DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and ITGAL

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_002200.2	Gene:	ITGAL / 3683	HGNCID:	6148	Length:	1170	Species:	Homo sapiens

Alignment Length:	1047	Identity:	230/1047 - (21%)
Similarity:	404/1047 - (38%)	Gaps:	255/1047 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 GGAMDGGTRDSDKFLV-----CAPRFYSINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEK 178
            |.|.|.|..|:.|.::     ....|.:..::...:.......|:..|.:|:.|.::.....::|
Human   265 GEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQK 329

  Fly   179 K-QVLKLADTNLIPYYSMGEL---GLSAHVSDDNSKLLMGAPGIDQWKGS-VHLKQEVPSIKTSS 238
            | .|::......:..::| ||   |:||.:|..::  ::||.|...|.|. :.||.::.. .|..
Human   330 KIYVIEGTSKQDLTSFNM-ELSSSGISADLSRGHA--VVGAVGAKDWAGGFLDLKADLQD-DTFI 390

  Fly   239 GRQRRGMNTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAY 303
            |.:           ...||.:      ..|.||.|:   :..|...|.|..:.||| ....|...
Human   391 GNE-----------PLTPEVR------AGYLGYTVT---WLPSRQKTSLLASGAPR-YQHMGRVL 434

  Fly   304 IFDIYEDSIY--KYHEFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDD---GAI 362
            :|...:...:  :.....|...|.|||..:...|::.||:|: ::|.|||:     |.:   |.:
Human   435 LFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLF-----YGEQRGGRV 494

  Fly   363 YVFINKGSFTFEE--RIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIYLGSE 425
            ::: .:....|||  .:...|....||||..::.:.|||.||..|||||||....|:|:|:.|..
Human   495 FIY-QRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRH 558

  Fly   426 NGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGA----------PNAEAVY 480
            .||...|||.::. :|..|  |...||..:....|::|:|..|.|:||          |..:.|.
Human   559 GGLSPQPSQRIEG-TQVLS--GIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVT 620

  Fly   481 LYRAYPV-VKIHAIIKPKLQNVNPEEERVNITVCYRLSSKSDSKAKALMEQ-------ELVIRID 537
            |....|. :.:|. ::......|..:|.||||:|:::        |:|:.|       .|...:.
Human   621 LMSFSPAEIPVHE-VECSYSTSNKMKEGVNITICFQI--------KSLIPQFQGRLVANLTYTLQ 676

  Fly   538 IDTKSKIKLAVF-DEEH--------GSQMSFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYEL 593
            :|.....:..:| ...|        .:.||....:||..:|.:..|        :||.:.:.:.|
Human   677 LDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLI--------SPINVSLNFSL 733

  Fly   594 -------------SKKIPNSGDFCEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINA 644
                         .|.||         .::.|:......| |.|...|..| .|.|:|::|...|
Human   734 WEEEGTPRDQRAQGKDIP---------PILRPSLHSETWE-IPFEKNCGEDKKCEANLRVSFSPA 788

  Fly   645 -SSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSL---------AQVPGNC-------K 692
             |..|.|...|.|.:..:::|..|.||..:..:....|||.         :|:|.:|       :
Human   789 RSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESR 853

  Fly   693 VNEAVMVCDLNHGQRMAKGDTDSLTISFD--VRQLRGRSLEIQAEVLSARDESN-PENNKLTNVL 754
            :....:.|::: ......|.:.:|.:.|:  |....|.|:|:.|.|....::|: .|:|..|.::
Human   854 LLSRALSCNVS-SPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTII 917

  Fly   755 SLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNV 819
            .:....:|.:...:.:                                 :||:....|.|....|
Human   918 PILYPINILIQDQEDS---------------------------------TLYVSFTPKGPKIHQV 949

  Fly   820 KHIVTSSPKIQSKYAHKIMP-INFIDQNNALANNFAIDHDQSTL-LFSATPQHENVGNLS--GIV 880
            ||:          |..:|.| |:              ||:..|| .....||..:.|.::  ..|
Human   950 KHM----------YQVRIQPSIH--------------DHNIPTLEAVVGVPQPPSEGPITHQWSV 990

  Fly   881 EQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQ----------LKPEELMNMTVS 935
            :..|.:....|||.........|....:..| ||..|.|..:|          ::...:.::..|
Human   991 QMEPPVPCHYEDLERLPDAAEPCLPGALFRC-PVVFRQEILVQVIGTLELVGEIEASSMFSLCSS 1054

  Fly   936 FTVNLKDADDIWEY----FVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVI 996
            .:::...:.....|    .:.|..:||..:         .||::            ::..::|.|
Human  1055 LSISFNSSKHFHLYGSNASLAQVVMKVDVV---------YEKQM------------LYLYVLSGI 1098

  Fly   997 VGILVFSAATYALYKRGFFKRAIK---------------DDLKQLI--RDSFEDGIIRTEMEENA 1044
            .|:|:.......|||.|||||.:|               :|.:||.  :::.:.|.::...|:::
Human  1099 GGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDS 1163

  Fly  1045 QSQGDAD 1051
            :|.|..|
Human  1164 ESGGGKD 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	25/78 (32%)
		Int_alpha	384..434	CDD:214549	23/49 (47%)
		Int_alpha	447..>492	CDD:214549	14/55 (25%)
		Integrin_alpha2	484..808	CDD:285619	71/374 (19%)
ITGAL	NP_002200.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	31..82
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	83..141
		vWA_integrins_alpha_subunit	155..323	CDD:238746	11/57 (19%)
		I-domain (insertion domain)	170..349		15/84 (18%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	390..445		15/75 (20%)
		Int_alpha	402..451	CDD:214549	12/52 (23%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	446..506		16/65 (25%)
		Int_alpha	456..503	CDD:214549	14/52 (27%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	507..563		23/55 (42%)
		Int_alpha	517..569	CDD:214549	25/51 (49%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	567..627		16/62 (26%)
		Int_alpha	579..>603	CDD:214549	7/23 (30%)
		Integrin_alpha2	612..983	CDD:285619	89/455 (20%)
		GFFKR motif	1115..1119		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1170		7/41 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840