DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS4 and ITGA4

DIOPT Version :9

Sequence 1:NP_611025.2 Gene:ItgaPS4 / 36693 FlyBaseID:FBgn0034005 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_000876.3 Gene:ITGA4 / 3676 HGNCID:6140 Length:1032 Species:Homo sapiens


Alignment Length:1144 Identity:275/1144 - (24%)
Similarity:472/1144 - (41%) Gaps:272/1144 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VIVLLALQSEI-NAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIR----EKSIMVAAPRANSSL 65
            |::||.|.... ..||:......:...|      .::.||:|:|:.    .:.::|.||.||  .
Human    20 VMLLLCLGVPTGRPYNVDTESALLYQGP------HNTLFGYSVVLHSHGANRWLLVGAPTAN--W 76

  Fly    66 EAQRNISEPGVIFRCYF--ESGNNCSPYNIDTKGNYKGMPND---GLLTAKNKDFRWLGGAMDGG 125
            .|..::..||.|:||..  ..|..|....:       |.||.   |....:.:|.:|||..:...
Human    77 LANASVINPGAIYRCRIGKNPGQTCEQLQL-------GSPNGEPCGKTCLEERDNQWLGVTLSRQ 134

  Fly   126 TRDSDKFLVCAPR----FYSINNENDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIE---KKQVLK 183
            ..::...:.|..|    || |.|||....|.||   ..|.:: .||:.:    ||.   :..|.|
Human   135 PGENGSIVTCGHRWKNIFY-IKNENKLPTGGCY---GVPPDL-RTELSK----RIAPCYQDYVKK 190

  Fly   184 LADTNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTN 248
            ..:.     ::..:.|:|:..:.|  .::|||||...|.||:.:               ..:.||
Human   191 FGEN-----FASCQAGISSFYTKD--LIVMGAPGSSYWTGSLFV---------------YNITTN 233

  Fly   249 R------KCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDI 307
            :      |.|:.     .||    ||.||:|.:|:|.|.:.:.|  |..||: :.|.|:||||.|
Human   234 KYKAFLDKQNQV-----KFG----SYLGYSVGAGHFRSQHTTEV--VGGAPQ-HEQIGKAYIFSI 286

  Fly   308 YEDSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYA-LRNSYDDGAIYVFINKGSF 371
            .|..:...||.:|...|.|||.||.|.|||.||.:|:::.||:.: :|   ::|.::|:||.||.
Human   287 DEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIR---EEGRVFVYINSGSG 348

  Fly   372 TFEERIIRSPAGS---GGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GSVFIYLGSENGLRDP 431
            .....:..:..||   ..|||.::..:|||:.||:.|||:|||...:  |:::||.|..:|:...
Human   349 AVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISST 413

  Fly   432 PSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKP 496
            .||.::  ..|.||..| |||..:|...|.|.||:.|.|:||..:::..|.|..|||.:.|.:. 
Human   414 FSQRIE--GLQISKSLS-MFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLS- 474

  Fly   497 KLQNVNPEEER---------------VNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKIKL 546
                 :||...               :::|:|:....|.......|...   :.:|::.|::...
Human   475 -----HPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYN---MSLDVNRKAESPP 531

  Fly   547 AVFDEEHGS--------QMSFKAKAFHEEICSEFQIEM--DKRAKFTPIALEMQYELSKKIPNSG 601
            ..:...:|:        |:|.:     |..|...|..|  |.|...|||.:|..|.|...:.:..
Human   532 RFYFSSNGTSDVITGSIQVSSR-----EANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKR 591

  Fly   602 DFCEDCAVVDP-----AEPKFVTEYITFNTGCATDVCVADLKISC-------INASSTLVLGTTA 654
            . .|:...:.|     .|...:.:.|.|...||.:.|.|||::|.       ....:.|.:|:..
Human   592 S-TEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMK 655

  Fly   655 VLRLTYNITNNGEFAYHPKFSVTNSAG------LSLAQVPGNCKV--NEAVMVCDLNHG----QR 707
            .|.|..::.|.|:.||.....|....|      |.|.:...||:|  |..|:..|.:.|    ..
Human   656 TLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH 720

  Fly   708 MAKGDTDSLTISF--DVRQL----RGRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSG 766
            :::.|     |||  ||..|    ...|:.:.|...:..:..|.:::::|..:.|:.:..:.|.|
Human   721 LSRID-----ISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG 780

  Fly   767 --------VQTNDHVVLKESPYT--AEVVNY-YEIKSHGPSTLENLTVSLYIPVAY--KTPDSTN 818
                    ..:||    :..|.|  .|.:|. :.:.:.|.|...|::|.:.:|.::  :|....|
Human   781 FVNPTSFVYGSND----ENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFN 841

  Fly   819 VKHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQN 883
            :..:.|::.:...:...::.               |::..:|.:           ..|.|||.  
Human   842 ILDVQTTTGECHFENYQRVC---------------ALEQQKSAM-----------QTLKGIVR-- 878

  Fly   884 PSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEI----------RLENGLQLKPEELMNMTVSFTV 938
                            .|:..|..:..|:..:.          ::|:|.:          .|..:
Human   879 ----------------FLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKE----------ASVHI 917

  Fly   939 NLKDADDIWEYFVIQTD---LKVHKIGDPTLSSFTIEKKIESNVICKHAEIAI-----------W 989
            .|:....|.|  :.:|.   .::...|.|..:...||...:.||    |.:.:           :
Human   918 QLEGRPSILE--MDETSALKFEIRATGFPEPNPRVIELNKDENV----AHVLLEGLHHQRPKRYF 976

  Fly   990 KIIV---SVIVGILVFSAATYALYKRGFFKRAIKDDLKQ 1025
            .|::   |:::|::|....:|.::|.|||||..|..|::
Human   977 TIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQE 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS4NP_611025.2 VCBS 335..408 CDD:290251 27/76 (36%)
Int_alpha 384..434 CDD:214549 20/54 (37%)
Int_alpha 447..>492 CDD:214549 18/44 (41%)
Integrin_alpha2 484..808 CDD:285619 82/389 (21%)
ITGA4NP_000876.3 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..100 18/72 (25%)
Int_alpha 48..105 CDD:214549 17/58 (29%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 110..177 20/71 (28%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 185..237 15/73 (21%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 238..291 24/64 (38%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 292..351 25/61 (41%)
Int_alpha 303..352 CDD:214549 22/51 (43%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 355..412 21/56 (38%)
Int_alpha 366..418 CDD:214549 21/51 (41%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 416..478 24/70 (34%)
Int_alpha 428..479 CDD:214549 21/57 (37%)
Integrin_alpha2 463..902 CDD:285619 95/506 (19%)
SG1 606..616 1/9 (11%)
GFFKR motif 1003..1007 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142026
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D105280at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23220
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
65.810

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