Protein Alignment ItgaPS4 and ITGAV

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_002201.2
• Gene: ITGAV / 3685
• HGNCID: 6150
• Length: 1048
• Species: Homo sapiens
• Alignment Length: 1144
• Identity: 282/1144 - (24%)
• Similarity: 466/1144 - (40%)
• Gaps: 227/1144 - (19%)

  Fly     4 LLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS------IMVAAPRAN 62
            ||..:||.|   ..|:|:.....:..:.||      .|||||::.....|      ::|.||:||
Human    19 LLSGLLLPL---CRAFNLDVDSPAEYSGPE------GSYFGFAVDFFVPSASSRMFLLVGAPKAN 74

  Fly    63 SSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTR 127
            ::   |..|.|.|.:.:|.:.|...|.|...|..||.....:|.|   :.|..:|.|.::   ..
Human    75 TT---QPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPL---EFKSHQWFGASV---RS 130

  Fly   128 DSDKFLVCAPRFY---SINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNL 189
            ..||.|.|||.::   .:..|.: ..|.|:..       |.|:.:|..|.|.:...    ||..
Human   131 KQDKILACAPLYHWRTEMKQERE-PVGTCFLQ-------DGTKTVEYAPCRSQDID----ADGQ- 182

  Fly   190 IPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNEC 254
              .:..|...:....:|   ::|:|.||...|:|.: :..:|..|.:........:..|
Human   183 --GFCQGGFSIDFTKAD---RVLLGGPGSFYWQGQL-ISDQVAEIVSKYDPNVYSIKYN------ 235

  Fly   255 NPEPKNFGQEEF--SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHE 317
            |.......|..|  ||.||:|:.|.|:...:..  :|:..||.....|..||:|  ..::...:.
Human   236 NQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDD--FVSGVPRAARTLGMVYIYD--GKNMSSLYN 296

  Fly   318 FRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNS----YDDGAIYVFINKGSFTFEERII 378
            |.|.....|||:||.|.|:|||...||.|.|||:..|.|    .:.|.:.|.:.:.|..|:...:
Human   297 FTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKL 361

  Fly   379 RSPAGSG----GRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIYLGSENGLRDPPSQCL 436
                 :|    .|||:.::.:||:::||:||:|:.||:.|   .|.|:|:.|...||...|||.|
Human   362 -----NGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQIL 421

  Fly   437 D----APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPK 497
            :    |.|..||      ||:.:...:|||.||:.|..:||...:...||||.||:.::|.::..
Human   422 EGQWAARSMPPS------FGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVY 480

  Fly   498 LQNVNPEEER------------VNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKIKLAVF- 549
            ...:|.:.:.            .|:..|.:...|.....|...:.||::. .:..|..|:.|:|
Human   481 PSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLD-KLKQKGAIRRALFL 544

  Fly   550 ---DEEHGSQMSFKAKAFH--EEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAV 609
               ...|...|:.......  ||:.:..:.|.:.|.|.|||.:.|:|.|..:  .:.|......:
Human   545 YSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYR--TAADTTGLQPI 607

  Fly   610 VDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYHPK 673
            ::...|..::........|..| ||...|::|..:....:.:|....|.|.....|.||.||..:
Human   608 LNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAE 672

  Fly   674 FSVTNSAGLSLAQVPGNCKVNEAV---------------MVCDLNHGQRMAKGDTDSLTISFDVR 723
            ..|  |..|. |...|..:.|||:               :||||  |..|..|......:.|.|.
Human   673 LIV--SIPLQ-ADFIGVVRNNEALARLSCAFKTENQTRQVVCDL--GNPMKAGTQLLAGLRFSVH 732

  Fly   724 QL--RGRSLEIQAEVLSAR--DESNPENNKLTNVLSLREKADIYVSGVQTNDHVVL-------KE 777
            |.  ...|::...::.|:.  |:.:|   .:::.:.|...|.:.:.||.:.|||.|       ||
Human   733 QQSEMDTSVKFDLQIQSSNLFDKVSP---VVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKE 794

  Fly   778 SPYTAE-----VVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHI-------VTSSPKIQ 830
            :|.|.|     |.:.||::::|||:.....:.|..|..|.......:.|.       .||..:|
Human   795 NPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEI- 858

  Fly   831 SKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSISLLNEDLPV 895
            :....||..:...::|:.:|.....||                             .:...||.:
Human   859 NPLRIKISSLQTTEKNDTVAGQGERDH-----------------------------LITKRDLAL 894

  Fly   896 N--NTLVLNCQDTNVTLCVPVEI---RLENG----LQLK----PEELMNM-TVSFTVNLKDADDI 946
            :  :...|.|   .|..|:.:..   ||:.|    |.:|    .|..||. ..:.:.:||.:.
Human   895 SEGDIHTLGC---GVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSA-- 954

  Fly   947 WEYFVIQ---TDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYA 1008
             .:.||:   .:|.:..|.:.||.:..:...|:...:    .:.:|.||::|:.|:|:.:...:.
Human   955 -SFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPM----PVPVWVIILAVLAGLLLLAVLVFV 1014

  Fly  1009 LYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEMEENAQSQ 1047
            :|:.|||||                  :|...||..:.|
Human  1015 MYRMGFFKR------------------VRPPQEEQEREQ 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	26/80 (33%)
		Int_alpha	384..434	CDD:214549	21/56 (38%)
		Int_alpha	447..>492	CDD:214549	16/44 (36%)
		Integrin_alpha2	486..808	CDD:462478	85/371 (23%)
ITGAV	NP_002201.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	32..98		20/74 (27%)
		Int_alpha	46..103	CDD:214549	19/59 (32%)
		WD40 repeat	51..120	CDD:293791	20/74 (27%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	109..170		17/74 (23%)
		WD40 repeat	126..183	CDD:293791	16/74 (22%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	173..225		13/62 (21%)
		WD40 repeat	188..248	CDD:293791	12/69 (17%)
		FG-GAP_3	221..271	CDD:433275	12/57 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	237..291		16/57 (28%)
		Int_alpha	248..>288	CDD:214549	14/43 (33%)
		WD40 repeat	254..298	CDD:293791	11/47 (23%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	292..357		23/64 (36%)
		Int_alpha	302..355	CDD:214549	21/52 (40%)
		WD40 repeat	307..362	CDD:293791	20/59 (34%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	358..415		20/61 (33%)
		Int_alpha	367..421	CDD:214549	22/53 (42%)
		WD40 repeat	371..422	CDD:293791	20/50 (40%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	419..482		23/68 (34%)
		Int_alpha	434..476	CDD:214549	16/41 (39%)
		Integrin_alpha2	468..914	CDD:462478	103/489 (21%)
		GFFKR motif	1019..1023		3/3 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1048		3/9 (33%)