Protein Alignment ItgaPS4 and ITGA1

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_852478.1
• Gene: ITGA1 / 3672
• HGNCID: 6134
• Length: 1179
• Species: Homo sapiens
• Alignment Length: 1053
• Identity: 235/1053 - (22%)
• Similarity: 411/1053 - (39%)
• Gaps: 239/1053 - (22%)

  Fly    96 KGNYKGMPNDGLLTAKNKDFRWLGGA-----------MDGGTRDSDKFLV----CAP---RFYSI 142
            :|..:.|...|:.||:.:.|....||           .||.:.|:.:...    |..   :.:||
Human   243 RGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNHRLKKVIQDCEDENIQRFSI 307

  Fly   143 NNENDYNNGMCYWLSDTPKNID-----STEVMEKWPLRIEKKQVL---------------KLADT 187
            .....||.|..    .|.|.::     ::|..||....:..:..|               ..||.
Human   308 AILGSYNRGNL----STEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEATADQ 368

  Fly   188 NLIPY-YSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQE----VPSIKTSSGRQRRGMNT 247
            :...: ..|.:.|.|||.|.|  .:::||.|...|.|:|.:::.    :|            .||
Human   369 SAASFEMEMSQTGFSAHYSQD--WVMLGAVGAYDWNGTVVMQKASQIIIP------------RNT 419

  Fly   248 NRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIFDIYEDSI 312
            .     .|.|.....:...||.||.|:|....|.:   |||:|..||.|:. |:..|:.:.:.:|
Human   420 T-----FNVESTKKNEPLASYLGYTVNSATASSGD---VLYIAGQPRYNHT-GQVIIYRMEDGNI 475

  Fly   313 YKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDV-IISAPLYALRNSYDDGAIYVF-INKGSFTFE- 374
            .......|...|.|||..:...|::.|..||: ::.||:|......:.|.:||: :|:..|.::
Human   476 KILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQGKVYVYALNQTRFEYQM 540

  Fly   375 --ERIIRSPAGS---------------GGRFGTTLSRIGDINKDGYNDVAVGAPFAGN--GSVFI 420
              |.|.::...|               |.||||.::.:.|:|.||:||:.:|||...:  |:|:|
Human   541 SLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVIGAPLEDDHGGAVYI 605

  Fly   421 YLGSENGLRDPPSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAY 485
            |.||...:|...:|.:  ||....|...: ||..:....|::|:|..|..||.....|::..|..
Human   606 YHGSGKTIRKEYAQRI--PSGGDGKTLKF-FGQSIHGEMDLNGDGLTDVTIGGLGGAALFWSRDV 667

  Fly   486 PVVKIHAIIKPKLQNV--------NPEEERVNITVCY--RLSSKSDSKAKALMEQELVIRIDIDT 540
            .|||:....:|...|:        ..|...:|.|||:  :|.||.|:    :.|.:|..|:.:|:
Human   668 AVVKVTMNFEPNKVNIQKKNCHMEGKETVCINATVCFDVKLKSKEDT----IYEADLQYRVTLDS 728

  Fly   541 KSKIKLAVFD--EEHGSQMSFKAKAFHEEICSEFQIEM-DKRAKFTPIALEMQYELSKKIPNSGD 602
            ..:|..:.|.  :|...|.:...:   :..|::....| ||......:.:.:.:.|:.  |.:|
Human   729 LRQISRSFFSGTQERKVQRNITVR---KSECTKHSFYMLDKHDFQDSVRITLDFNLTD--PENG- 787

  Fly   603 FCEDCAVVDPAEPKFVTEYITFNTGCAT-DVCVADLKISCINASSTLVL--GTTAVLRLTYNITN 664
                 .|:|.:.|..|.|||.|...|.. :.|::||.:........|::  .......::..:.|
Human   788 -----PVLDDSLPNSVHEYIPFAKDCGNKEKCISDLSLHVATTEKDLLIVRSQNDKFNVSLTVKN 847

  Fly   665 NGEFAYHPKFSVTNSAGLSLAQVPGNCKVNEAVM--VCDLNHG-------QRMAKGD--TDSLTI 718
            ..:.||:.:..|..|..|..:.:       ||:.  .|:.||.       ..:.:|:  |..:..
Human   848 TKDSAYNTRTIVHYSPNLVFSGI-------EAIQKDSCESNHNITCKVGYPFLRRGEMVTFKILF 905

  Fly   719 SFDVRQLRGRSLEIQAEVLSA-RDESNPENNKLTNVLSLREKADIYVSGVQ-----TNDHVVLKE 777
            .|:...|    :|.....||| .|...|......||:::..... |..|:|     :..|:.:..
Human   906 QFNTSYL----MENVTIYLSATSDSEEPPETLSDNVVNISIPVK-YEVGLQFYSSASEYHISIAA 965

  Fly   778 SPYTAEVVN-----------YYEIKSHGPSTLENLTVSLYI--------PVAYKT----PDSTNV 819
            :....||:|           :|.|:..|...:..|.:|:..        ||.|.|    .::.|.
Human   966 NETVPEVINSTEDIGNEINIFYLIRKSGSFPMPELKLSISFPNMTSNGYPVLYPTGLSSSENANC 1030

  Fly   820 KHIVTSSPKIQSKYAHKIMPINFIDQNNALANNFAIDH-DQSTLLFSATPQHENVG-NLSGIVEQ 882
            :..:...|               ...|:......:.|| .:.|:|...|.:...:. ||:
Human  1031 RPHIFEDP---------------FSINSGKKMTTSTDHLKRGTILDCNTCKFATITCNLT----- 1075

  Fly   883 NPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDADDIW 947
            :..||.:|..|.:.....:....:::.|.:..|:|.||.         ::.:| :.|.|.
Human  1076 SSDISQVNVSLILWKPTFIKSYFSSLNLTIRGELRSENA---------SLVLS-SSNQKR----- 1125

  Fly   948 EYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGILVFSAATYALYKR 1012
                 :..:::.|.|.|                   ..:.:|.|::|...|:|:......||:|.
Human  1126 -----ELAIQISKDGLP-------------------GRVPLWVILLSAFAGLLLLMLLILALWKI 1166

  Fly  1013 GFFKRAIKDDLKQ 1025
            |||||.:|..:::
Human  1167 GFFKRPLKKKMEK 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	26/92 (28%)
		Int_alpha	384..434	CDD:214549	22/66 (33%)
		Int_alpha	447..>492	CDD:214549	13/44 (30%)
		Integrin_alpha2	486..808	CDD:462478	77/373 (21%)
ITGA1	NP_852478.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	30..91
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	101..160
		vWA_integrins_alpha_subunit	171..351	CDD:238746	23/111 (21%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	365..417		16/65 (25%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	422..475		18/56 (32%)
		Int_alpha	434..474	CDD:214549	16/43 (37%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	476..538		17/61 (28%)
		Int_alpha	486..>529	CDD:214549	13/42 (31%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	557..615		20/57 (35%)
		Int_alpha	568..621	CDD:214549	22/52 (42%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	619..679		17/62 (27%)
		Integrin_alpha2	665..1033	CDD:462478	83/394 (21%)
		GFFKR motif	1167..1171		3/3 (100%)