Protein Alignment ItgaPS4 and ITGA2

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_002194.2
• Gene: ITGA2 / 3673
• HGNCID: 6137
• Length: 1181
• Species: Homo sapiens
• Alignment Length: 1123
• Identity: 263/1123 - (23%)
• Similarity: 445/1123 - (39%)
• Gaps: 295/1123 - (26%)

  Fly    54 IMVAAPRANS--SLEAQRNISEPGVIFRCYFESGNNCSP-----------------YNIDTKGNY 99
            ::|....:||  ..:|.:|..|.       |..|.:..|                 :|::|   |
Human   175 VVVVCDESNSIYPWDAVKNFLEK-------FVQGLDIGPTKTQVGLIQYANNPRVVFNLNT---Y 229

  Fly   100 KGMPNDGLLTAKNKDF---------------RWLGGAMDGGTRDSDKFLVCAPRFYS-------- 141
            |......:.|::...:               ::...|..||.|.:.|.:|......|
Human   230 KTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKA 294

  Fly   142 ----INNENDYNNGMCY--WLS----DTPKNIDSTEVMEKWPLR------------IEK-----K 179
                .|::|....|:..  :|:    ||...|...:.:...|..            :||     :
Human   295 VIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGE 359

  Fly   180 QVLKLADT-----NLIPYYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSG 239
            |:..:..|     |.  ...|.::|.||..|..|..|::||.|...|.|::       ..|||.|
Human   360 QIFSIEGTVQGGDNF--QMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTI-------VQKTSHG 415

  Fly   240 RQRRGMNTNRKCNECNPEPKNFGQEEF----------SYFGY---AVSSGYFDSSNLSTVLYVAT 291
            .                  ..|.::.|          ||.||   |:|:|  :|::     :||.
Human   416 H------------------LIFPKQAFDQILQDRNHSSYLGYSVAAISTG--ESTH-----FVAG 455

  Fly   292 APRGNNQFGEAYIFDIYED---SIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDV-IISAPLYA 352
            |||. |..|:..::.:.|:   ::.:.|  ||:..|.|||..:.:.|::.|..||| ::.||:|.
Human   456 APRA-NYTGQIVLYSVNENGNITVIQAH--RGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYM 517

  Fly   353 LRNSYDDGAIYVFINKGSFTFEERIIRSPAG-SGGRFGTTLSRIGDINKDGYNDVAVGAPF--AG 414
            .....::|.:|:|..|.....:.:.:..|.| ...|||:.::.:.|||.||:|||.||:|.  ..
Human   518 SDLKKEEGRVYLFTIKEGILGQHQFLEGPEGIENTRFGSAIAALSDINMDGFNDVIVGSPLENQN 582

  Fly   415 NGSVFIYLGSENGLRDPPSQCL---DAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNA 476
            :|:|:||.|.:..:|...||.:   |...:...:|    ||..|....|::|:...|.:||| ..
Human   583 SGAVYIYNGHQGTIRTKYSQKILGSDGAFRSHLQY----FGRSLDGYGDLNGDSITDVSIGA-FG 642

  Fly   477 EAVYLY-RAYPVVKIHAIIKP-KLQNVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIRIDID 539
            :.|.|: ::...|.|.|...| |:..|| :..::.:.:|:   |......|...:..:|..|.:|
Human   643 QVVQLWSQSIADVAIEASFTPEKITLVN-KNAQIILKLCF---SAKFRPTKQNNQVAIVYNITLD 703

  Fly   540 TKSKIKLAVFDEEHGSQMSFKAKAFHEEICSEFQIEMDKRAKFTPIALEMQYELSKKIPNSGDFC 604
            ...      |.....|:..||.   :.|.|.:..:.:: :|:..|..:....|.| .:.||.|..
Human   704 ADG------FSSRVTSRGLFKE---NNERCLQKNMVVN-QAQSCPEHIIYIQEPS-DVVNSLDLR 757

  Fly   605 EDCAVVDPAEPKFVTEY--------ITFNTGCATD-VCVADL-----KISCINASSTLVLGTTAV 655
            .|.::.:|.....:..|        |.|:..|..| :|::||     :|........:|.....
Human   758 VDISLENPGTSPALEAYSETAKVFSIPFHKDCGEDGLCISDLVLDVRQIPAAQEQPFIVSNQNK- 821

  Fly   656 LRLTYNIT--NNGEFAYHPKFSVTNSAGLSLAQ----VPG---NCKV--NEAVMVCDLNHGQRMA 709
             |||:::|  |..|.||:....|..|..|..|.    |.|   .|:|  ::..:.||:.: ..:.
Human   822 -RLTFSVTLKNKRESAYNTGIVVDFSENLFFASFSLPVDGTEVTCQVAASQKSVACDVGY-PALK 884

  Fly   710 KGDTDSLTISFD--VRQLRGR-SLEIQAEVLSARDESNPENNKLTNVLSLREKADIYVSGVQTND 771
            :....:.||:||  ::.|:.: ||..||  ||...|.|..:|.:...:.|...|:|:::. .||
Human   885 REQQVTFTINFDFNLQNLQNQASLSFQA--LSESQEENKADNLVNLKIPLLYDAEIHLTR-STN- 945

  Fly   772 HVVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVKHIVTSSPKIQSKYAHK 836
                         :|:|||.|.|                       ||..||.|...:..|:...
Human   946 -------------INFYEISSDG-----------------------NVPSIVHSFEDVGPKFIFS 974

  Fly   837 I------MPINFIDQNNALANNFAIDH------DQSTLLFSATPQHENVGNLSGIVEQNP----- 884
            :      :|::...         .|.|      :::.|::....|.:..|::|...:.||
Human   975 LKVTTGSVPVSMAT---------VIIHIPQYTKEKNPLMYLTGVQTDKAGDISCNADINPLKIGQ 1030

  Fly   885 ---SISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSF---------- 936
               |:|..:|:.  .:|..|||:..:   |..|...|:: :.:|.|..:|:|...
Human  1031 TSSSVSFKSENF--RHTKELNCRTAS---CSNVTCWLKD-VHMKGEYFVNVTTRIWNGTFASSTF 1089

  Fly   937 -TVNLKDADDIWEYFVIQTDLKVHKIGDPTLS-SFTIEKKIESNVICKHAEIAIWKIIVSVIVGI 999
             ||.|..|.:|..|     :.:::.|.|.|:: ...|.|..|.      ||:....||.|:|.||
Human  1090 QTVQLTAAAEINTY-----NPEIYVIEDNTVTIPLMIMKPDEK------AEVPTGVIIGSIIAGI 1143

  Fly  1000 LVFSAATYALYKRGFFKR 1017
            |:..|....|:|.|||||
Human  1144 LLLLALVAILWKLGFFKR 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	25/74 (34%)
		Int_alpha	384..434	CDD:214549	20/51 (39%)
		Int_alpha	447..>492	CDD:214549	13/45 (29%)
		Integrin_alpha2	486..808	CDD:462478	81/350 (23%)
ITGA2	NP_002194.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	34..92
		Int_alpha	47..95	CDD:214549
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	101..161
		vWA_integrins_alpha_subunit	173..353	CDD:238746	29/187 (16%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	366..420		18/80 (23%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	423..475		17/59 (29%)
		Int_alpha	433..475	CDD:214549	16/49 (33%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	477..539		19/63 (30%)
		Int_alpha	487..>532	CDD:214549	15/44 (34%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	540..598		21/57 (37%)
		Int_alpha	551..604	CDD:214549	22/52 (42%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	602..664		17/66 (26%)
		Int_alpha	614..>642	CDD:214549	10/32 (31%)
		Integrin_alpha2	655..1060	CDD:462478	105/476 (22%)
		Interaction with HPS5	1155..1161		4/5 (80%)
		GFFKR motif	1157..1161		3/3 (100%)