DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS4 and ITGAV

DIOPT Version :9

Sequence 1:NP_611025.2 Gene:ItgaPS4 / 36693 FlyBaseID:FBgn0034005 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_002201.2 Gene:ITGAV / 3685 HGNCID:6150 Length:1048 Species:Homo sapiens


Alignment Length:1145 Identity:281/1145 - (24%)
Similarity:467/1145 - (40%) Gaps:229/1145 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS------IMVAAPRAN 62
            ||..:||.|   ..|:|:.....:..:.||      .|||||::.....|      ::|.||:||
Human    19 LLSGLLLPL---CRAFNLDVDSPAEYSGPE------GSYFGFAVDFFVPSASSRMFLLVGAPKAN 74

  Fly    63 SSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTR 127
            ::   |..|.|.|.:.:|.:.|...|.|...|..||.....:|.|   :.|..:|.|.::   ..
Human    75 TT---QPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPL---EFKSHQWFGASV---RS 130

  Fly   128 DSDKFLVCAPRFY---SINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNL 189
            ..||.|.|||.::   .:..|.: ..|.|:..       |.|:.:|..|.|.:...    ||.. 
Human   131 KQDKILACAPLYHWRTEMKQERE-PVGTCFLQ-------DGTKTVEYAPCRSQDID----ADGQ- 182

  Fly   190 IPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNEC 254
              .:..|...:....:|   ::|:|.||...|:|.: :..:|..|.:........:..|      
Human   183 --GFCQGGFSIDFTKAD---RVLLGGPGSFYWQGQL-ISDQVAEIVSKYDPNVYSIKYN------ 235

  Fly   255 NPEPKNFGQEEF--SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHE 317
            |.......|..|  ||.||:|:.|.|:...:..  :|:..||.....|..||:|  ..::...:.
Human   236 NQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDD--FVSGVPRAARTLGMVYIYD--GKNMSSLYN 296

  Fly   318 FRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNS----YDDGAIYVFINKGSFTFEERII 378
            |.|.....|||:||.|.|:|||...||.|.|||:..|.|    .:.|.:.|.:.:.|..|:...:
Human   297 FTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKL 361

  Fly   379 RSPAGSG----GRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIYLGSENGLRDPPSQCL 436
                 :|    .|||:.::.:||:::||:||:|:.||:.|   .|.|:|:.|...||...|||.|
Human   362 -----NGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQIL 421

  Fly   437 D----APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPK 497
            :    |.|..||      ||:.:...:|||.||:.|..:||...:...||||.||:.::|.::..
Human   422 EGQWAARSMPPS------FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVY 480

  Fly   498 LQNVNPEEER------------VNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKIKLAVF- 549
            ...:|.:.:.            .|:..|.:...|.....|...:.||::. .:..|..|:.|:| 
Human   481 PSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLD-KLKQKGAIRRALFL 544

  Fly   550 ---DEEHGSQMSFKAKAFH--EEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAV 609
               ...|...|:.......  ||:.:..:.|.:.|.|.|||.:.|:|.|..:  .:.|......:
Human   545 YSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYR--TAADTTGLQPI 607

  Fly   610 VDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYHPK 673
            ::...|..::........|..| ||...|::|..:....:.:|....|.|.....|.||.||..:
Human   608 LNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAE 672

  Fly   674 FSVTNSAGLSL-AQVPGNCKVNEAV---------------MVCDLNHGQRMAKGDTDSLTISFDV 722
            ..|:    :.| |...|..:.|||:               :||||  |..|..|......:.|.|
Human   673 LIVS----IPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDL--GNPMKAGTQLLAGLRFSV 731

  Fly   723 RQL--RGRSLEIQAEVLSAR--DESNPENNKLTNVLSLREKADIYVSGVQTNDHVVL-------K 776
            .|.  ...|::...::.|:.  |:.:|   .:::.:.|...|.:.:.||.:.|||.|       |
Human   732 HQQSEMDTSVKFDLQIQSSNLFDKVSP---VVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHK 793

  Fly   777 ESPYTAE-----VVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHI-------VTSSPKI 829
            |:|.|.|     |.:.||::::|||:.....:.|..|..|.......:.|.       .||..:|
Human   794 ENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEI 858

  Fly   830 QSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLP 894
             :....||..:...::|:.:|.....||                             .:...||.
Human   859 -NPLRIKISSLQTTEKNDTVAGQGERDH-----------------------------LITKRDLA 893

  Fly   895 VN--NTLVLNCQDTNVTLCVPVEI---RLENG----LQLK----PEELMNM-TVSFTVNLKDADD 945
            ::  :...|.|   .|..|:.:..   ||:.|    |.:|    .|..||. ..:.:.:||.:. 
Human   894 LSEGDIHTLGC---GVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSA- 954

  Fly   946 IWEYFVIQ---TDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATY 1007
              .:.||:   .:|.:..|.:.||.:..:...|:...:    .:.:|.||::|:.|:|:.:...:
Human   955 --SFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPM----PVPVWVIILAVLAGLLLLAVLVF 1013

  Fly  1008 ALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEMEENAQSQ 1047
            .:|:.|||||                  :|...||..:.|
Human  1014 VMYRMGFFKR------------------VRPPQEEQEREQ 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS4NP_611025.2 VCBS 335..408 CDD:290251 26/80 (33%)
Int_alpha 384..434 CDD:214549 21/56 (38%)
Int_alpha 447..>492 CDD:214549 16/44 (36%)
Integrin_alpha2 484..808 CDD:285619 85/374 (23%)
ITGAVNP_002201.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 32..98 20/74 (27%)
Int_alpha 46..103 CDD:214549 19/59 (32%)
WD40 repeat 51..120 CDD:293791 20/74 (27%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 109..170 17/74 (23%)
WD40 repeat 126..183 CDD:293791 16/74 (22%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 173..225 13/62 (21%)
WD40 repeat 188..248 CDD:293791 12/69 (17%)
VCBS 221..271 CDD:316075 12/57 (21%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 237..291 16/57 (28%)
Int_alpha 248..>288 CDD:214549 14/43 (33%)
WD40 repeat 254..298 CDD:293791 11/47 (23%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 292..357 23/64 (36%)
Int_alpha 302..355 CDD:214549 21/52 (40%)
WD40 repeat 307..362 CDD:293791 20/59 (34%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 358..415 20/61 (33%)
Int_alpha 367..421 CDD:214549 22/53 (42%)
WD40 repeat 371..422 CDD:293791 20/50 (40%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 419..482 23/68 (34%)
Int_alpha 434..476 CDD:214549 16/41 (39%)
Integrin_alpha2 467..914 CDD:312071 103/491 (21%)
GFFKR motif 1019..1023 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1027..1048 3/9 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141978
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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