DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and itga6a

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_005167466.1	Gene:	itga6a / 503893	ZFINID:	ZDB-GENE-050309-23	Length:	1092	Species:	Danio rerio

Alignment Length:	1188	Identity:	269/1188 - (22%)
Similarity:	476/1188 - (40%)	Gaps:	288/1188 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NAYNISPYPNSVLNFPELEGNRRSSYFGFSLVI------REKSI-MVAAPRANSSLEAQRNISEP 74
            :|:|:.  ..:||.    :..:..|.||||:.:      .:|:| ::.||:|.:......|::
Zfish    24 SAFNLD--TQNVLR----KSGQPGSLFGFSIALHRQLQPHDKTILLIGAPKARALSNQGANVT-- 80

  Fly    75 GVIFRCYFES-GNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMD----GGTRDSDKFLV 134
            |.::.|...: .|:||..:.|         ||..:..:||:.:|:|..:.    ||     |.:.
Zfish    81 GGLYSCDITTHPNDCSRVDFD---------NDVDVRVENKENQWMGVTVQSQGPGG-----KIVT 131

  Fly   135 CAPRFYSI---NNENDYNN--GMCYWLS-DTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLIPYY 193
            ||.|:..:   |...:..:  |.||.|| |...:..|.|....|          |..|.....:.
Zfish   132 CAHRYQRLLFPNTPQEARDITGRCYMLSQDLSIDNQSDEDGGNW----------KFCDGRTRGHE 186

  Fly   194 SMG--ELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKT----SSGRQRRGMNTNRKCN 252
            ..|  :.||:|..:.|...::.||||...|||.|.::|:..::..    ..|....| :.||...
Zfish   187 RFGACQQGLAATFTKDYHYVIFGAPGAYNWKGIVRIEQKNNTLLEMGLFDDGPYEVG-DENRLDP 250

  Fly   253 ECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKY-- 315
            ...|.|.|      ||.|:::.||: ..:....::.|:.|||.|:  ..|.:|...|..:...
Zfish   251 NLVPVPAN------SYLGFSLDSGH-SITEKGKLIIVSGAPRANH--SGAVVFLRKEGELSSMLT 306

  Fly   316 --HEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDGAIYVFINKGSFTFEERII 378
              |...|......|||.|...||||||..||::.||.:..|:....||:||:|||.....:...:
Zfish   307 PEHILEGPGLASSFGYDVAVVDLNGDGWQDVVVGAPQFFQRDEEVGGAVYVYINKAGRWRDVTPV 371

  Fly   379 RSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFA--GNGSVFIYLGSENGLRDPPSQCLDAPSQ 441
            |........||.::..|||:|.|.:.|:|||||:|  |.|||:||.||.:|:...|:|.|:.
Zfish   372 RLNGTKDSMFGLSVENIGDVNLDSFEDIAVGAPYADSGFGSVYIYHGSADGISTKPAQILEG--- 433

  Fly   442 QPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEEE 506
              .::.:.|||:.|:...|:|.|.:.|.|:|: .::.|::||:..|:.|...||...:.::..::
Zfish   434 --KQHNTKMFGYSLAGNMDLDHNSYPDLAVGS-LSDTVFIYRSKNVISIKKDIKVTPKEIDLTKK 495

  Fly   507 RVNITVCYRLSSKSDSKA-----------KALMEQE-------LVIRIDIDTKSKIKLAVFDEEH 553
            ....::|..:.:....:|           ....|.|       |..|:....|::|     |:::
Zfish   496 TCGNSICLTVEACFSYRANPTTYNPKITISCTFEAEWYRRKLGLPSRVVFLDKTEI-----DQDY 555

  Fly   554 GSQMSFKAKAFHEEICSEFQIEMD----KRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAE 614
            .|..:.:.:..:::.|.:.::.:.    .:.:..||.:.:..:.:|:........:...::|...
Zfish   556 QSTGTLELRGQNKKACYKTKLRLQDGIRDKLRAIPIEVSVAIQSAKRGKRQSSLPQLVPILDSTV 620

  Fly   615 P-KFVTEYITFNTGCATD-VCVADLKIS---CI--------------NASSTLVLGTTAVLRLTY 660
            | |.:||......||.|| :|.::|.:.   |.              |....:.|.....:.|..
Zfish   621 PNKTLTEVNFLKEGCGTDNICQSNLNLQYRFCYRESKQDIFPPLPLENGVPVISLSDQKDIALEV 685

  Fly   661 NITN-NGEFAYHPKF------SVTNSAGLSLAQVPGNCKVNEAVMVCDLNHGQRMA--------K 710
            .:.| ||:.|:..|.      |::.|...||       :.|:..::|..|....:|        |
Zfish   686 TVRNRNGDDAHEAKLVSHFDDSLSYSGFRSL-------RTNDKHVICAANQNGSLADCELGNPFK 743

  Fly   711 GDTD--------SLTISFDVRQLRGRSLEIQAEVLSARDESNPENNK-------LTNVLSLREKA 760
            .|::        :..||.:.:::   .:::|.|..|:::..:....|       |.:|..:.:.:
Zfish   744 RDSEVTFYIILSTGKISLETKEV---EIDLQLETTSSQEGLSKVKAKAKVVIELLLSVQGVAKPS 805

  Fly   761 DIYVSGVQTNDHVVLKES------PYTAEVVNYYE-IKSHGPSTLENLTVSLYIPVAYKTPDSTN 818
            .:|..|.......:.||.      .|...|:|..: :||.|       |.||.|    :.|..::
Zfish   806 QVYFGGEVKGMSAMKKEEEVGSLIEYEFRVINLGKPLKSFG-------TASLNI----QWPKESS 859

  Fly   819 VKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHE----------NV 873
            |           .|:...:|.||..|..                |.:.:|:.|          ::
Zfish   860 V-----------GKWLLYLMKINTRDLQ----------------LVTCSPEREINPLKLREDSSI 897

  Fly   874 GNLSGIVEQNPS----ISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQ------LKPEE 928
            .....:.|:.||    |||..:.   ....:|:|  :....||.::..|: ||.      || ..
Zfish   898 RKKRELEERRPSEGNKISLFTDK---RKHKILSC--SGDARCVEIKCPLQ-GLDSTAVIVLK-SR 955

  Fly   929 LMNMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAI----- 988
            |.|.|.        .:|...|..:...:|         :|.:::...: |::.|:.|..:
Zfish   956 LWNSTF--------LEDFASYNYLDIIVK---------ASISLDVSAK-NIVLKNPETQVRLTVF 1002

  Fly   989 -------------WKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGI----- 1035
                         |.|:|:|:.|||:.:.....|:|.|||||:           .:||.:
Zfish  1003 PETTATPFGGVPWWIILVAVLAGILMLALLVLLLWKCGFFKRS-----------KYEDSVPKYHA 1056

  Fly  1036 IRTEMEENAQSQGDADLD 1053
            :|...|......|...||
Zfish  1057 VRIRKETRLLKDGKVMLD 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	27/72 (38%)
		Int_alpha	384..434	CDD:214549	24/51 (47%)
		Int_alpha	447..>492	CDD:214549	15/44 (34%)
		Integrin_alpha2	484..808	CDD:285619	69/401 (17%)
itga6a	XP_005167466.1	Int_alpha	40..101	CDD:214549	16/62 (26%)
		Int_alpha	257..>293	CDD:214549	12/44 (27%)
		Int_alpha	318..368	CDD:214549	22/49 (45%)
		Int_alpha	378..431	CDD:214549	25/52 (48%)
		Int_alpha	440..>463	CDD:214549	9/22 (41%)
		Integrin_alpha2	476..939	CDD:285619	90/520 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574972
Domainoid	1	1.000	61	1.000	Domainoid score	I10420
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740