DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS4 and ITGA5

DIOPT Version :9

Sequence 1:NP_611025.2 Gene:ItgaPS4 / 36693 FlyBaseID:FBgn0034005 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_002196.4 Gene:ITGA5 / 3678 HGNCID:6141 Length:1049 Species:Homo sapiens


Alignment Length:1126 Identity:276/1126 - (24%)
Similarity:465/1126 - (41%) Gaps:234/1126 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREK-----SIMVAAPRANSS 64
            |:::||.....:..:|:.....:||:.|.      .|:||||:.....     |::|.||:||:|
Human    28 LLLLLLPPPPRVGGFNLDAEAPAVLSGPP------GSFFGFSVEFYRPGTDGVSVLVGAPKANTS 86

  Fly    65 LEAQRNISEPGVIFRC-YFESGNNCSPYNIDTKGN----YKGMPNDGLLTAKNKDFRWLGGAMDG 124
               |..:.:.|.::.| :..|...|:|...|:||:    .....::|....:.|..:|.|..:  
Human    87 ---QPGVLQGGAVYLCPWGASPTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATV-- 146

  Fly   125 GTRDSDKFLVCAPRFYSINNENDYNN---GMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLAD 186
             .......|.||| .||...|.:..:   |.||..:|     :.|.::|..|.|.:........ 
Human   147 -RAHGSSILACAP-LYSWRTEKEPLSDPVGTCYLSTD-----NFTRILEYAPCRSDFSWAAGQG- 203

  Fly   187 TNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQR-----RGMN 246
                  |..|  |.||..: ...::::|.||...|:|.: |......|..|...:.     :|..
Human   204 ------YCQG--GFSAEFT-KTGRVVLGGPGSYFWQGQI-LSATQEQIAESYYPEYLINLVQGQL 258

  Fly   247 TNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDS 311
            ..|:.:....:         ||.||:|:.|.|...:  |..:||..|:||..:|  |:..:....
Human   259 QTRQASSIYDD---------SYLGYSVAVGEFSGDD--TEDFVAGVPKGNLTYG--YVTILNGSD 310

  Fly   312 IYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALR----NSYDDGAIYVFINKGSFT 372
            |...:.|.|.....||||:|.|.|:||||..|:::.|||...|    ...:.|.:||:       
Human   311 IRSLYNFSGEQMASYFGYAVAATDVNGDGLDDLLVGAPLLMDRTPDGRPQEVGRVYVY------- 368

  Fly   373 FEERIIRSPAG---------SG----GRFGTTLSRIGDINKDGYNDVAVGAPFAG---NGSVFIY 421
                 ::.|||         :|    ||||::|:.:||:::|||||||:||||.|   .|.||::
Human   369 -----LQHPAGIEPTPTLTLTGHDEFGRFGSSLTPLGDLDQDGYNDVAIGAPFGGETQQGVVFVF 428

  Fly   422 LGSENGLRDPPSQCLD---APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYR 483
            .|...||...|||.|.   |.|..|..:||.:.|     |.|:||||:.|..:|:...:...:||
Human   429 PGGPGGLGSKPSQVLQPLWAASHTPDFFGSALRG-----GRDLDGNGYPDLIVGSFGVDKAVVYR 488

  Fly   484 AYPVVKIHAIIKPKLQNVNPEEER----------VNITVCYRLSSK--SDSKAKALMEQELVIRI 536
            ..|:|...|.:.......||||..          :|::.|...|.|  :||..       ..:.:
Human   489 GRPIVSASASLTIFPAMFNPEERSCSLEGNPVACINLSFCLNASGKHVADSIG-------FTVEL 546

  Fly   537 DID---TKSKIKLAVF--DEEHGSQMSFKAKAFHEEICSEFQI----EMDKRAKFTPIALEMQYE 592
            .:|   .|..::.|:|  ..:.....:...:....|.|.|.:|    |.:.|.|.:||.:.:.:.
Human   547 QLDWQKQKGGVRRALFLASRQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFS 611

  Fly   593 LSKKIPNSGDFCEDCAVVDPA----EPKFVTEYITFNTGCATD-VCVADLKISCINASSTLVLGT 652
            |..:.|      .|...:.||    ....:.:.......|..| :||.||::......:.:.||.
Human   612 LDPQAP------VDSHGLRPALHYQSKSRIEDKAQILLDCGEDNICVPDLQLEVFGEQNHVYLGD 670

  Fly   653 TAVLRLTYNITNNGE-FAYHPKFSVT---NSAGLSLAQVPGN-----C---KVNEA-VMVCDLNH 704
            ...|.||::..|.|| .||..:..||   .:....|.:.|||     |   .||:: ::||||  
Human   671 KNALNLTFHAQNVGEGGAYEAELRVTAPPEAEYSGLVRHPGNFSSLSCDYFAVNQSRLLVCDL-- 733

  Fly   705 GQRMAKGDTDSLTISFDVRQLRG--RSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGV 767
            |..|..|.:....:.|.|..||.  ::::...::|| ::.:|.:::.::..||:..:|.:.::||
Human   734 GNPMKAGASLWGGLRFTVPHLRDTKKTIQFDFQILS-KNLNNSQSDVVSFRLSVEAQAQVTLNGV 797

  Fly   768 QTNDHVVL------------KESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVK 820
            ...:.|:.            ||......|.:.||:.:.|||::....:.|..|.|.:..      
Human   798 SKPEAVLFPVSDWHPRDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQALEGQ------ 856

  Fly   821 HIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPS 885
                     |..|..::..:|....:........:|.:.|.       .|:.       ..:.||
Human   857 ---------QLLYVTRVTGLNCTTNHPINPKGLELDPEGSL-------HHQQ-------KREAPS 898

  Fly   886 ISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIWEYF 950
            .|..:     :...:|.|.:..   |  ..:|.|.| .|..:|..::.:.|.|        |...
Human   899 RSSAS-----SGPQILKCPEAE---C--FRLRCELG-PLHQQESQSLQLHFRV--------WAKT 944

  Fly   951 VIQTD-----LKVHKIGDPTLSSFTI--------EKKIESNVICKHAE----IAIWKIIVSVIVG 998
            .:|.:     |:...:.......:.|        |:::.:.|....||    :.:|.||::::.|
Human   945 FLQREHQPFSLQCEAVYKALKMPYRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFG 1009

  Fly   999 ILVFSAATYALYKRGFFKRAI 1019
            :|:.....|.|||.|||||::
Human  1010 LLLLGLLIYILYKLGFFKRSL 1030

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS4NP_611025.2 VCBS 335..408 CDD:290251 30/89 (34%)
Int_alpha 384..434 CDD:214549 27/56 (48%)
Int_alpha 447..>492 CDD:214549 15/44 (34%)
Integrin_alpha2 484..808 CDD:285619 85/376 (23%)
ITGA5NP_002196.4 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 43..108 20/73 (27%)
Int_alpha 56..114 CDD:214549 18/66 (27%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 128..188 16/68 (24%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 192..245 13/63 (21%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 259..311 16/64 (25%)
Int_alpha 268..>310 CDD:214549 15/54 (28%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 312..377 24/76 (32%)
Int_alpha 322..379 CDD:214549 22/68 (32%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 378..437 26/58 (45%)
Int_alpha 389..443 CDD:214549 28/53 (53%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 441..504 21/67 (31%)
Int_alpha 455..498 CDD:214549 15/47 (32%)
Integrin_alpha2 490..921 CDD:312071 99/485 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..907 6/48 (13%)
Interaction with HPS5 1021..1028 5/6 (83%)
GFFKR motif 1024..1028 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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