DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ItgaPS4 and Itga3

DIOPT Version :9

Sequence 1:	NP_611025.2	Gene:	ItgaPS4 / 36693	FlyBaseID:	FBgn0034005	Length:	1069	Species:	Drosophila melanogaster
Sequence 2:	NP_001359143.1	Gene:	Itga3 / 360606	RGDID:	1310333	Length:	1067	Species:	Rattus norvegicus

Alignment Length:	1122	Identity:	259/1122 - (23%)
Similarity:	436/1122 - (38%)	Gaps:	296/1122 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SYFGFSLVIREKS-------IMVAAPRANSSLEAQRNISEPGVIFRCYFES-GNNCSPYNIDTKG 97
            |.||:|:.:..::       ::..|||..:..:...|  ..|.::.|...: .|:|...:|..|.
  Rat    50 SLFGYSVALHRQTERQQRYLLLAGAPRDLAVDDDYTN--RTGAVYLCPLTALKNDCERMDISEKS 112

  Fly    98 NYKGMPNDGLLTAKNKDFRWLGGAMDGGTRDSDKFLVCAPRF------------------YSINN 144
            :    |:..::     :..|||..: .....:.:.||||.|:                  |...|
  Rat   113 D----PDHHII-----EDMWLGVTV-ASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVGKCYVRGN 167

  Fly   145 E---------NDYNNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLIPYYSMGELGL 200
            :         ..|:|.||.         .:|:.::.                      .|.:||.
  Rat   168 DLQLDPGDDWQTYHNEMCN---------SNTDYLQT----------------------GMCQLGT 201

  Fly   201 SAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRGMNTNRKCNECNPEPKNFGQEE 265
            |...:.:.  :..||||...|||:.::.|.                            |::...|
  Rat   202 SGGFTQNT--VYFGAPGAYNWKGNSYMIQR----------------------------KDWDLSE 236

  Fly   266 FS----------YFGYAVSSGYFDSSNL--STVLYVATAPRGNNQFGEAYIFDIYEDS---IYKY 315
            :|          |.||.:..|   |:.|  |.:..|..|||..:.   ..:|.:.::|   :.:.
  Rat   237 YSYRGSEDQGNLYIGYTMQVG---SAILHPSEITLVTGAPRHQHM---GAVFLLKQESGGDLQRR 295

  Fly   316 HEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYALRNSYDDGAIYVFINKGSFTFEER---I 377
            ...:|...|.|||.::...|||.||..|:::.||.|..|.....||:|||:|:...:|.::   :
  Rat   296 QVLKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAVYVFMNQAGTSFPDQPSLL 360

  Fly   378 IRSPAGSGGRFGTTLSRIGDINKDGYNDVAVGAPFAGNGSVFIYLGSENGLRDPPSQ-----CLD 437
            :..|:.|.  ||.:::.|||||:||:.|:||||||.|.|.|:||..|..||...|.|     .|.
  Rat   361 LHGPSRSA--FGISVASIGDINQDGFQDIAVGAPFEGLGKVYIYHSSSGGLLKQPQQIIHGETLG 423

  Fly   438 APSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKI-H-------AII 494
            .|       |...||:.||...|:|.|.:.|..:|: .::.:.|.||.||:.| |       |::
  Rat   424 LP-------GLATFGYSLSGKMDVDENLYPDLLVGS-LSDHIVLLRARPVINILHRTLVARPAVL 480

  Fly   495 KPKLQNV-----------------NPEEERVNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKS 542
            .|.|..|                 ||...| |||:.|.:.:..|.:...|            ..:
  Rat   481 DPSLCTVTSCVQVELCFAYNQSAGNPNYRR-NITLAYTVEADRDRRPPRL------------RFA 532

  Fly   543 KIKLAVFDEEHGSQMSFKAKAFHEEICSEFQ-IEMDK-RAKFTPIALEMQYELSKKIPNSGDF-- 603
            :.:.:||   ||   .|.....|   |...: :.||. |.|..||.:.|.|.|..::|:....
  Rat   533 RSQSSVF---HG---FFSMPETH---CQTLELLLMDNVRDKLRPIVITMNYSLPLRMPDRLKLGL 588

  Fly   604 --CEDCAVVDPAEPKFVTEYITFNTGCATD-VCVADLKISCINASSTL-------VLGTTAVLRL 658
              .:...|::.|:.......:.|...|..| .|.::|::.....|..|       ....|..|.|
  Rat   589 RSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSNLQMRAAFVSEQLQPLSRLQYSRDTKKLFL 653

  Fly   659 TYNITNN------GEFAYHPKFSVTNSAGLSLAQV--PGNCKVNEAVMVCDLNH----GQRMAKG 711
            :.|:||:      ||.|:....::..|:.|.|:.|  .|.|:.||...||:|.:    .|||
  Rat   654 SINVTNSPSRQRAGEDAHEALLTLEVSSALLLSSVRPAGTCQANETNTVCELGNPFKRNQRM--- 715

  Fly   712 DTDSLTISFDVR--QLRGRSLEIQAEVLSARDESNPENNKLT---------NVLSLREKADIYVS 765
               .|.|:|:|.  .|..|.|....::.::..:.|.:...||         ::..:..:...:.|
  Rat   716 ---ELLIAFEVTGVTLHTRDLRAHLQLSTSSHQDNLQPMFLTLQVDYTLQASLSLMNHRLQSFFS 777

  Fly   766 GVQTNDHVV--LKE--SPYTAEVVNYYEIK--SHGPSTLENLTVSLYIPVAYKTPDSTNVKHIV- 823
            |....:..:  :|:  ||...|    :::.  ..|.:.|..|.:.|..|.     :.||.|.::
  Rat   778 GTVMGEAAMKTVKDVGSPLKYE----FQVSPVGDGLAALGTLVLGLEWPY-----EVTNGKWLLY 833

  Fly   824 TSSPKIQSKYAHKIMPI-NFIDQNNALANNFAIDHDQSTLLFSATPQHENVGNLSGIVEQNPSIS 887
            .:...|.|..:....|. |.::..|...::..:.        ..:||... ..|....:|.|...
  Rat   834 PTEITIHSNGSWPCQPHGNLVNPLNLTLSDPGVK--------PLSPQRRR-RQLDPGGDQGPPPV 889

  Fly   888 LLNEDLPVNNTLVLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTV-------SFTVNLKDAD- 944
            .|.......:..||.|.:.... ||.:|..|.:.     ..:.|:||       :|..:.||.|
  Rat   890 TLAAAKKAKSETVLTCSNGRAR-CVWLECPLPDA-----SNITNVTVKARVWNSTFIEDYKDFDR 948

  Fly   945 ---DIWEYFVIQTDLKVHKIGDPTLSS------FTIEKKIESNVICK-HAEIAIWKIIVSVIVGI 999
               |.|....::|.:       ||::.      |:::  |:|.::.: .|||.:|.::|:|..|:
  Rat   949 VRVDGWATLFLRTSI-------PTINMENKTTWFSVD--IDSELVEELPAEIELWLVLVAVGAGL 1004

  Fly  1000 LVFSAATYALYKRGFFK 1016
            |:.......|:|..|||
  Rat  1005 LLLGLIIILLWKCDFFK 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ItgaPS4	NP_611025.2	VCBS	335..408	CDD:290251	29/75 (39%)
		Int_alpha	384..434	CDD:214549	26/49 (53%)
		Int_alpha	447..>492	CDD:214549	17/52 (33%)
		Integrin_alpha2	484..808	CDD:285619	87/391 (22%)
Itga3	NP_001359143.1	Int_alpha	48..108	CDD:214549	12/59 (20%)
		Int_alpha	304..352	CDD:214549	20/47 (43%)
		Int_alpha	367..417	CDD:214549	27/51 (53%)
		Integrin_alpha2	462..917	CDD:369878	107/501 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840