Protein Alignment ItgaPS4 and ITGA2B

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: XP_011523051.2
• Gene: ITGA2B / 3674
• HGNCID: 6138
• Length: 1056
• Species: Homo sapiens
• Alignment Length: 1105
• Identity: 276/1105 - (24%)
• Similarity: 445/1105 - (40%)
• Gaps: 248/1105 - (22%)

  Fly    18 AYNISPYPNSVLNFPELEGNRRSSYFGFSLVIREKS-----IMVAAPRANSSLEAQRNISEPGVI 77
            |.|:.|...:....|      ..|.|||||...:.|     |:|.|||.....:     .|.|.:
Human    82 ALNLDPVQLTFYAGP------NGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQ-----EETGGV 135

  Fly    78 FRCYFES-GNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRFYS 141
            |.|.:.: |..|.....|.:...:.:.:..|.|.|.:  :.||.::   ...||..:.|||
Human   136 FLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKAR--QGLGASV---VSWSDVIVACAP---- 191

  Fly   142 INNENDYNNGMCYWLSDTPKNIDSTEVMEKWPL------------RIE--------KKQVLKLAD 186
                      ..:|     ..::.||..||.|:            |.|        ..::....|
Human   192 ----------WQHW-----NVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVEND 241

  Fly   187 TNLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGM------ 245
            .:....|.  |.|.|:.|: ...:|::||||...:.|   |..:.|.....|. .|.|:
Human   242 FSWDKRYC--EAGFSSVVT-QAGELVLGAPGGYYFLG---LLAQAPVADIFSS-YRPGILLWHVS 299

  Fly   246 NTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYED 310
            :.:...:..|||..:      .|:||:|:.|.|| .:|:|..||..||..:...|...|.|.|
Human   300 SQSLSFDSSNPEYFD------GYWGYSVAVGEFD-GDLNTTEYVVGAPTWSWTLGAVEILDSY-- 355

  Fly   311 SIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLY----ALRNSYDDGAIYVFINKGSF 371
             ..:.|..||.....|||:||...|:||||:.|:::.||||    |.|...:.|.:|:|:..
Human   356 -YQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQP--- 416

  Fly   372 TFEERIIRSPAGSG------------GRFGTTLSRIGDINKDGYNDVAVGAPF---AGNGSVFIY 421
                   |.|...|            ||||:.::.:||:::|||||:||.||:   :|.|.|.::
Human   417 -------RGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVF 474

  Fly   422 LGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYP 486
            ||...|||..|||.||:|....|     .||..|....|||.||:.|..:||..|..|.:|||.|
Human   475 LGQSEGLRSRPSQVLDSPFPTGS-----AFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQP 534

  Fly   487 VVK------IHAIIKPKLQN-VNPEEER----VNITVCYRLSSKSDSKAKALMEQELVIRIDIDT 540
            |||      :...:.|.::: |.|:.:.    .||.:|...:..:..: |..:..||.:......
Human   535 VVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQ-KLSLNAELQLDRQKPR 598

  Fly   541 KSKIKLAVFDEEHGSQMSFKAKAFHEEIC----SEFQIEMDKRAKFTPIALEMQYELSKKIPNSG 601
            :.:..|.:..::.|:.::......|..||    :..:.|.|.|.|.:||.|.:...|.   |...
Human   599 QGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMAFLRDEADFRDKLSPIVLSLNVSLP---PTEA 660

  Fly   602 DFCEDCAVVDPAEPKFVTEYITFNTGCA-TDVCVADLKISCINASSTLVLGTTAVLRLTYNITNN 665
            ....  |||...: ..|.|.......|. .||||..|:::.....|.|::|...||.|..:..|.
Human   661 GMAP--AVVLHGD-THVQEQTRIVLDCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANE 722

  Fly   666 GEFAYHPKFSVTNSAGL----SLAQVPG-------NCKVNEA-VMVCDLNHGQRMAKGDTDSLTI 718
            ||.||..:.:|....|.    :|:.|.|       ..|.||. |::|:|  |..|.|.....:.:
Human   723 GEGAYEAELAVHLPQGAHYMRALSNVEGFERLICNQKKENETRVVLCEL--GNPMKKNAQIGIAM 785

  Fly   719 SFDVRQLR--GRSLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTNDH----VVLKE 777
            ...|..|.  |.|:..|.::.| ::..||.:..:...:.:|.:|.:.:.|   |..    ||..|
Human   786 LVSVGNLEEAGESVSFQLQIRS-KNSQNPNSKIVLLDVPVRAEAQVELRG---NSFPASLVVAAE 846

  Fly   778 ---------SPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPK--IQS 831
                     ..:..:|.:.||:.::||.|:..|.:|:::|...:..|   :.:|:...|:  :|.
Human   847 EGEREQNSLDSWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSD---LLYILDIQPQGGLQC 908

  Fly   832 KYAHKIMPINFIDQNNALANNFAI-------DHDQSTLLFSATPQHENVGNLSGIVEQNPSISLL 889
            .....:.|:. :|....:.:...|       |..|..|     |:.|....|     |:|
Human   909 FPQPPVNPLK-VDWGLPIPSPSPIHPAHHKRDRRQIFL-----PEPEQPSRL-----QDP----- 957

  Fly   890 NEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIW--EYFVI 952
                     ::::|....   |..|:..|:.  ..:.:..|...::|         :|  ..:.:
Human   958 ---------VLVSCDSAP---CTVVQCDLQE--MARGQRAMVTVLAF---------LWLPSLYQV 999

  Fly   953 QTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKRGFFKR 1017
            .|.|.               :.:|...      |.||.::|.|:.|:|:.:....|::|.|||||
Human  1000 WTQLL---------------RALEERA------IPIWWVLVGVLGGLLLLTILVLAMWKVGFFKR 1043

  Fly  1018  1017
            Human  1044  1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	29/88 (33%)
		Int_alpha	384..434	CDD:214549	25/64 (39%)
		Int_alpha	447..>492	CDD:214549	20/50 (40%)
		Integrin_alpha2	486..808	CDD:462478	86/364 (24%)
ITGA2B	XP_011523051.2	Int_alpha	97..153	CDD:214549	18/60 (30%)
		Int_alpha	313..>353	CDD:214549	15/46 (33%)
		Int_alpha	367..418	CDD:214549	20/60 (33%)
		Int_alpha	435..489	CDD:214549	26/53 (49%)
		Int_alpha	496..>536	CDD:214549	18/44 (41%)
		Integrin_alpha2	533..972	CDD:462478	105/482 (22%)
		Integrin_alpha	1037..1051	CDD:459778	6/7 (86%)