Protein Alignment ItgaPS4 and itga5

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001004288.2
• Gene: itga5 / 386787
• ZFINID: ZDB-GENE-031116-52
• Length: 1053
• Species: Danio rerio
• Alignment Length: 1123
• Identity: 295/1123 - (26%)
• Similarity: 477/1123 - (42%)
• Gaps: 219/1123 - (19%)

  Fly     4 LLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFS----LVIREKSIMVAAPRANSS 64
            |.:::||.|..   |:|:.....:|.|.|.      .||||:|    :.....||:|.||:||:|
Zfish    21 LSLLILLPLSV---AFNLDVENPAVYNGPS------GSYFGYSVDFYMTDSSVSIIVGAPKANTS 76

  Fly    65 LEAQRNISEPGVIFRCYFE-SGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRD 128
               |..|:|.|.:|.|.:. |.:.||....|..|:.....||.....:.|..:|.|..:   ...
Zfish    77 ---QPKITEGGSVFYCPWSLSQSQCSSIEFDRLGDLNMSVNDTDHQGEFKSHQWFGATV---RVH 135

  Fly   129 SDKFLVCAPRFYSINNENDY----NNGMCYWLSDTPKNIDSTEVMEKWPLRIE----KKQVLKLA 185
            .|..|.||| .||...:.|.    ..|.|:.   :.||.  |:.:|..|.|.|    |.|
Zfish   136 QDSVLACAP-LYSWRTKEDTPHADTTGSCFM---SVKNF--TKFVEYAPCRTEFRGRKGQ----- 189

  Fly   186 DTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSV--HLKQEVPSIK--------TSSGR 240
                  .|..|  |.||..:.: .|:::|.||...|:|.|  ..|||:  :|        ||.|.
Zfish   190 ------GYCQG--GFSADFTQE-GKVVLGGPGSYFWQGQVITAFKQEI--VKAYYPGYFLTSVGG 243

  Fly   241 QRRGMNTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIF 305
            |   :.|.::        |....:: :|.||:|:.|.|...:...  :|...|||....|:.
Zfish   244 Q---IQTKQR--------KEIRFDD-TYMGYSVAVGEFTGDDDED--FVTGVPRGVRLHGQV--- 291

  Fly   306 DIYEDSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNS----YDDGAIYVFI 366
            .|...|:.....|.|...|.|:||||.|.|:|.||..|:::.||::.:|:|    .:.|.:||::
Zfish   292 SILNSSLDVLKMFTGEQMGSYYGYSVAATDINNDGMMDLLVGAPMFMVRDSDGRLEELGRVYVYM 356

  Fly   367 NKGSFTFEERIIRSPAGSG----GRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIYLGS 424
            .||..   :.|.:.|..:|    .|||::::.:||:|:|||||||:.:||.|   .|.|.||.|:
Zfish   357 QKGPL---DLIPQLPHLTGTQMFARFGSSITPLGDLNQDGYNDVAISSPFGGEDKQGLVLIYNGN 418

  Fly   425 ENGLRDPPSQCLDAP------SQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYR 483
            ..|||:.|||.:...      |..|:.     ||:.|..|.|:|.||:.|..:||..|:...|||
Zfish   419 AGGLREKPSQVISGQWASAGLSAIPAS-----FGYALRGGKDLDNNGYPDLIVGAFGADKAVLYR 478

  Fly   484 AYPVVKIHAIIKPKLQNVNPEEE-----RVNITV---CYRLSSKSDSKAKALMEQ-ELVIRIDID 539
            :.|:|...||:......:||||:     |.|.|:   |..||....:..|.|... |..:.:.:|
Zfish   479 SRPIVNTSAILNVYPIMINPEEKVCAISRGNETLHVSCVNLSFCLSANGKHLPNHLEFNVEVQLD 543

  Fly   540 -----TKSKIKLAVFDEEHGSQMSFKAKAFHE--------EICSEFQI----EMDKRAKFTPIAL 587
                 .|..::.|:|       :..:..|.|.        .:||:.:|    |.|.|.|.:||.:
Zfish   544 RLKQQQKGAVRRALF-------LETQLPALHRTLTVPNGARVCSDTKIYLRDEKDFRDKLSPIFV 601

  Fly   588 EMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLG 651
            .:.:.|:.:........:.......||  .:.:.......|..| :||.|||:|.......:.:|
Zfish   602 ALNFSLNPQAAADRHGLQPILNYQTAE--LIEQKAQILLDCGEDNICVPDLKLSVHGDRKEVYMG 664

  Fly   652 TTAVLRLTYNITNNGEFAYHPKFSV-----TNSAGL-----SLAQVPGNCKVNEAV--MVCDLNH 704
            ....|.||:|..|:|..||..:..|     .:.:|:     ||.|:..:.:.....  :.|||
Zfish   665 DDNSLTLTFNAKNDGGGAYEAELYVVLPPEADYSGIARNNESLTQLTCSYETENQTRYLSCDL-- 727

  Fly   705 GQRMAKGDTDSLTISFDVRQLRGRSLEIQAEV-LSARDESNPENNKLTNVLSLREKADIYVSGVQ 768
            |..|..|.:....:.|.|.:|:.....:|.:: :.:::|:|.::..:...|.:..::|:.:.||.
Zfish   728 GNPMKSGTSLWAGLRFTVPRLKDTHNFVQFDLQIRSKNENNSQSEVVPYKLEVVVRSDVILQGVS 792

  Fly   769 TNDHV------------VLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKH 821
            ..|.|            |:.|......|.:.||:.::|||.:.:..:.|..|:...:........
Zfish   793 RPDKVFFPPPNWKLTKNVMVEQNVGPSVQHTYELVNNGPSRISHTLLQLKCPMRLHSNRFIYPLE 857

  Fly   822 IVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQH-ENVGNLSGIVEQNPS 885
            :.|..| :.....:.|.|:|...|.::.        :|..:..|....| |......|.:.|..:
Zfish   858 VTTEGP-VNCTTHNIINPLNLKLQQSST--------EQPPVRDSGHEHHIEKRDTHKGELSQLTN 913

  Fly   886 ISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGL--------QLKPEELMNMTVSFTVNLKD 942
            :|..:.|     ...|.|   ||.|       ||.|.        ::..|..|..|
Zfish   914 LSCSSVD-----CWTLMC---NVGL-------LERGTSAILHVRSRIWAETFMENT--------- 954

  Fly   943 ADDIWEYFVIQ--TDLKVHKIGDPTLSSFTI--EKKIESNVICKHAE----IAIWKIIVSVIVGI 999
                ::.|:::  ...||.|:....|...|.  .||:.:.|:....:    :.:|.||::::.|:
Zfish   955 ----YKNFILECHASYKVEKMPYAILPKVTPSGSKKMVTPVVWNKPDSSYAVPLWIIILAILAGL 1015

  Fly  1000 LVFSAATYALYKRGFFKR 1017
            |:.:...|.|||.|||||
Zfish  1016 LLLALLIYVLYKLGFFKR 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	29/80 (36%)
		Int_alpha	384..434	CDD:214549	26/56 (46%)
		Int_alpha	447..>492	CDD:214549	17/44 (39%)
		Integrin_alpha2	486..808	CDD:462478	84/373 (23%)
itga5	NP_001004288.2	Int_alpha	47..104	CDD:214549	22/65 (34%)
		FG-GAP	260..294	CDD:460357	10/38 (26%)
		Int_alpha	309..>357	CDD:214549	19/47 (40%)
		Int_alpha	375..430	CDD:214549	27/54 (50%)
		Int_alpha	446..>484	CDD:214549	16/37 (43%)
		Integrin_alpha2	480..926	CDD:462478	100/470 (21%)