DRSC/TRiP Functional Genomics Resources

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Protein Alignment ItgaPS4 and ITGA6

DIOPT Version :9

Sequence 1:NP_611025.2 Gene:ItgaPS4 / 36693 FlyBaseID:FBgn0034005 Length:1069 Species:Drosophila melanogaster
Sequence 2:NP_001381857.1 Gene:ITGA6 / 3655 HGNCID:6142 Length:1130 Species:Homo sapiens


Alignment Length:1192 Identity:280/1192 - (23%)
Similarity:458/1192 - (38%) Gaps:283/1192 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 CLLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIR-------EKSIMVAAPR 60
            |||.:....|.....|:|:....::|:.    :.....|.|||||.:.       ::.::|.|||
Human     8 CLLYLSAGLLSRLGAAFNLDTREDNVIR----KYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPR 68

  Fly    61 ANSSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMD-- 123
            | .:|..|| .:..|.::.|...:...|:....|         ||...|:::|:.:|:|..:.  
Human    69 A-EALPLQR-ANRTGGLYSCDITARGPCTRIEFD---------NDADPTSESKEDQWMGVTVQSQ 122

  Fly   124 --GGTRDSDKFLVCAPRF---YSINNENDYNN--GMCYWLSDTPKNIDSTEVME--KWPLRIEKK 179
              ||     |.:.||.|:   ..:|.:.:..:  |.||.||   :|:...:.|:  .|       
Human   123 GPGG-----KVVTCAHRYEKRQHVNTKQESRDIFGRCYVLS---QNLRIEDDMDGGDW------- 172

  Fly   180 QVLKLADTNLIPYYSMG--ELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQE------------ 230
               ...|..|..:...|  :.|::|..:.|...::.||||...|||.|.::|:            
Human   173 ---SFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFED 234

  Fly   231 -----------------VPS---------------------IKTSSGRQRRGMNTNRKCNECNPE 257
                             ||:                     .||...|:               :
Human   235 GPYEVGGETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPRE---------------Q 284

  Fly   258 PKNFGQEEF-SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIF--DIYEDSIYKYHEFR 319
            |..|..... ||.|:::.||....|. ..:.:|:.|||.|:. |...:.  |:....:...|.|.
Human   285 PDTFPDVMMNSYLGFSLDSGKGIVSK-DEITFVSGAPRANHS-GAVVLLKRDMKSAHLLPEHIFD 347

  Fly   320 GNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDGAIYVFINKGSFTFEERIIRSPAGS 384
            |......|||.|...|||.||..|::|.||.|..|:....||:||::|:.......:.||.....
Human   348 GEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTK 412

  Fly   385 GGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSY 449
            ...||..:..|||||:|||.|:|||||:...|.||||.||.||:...|:|.|        |..|.
Human   413 DSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVL--------KGISP 469

  Fly   450 MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEEERVNIT--- 511
            .||:.::...|:|.|.:.|.|:|: .:::|.::|:.||:.|...|     .|.|  .|:::.   
Human   470 YFGYSIAGNMDLDRNSYPDVAVGS-LSDSVTIFRSRPVINIQKTI-----TVTP--NRIDLRQKT 526

  Fly   512 -------VCYRLSSKSDSKAK-----------ALMEQELVIRIDIDTKSKIKLAVFDEEHGSQMS 558
                   :|.::.|..:..|.           ..:|.|...|     ||.:...|.....||:..
Human   527 ACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERR-----KSGLSSRVQFRNQGSEPK 586

  Fly   559 F----KAKAFHEEICSE--FQIEMDKRAKFTPI----ALEMQYELSKKIPNSGDFCEDCAVVDPA 613
            :    ..|...:::|.|  ..::.:.|.|..||    ::|:|...|::..||  ..|...:::..
Human   587 YTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNS--LPEVLPILNSD 649

  Fly   614 EPKFVTEYIT---FNTGCATD-VCVADLKIS---CINASS--------------TLVLGTTAVLR 657
            |||  |.:|.   ...||..| ||.::||:.   |....:              .|||.....:.
Human   650 EPK--TAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIA 712

  Fly   658 LTYNITN----------NGEFAYHPKF------SVTNSAGLSLAQVPG---NCKVNE--AVMVCD 701
            |...:||          :|:.|:..|.      ::|.||...|...|.   :|..|:  :...|:
Human   713 LEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCE 777

  Fly   702 LNHGQRMAKGDTDSLTIS-----FDVRQLRGRSLEIQAEVLSARDESNPENNK-------LTNVL 754
            |.:..:.....|..|.:|     ||...|   .:.::.|..|.:|...|...|       |.:|.
Human   778 LGNPFKRNSNVTFYLVLSTTEVTFDTPDL---DINLKLETTSNQDNLAPITAKAKVVIELLLSVS 839

  Fly   755 SLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLENL-TVSLYIPVAYKTPDSTN 818
            .:.:.:.:|..|....:..:..|....:.:...:.:.:.| ..|.|| |.:|.|....:..:...
Human   840 GVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLG-KPLTNLGTATLNIQWPKEISNGKW 903

  Fly   819 VKHIVTSSPKIQSKYAHK--------IMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGN 875
            :.::|    |::||...|        |..:|..:.:|:.... .|...|                
Human   904 LLYLV----KVESKGLEKVTCEPQKEINSLNLTESHNSRKKR-EITEKQ---------------- 947

  Fly   876 LSGIVEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKP-----EELMNMTVS 935
                ::.|...||..|    .....||| ..||. ||.:...| .||..|.     ..|.|.|..
Human   948 ----IDDNRKFSLFAE----RKYQTLNC-SVNVN-CVNIRCPL-RGLDSKASLILRSRLWNSTFL 1001

  Fly   936 FTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGIL 1000
            ...:..:..||.....|........|..|...:........|..:.:::.:..|.|:|:::.|||
Human  1002 EEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGIL 1066

  Fly  1001 VFSAATYALYKRGFFKRAIKDD 1022
            :.:...:.|:|.|||||:..||
Human  1067 MLALLVFILWKCGFFKRSRYDD 1088

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ItgaPS4NP_611025.2 VCBS 335..408 CDD:290251 29/72 (40%)
Int_alpha 384..434 CDD:214549 26/49 (53%)
Int_alpha 447..>492 CDD:214549 14/44 (32%)
Integrin_alpha2 484..808 CDD:285619 84/409 (21%)
ITGA6NP_001381857.1 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 30..95 17/70 (24%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 101..166 19/72 (26%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 176..229 15/52 (29%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 283..339 15/72 (21%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 340..402 23/61 (38%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 403..458 27/54 (50%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 459..518 21/74 (28%)
Interaction with HPS5 1077..1083 4/5 (80%)
GFFKR motif 1079..1083 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142032
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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