Protein Alignment ItgaPS4 and ITGA6

DIOPT Version :10

• Sequence 1: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Sequence 2: NP_001381857.1
• Gene: ITGA6 / 3655
• HGNCID: 6142
• Length: 1130
• Species: Homo sapiens
• Alignment Length: 1192
• Identity: 280/1192 - (23%)
• Similarity: 458/1192 - (38%)
• Gaps: 283/1192 - (23%)

  Fly     3 CLLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLVIR-------EKSIMVAAPR 60
            |||.:....|.....|:|:....::|:.    :.....|.|||||.:.       ::.::|.|||
Human     8 CLLYLSAGLLSRLGAAFNLDTREDNVIR----KYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPR 68

  Fly    61 ANSSLEAQRNISEPGVIFRCYFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMD-- 123
            | .:|..|| .:..|.::.|...:...|:....|         ||...|:::|:.:|:|..:.
Human    69 A-EALPLQR-ANRTGGLYSCDITARGPCTRIEFD---------NDADPTSESKEDQWMGVTVQSQ 122

  Fly   124 --GGTRDSDKFLVCAPRF---YSINNENDYNN--GMCYWLSDTPKNIDSTEVME--KWPLRIEKK 179
              ||     |.:.||.|:   ..:|.:.:..:  |.||.||   :|:...:.|:  .|
Human   123 GPGG-----KVVTCAHRYEKRQHVNTKQESRDIFGRCYVLS---QNLRIEDDMDGGDW------- 172

  Fly   180 QVLKLADTNLIPYYSMG--ELGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQE------------ 230
               ...|..|..:...|  :.|::|..:.|...::.||||...|||.|.::|:
Human   173 ---SFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFED 234

  Fly   231 -----------------VPS---------------------IKTSSGRQRRGMNTNRKCNECNPE 257
                             ||:                     .||...|:               :
Human   235 GPYEVGGETEHDESLVPVPANSYLGLLFLTSVSYTDPDQFVYKTRPPRE---------------Q 284

  Fly   258 PKNFGQEEF-SYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIF--DIYEDSIYKYHEFR 319
            |..|..... ||.|:::.||....|. ..:.:|:.|||.|:. |...:.  |:....:...|.|.
Human   285 PDTFPDVMMNSYLGFSLDSGKGIVSK-DEITFVSGAPRANHS-GAVVLLKRDMKSAHLLPEHIFD 347

  Fly   320 GNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDGAIYVFINKGSFTFEERIIRSPAGS 384
            |......|||.|...|||.||..|::|.||.|..|:....||:||::|:.......:.||.....
Human   348 GEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTK 412

  Fly   385 GGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIYLGSENGLRDPPSQCLDAPSQQPSKYGSY 449
            ...||..:..|||||:|||.|:|||||:...|.||||.||.||:...|:|.|        |..|.
Human   413 DSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVL--------KGISP 469

  Fly   450 MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHAIIKPKLQNVNPEEERVNIT--- 511
            .||:.::...|:|.|.:.|.|:|: .:::|.::|:.||:.|...|     .|.|  .|:::.
Human   470 YFGYSIAGNMDLDRNSYPDVAVGS-LSDSVTIFRSRPVINIQKTI-----TVTP--NRIDLRQKT 526

  Fly   512 -------VCYRLSSKSDSKAK-----------ALMEQELVIRIDIDTKSKIKLAVFDEEHGSQMS 558
                   :|.::.|..:..|.           ..:|.|...|     ||.:...|.....||:..
Human   527 ACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERR-----KSGLSSRVQFRNQGSEPK 586

  Fly   559 F----KAKAFHEEICSE--FQIEMDKRAKFTPI----ALEMQYELSKKIPNSGDFCEDCAVVDPA 613
            :    ..|...:::|.|  ..::.:.|.|..||    ::|:|...|::..||  ..|...:::..
Human   587 YTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNS--LPEVLPILNSD 649

  Fly   614 EPKFVTEYIT---FNTGCATD-VCVADLKIS---CINASS--------------TLVLGTTAVLR 657
            |||  |.:|.   ...||..| ||.::||:.   |....:              .|||.....:.
Human   650 EPK--TAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIA 712

  Fly   658 LTYNITN----------NGEFAYHPKF------SVTNSAGLSLAQVPG---NCKVNE--AVMVCD 701
            |...:||          :|:.|:..|.      ::|.||...|...|.   :|..|:  :...|:
Human   713 LEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCE 777

  Fly   702 LNHGQRMAKGDTDSLTIS-----FDVRQLRGRSLEIQAEVLSARDESNPENNK-------LTNVL 754
            |.:..:.....|..|.:|     ||...|   .:.::.|..|.:|...|...|       |.:|.
Human   778 LGNPFKRNSNVTFYLVLSTTEVTFDTPDL---DINLKLETTSNQDNLAPITAKAKVVIELLLSVS 839

  Fly   755 SLREKADIYVSGVQTNDHVVLKESPYTAEVVNYYEIKSHGPSTLENL-TVSLYIPVAYKTPDSTN 818
            .:.:.:.:|..|....:..:..|....:.:...:.:.:.| ..|.|| |.:|.|....:..:...
Human   840 GVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLG-KPLTNLGTATLNIQWPKEISNGKW 903

  Fly   819 VKHIVTSSPKIQSKYAHK--------IMPINFIDQNNALANNFAIDHDQSTLLFSATPQHENVGN 875
            :.::|    |::||...|        |..:|..:.:|:.... .|...|
Human   904 LLYLV----KVESKGLEKVTCEPQKEINSLNLTESHNSRKKR-EITEKQ---------------- 947

  Fly   876 LSGIVEQNPSISLLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKP-----EELMNMTVS 935
                ::.|...||..|    .....||| ..||. ||.:...| .||..|.     ..|.|.|..
Human   948 ----IDDNRKFSLFAE----RKYQTLNC-SVNVN-CVNIRCPL-RGLDSKASLILRSRLWNSTFL 1001

  Fly   936 FTVNLKDADDIWEYFVIQTDLKVHKIGDPTLSSFTIEKKIESNVICKHAEIAIWKIIVSVIVGIL 1000
            ...:..:..||.....|........|..|...:........|..:.:::.:..|.|:|:::.|||
Human  1002 EEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQVRVTVFPSKTVAQYSGVPWWIILVAILAGIL 1066

  Fly  1001 VFSAATYALYKRGFFKRAIKDD 1022
            :.:...:.|:|.|||||:..||
Human  1067 MLALLVFILWKCGFFKRSRYDD 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	29/72 (40%)
		Int_alpha	384..434	CDD:214549	26/49 (53%)
		Int_alpha	447..>492	CDD:214549	14/44 (32%)
		Integrin_alpha2	486..808	CDD:462478	84/407 (21%)
ITGA6	NP_001381857.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	30..95		17/70 (24%)
		Int_alpha	40..100	CDD:214549	17/61 (28%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	101..166		19/72 (26%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	176..229		15/52 (29%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	283..339		15/72 (21%)
		Int_alpha	293..345	CDD:214549	13/53 (25%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	340..402		23/61 (38%)
		Int_alpha	353..406	CDD:214549	20/52 (38%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	403..458		27/54 (50%)
		Int_alpha	413..464	CDD:214549	27/50 (54%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	459..518		21/74 (28%)
		Int_alpha	470..>493	CDD:214549	7/22 (32%)
		Integrin_alpha2	504..978	CDD:462478	106/524 (20%)
		Interaction with HPS5	1077..1083		4/5 (80%)
		GFFKR motif	1079..1083		3/3 (100%)