DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and ITGAD

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	XP_011544137.1	Gene:	ITGAD / 3681	HGNCID:	6146	Length:	1190	Species:	Homo sapiens

Alignment Length:	903	Identity:	218/903 - (24%)
Similarity:	360/903 - (39%)	Gaps:	186/903 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 LLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEEF----SYFGY 271
            |.:||.|...|.|...|..  |::                    :|...|..||..    ||.||
Human   375 LFLGAVGSFSWSGGAFLYP--PNM--------------------SPTFINMSQENVDMRDSYLGY 417

  Fly   272 AVSSGYFDS-SNLSTVLYVATAPRGNNQFGEAYIFDIYEDSIYKYHEFRGNHFGEYFGYSVLAED 335
            :.....:.. .||     |..|||..:. |:|.||........|..|..|...|.|||.|:.:.|
Human   418 STELALWKGVQNL-----VLGAPRYQHT-GKAVIFTQVSRQWRKKAEVTGTQIGSYFGASLCSVD 476

  Fly   336 LNGDGKTD-VIISAPLYALRNSYDD---GAIYVF-INKGS-FTFE-ERIIRSPAG-SGGRFGTTL 392
            ::.||.|| ::|.||.|     |:.   |.:.|. :.:|. ..:: :.::|...| ..||||..|
Human   477 VDSDGSTDLILIGAPHY-----YEQTRGGQVSVCPLPRGQRVQWQCDAVLRGEQGHPWGRFGAAL 536

  Fly   393 SRIGDINKDGYNDVAVGAP--FAGNGSVFIYLG-SENGLRDPPSQCLDAPSQQPSKYGSYMFGHG 454
            :.:||:|:|...|||:|||  ....|:|:::.| ||:|:  .||......|.|.|....| ||..
Human   537 TVLGDVNEDKLIDVAIGAPGEQENRGAVYLFHGASESGI--SPSHSQRIASSQLSPRLQY-FGQA 598

  Fly   455 LSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEE-------------- 505
            ||.|.|:..:|..|.|:||..  .|.|.|:.||:|:...::     .:|.|
Human   599 LSGGQDLTQDGLMDLAVGARG--QVLLLRSLPVLKVGVAMR-----FSPVEVAKAVYRCWEEKPS 656

  Fly   506 --ERVNITVCYRLSSKSDSKAKALMEQELVIRID--IDTKSKIKLAVFDEEHGSQMSFK---AKA 563
              |..:.|||..:..   |....|.:.:..:|.|  :|.......|:|:|.....::.:   ...
Human   657 ALEAGDATVCLTIQK---SSLDQLGDIQSSVRFDLALDPGRLTSRAIFNETKNPTLTRRKTLGLG 718

  Fly   564 FHEEICSEFQIEMDKRAK--FTPIALEMQYELSKK-IPNSGDFCEDCAVVDPAEPKFVTEYITFN 625
            .|   |...::.:....:  .:||.|.:.:.|.:: ||:..:.....||   ......|..:.|.
Human   719 IH---CETLKLLLPDCVEDVVSPIILHLNFSLVREPIPSPQNLRPVLAV---GSQDLFTASLPFE 777

  Fly   626 TGCATD-VCVADLKIS-CINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQVP 688
            ..|..| :|..||.:: ..:...||.:|::..|.:...:.|.||.:|....|:...||||..:|.
Human   778 KNCGQDGLCEGDLGVTLSFSGLQTLTVGSSLELNVIVTVWNAGEDSYGTVVSLYYPAGLSHRRVS 842

  Fly   689 GNCK---------VNEAVMV---------CDLNHGQRMAKGDTDSLTISFDV--RQLRGRSLEIQ 733
            |..|         ..|.|..         |.:|| ....:|...:..::|||  :...|..:.::
Human   843 GAQKQPHQSALRLACETVPTEDEGLRSSRCSVNH-PIFHEGSNGTFIVTFDVSYKATLGDRMLMR 906

  Fly   734 AEVLSARDESN-PENNKLTNVLSLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPST 797
            |   ||..|:| ..::|.|..|.|..|..:|         .::...|.....:        ||..
Human   907 A---SASSENNKASSSKATFQLELPVKYAVY---------TMISRCPVPGLPL--------GPLA 951

  Fly   798 LENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTL 862
            .      ||   |:: .:||...:..||..|...:..|:....|...::.|::.||.:
Human   952 F------LY---AWQ-EESTKYFNFATSDEKKMKEAEHRYRVNNLSQRDLAISINFWV------- 999

  Fly   863 LFSATPQHENVGNLSGIVEQNPSISL--LNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLK 925
                 |...|...:..:|.:.||.||  ::|..|..::..|    |.::....::..:.:.||.:
Human  1000 -----PVLLNGVAVWDVVMEAPSQSLPCVSERKPPQHSDFL----TQISRSPMLDCSIADCLQFR 1055

  Fly   926 ---PEELMNMTVSFTV--NLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEK--------KIES 977
               |...:...:.||:  ||...   |....:|..:.|..:.:.|..:....:        :.:.
Human  1056 CDVPSFSVQEELDFTLKGNLSFG---WVRETLQKKVLVVSVAEITFDTSVYSQLPGQEAFMRAQM 1117

  Fly   978 NVICKHAEI--AIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFED 1033
            .::.:..|:  ||..|:.|.:..:|:.:..|..|||.|||||    ..|:::.|..||
Human  1118 EMVLEEDEVYNAIPIIMGSSVGALLLLALITATLYKLGFFKR----HYKEMLEDKPED 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	26/80 (33%)
		Int_alpha	384..434	CDD:214549	22/52 (42%)
		Int_alpha	447..>492	CDD:214549	18/44 (41%)
		Integrin_alpha2	484..808	CDD:285619	76/370 (21%)
ITGAD	XP_011544137.1	vWA_integrins_alpha_subunit	149..324	CDD:238746
		Int_alpha	464..>506	CDD:214549	17/46 (37%)
		Int_alpha	528..583	CDD:214549	23/56 (41%)
		Int_alpha	593..>625	CDD:214549	14/34 (41%)
		Integrin_alpha2	628..>933	CDD:285619	70/322 (22%)
		Integrin_alpha	1153..1167	CDD:278771	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840