DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ItgaPS4 and ITGA3

DIOPT Version :9

Sequence 1:NP_611025.2 Gene:ItgaPS4 / 36693 FlyBaseID:FBgn0034005 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_002195.1 Gene:ITGA3 / 3675 HGNCID:6139 Length:1051 Species:Homo sapiens


Alignment Length:1149 Identity:268/1149 - (23%)
Similarity:457/1149 - (39%) Gaps:272/1149 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFCLLVIVLLALQSEINAYNISPYPNSVLNFPEL-EGNRRSSYFGFSLVIREKS-------IMVA 57
            |.|.|.:::.|....::|:|:.      ..|..: |.....|.||:|:.:..::       ::..
Human    15 MLCALALMVAAGGCVVSAFNLD------TRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAG 73

  Fly    58 APRANSSLEAQRNISEPGVIFRCYFES-GNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGA 121
            |||..:..:...|  ..|.::.|...: .::|...||..|.:    |...::     :..|||..
Human    74 APRELAVPDGYTN--RTGAVYLCPLTAHKDDCERMNITVKND----PGHHII-----EDMWLGVT 127

  Fly   122 MDGGTRDSDKFLVCAPRFYSI--NNENDYNN--GMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVL 182
            : .....:.:.||||.|:..:  :...|...  |.|| :......:||::..:.:.        .
Human   128 V-ASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCY-VRGNDLELDSSDDWQTYH--------N 182

  Fly   183 KLADTNLIPYYSMG--ELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGM 245
            ::.::| ..|...|  :||.|...:.:.  :..||||...|||:.::.|.               
Human   183 EMCNSN-TDYLETGMCQLGTSGGFTQNT--VYFGAPGAYNWKGNSYMIQR--------------- 229

  Fly   246 NTNRKCNECNPEPKNFGQEEFS----------YFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFG 300
                         |.:...|:|          |.||.:..|.| ..:...:..|..||| :...|
Human   230 -------------KEWDLSEYSYKDPEDQGNLYIGYTMQVGSF-ILHPKNITIVTGAPR-HRHMG 279

  Fly   301 EAYIF------DIYEDSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDD 359
            ..::.      |:....:     ..|:..|.|||.::...|||.||..|:::.||.|..|.....
Human   280 AVFLLSQEAGGDLRRRQV-----LEGSQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVG 339

  Fly   360 GAIYVFINKGSFTFEER---IIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIY 421
            ||||||:|:...:|...   ::..|:||.  ||.:::.|||||:||:.|:||||||.|.|.|:||
Human   340 GAIYVFMNQAGTSFPAHPSLLLHGPSGSA--FGLSVASIGDINQDGFQDIAVGAPFEGLGKVYIY 402

  Fly   422 LGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYP 486
            ..|..||...|.|.:.  .::....|...||:.||...|:|.|.:.|..:|: .::.:.|.||.|
Human   403 HSSSKGLLRQPQQVIH--GEKLGLPGLATFGYSLSGQMDVDENFYPDLLVGS-LSDHIVLLRARP 464

  Fly   487 VVKI-H-------AIIKPKL----------------QNVNPEEERVNITVCYRLSSKSDSKAKAL 527
            |:.| |       |::.|.|                |:......|.|||:.|.|.:..|.:    
Human   465 VINIVHKTLVPRPAVLDPALCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRR---- 525

  Fly   528 MEQELVIRIDIDTKSKIKLAVFDEEHGSQMSFKAKAFH------EEICSEFQ-IEMDK-RAKFTP 584
                         ..:::.|      ||:    :..||      |..|.:.: :.||. |.|..|
Human   526 -------------PPRLRFA------GSE----SAVFHGFFSMPEMRCQKLELLLMDNLRDKLRP 567

  Fly   585 IALEMQYELSKKIPNSGDF----CEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADL------- 637
            |.:.|.|.|..::|:....    .:...:::.|:.......:.|...|..| .|.::|       
Human   568 IIISMNYSLPLRMPDRPRLGLRSLDAYPILNQAQALENHTEVQFQKECGPDNKCESNLQMRAAFV 632

  Fly   638 -----KISCINASSTLVLGTTAVLRLTYNITN------NGEFAYHPKFSVTNSAGLSLAQV--PG 689
                 |:|.:..|..:     ..|.|:.|:||      :||.|:....::.....|.|:.|  ||
Human   633 SEQQQKLSRLQYSRDV-----RKLLLSINVTNTRTSERSGEDAHEALLTLVVPPALLLSSVRPPG 692

  Fly   690 NCKVNEAVMVCDLNH----GQRMAKGDTDSLTISFDV--RQLRGRSLEIQAEVLSARDESNPENN 748
            .|:.||.:. |:|.:    .|||      .|.|:|:|  ..|..|.|::|.::    ..|:.::|
Human   693 ACQANETIF-CELGNPFKRNQRM------ELLIAFEVIGVTLHTRDLQVQLQL----STSSHQDN 746

  Fly   749 KLTNVLSLREKADIYVSGVQTNDHV-------VLKESPY-TAEVVN---YYEIK----SHGPSTL 798
            ....:|:|.....:..|....|..:       |:.||.. |.|.|.   .||.:    ..|...|
Human   747 LWPMILTLLVDYTLQTSLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLVGL 811

  Fly   799 ENLTVSLYIPVAYKTPDSTNVKHIV-TSSPKIQSKYAHKIMPINFIDQNNALANNFAIDHDQSTL 862
            ..|.:.|..|.     :.:|.|.:: .:...:....:....|..  |..|.|....:...|:   
Human   812 GTLVLGLEWPY-----EVSNGKWLLYPTEITVHGNGSWPCRPPG--DLINPLNLTLSDPGDR--- 866

  Fly   863 LFSATPQHENVGNLSGIVEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPE 927
              .::||........|..:..|.::|.......:.| ||.|. |....||.:|..:.:.     .
Human   867 --PSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSET-VLTCA-TGRAHCVWLECPIPDA-----P 922

  Fly   928 ELMNMTV-------SFTVNLKDADDI----WEYFVIQTDLKVHKIGDPTLSS------FTIEKKI 975
            .:.|:||       :|..:.:|.|.:    |....::|.:       ||::.      |:::  |
Human   923 VVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSI-------PTINMENKTTWFSVD--I 978

  Fly   976 ESNVICK-HAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKRA 1018
            :|.::.: .|||.:|.::|:|..|:|:.......|:|.||||||
Human   979 DSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFKRA 1022

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS4NP_611025.2 VCBS 335..408 CDD:290251 31/75 (41%)
Int_alpha 384..434 CDD:214549 26/49 (53%)
Int_alpha 447..>492 CDD:214549 17/52 (33%)
Integrin_alpha2 484..808 CDD:285619 89/401 (22%)
ITGA3NP_002195.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 38..103 12/66 (18%)
Int_alpha 48..108 CDD:214549 11/61 (18%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 110..171 14/71 (20%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 185..235 15/80 (19%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 236..292 12/57 (21%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 293..354 22/65 (34%)
Int_alpha 304..352 CDD:214549 21/47 (45%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 356..411 27/56 (48%)
Int_alpha 365..417 CDD:214549 28/53 (53%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 415..477 18/64 (28%)
Int_alpha 430..481 CDD:214549 17/51 (33%)
Integrin_alpha2 462..916 CDD:285619 109/510 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 855..889 6/38 (16%)
Interaction with HPS5 1015..1021 4/5 (80%)
GFFKR motif 1017..1021 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142011
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.