Protein Alignment ItgaPS4 and itga6b

DIOPT Version :9

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001013466.1
• Gene: itga6b / 541320
• ZFINID: ZDB-GENE-050320-5
• Length: 1085
• Species: Danio rerio
• Alignment Length: 1185
• Identity: 274/1185 - (23%)
• Similarity: 467/1185 - (39%)
• Gaps: 254/1185 - (21%)

  Fly     5 LVIVLLAL--QSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIR-------EKSIMVAAPR 60
            |.:.||:|  .:.|:|:|:     ..:|.....|: .:|.||||:.:.       ::.::|.:|:
Zfish     7 LTVPLLSLLGLTLISAFNL-----DTVNVIRKTGD-ANSLFGFSMAMHRQLRPADKRMLLVGSPK 65

  Fly    61 ANSSLEAQRNISEPGVIFRCYFE-SGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMD- 123
            |.:....:..|:  |.::.|... .|.:|.....|.:.|         |..:||:.:|:|..:.
Zfish    66 AKALPNQRSKIT--GGLYNCDINIPGQSCQRVMFDNEEN---------LQTENKENQWMGVTVQS 119

  Fly   124 ---GGTRDSDKFLVCAPRFY------SINNENDYNNGMCYWLS-DTPKNIDSTEVMEKWPL---- 174
               ||     |.||||.|:.      |:....|. .|.||.|| |...|..|.|....|..
Zfish   120 QGPGG-----KILVCAHRYQRRLFVGSVQELRDL-TGRCYVLSEDVTINEISDEDGGDWMFCNGR 178

  Fly   175 -RIEKKQVLKLADTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKT-- 236
             |..::             :...:.|:||..:.|...|:.||||...|||.|.|:|:..|:..
Zfish   179 NRGHER-------------FGSCQQGMSATFTKDYHYLVFGAPGAYNWKGIVRLEQKNTSLFDKD 230

  Fly   237 --SSGRQRRGMNTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQF 299
              ..|....| :.||...|..|.|.|      ||.|:::.||.. .:....:..||.|||.|:.
Zfish   231 IFDDGPYEVG-DENRLDAELVPVPAN------SYLGFSLDSGKM-LTKRGQLTIVAGAPRANHS- 286

  Fly   300 GEAYIF--DIYEDSIY-KYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDGA 361
            |...:.  |..:.|:. ..:...|:.....|||.:...|:||||..|:::.||.|.:::....||
Zfish   287 GAVVLLKKDEAKSSLLTAEYTLEGSGLASSFGYDLAVLDINGDGWQDIVVGAPQYFIKDGDIGGA 351

  Fly   362 IYVFIN-KGSF-TFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GSVFIYL 422
            |||::| :|:: ....:.|..||.|  .||..:..:||:|.|||.||||.||:..|  |:|.|:.
Zfish   352 IYVYLNEEGAWDKITPKRIDGPAYS--MFGLAVENMGDVNLDGYQDVAVSAPYDSNGAGNVIIFH 414

  Fly   423 GSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 487
            ||..||:  .||.|..     ..:...:||:.|:...|:|.|.:.|.|||: .:::|::||:..|
Zfish   415 GSPQGLK--KSQVLGG-----KDHNVKLFGYSLAGNMDLDRNNYPDLAIGS-LSDSVFVYRSRSV 471

  Fly   488 VKIHAIIKPKLQNVNPEEERVN--------ITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKI 544
            :.|...:....:.::..::..|        :..|::.|.|..:....| :....||::.:.| |:
Zfish   472 INIEKTVTTTPKELDLTKKNCNNGNNICLDVKACFKFSVKPKTYNPTL-KVAYTIRVESERK-KL 534

  Fly   545 KL---AVF------DEEHGSQMSFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYELSKK---- 596
            .|   .:|      |.|....:..|.:.....|.....::...:.|...|.:|:..|:..:
Zfish   535 NLPSRVIFNPRSNNDYESTGIVELKGQGTESCIYRNLMLQETLKDKLRGIPIEVSVEILNQNKRR 599

  Fly   597 -----IPN------SGDFCEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISC-------- 641
                 :||      |.......|:|     :|:.|      ||..| :|.:||::..
Zfish   600 RRQAALPNLLPILDSNQEATTVAMV-----QFIKE------GCGADHLCQSDLQLQYKFHTREPN 653

  Fly   642 ---------INASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQVPG-------N 690
                     ......|.|.....:.|.....|.||.||..:.:.:....||.:.|..       :
Zfish   654 KDNFFPFDEEKGVPILSLSDQKEIALEIKAVNLGEDAYETQLTASFPKSLSYSAVRTQSGDKQIS 718

  Fly   691 CKVNEAVMVCDLNHGQRMAKGDTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLTNVLS 755
            |.||:.....|.:.|....|   |:.|..:.:....|.||:.....:..:.::..|..:|.   :
Zfish   719 CLVNQNGSQADCDLGNPFKK---DAQTTFYIILSTGGISLDTTEIEIDLKLKTTSEQKQLQ---A 777

  Fly   756 LREKADIYV------SGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTP 814
            ::.||.:.:      |||.....|.     :|.||.....:|..|         .:..|:.|
Zfish   778 VKAKAIVKIQLLLSLSGVAKPSQVF-----FTGEVKGESAMKVAG---------DVGSPIDY--- 825

  Fly   815 DSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGI 879
                 :..||:..|....:....|.|.:...|:.......:....||.|.|.:..:.:..|..|:
Zfish   826 -----EFRVTNLDKPLKSFGRASMIIQWPKHNSQGKWLLYLMKMTSTGLDSLSCTNSDEVNKLGL 885

  Fly   880 VEQNPSISLLNEDLPVNNT----------------LVLNCQD--TNVTLCVPVEIRLENGLQLKP 926
            .|    :|:......|..|                .:|:|.|  ..:|...|:     .|:.
Zfish   886 KE----LSVSRTKREVGETSAAEGKTAFFTDKRKYTLLSCDDGAECITFICPL-----TGMD--- 938

  Fly   927 EELMNMTVSFTVNLKDADDIWEYFVIQ--------------TDLKVHKIGDPTLSSFTI--EKKI 975
               .|..:|....|.:|..:.:|..:.              |...:....:|:....|:  |:|
Zfish   939 ---SNAVISLRAYLWNATFLEDYAKLNYVDIIAKASLDFKTTATNIQLKNEPSQVRVTVFPERK- 999

  Fly   976 ESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEM 1040
                :.::..:..|.|:|::::|:|:.....:.|:|.|||||:..||..    .|:....|:.|.
Zfish  1000 ----VAQYGGMPWWVILVAILLGLLLLGLLVFLLWKCGFFKRSKYDDSV----PSYNAVRIKREE 1056

  Fly  1041 EENAQSQGDADLDEK 1055
            .:|...:.:.|..||
Zfish  1057 RDNLSGKDEMDSSEK 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	30/74 (41%)
		Int_alpha	384..434	CDD:214549	23/51 (45%)
		Int_alpha	447..>492	CDD:214549	15/44 (34%)
		Integrin_alpha2	484..808	CDD:285619	69/386 (18%)
itga6b	NP_001013466.1	Int_alpha	37..98	CDD:214549	13/62 (21%)
		Int_alpha	254..>292	CDD:214549	13/45 (29%)
		Int_alpha	315..365	CDD:214549	19/49 (39%)
		Int_alpha	374..425	CDD:214549	25/54 (46%)
		Integrin_alpha2	468..932	CDD:285619	91/508 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574971
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740