DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and ITGAE

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_024306508.1	Gene:	ITGAE / 3682	HGNCID:	6147	Length:	1217	Species:	Homo sapiens

Alignment Length:	988	Identity:	220/988 - (22%)
Similarity:	350/988 - (35%)	Gaps:	321/988 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 YYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNP 256
            :|.:.::|.||.:.|:. ::|:||.|...|.|...|...         |.|||    |..|:...
Human   415 HYQLAQIGFSAQILDER-QVLLGAVGAFDWSGGALLYDT---------RSRRG----RFLNQTAA 465

  Fly   257 EPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYH----- 316
            ...:....::||.||||:. ...:.:||   |:|.|||                  ||:|
Human   466 AAADAEAAQYSYLGYAVAV-LHKTCSLS---YIAGAPR------------------YKHHGAVFE 508

  Fly   317 ------------EFRGNHFGEYFGYSVLAEDLNGDGKTD-VIISAPLYALRNSYDDGAIYVF--- 365
                        ...|...|.|||..:...|::.||.|| ::::||.|.:..  ::|.:||:
Human   509 LQKEGREASFLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHG--EEGRVYVYRLS 571

  Fly   366 INKGSFTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAG--------NGSVFIYL 422
            ...|||:....:...|..:..|||..::.:||:::|...|||:|||..|        .|||:||.
Human   572 EQDGSFSLARILSGHPGFTNARFGFAMAAMGDLSQDKLTDVAIGAPLEGFGADDGASFGSVYIYN 636

  Fly   423 GSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 487
            |..:||...|||.:.|.:..|   |...||..::.|.||.|:|..|..:|......|  :|:.||
Human   637 GHWDGLSASPSQRIRASTVAP---GLQYFGMSMAGGFDISGDGLADITVGTLGQAVV--FRSRPV 696

  Fly   488 V--KIHAIIKPKLQNVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIRIDIDT-KSKIKLAVF 549
            |  |:.....|....:. ....||:.:|:.:||.:.:....|.|..|...:|:|. |.:.:|...
Human   697 VRLKVSMAFTPSALPIG-FNGVVNVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCS 760

  Fly   550 DE----------EHGSQMSFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFC 604
            |.          ..|||           :|.:..:                      :|..|:.|
Human   761 DVRSCLGCLREWSSGSQ-----------LCEDLLL----------------------MPTEGELC 792

  Fly   605 -EDC-----------------------AVVDPAEPKFVTEYITFNTGCATDV-CVADLKISCINA 644
             |||                       .::|.....|....:.:...|...: |||:|:::...:
Human   793 EEDCFSNASVKVSYQLQTPEGQTDHPQPILDRYTEPFAIFQLPYEKACKNKLFCVAELQLATTVS 857

  Fly   645 SSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQV-----PG--------------- 689
            ...||:|.|..|.|..|:||:||.:|....::.....|.|.::     |.
Human   858 QQELVVGLTKELTLNINLTNSGEDSYMTSMALNYPRNLQLKRMQKPPSPNIQCDDPQPVASVLIM 922

  Fly   690 NCKVNEAVM---------------------VCDLNHGQRMAKGDTDSLTISFDVRQLRGRSLEIQ 733
            ||::...|:                     .|.|.|         .|:....:......|:.:|.
Human   923 NCRIGHPVLKRSSVSRFGLIRSSHHPAVGVFCILAH---------VSVVWQLEENAFPNRTADIT 978

  Fly   734 AEVLSARDESNPENNKLTNVLSLR--------EKADIYVSGVQTNDH------VVLKESPYTAEV 784
            ..|.::.:..:..|.  |:.|..|        :.:.:||:..|...|      .|..|:.:.||
Human   979 VTVTNSNERRSLANE--THTLQFRHGFVAVLSKPSIMYVNTGQGLSHHKEFLFHVHGENLFGAE- 1040

  Fly   785 VNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYA--------HKIMPIN 841
               |:::...|:.|..|.|     ||.|....|....:.|.|.:....|:        |.:..:.
Human  1041 ---YQLQICVPTKLRGLQV-----VAVKKLTRTQASTVCTWSQERACAYSSVQHVEEWHSVSCVI 1097

  Fly   842 FIDQNN-ALANNFAIDHDQSTLLFSATPQHENVGNLS--GIVEQNPSISLLNEDLPVNNTLVLNC 903
            ..|:.| .:|...:.||.:..|        ::|..|.  |.:..|.|   |.|.|...|
Human  1098 ASDKENVTVAAEISWDHSEELL--------KDVTELQILGEISFNKS---LYEGLNAEN------ 1145

  Fly   904 QDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSS 968
            ..|.:|:                           |.|||.             |.|.:  |.
Human  1146 HRTKITV---------------------------VFLKDE-------------KYHSL--PI--- 1165

  Fly   969 FTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFED 1033
                                  ||...:.|:||.......|:|.|||||    ..:||..:|...
Human  1166 ----------------------IIKGSVGGLLVLIVILVILFKCGFFKR----KYQQLNLESIRK 1204

  Fly  1034 GIIRTE---MEEN 1043
            ..:::|   .|||
Human  1205 AQLKSENLLEEEN 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	23/76 (30%)
		Int_alpha	384..434	CDD:214549	22/57 (39%)
		Int_alpha	447..>492	CDD:214549	16/46 (35%)
		Integrin_alpha2	484..808	CDD:285619	77/416 (19%)
ITGAE	XP_024306508.1	vWA_integrins_alpha_subunit	218..395	CDD:238746
		Int_alpha	527..578	CDD:214549	17/52 (33%)
		Int_alpha	591..650	CDD:214549	24/58 (41%)
		Int_alpha	660..>695	CDD:214549	11/36 (31%)
		Integrin_alpha2	693..>942	CDD:312071	53/282 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840