:.:::||.|...|.|:|.::.    .||...|..                |
Zfish   374 MSQAGFSAHTS--KAGVMLGAVGAFDWNGTVVMQAGNEFVVPKKNTFH----------------N 420

  Fly   256 PEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHEFRG 320
            |..:.: :....|.||.|.|.|..:.    |||:..|||.|:. |...::....:::......:|
Zfish   421 PSVQRY-EGMAGYVGYDVQSAYTPNG----VLYITGAPRFNHS-GRVTVYRFDGENVTIVQTLKG 479

  Fly   321 NHFGEYFGYSVLAEDLNGDGKTDV-IISAPLYALRNSYDDGAIYVFINKGSFTFEERIIRSPAGS 384
            ...|.|||..:...|::||..||: :::||::......:.|.:||:....|..||..:...|...
Zfish   480 EQIGSYFGSVLQTHDIDGDNYTDILLVAAPMFMGPERDEQGQVYVYKLNESGLFEHEMTLKPVNQ 544

  Fly   385 --------------------GGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GSVFIYLGSENG 427
                                |.||||.::.:.|:|.|.::|:.:|:|...:  |:|:||.||:..
Zfish   545 TCCSGHSHNNCKIVSKNEPCGARFGTAIAAVPDLNLDKFSDIVIGSPLENDHRGAVYIYHGSQKS 609

  Fly   428 LRDPPSQCLDAPSQQPS-KYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIH 491
            :::...|.:.|.....| |:    ||..:....|::.:|..|..||.....|:|..|  .|.::.
Zfish   610 IKEKYVQRIAAGGDGESMKF----FGQSIHGIMDLNDDGIIDVTIGGIGGAALYWSR--DVAELL 668

  Fly   492 A-----IIKPKLQNVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIR--IDIDTKSKIKLAVF 549
            |     .||..||:......:..:.|..|:..|...|:...|....|||  :.:|:...:....|
Zfish   669 AEMTFDPIKINLQHTCQVHGKTTVCVKTRVCFKYRIKSVKEMNTGTVIRYSLTLDSLRAVARGRF 733

  Fly   550 DEEHGSQMSFKAKAFHEEICSEFQIEMDKRAKF-TPIALEMQYELSKKIPNSGDFCEDCAVVDPA 613
            :|....::. |.::...:.|.|.......:..| .||.:.:::.|:.:        :...|:|..
Zfish   734 NETEDRRLQ-KNESIRNKFCREHTFYTSDKLDFRDPIMVTLEFGLADE--------DKGPVLDGE 789

  Fly   614 EPKFVTEYITFNTGCATDVCVADLKI-SCINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVT 677
            .|..:.:.|......:.:.|||:|.: :..|.||.|:........:..:|.|.|:.||:.|.:::
Zfish   790 LPTSLNKTIALVDCGSNEKCVANLHLQASANISSLLIKSNQEKFYVNIDIKNTGDNAYNTKVTLS 854

  Fly   678 NSAGLSLAQV---PGNCKVNEAVMVCDLNHGQRMAKGDTDSLTISFDVRQLRGRS---LEIQAEV 736
            ::..::..:|   ..:|:.|...:||.:.:.....| |.::..|.|:......|.   :.:.|..
Zfish   855 HTENINYVKVEPKDKDCETNHTRIVCAVGYPFLKTK-DRETFKIQFEPNPSLIRKDIVINVTATT 918

  Fly   737 LSARDESNPENNKLTNVLSLREKADIYVSG--VQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLE 799
            .|.:.:|..:.|..|.::.:|.:|.:..:.  ....||::|||......|.|:..:
Zfish   919 DSEQSDSALKRNFETIIIPVRHEASMRFTANKYMKEDHIILKEKETIPSVFNHTSV--------- 974

  Fly   800 NLTVSLYIPVAY---KTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQST 861
               :...:.::|   |.||        ..||.::       :.|.|..|.:  |.||
Zfish   975 ---IGDEVKISYTIEKDPD--------MPSPPVK-------LTIMFPYQTS--AKNF-------- 1011

  Fly   862 LLFSATPQHENVG--------NLSGIVEQNP-SISLLNEDLPVNNTLVLNCQD-----TNVTLCV 912
             |...|......|        |...|....| |::...|.|.:   .:|:|::     .:.:..:
Zfish  1012 -LLYLTDLSYTAGIRCSADWINPLKIQPSKPHSLNTKKETLSI---YLLSCKEKENPCQSFSCFI 1072

  Fly   913 P--------VEIRLENGLQLKPE-ELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSS 968
            |        ...||.....:|.| ..::|.|...:..::.|    .||:..::|..::      .
Zfish  1073 PSGDFNQINTTFRLWRPTFIKGEFSTIHMAVDAKLETQNTD----LFVLNENIKTREV------R 1127

  Fly   969 FTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDS 1030
            ..:.|.|.:.       |.:|.||:|:::|:|:.:...:||:|.|||||...:::.:..:|:
Zfish  1128 IQVTKDIRTG-------IPLWIIILSILIGLLILALVIFALWKAGFFKRKSVEEMNEDKKDT 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	23/93 (25%)
		Int_alpha	384..434	CDD:214549	17/71 (24%)
		Int_alpha	447..>492	CDD:214549	11/44 (25%)
		Integrin_alpha2	484..808	CDD:285619	66/340 (19%)
itga1	XP_021334930.1	vWFA	167..348	CDD:320736
		Int_alpha	482..532	CDD:214549	15/49 (31%)
		Int_alpha	565..618	CDD:214549	18/52 (35%)
		Integrin_alpha2	661..1070	CDD:312071	90/461 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840