DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS4 and ITGA2B

DIOPT Version :9

Sequence 1:NP_611025.2 Gene:ItgaPS4 / 36693 FlyBaseID:FBgn0034005 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_000410.2 Gene:ITGA2B / 3674 HGNCID:6138 Length:1039 Species:Homo sapiens


Alignment Length:1118 Identity:280/1118 - (25%)
Similarity:456/1118 - (40%) Gaps:240/1118 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 AYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS-----IMVAAPRANSSLEAQRNISEPGVI 77
            |.|:.|...:....|      ..|.|||||...:.|     |:|.|||.....:     .|.|.:
Human    31 ALNLDPVQLTFYAGP------NGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQ-----EETGGV 84

  Fly    78 FRCYFES-GNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRFYS 141
            |.|.:.: |..|.....|.:...:.:.:..|.|.|.:  :.||.::   ...||..:.|||    
Human    85 FLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKAR--QGLGASV---VSWSDVIVACAP---- 140

  Fly   142 INNENDYNNGMCYWLSDTPKNIDSTEVMEKWPL------------RIE--------KKQVLKLAD 186
                      ..:|     ..::.||..||.|:            |.|        ..::....|
Human   141 ----------WQHW-----NVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVEND 190

  Fly   187 TNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGM------ 245
            .:....|.  |.|.|:.|: ...:|::||||...:.|   |..:.|.....|. .|.|:      
Human   191 FSWDKRYC--EAGFSSVVT-QAGELVLGAPGGYYFLG---LLAQAPVADIFSS-YRPGILLWHVS 248

  Fly   246 NTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYED 310
            :.:...:..|||..:      .|:||:|:.|.|| .:|:|..||..||..:...|...|.|.|  
Human   249 SQSLSFDSSNPEYFD------GYWGYSVAVGEFD-GDLNTTEYVVGAPTWSWTLGAVEILDSY-- 304

  Fly   311 SIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLY----ALRNSYDDGAIYVFINKGSF 371
             ..:.|..||.....|||:||...|:||||:.|:::.||||    |.|...:.|.:|:|:..   
Human   305 -YQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQP--- 365

  Fly   372 TFEERIIRSPAGSG------------GRFGTTLSRIGDINKDGYNDVAVGAPF---AGNGSVFIY 421
                   |.|...|            ||||:.::.:||:::|||||:||.||:   :|.|.|.::
Human   366 -------RGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVF 423

  Fly   422 LGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYP 486
            ||...|||..|||.||:|....|     .||..|....|||.||:.|..:||..|..|.:|||.|
Human   424 LGQSEGLRSRPSQVLDSPFPTGS-----AFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQP 483

  Fly   487 VVK------IHAIIKPKLQN-VNPEEER----VNITVCYRLSSKSDSKAKALMEQELVIRIDIDT 540
            |||      :...:.|.::: |.|:.:.    .||.:|...:..:..: |..:..||.:......
Human   484 VVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQ-KLSLNAELQLDRQKPR 547

  Fly   541 KSKIKLAVFDEEHGSQMSFKAKAFHEEIC----SEFQIEMDKRAKFTPIALEMQYELSKKIPNSG 601
            :.:..|.:..::.|:.::......|..||    :..:.|.|.|.|.:||.|.:...|.   |...
Human   548 QGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLP---PTEA 609

  Fly   602 DFCEDCAVVDPAEPKFVTEYITFNTGCA-TDVCVADLKISCINASSTLVLGTTAVLRLTYNITNN 665
            ....  |||...: ..|.|.......|. .||||..|:::.....|.|::|...||.|..:..|.
Human   610 GMAP--AVVLHGD-THVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANE 671

  Fly   666 GEFAYHPKFSVTNSAGL----SLAQVPG-------NCKVNEA-VMVCDLNHGQRMAKGDTDSLTI 718
            ||.||..:.:|....|.    :|:.|.|       ..|.||. |::|:|  |..|.|.....:.:
Human   672 GEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCEL--GNPMKKNAQIGIAM 734

  Fly   719 SFDVRQLR--GRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDH----VVLKE 777
            ...|..|.  |.|:..|.::.| ::..||.:..:...:.:|.:|.:.:.|   |..    ||..|
Human   735 LVSVGNLEEAGESVSFQLQIRS-KNSQNPNSKIVLLDVPVRAEAQVELRG---NSFPASLVVAAE 795

  Fly   778 ---------SPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPK--IQS 831
                     ..:..:|.:.||:.::||.|:..|.:|:::|...:..|   :.:|:...|:  :|.
Human   796 EGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSD---LLYILDIQPQGGLQC 857

  Fly   832 KYAHKIMPINFIDQNNALANNFAI-------DHDQSTLLFSATPQHENVGNLSGIVEQNPSISLL 889
            .....:.|:. :|....:.:...|       |..|..|     |:.|....|     |:|     
Human   858 FPQPPVNPLK-VDWGLPIPSPSPIHPAHHKRDRRQIFL-----PEPEQPSRL-----QDP----- 906

  Fly   890 NEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIW------- 947
                     ::::|....   |..|:..|:.  ..:.:..|...::|         :|       
Human   907 ---------VLVSCDSAP---CTVVQCDLQE--MARGQRAMVTVLAF---------LWLPSLYQR 948

  Fly   948 --EYFVIQT----DLKVHKIGDPTLSSFTIEKKIESNVI--CKHAEIAIWKIIVSVIVGILVFSA 1004
              :.||:|:    ::.......|.||....|.::.:.::  .:...|.||.::|.|:.|:|:.:.
Human   949 PLDQFVLQSHAWFNVSSLPYAVPPLSLPRGEAQVWTQLLRALEERAIPIWWVLVGVLGGLLLLTI 1013

  Fly  1005 ATYALYKRGFFKR 1017
            ...|::|.|||||
Human  1014 LVLAMWKVGFFKR 1026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS4NP_611025.2 VCBS 335..408 CDD:290251 29/88 (33%)
Int_alpha 384..434 CDD:214549 25/64 (39%)
Int_alpha 447..>492 CDD:214549 20/50 (40%)
Integrin_alpha2 484..808 CDD:285619 87/366 (24%)
ITGA2BNP_000410.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96 19/71 (27%)
Int_alpha 46..102 CDD:214549 18/60 (30%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 110..173 17/86 (20%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 187..238 15/57 (26%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 251..305 20/63 (32%)
Int_alpha 262..>302 CDD:214549 15/46 (33%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 306..371 25/74 (34%)
Int_alpha 316..367 CDD:214549 20/60 (33%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 373..432 22/58 (38%)
Int_alpha 384..438 CDD:214549 26/53 (49%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 435..496 26/65 (40%)
Int_alpha 445..>485 CDD:214549 18/44 (41%)
Integrin_alpha2 481..921 CDD:285619 106/483 (22%)
Integrin_alpha 1020..1034 CDD:278771 6/7 (86%)
GFFKR motif 1022..1026 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142020
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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