Protein Alignment ItgaPS4 and Itgax

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001406686.1
• Gene: Itgax / 499271
• RGDID: 1561123
• Length: 1182
• Species: Rattus norvegicus
• Alignment Length: 1291
• Identity: 266/1291 - (20%)
• Similarity: 409/1291 - (31%)
• Gaps: 484/1291 - (37%)

  Fly    43 FGFSLVIREKS-IMVAAPRANSSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDG 106
            ||.|:|....| ::|.||:   .::|...|   |.:::|.:.:| .|...::........|....
  Rat    37 FGHSVVQYGGSWVVVGAPK---EIQATNQI---GGLYKCGYHTG-MCESISLQVPPEAVNMSLGL 94

  Fly   107 LLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRFYSINNENDYNNGMCYWL--------------- 156
            .|||.|..  ||              |.|.|..:.|..||.|..|:|:.|
  Rat    95 SLTATNPS--WL--------------LACGPTVHHICRENTYLTGLCFLLDSSFRQNQNFPAAQQ 143

  Fly   157 ----------------------------------------------------------------- 156
                                                                             
  Rat   144 GCPRQDQDIVFLIDGSGSITYTDFEKMLAFVKAVMSQLQQSSTRFSLMQFSHTFRTHFTFNDFIS 208

  Fly   157 SDTPKNI---------------------------------DSTEVM------EKWPLRIEKKQVL 182
            :.:|..:                                 |:|:::      .|...|::...|:
  Rat   209 TSSPLRLLDFVNQLRGSTRTASAIKHVITELFTTQKGARKDATKILIVITDGRKEGDRLDYGDVI 273

  Fly   183 KLADTNLIPYYSMG--------------------------------------------------- 196
            .:|:...|..|::|
  Rat   274 PMAEAAGIIRYAIGVGQAFYQAQSRQELKDIASSPSREYVFSVENFDALKDIQNQLKEKIFAIEG 338

  Fly   197 ---------EL-----GLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNT 247
                     ||     |.||..:.|..  ::||.|...|.|...|...               ||
  Rat   339 TETPSSSSFELEMSQEGFSAVFTPDGP--VLGAVGSFGWSGGAFLYPP---------------NT 386

  Fly   248 NRKCNECNPEPKNFGQEEF----SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIY 308
                   .|...|..||..    ||.||:.:..::...: |.:|   .||| :...|:..||...
  Rat   387 -------RPTFINMSQENVDMRDSYLGYSTAVAFWKGVH-SLIL---GAPR-HQHTGKVVIFTQE 439

  Fly   309 EDSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDDGAIYVFINKGSFT 372
            ........|.||...|.|||.|:.:.|::.|..|| |:|.||.|..:......::......||..
  Rat   440 ARHWRPKSEVRGTQIGSYFGASLCSVDMDRDDSTDLVLIGAPHYYEQTRGGQVSVCPVPGVGSRW 504

  Fly   373 FEERIIRSPAG-SGGRFGTTLSRIGDINKDGYNDVAVGAP--FAGNGSVFIYLGSENGLRDPPSQ 434
            ..|..:....| ..||||..|:.:||:|.|...|||:|||  ....|:|:|:.|:.. |...||
  Rat   505 QCEATLHGEQGHPWGRFGAALTVLGDVNGDDLADVAIGAPGEEESRGAVYIFHGASR-LEISPS- 567

  Fly   435 CLDAPSQQPSKYGSY----MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIK 495
                |||:.|....:    .||..||.|.|:.|:|..|.|:|:..  .:.|.|..|::::.:.|:
  Rat   568 ----PSQRISASRIFPRLQYFGQSLSGGQDLTGDGLVDLAVGSKG--HLLLLRTRPILRMSSTIQ 626

  Fly   496 --P--------KLQ-NVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIRID--IDTKSKIKLA 547
              |        :.| .|..|:.....|||.|....|.::...|   :.::..|  :|.......|
  Rat   627 FTPTEISRSVFECQGQVTREQTLGTATVCLRTYESSKTQRGDL---QSIVTFDLALDPGRLSPRA 688

  Fly   548 VFDEEHGSQMSFKAKAF----HEE-------ICSEFQIEMDKRAKFTPIALEMQYEL-SKKIPNS 600
            :| :|..:|...|.:..    |.|       .|.|..:        |||.|.:.:.| ...||:.
  Rat   689 IF-KETKTQALTKVRTLGLSSHCEPVTLLLPACVEDSV--------TPITLRLNFSLVGVPIPSL 744

  Fly   601 GDFCEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISC-INASSTLVLGTTAVLRLTYNIT 663
            .:. :....||  |..:.|..:.|...|..| :|..||.|.. .....|||:|:...|.:...:|
  Rat   745 QNL-QPMLAVD--EQTYFTASLPFEKNCGADHICQDDLGIIFGFPDLKTLVVGSNLELSVAVTVT 806

  Fly   664 NNGEFAYHPKFSVTNSAGLSLAQVPGNCKVNEAVMVCDLNHGQRMAKGDTDSLTISFDVRQLRGR 728
            |:||.:|....::....|||.                     :|:|:......|......|.:||
  Rat   807 NDGEDSYGTTITLFYPVGLSF---------------------RRVAEAQVFLRTEDTQQWQQQGR 850

  Fly   729 -SLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKS 792
             ||.:..       :|.|:.::.....|...:..|:..|.|....|....|| .||:.:...:::
  Rat   851 HSLHLMC-------DSTPDRSQGIWSTSCSSRHVIFRGGSQMTFLVTFDVSP-KAELGDRLLLRA 907

  Fly   793 -----HGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANN 852
                 :|.......|..|.:||.|..       :.|.||
  Rat   908 RVSSENGVPETRKTTFQLELPVKYAV-------YTVISS-------------------------- 939

  Fly   853 FAIDHDQST--LLFSATPQHENVGNLSGIVEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVE 915
                |||.|  |.|||:              :...:|::.....|||   |..:|      :||.
  Rat   940 ----HDQFTKYLNFSAS--------------EKSRVSVVEHRFQVNN---LGQRD------LPVS 977

  Fly   916 IRLENGLQLKPEELMNMTVSFTVN---------LKDADDIWEYFVIQTDLKVHKIGDPTLS---- 967
            |......:||.|.:..:.||...|         ||..         |.||..|....|.|.
  Rat   978 INFRVPTELKGETVWTVMVSHPQNPSTQCYQNRLKPT---------QFDLLTHMQKSPVLDCSIA 1033

  Fly   968 -------------------------------SFTIEKKIESNVICKHAEIA-------------- 987
                                           |.|::||:   ::...|||:
  Rat  1034 DCLHFRCDIPSLGIQDELDFILKGNLSFGWISQTLQKKV---LLVSEAEISFDTSVYSQLPGQEA 1095

  Fly   988 ------------------IWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQ 1025
                              :..|:.|.:.|:|:.:..|..|||.|||||..|:.|.:
  Rat  1096 FLRAQAKTTLEMYEVHNPVPLIVGSSVGGLLLLALITAVLYKAGFFKRQYKEMLAE 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	24/74 (32%)
		Int_alpha	384..434	CDD:214549	21/51 (41%)
		Int_alpha	447..>492	CDD:214549	14/48 (29%)
		Integrin_alpha2	486..808	CDD:462478	76/354 (21%)
Itgax	NP_001406686.1	vWA_integrins_alpha_subunit	150..325	CDD:238746	10/174 (6%)
		Int_alpha	454..510	CDD:214549	17/55 (31%)
		Int_alpha	517..572	CDD:214549	25/60 (42%)
		Int_alpha	582..>606	CDD:214549	10/23 (43%)
		Integrin_alpha2	616..1040	CDD:462478	113/536 (21%)