DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and scb

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster

Alignment Length:	1132	Identity:	578/1132 - (51%)
Similarity:	761/1132 - (67%)	Gaps:	107/1132 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFCLLVIVLLALQSEINAYNISPYPNSVLNFPE-LE---GNRRSSYFGFSLVIREKSIMVAAPRA 61
            ||..:.:.||||.|.|.|:|..|.|:.|:|.|: |:   ...||||||::||||:.||:|.||||
  Fly     7 MFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTSIIVGAPRA 71

  Fly    62 NSSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGT 126
            .|:||:||.|:|.|.|:||...:| .||||.:|::||.....::....::.|||:||||:|||||
  Fly    72 QSTLESQRTINETGAIYRCSLTNG-VCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGT 135

  Fly   127 RDSDKFLVCAPRFYSINNENDYNNGMCYWLSD----TPKNIDSTEVMEKWPLRIEKKQVLKLADT 187
            :|:||.||||||||:.::.:::.:|:|||:::    ||:::  |.:.   |||::.:||.:..:.
  Fly   136 KDTDKLLVCAPRFYAPSSRDNHLHGVCYWVNNTVASTPQHV--TRIS---PLRLKSEQVKEEDNG 195

  Fly   188 NLIP-YYSMGELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRK- 250
            |... :|.||||||||||:|||:|.|:|||||:.|:|||.|.::|..:...:..:|......|:
  Fly   196 NKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRT 260

  Fly   251 -----CNECNPE--------PKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEA 302
                 .|:..||        |..:||||.||||||||||:|||||.:.:|||||||:.|.|.|||
  Fly   261 YRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEA 325

  Fly   303 YIFDIYEDSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDGAIYVFIN 367
            ||||:...||:|||.|||..|||||||||||||||||||||||:|||.:||.:|:|:||||||||
  Fly   326 YIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFIN 390

  Fly   368 KGSFTFEERIIRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIYLGSENGLRDPP 432
            ||.|.||.:|:|||..:..||||.|||:||||.||||||||||||||||:|||||||||||||.|
  Fly   391 KGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQP 455

  Fly   433 SQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPK 497
            ||.|||||||||||||:||||||||||||||||||||||||||||||||||||||||:||.:|.:
  Fly   456 SQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSE 520

  Fly   498 LQNVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSKIKLAVFDEEHGSQMSFKAK 562
            .:.:.||:|:|.||.|||||:.|..  |.:.||||.|||.:|  .::|...|.:...:::|||..
  Fly   521 SREIKPEQEKVKITACYRLSTTSTD--KLVQEQELAIRIAMD--KQLKRVKFTQTQTNEISFKVN 581

  Fly   563 AFHEEICSEF--QIEMDKRAKFTPIALEMQYELSKKIPNSGDFCEDCAVVDPAEPKFVTEYITFN 625
            |...|.|.:|  |:...::..||||.|||.|||:||:|:|.:|||.||:|||.|||..|:.|.|:
  Fly   582 ANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFS 646

  Fly   626 TGCATDVCVADLKISCINASSTLVLGTTAVLRLTYNITNNGEFAYHPKFSVTNSAGLSLAQVPGN 690
            ||||||||.|||::...:.|.|.:||:...|||.|.|||.||.||.|:|:||:::.|:.||||||
  Fly   647 TGCATDVCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGN 711

  Fly   691 CKVNEAVMVCDLNHGQRMAKGDTDSLTISFDVRQLRGRSLEIQAEVLSARDESNPENNKLTNVLS 755
            |||.:||||||||.|:.:|||||||:||||||.||.|:||.|.|||.|...|.||.:|:.|||:.
  Fly   712 CKVVDAVMVCDLNRGRPLAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIG 776

  Fly   756 LREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLENLTVSLYIPVAYKTPDSTNVK 820
            |:|..:|..||.|||..:.|:....:||:||.|||||:|||.:|.||||.|||:|||...||.:.
  Fly   777 LKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAII 841

  Fly   821 HIV-TSSPKIQSKYAHKIMPINFIDQNNAL----------------------ANNFAID-----H 857
            .|: .:|.|:|:.|..:::.|:..||||.:                      .|..:.|     |
  Fly   842 PIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGH 906

  Fly   858 DQSTL-------------------LFSATPQHENVGNLSGIVEQNPSISLLNED----LPVNNTL 899
            ...|:                   |.:.|...|....:|.:...:    ||::|    ||||.|:
  Fly   907 VHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHD----LLSDDFKGKLPVNRTI 967

  Fly   900 VLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNLKDAD----DIWEYFVIQTDLKVHK 960
            |.||:|..:|:||..|:|    :..:||:.:|:.:.::|:|.:.:    |.||||||.||||:.|
  Fly   968 VFNCRDPEMTICVRAEMR----VHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQK 1028

  Fly   961 IGDPTLSSFTIEKKIESNVICKHAE--IAIWKIIVSVIVGILVFSAATYALYKRGFFKRAIKDDL 1023
            .||||.:||:|.::||.|:|.||.|  :.||.||||||.|:|:.||.:|.|||.|||.|..||:|
  Fly  1029 KGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDEL 1093

  Fly  1024 KQLIRDSFEDGIIRTEME-ENAQSQGD 1049
            .:|::.:      ..|.| ||..|.|:
  Fly  1094 DRLVQQN------PVEPEAENLNSGGN 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	52/72 (72%)
		Int_alpha	384..434	CDD:214549	41/49 (84%)
		Int_alpha	447..>492	CDD:214549	42/44 (95%)
		Integrin_alpha2	484..808	CDD:285619	174/325 (54%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	31/52 (60%)
		FG-GAP	350..388	CDD:280083	30/37 (81%)
		Int_alpha	409..459	CDD:214549	43/49 (88%)
		Int_alpha	473..>515	CDD:214549	40/41 (98%)
		Integrin_alpha2	507..829	CDD:285619	174/325 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470094
Domainoid	1	1.000	61	1.000	Domainoid score	I10420
eggNOG	1	0.900	-	-		E1_KOG3637
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	724	1.000	Inparanoid score	I1731
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27051
OrthoDB	1	1.010	-	-		D10102at7147
OrthoFinder	1	1.000	-	-		FOG0012678
OrthoInspector	1	1.000	-	-		mtm9718
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10533
	11	10.910